ACG clinical guidelines: Diagnosis and management of celiac disease

American Journal of Gastroenterology

Volumn 108, Issue 5, 2013, Pages 656-676

  Rubio Tapia, Alberto ^a   Hill, Ivor D ^b   Kelly, Ciarán P ^c   Calderwood, Audrey H ^d   Murray, Joseph A ^a  

^a MAYO CLINIC   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AZATHIOPRINE; BUDESONIDE; CLADRIBINE; CORTICOSTEROID; CYCLOSPORIN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MERCAPTOPURINE; METHOTREXATE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ABDOMINAL PAIN; AMENORRHEA; ARTICLE; BARLEY; BLOATING; BLOOD CELL COUNT; BONE DENSITY; CAPSULE ENDOSCOPY; CELIAC DISEASE; CHRONIC FATIGUE SYNDROME; DIAGNOSTIC ACCURACY; DIARRHEA; DISEASE SEVERITY; DUODENUM BIOPSY; DUODENUM MUCOSA; DYSPEPSIA; FLATULENCE; FOLLOW UP; GLUTEN FREE DIET; HISTOPATHOLOGY; HUMAN; IMMUNOGLOBULIN DEFICIENCY; INFLAMMATION; INTESTINE VILLUS ATROPHY; IRON DEFICIENCY ANEMIA; IRRITABLE COLON; MICROSCOPIC COLITIS; PATIENT EDUCATION; PATIENT MONITORING; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; RISK REDUCTION; RYE; SCREENING TEST; SEROLOGY; SKIN DISEASE; SMALL INTESTINE; SMALL INTESTINE MUCOSA; STEATORRHEA; WEIGHT REDUCTION; WHEAT;

ABDOMINAL PAIN; ANTIBODIES; ATROPHY; CELIAC DISEASE; CEREALS; CLINICAL TRIALS AS TOPIC; DIAGNOSIS, DIFFERENTIAL; DIARRHEA; DIET, GLUTEN-FREE; ENDOSCOPY, GASTROINTESTINAL; EVIDENCE-BASED MEDICINE; FLATULENCE; GENETIC PREDISPOSITION TO DISEASE; GLIADIN; GLUTENS; GTP-BINDING PROTEINS; HLA-DQ ANTIGENS; HUMANS; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; INTESTINE, SMALL; PATIENT EDUCATION AS TOPIC; SENSITIVITY AND SPECIFICITY; STEATORRHEA; TRANSGLUTAMINASES; WEIGHT LOSS;

EID: 84877576026     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2013.79     Document Type: Article

References (264)

1. Atkins D, Best D, Briss PA et al. Grading quality of evidence and strength of recommendations . BMJ 2004; 328: 1490.
2. Di Sabatino A, Corazza GR . Coeliac disease . Lancet 2009; 373: 1480-93.
3. Reilly NR, Fasano A, Green PH . Presentation of celiac disease . Gastrointest Endosc Clin N Am 2012; 22: 613-21.
4. Murray JA, Watson T, Clearman B et al. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease . Am J Clin Nutr 2004; 79 : 669-73.
5. Rostom A, Murray JA, Kagnoff MF . American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease . Gastroenterology 2006; 131: 1981-2002.
6. Rubio-Tapia A, Murray JA . Classifi cation and management of refractory coeliac disease . Gut 2010; 59: 547-57.
7. Catassi C, Kryszak D, Louis-Jacques O et al. Detection of celiac disease in primary care: a multicenter case-fi nding study in North America. Am J Gastroenterol 2007; 102: 1454-60.
8. Lebwohl B, Rubio-Tapia A, Assiri A et al. Diagnosis of celiac disease. Gastrointest Endosc Clin N Am 2012; 22: 661-77.
9. van der Windt DA, Jellema P, Mulder CJ et al. Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review. JAMA 2010; 303: 1738-46.
10. Ford AC, Chey WD, Talley NJ et al. Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis . Arch Intern Med 2009; 169: 651-8.
11. Aziz I, Sanders DS . Th e irritable bowel syndrome-celiac disease connection. Gastrointest Endosc Clin N Am 2012; 22: 623-37.
12. Ford AC, Ching E, Moayyedi P . Meta-analysis: yield of diagnostic tests for coeliac disease in dyspepsia . Aliment Pharmacol Th er 2009; 30: 28-36.
13. Lacy BE, Talley NJ, Locke GR III et al. Review article: current treatment options and management of functional dyspepsia . Aliment Pharmacol Th er 2012; 36: 3-15.
