Nutritional consequences of celiac disease and the gluten-free diet

Expert Review of Gastroenterology and Hepatology

Volumn 8, Issue 2, 2014, Pages 123-129

  Theethira, Thimmaiah G ^a   Dennis, Melinda ^a   Leffler, Daniel A ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Celiac Disease; Gluten Free Diet; Macro And Micronutrients; Malabsorption; Nutritional Deficiency

Indexed keywords

CALCIUM; CYANOCOBALAMIN; FOLIC ACID; IRON; MINERAL; RETINOL; TRACE ELEMENT; VITAMIN D;

ARTICLE; BODY MASS; CALCIUM DEFICIENCY; CELIAC DISEASE; CYANOCOBALAMIN DEFICIENCY; DIETARY FIBER; DIETARY INTAKE; DISEASE ASSOCIATION; FOLIC ACID DEFICIENCY; GLUTEN FREE DIET; HUMAN; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MALNUTRITION; MINERAL DEFICIENCY; NUTRITIONAL COUNSELING; NUTRITIONAL DEFICIENCY; NUTRITIONAL STATUS; PATIENT MONITORING; RETINOL DEFICIENCY; VITAMIN D DEFICIENCY; VITAMIN INTAKE;

ANEMIA, IRON-DEFICIENCY; CELIAC DISEASE; DIET, GLUTEN-FREE; FOLIC ACID DEFICIENCY; HUMANS; NUTRITIONAL STATUS; TREATMENT OUTCOME; VITAMIN B 12 DEFICIENCY; VITAMIN D DEFICIENCY;

EID: 84893089547     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2014.876360     Document Type: Article

References (65)

1. Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013;62(1):43-52
2. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology 1992;102(1):330-54
3. Garcia-Manzanares A, Lucendo AJ. Nutritional and dietary aspects of celiac disease. Nutr Clin Pract 2011;26(2):163-73
4. Hollen E, Hogberg L, Stenhammar L, et al. Antibodies to oat prolamines (avenins) in children with coeliac disease. Scand J Gastroenterol 2003;38(7):742-6
5. Richman E. The safety of oats in the dietary treatment of coeliac disease. Proc Nutr Soc 2012;71(4):534-7
6. Sey MS, Parfitt J, Gregor J. Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN J Parenter Enteral Nutr 2011;35(4):459-64
7. Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357(17):1731-43
8. Kinsey L, Burden ST, Bannerman E. A dietary survey to determine if patients with coeliac disease are meeting current healthy eating guidelines and how their diet compares to that of the British general population. Eur J Clin Nutr 2008;62(11):1333-42
9. Bardella MT, Fredella C, Prampolini L, et al. Body composition and dietary intakes in adult celiac disease patients consuming a strict gluten-free diet. Am J Clin Nutr 2000;72(4):937-9
10. Thompson T. Folate, iron, and dietary fiber contents of the gluten-free diet. J Am Diet Assoc 2000;100(11):1389-96
11. Thompson T. Thiamin, riboflavin, and niacin contents of the gluten-free diet: is there cause for concern? J Am Diet Assoc 1999;99(7):858-62
12. Barton SH, Kelly DG, Murray JA. Nutritional deficiencies in celiac disease. Gastroenterol Clin North Am 2007;36(1): 93-108
13. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001;120(3):636-51
14. Grisolano SW, Oxentenko AS, Murray JA, et al. The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia. J Clin Gastroenterol 2004;38(9): 756-60
15. Hershko C, Patz J. Ironing out the mechanism of anemia in celiac disease. Haematologica 2008;93(12):1761-5
16. Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J 2011; 434(3):365-81
17. Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol 2001;96(3):745-50
18. Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood 2007;109(2):412-21
19. Tikkakoski S, Savilahti E, Kolho KL. Undiagnosed coeliac disease and nutritional deficiencies in adults screened in primary health care. Scand J Gastroenterol 2007; 42(1):60-5
20. Bode S, Gudmand-Hoyer E. Symptoms and haematologic features in consecutive adult coeliac patients. Scand J Gastroenterol 1996;31(1):54-60
21. Rajan S, Wallace JI, Brodkin KI, et al. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. J Am Geriatr Soc 2002;50(11): 1789-95
22. Bondarenko VM, Lykova EA, Matsulevich TV. Microecological aspects of small intestinal bacterial overgrowth syndrome. Zh Mikrobiol Epidemiol Immunobiol 2006;(6):57-63
23. Chakravarthi SD, Jain K, Kochhar R, et al. Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients. Indian J Gastroenterol 2012;31(4):165-70
24. Lerner A, Shapira Y, Agmon-Levin N, et al. The clinical significance of 25OH-Vitamin D status in celiac disease. Clin Rev Allergy Immunol 2012;42(3):322-30
25. Corazza GR, Di Stefano M, Maurino E, Bai JC. Bones in coeliac disease: diagnosis and treatment. Best Pract Res Clin Gastroenterol 2005;19(3):453-65
26. Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int 2005;16(7):713-16
27. Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, et al. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 2013;5(10):3975-92
28. Kemppainen TA, Kosma VM, Janatuinen EK, et al. Nutritional status of newly diagnosed celiac disease patients before and after the institution of a celiac disease diet-Association with the grade of mucosal villous atrophy. Am J Clin Nutr 1998;67(3):482-7
29. See J, Murray JA. Gluten-free diet: the medical and nutrition management of celiac disease. Nutr Clin Pract 2006;21(1):1-15
30. Reinken L, Zieglauer H. Vitamin B-6 absorption in children with acute celiac disease and in control subjects. J Nutr 1978;108(10):1562-5
31. Reinken L, Zieglauer H, Berger H. Vitamin B6 nutriture of children with acute celiac disease, celiac disease in remission, and of children with normal duodenal mucosa. Am J Clin Nutr 1976;29(7):750-3
32. Haines ML, Anderson RP, Gibson PR. Systematic review: the evidence base for long-term management of coeliac disease. Aliment Pharmacol Ther 2008;28(9): 1042-66
33. Altuntas B, Filik B, Ensari A, et al. Can zinc deficiency be used as a marker for the diagnosis of celiac disease in Turkish children with short stature? Pediatr Int 2000;42(6):682-4
34. Tran CD, Katsikeros R, Manton N, et al. Zinc homeostasis and gut function in children with celiac disease. Am J Clin Nutr 2011;94(4):1026-32
35. Singhal N, Alam S, Sherwani R, Musarrat J. Serum zinc levels in celiac disease. Indian Pediatr 2008;45(4):319-21
36. Halfdanarson TR, Kumar N, Hogan WJ, Murray JA. Copper deficiency in celiac disease. J Clin Gastroenterol 2009;43(2): 162-4
37. Stazi AV, Trinti B. Selenium deficiency in celiac disease: risk of autoimmune thyroid diseases. Minerva Med 2008;99(6):643-53
38. Cheng J, Brar PS, Lee AR, Green PH. Body mass index in celiac disease: beneficial effect of a gluten-free diet. J Clin Gastroenterol 2010;44(4):267-71
39. Valletta E, Fornaro M, Cipolli M, et al. Celiac disease and obesity: need for nutritional follow-up after diagnosis. Eur J Clin Nutr 2010;64(11):1371-2
40. Jamma S, Rubio-Tapia A, Kelly CP, et al. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010;8(7):587-90
41. Malandrino N, Capristo E, Farnetti S, et al. Metabolic and nutritional features in adult celiac patients. Dig Dis 2008;26(2):128-33
42. Rubio-Tapia A, Hill ID, Kelly CP, American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 2013;108(5):656-76; quiz 677
43. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006;131(6):1981-2002
44. Hallert C, Grant C, Grehn S, et al. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years. Aliment Pharmacol Ther 2002;16(7):1333-9
45. Wild D, Robins GG, Burley VJ, Howdle PD. Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet. Aliment Pharmacol Ther 2010;32(4):573-81
46. Thompson T, Dennis M, Higgins LA, et al. Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods? J Hum Nutr Diet 2005;18(3): 163-9
47. Hopman EG, le Cessie S, von Blomberg BM, Mearin ML. Nutritional management of the gluten-free diet in young people with celiac disease in The Netherlands. J Pediatr Gastroenterol Nutr 2006;43(1):102-8
48. Ohlund K, Olsson C, Hernell O, Ohlund I. Dietary shortcomings in children on a gluten-free diet. J Hum Nutr Diet 2010; 23(3):294-300
49. Martin J, Geisel T, Maresch C, et al. Inadequate nutrient intake in patients with celiac disease: results from a German dietary survey. Digestion 2013;87(4):240-6
50. Mariani P, Viti MG, Montuori M, et al. The gluten-free diet: a nutritional risk factor for adolescents with celiac disease? J Pediatr Gastroenterol Nutr 1998;27(5):519-23
51. Lee AR, Ng DL, Dave E, et al. The effect of substituting alternative grains in the diet on the nutritional profile of the gluten-free diet. J Hum Nutr Diet 2009;22(4):359-63
52. Becker W. New Nordic nutrition recommendations 2004. Physical activity as important as good nourishing food. Lakartidningen 2005;102(39):2757-8; 2760-2
53. Shepherd SJ, Gibson PR. Nutritional inadequacies of the gluten-free diet in both recently-diagnosed and long-term patients with coeliac disease. J Hum Nutr Diet 2013;26(4):349-58
54. Saturni L, Ferretti G, Bacchetti T. The gluten-free diet: safety and nutritional quality. Nutrients 2010;2(1):16-34
55. Thompson T. Folate, iron, and dietary fiber contents of the gluten-free diet. J Am Diet Assoc 2000;100(11):1389-96
56. Hallert C, Granno C, Grant C, et al. Quality of life of adult coeliac patients treated for 10 years. Scand J Gastroenterol 1998;33(9):933-8
57. Nygard O, Vollset SE, Refsum H, et al. Total homocysteine and cardiovascular disease. J Intern Med 1999;246(5):425-54
58. Hallert C, Svensson M, Tholstrup J, Hultberg B. Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet. Aliment Pharmacol Ther 2009;29(8):811-16
59. Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients 2011;3(3):370-84
60. Subar AF, Krebs-Smith SM, Cook A, Kahle LL. Dietary sources of nutrients among US adults, 1989 to 1991. J Am Diet Assoc 1998;98(5):537-47
61. Ukkola A, Maki M, Kurppa K, et al. Changes in body mass index on a gluten-free diet in coeliac disease: a nationwide study. Eur J Intern Med 2012; 23(4):384-8
62. Kabbani TA, Goldberg A, Kelly CP, et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther 2012;35(6): 723-9
63. Kabbani TA, Kelly CP, Betensky RA, et al. Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. Gastroenterology 2013;144(5):912-917.e1
64. Sonti R, Green PH. Celiac disease: obesity in celiac disease. Nat Rev Gastroenterol Hepatol 2012;9(5):247-8 65.
65. NIH Consensus development conference on celiac disease. NIH Consens State Sci Statements 2004;21(1):1-23