14. Norstrom F, Sandstrom O, Lindholm L et al. A gluten-free diet Effectively reduces symptoms and health care consumption in a Swedish celiac disease population . BMC Gastroenterol 2012; 12: 125.
15. Talley NJ, Vakil NB, Moayyedi P . American gastroenterological association technical review on the evaluation of dyspepsia . Gastroenterology 2005; 129: 1756-80.
16. Rubio-Tapia A, Van Dyke CT, Lahr BD et al. Predictors of family risk for celiac disease: a population-based study . Clin Gastroenterol Hepatol 2008; 6: 983-7.
17. Murray JA . Celiac disease in patients with an aff ected member, type 1 diabetes, iron-defi ciency, or osteoporosis? Gastroenterology 2005; 128 : S52-6.
18. Fasano A, Berti I, Gerarduzzi T et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study . Arch Intern Med 2003; 163: 286-92.
19. Book L, Zone JJ, Neuhausen SL . Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families . Am J Gastroenterol 2003; 98: 377-81.
20. Kinos S, Kurppa K, Ukkola A et al. Burden of illness in screen-detected children with celiac disease and their families . J Pediatr Gastroenterol Nutr 2012; 55: 412-6.
21. Vilppula A, Kaukinen K, Luostarinen L et al. Clinical benefi t of gluten-free diet in screen-detected older celiac disease patients . BMC Gastroenterol 2011; 11: 136.
22. Paavola A, Kurppa K, Ukkola A et al. Gastrointestinal symptoms and quality of life in screen-detected celiac disease . Dig Liver Dis 2012; 44: 814-8.
23. Ukkola A, Maki M, Kurppa K et al. Diet improves perception of health and well-being in symptomatic, but not asymptomatic, patients with celiac disease . Clin Gastroenterol Hepatol 2011; 9: 118-23.
24. Kamath PS . Clinical approach to the patient with abnormal liver test results . Mayo Clin Proc 1996; 71: 1089-94; quiz 1094-5.
25. Korpimaki S, Kaukinen K, Collin P et al. Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and oft en subclinical fi nding. Am J Gastroenterol 2011; 106: 1689-96.
26. Rubio-Tapia A, Murray JA . Th e liver in celiac disease . Hepatology 2007; 46: 1650-8.
27. Sainsbury A, Sanders DS, Ford AC . Meta-analysis: coeliac disease and hypertransaminasaemia . Aliment Pharmacol Th er 2012; 34: 33-40.
28. Kaukinen K, Halme L, Collin P et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure . Gastroenterology 2002; 122: 881-8.
29. Rubio-Tapia A, Abdulkarim AS, Wiesner RH et al. Celiac disease autoantibodies in severe autoimmune liver disease and the Effect of liver transplantation . Liver Int 2008; 28: 467-76.
30. Dube C, Rostom A, Sy R et al. Th e prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology 2005; 128: S57-67.
31. Gillett PM, Gillett HR, Israel DM et al. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase . Can J Gastroenterol 2001; 15: 297-301.
32. Holmes GK . Screening for coeliac disease in type 1 diabetes . Arch Dis Child 2002; 87: 495-8.
33. Amin R, Murphy N, Edge J et al. A longitudinal study of the Effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease . Diabetes Care 2002; 25: 1117-22.
34. Simmons JH, Klingensmith GJ, McFann K et al. Celiac autoimmunity in children with type 1 diabetes: a two-year follow-up . J Pediatr 2011; 158: 276-81 e1.
35. Rewers M, Eisenbarth GS . Autoimmunity: celiac disease in T1DM-the need to look long term . Nat Rev Endocrinol 2011; 8: 5-6, 7-8.
36. Mollazadegan K, Kugelberg M, Montgomery SM et al. A population-based study of the risk of diabetic retinopathy in patients with type 1 diabetes and celiac disease . Diabetes Care 2013; 36: 316-21.
37. Leeds JS, Hopper AD, Hadjivassiliou M et al. High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease . Diabetes Care 2011; 34: 2158-63.
38. Hummel S, Hummel M, Banholzer J et al. Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding . Diabetologia 2007; 50: 390-4.
39. Hummel M, Bonifacio E, Stern M et al. Development of celiac diseaseassociated antibodies in off spring of parents with type I diabetes. Diabetologia 2000; 43: 1005-11.
40. Jaeger C, Hatziagelaki E, Petzoldt R et al. Comparative analysis of organspecifi c autoantibodies and celiac disease-associated antibodies in type 1 diabetic patients, their fi rst-degree relatives, and healthy control subjects. Diabetes Care 2001; 24: 27-32.
41. Lewis NR, Scott BB . Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease . Aliment Pharmacol Th er 2010; 31: 73-81.
42. Li M, Yu L, Tiberti C et al. A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease . Am J Gastroenterol 2009; 104: 154-63.
43. Leffler DA, Schuppan D . Update on serologic testing in celiac disease. Am J Gastroenterol 2010; 105: 2520-4.
44. Klapp G, Masip E, Bolonio M et al. Coeliac disease: the new proposed ESPGHAN diagnostic criteria do work well in a selected population. J Pediatr Gastroenterol Nutr 2013; 56: 251-6.
45. Cranney A, Rostom A, Sy R et al. Consequences of testing for celiac disease. Gastroenterology 2005; 128: S109-20.
46. Harewood GC, Murray JA . Diagnostic approach to a patient with suspected celiac disease: a cost analysis . Dig Dis Sci 2001; 46: 2510-4.
47. Jabri B, Sollid LM . Mechanisms of disease: immunopathogenesis of celiac disease . Nat Clin Pract Gastroenterol Hepatol 2006; 3: 516-25.
48. Dieterich W, Ehnis T, Bauer M et al. Identifi cation of tissue transglutaminase as the autoantigen of celiac disease . Nat Med 1997; 3: 797-801.
49. Conrad K, Roggenbuck D, Ittenson A et al. A new dot immunoassay for simultaneous detection of celiac specifi c antibodies and IgA-defi ciency. Clin Chem Lab Med 2012; 50: 337-43.
50. McGowan KE, Lyon ME, Butzner JD . Celiac disease and IgA defi ciency: complications of serological testing approaches encountered in the clinic. Clin Chem 2008; 54: 1203-9.
51. Villalta D, Alessio MG, Tampoia M et al. Testing for IgG class antibodies in celiac disease patients with selective IgA defi ciency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG antigliadin and 1 IgG anti-deaminated gliadin peptide antibody assays . Clin Chim Acta 2007; 382: 95-9.
52. Villalta D, Tonutti E, Prause C et al. IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA defi ciency. Clin Chem 2010; 56: 464-8.
53. Lowbeer C, Wallinder H . Undetectable anti-tissue transglutaminase IgA antibody measured with EliA Celikey indicates selective IgA defi ciency. Clin Chim Acta 2010; 411: 612.
54. Sinclair D, Saas M, Turk A et al. Do we need to measure total serum IgA to exclude IgA defi ciency in coeliac disease? J Clin Pathol 2006; 59: 736-9.
55. Malamut G, Verkarre V, Suarez F et al. Th e enteropathy associated with common variable immunodefi ciency: the delineated frontiers with celiac disease . Am J Gastroenterol 2010; 105: 2262-75.
56. Casella S, Zanini B, Lanzarotto F et al. Celiac disease in elderly adults: clinical, serological, and histological characteristics and the Effect of a gluten-free diet . J Am Geriatr Soc 2012; 60: 1064-9.
57. Rashtak S, Ettore MW, Homburger HA et al. Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease . Clin Gastroenterol Hepatol 2008; 6: 426-32; quiz 370.
58. Zanini B, Lanzarotto F, Mora A et al. Five year time course of celiac disease serology during gluten free diet: results of a community based " CD-Watch " program . Dig Liver Dis 2010; 42: 865-70.
59. Rashtak S, Ettore MW, Homburger HA et al. Combination testing for antibodies in the diagnosis of coeliac disease: comparison of multiplex immunoassay and ELISA methods . Aliment Pharmacol Th er 2008; 28: 805-13.
60. Burgin-Wolff A, Gaze H, Hadziselimovic F et al. Antigliadin and antiendomysium antibody determination for coeliac disease . Arch Dis Child 1991; 66: 941-7.
61. Lagerqvist C, Dahlbom I, Hansson T et al. Antigliadin immunoglobulin A best in fi nding celiac disease in children younger than 18 months of age. J Pediatr Gastroenterol Nutr 2008; 47: 428-35.
62. Aberg AK, Olcen P . Serologic screening for celiac disease in children: a comparison between established assays and tests with deamidated gliadin-derived peptides plus conjugates for both IgA and IgG antibodies. Apmis 2009; 117: 808-13.
63. Basso D, Guariso G, Fogar P et al. Antibodies against synthetic deamidated gliadin peptides for celiac disease diagnosis and follow-up in children. Clin Chem 2009; 55: 150-7.
64. Hill ID . What are the sensitivity and specifi city of serologic tests for celiac disease? Do sensitivity and specifi city vary in diff erent populations? Gastroenterology 2005; 128: S25-32.
65. Rostom A, Dube C, Cranney A et al. Th e diagnostic accuracy of serologic tests for celiac disease: a systematic review . Gastroenterology 2005; 128: S38-46.
66. Giersiepen K, Lelgemann M, Stuhldreher N et al. Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report . J Pediatr Gastroenterol Nutr 2012; 54: 229-41.
67. O ' Leary C, Wieneke P, Buckley S et al. Celiac disease and irritable boweltype symptoms . Am J Gastroenterol 2002; 97: 1463-7.
68. Sainsbury A, Sanders DS, Ford AC . Prevalence of irritable bowel syndrometype symptoms in patients with celiac disease: a meta-analysis . Clin Gastroenterol Hepatol 2013; 11: 359-65.
69. Campanella J, Biagi F, Ilaria Bianchi P et al. Clinical response to gluten withdrawal is not an indicator of coeliac disease . Scand J Gastroenterol 2008; 43: 1311-4.
70. Biesiekierski JR, Newnham ED, Irving PM et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial . Am J Gastroenterol 2011; 106: 508-14 ; quiz 515.
71. Wahnschaffe U, Schulzke JD, Zeitz M et al. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome . Clin Gastroenterol Hepatol 2007; 5: 844-50; quiz 769.
72. Salmi TT, Collin P, Korponay-Szabo IR et al. Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits. Gut 2006; 55: 1746-53.
73. Rubio-Tapia A, Rahim MW, See JA et al. Mucosal recovery and mortality in adults with celiac disease aft er treatment with a gluten-free diet . Am J Gastroenterol 2010; 105: 1412-20.
74. Kaukinen K, Partanen J, Maki M et al. HLA-DQ typing in the diagnosis of celiac disease . Am J Gastroenterol 2002; 97: 695-9.
75. Shiner M . Small intestinal biopsy: diagnostic and research value . Proc R Soc Med 1959; 52: 10-4.
76. McNeish AS, Harms HK, Rey J et al. Th e diagnosis of coeliac disease. A commentary on the current practices of members of the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN) . Arch Dis Child 1979; 54: 783-6.
77. Guandalini S, Ventura A, Ansaldi N et al. Diagnosis of coeliac disease: time for a change? Arch Dis Child 1989; 64: 1320-4; discussion 1324-5.
78. Hadithi M, von Blomberg BM, Crusius JB et al. Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease . Ann Intern Med 2007; 147: 294-302.
79. Marsh MN . Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (' celiac sprue ') . Gastroenterology 1992; 102: 330-54.
80. Oberhuber G . Histopathology of celiac disease . Biomed Pharmacother 2000; 54: 368-72.
81. Corazza GR, Villanacci V, Zambelli C et al. Comparison of the interobserver reproducibility with diff erent histologic criteria used in celiac disease. Clin Gastroenterol Hepatol 2007; 5: 838-43.
82. Owens SR, Greenson JK . Th e pathology of malabsorption: current concepts . Histopathology 2007; 50: 64-82.
83. Yantiss RK, Odze RD . Optimal approach to obtaining mucosal biopsies for assessment of infl ammatory disorders of the gastrointestinal tract. Am J Gastroenterol 2009; 104: 774-83.
84. Husby S, Koletzko S, Korponay-Szabo IR et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease . J Pediatr Gastroenterol Nutr 2012; 54: 136-60.
85. Wakim-Fleming J, Pagadala MR, Lemyre MS et al. Diagnosis of celiac disease in adults based on serology test results, without small-bowel biopsy. Clin Gastroenterol Hepatol 2013 ( e-pub ahead of print ).
86. Klapp G, Masip E, Bolonio M et al. Coeliac disease: the new proposed ESPGHAN diagnostic criteria do work well in a selected population. J Pediatr Gastroenterol Nutr 2013; 56: 251-6.
87. Kurppa K, Salminiemi J, Ukkola A et al. Utility of the new ESPGHAN criteria for the diagnosis of celiac disease in at-risk groups . J Pediatr Gastroenterol Nutr 2012; 54: 387-91.
88. Swallow K, Wild G, Sargur R et al. Quality not quantity for transglutaminase antibody 2: the performance of an endomysial and tissue transglutaminase test in screening coeliac disease remains stable over time . Clin Exp Immunol 2013; 171: 100-6.
89. Ravelli A, Bolognini S, Gambarotti M et al. Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy . Am J Gastroenterol 2005; 100: 177-85.
90. Ravelli A, Villanacci V, Monfredini C et al. How patchy is patchy villous atrophy?: distribution pattern of histological lesions in the duodenum of children with celiac disease . Am J Gastroenterol 2010; 105: 2103-10.
91. Weir DC, Glickman JN, Roiff T et al. Variability of histopathological changes in childhood celiac disease . Am J Gastroenterol 2010; 105: 207-12.
92. Bonamico M, Mariani P, Thanasi E et al. Patchy villous atrophy of the duodenum in childhood celiac disease . J Pediatr Gastroenterol Nutr 2004; 38: 204-7.
93. Hopper AD, Cross SS, Sanders DS . Patchy villous atrophy in adult patients with suspected gluten-sensitive enteropathy: is a multiple duodenal biopsy strategy appropriate? Endoscopy 2008; 40: 219-24.
94. Lebwohl B, Kapel RC, Neugut AI et al. Adherence to biopsy guidelines increases celiac disease diagnosis . Gastrointest Endosc 2011; 74: 103-9.
95. Lebwohl B, Tennyson CA, Holub JL et al. Sex and racial disparities in duodenal biopsy to evaluate for celiac disease . Gastrointest Endosc 2012; 76: 779-85.
96. Evans KE, Aziz I, Cross SS et al. A prospective study of duodenal bulb biopsy in newly diagnosed and established adult celiac disease . Am J Gastroenterol 2011; 106: 1837-742.
97. Gonzalez S, Gupta A, Cheng J et al. Prospective study of the role of duodenal bulb biopsies in the diagnosis of celiac disease . Gastrointest Endosc 2010; 72: 758-65.
98. Bonamico M, Thanasi E, Mariani P et al. Duodenal bulb biopsies in celiac disease: a multicenter study . J Pediatr Gastroenterol Nutr 2008; 47: 618-22.
99. Kurien M, Evans KE, Hopper AD et al. Duodenal bulb biopsies for diagnosing adult celiac disease: is there an optimal biopsy site? Gastrointest Endosc 2012; 75: 1190-6.
100. Walker MM, Murray JA, Ronkainen J et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study . Gastroenterology 2010; 139: 112-9.
101. Jarvinen TT, Kaukinen K, Laurila K et al. Intraepithelial lymphocytes in celiac disease . Am J Gastroenterol 2003; 98: 1332-7.
102. Vande Voort JL, Murray JA, Lahr BD et al. Lymphocytic duodenosis and the spectrum of celiac disease . Am J Gastroenterol 2009; 104: 142-8.
103. Aziz I, Evans KE, Hopper AD et al. A prospective study into the aetiology of lymphocytic duodenosis . Aliment Pharmacol Th er 2010; 32: 1392-7.
104. Tuire I, Marja-Leena L, Teea S et al. Persistent duodenal intraepithelial lymphocytosis despite a long-term strict gluten-free diet in celiac disease. Am J Gastroenterol 2012; 107: 1563-9.
105. Shmidt E, Smyrk TC, Faubion WA et al. Duodenal intraepithelial lymphocytosis with normal villous architecture in pediatric patients, 2000-2009: Th e Mayo Clinic Experience . J Pediatr Gastroenterol Nutr 2013; 56: 51-5.
106. Kurppa K, Ashorn M, Iltanen S et al. Celiac disease without villous atrophy in children: a prospective study . J Pediatr 2010; 157: 373-80, 380 e1.
107. Kurppa K, Collin P, Viljamaa M et al. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study . Gastroenterology 2009; 136: 816-23.
108. Lundin KE, Gjertsen HA, Scott H et al. Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease . Hum Immunol 1994; 41: 24-7.
109. Paulsen G, Lundin KE, Gjertsen HA et al. HLA-DQ2-restricted T-cell recognition of gluten-derived peptides in celiac disease. Infl uence of amino acid substitutions in the membrane distal domain of DQ beta 1*0201. Hum Immunol 1995; 42: 145-53.
110. Kim CY, Quarsten H, Bergseng E et al. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease . Proc Natl Acad Sci USA 2004; 101: 4175-9.
111. Sollid LM, Markussen G, Ek J et al. Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer . J Exp Med 1989; 169: 345-50.
112. Sollid LM, Thorsby E . Th e primary association of celiac disease to a given HLA-DQ alpha/beta heterodimer explains the divergent HLA-DR associations observed in various Caucasian populations . Tissue Antigens 1990; 36: 136-7.
113. Karell K, Louka AS, Moodie SJ et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease . Hum Immunol 2003; 64: 469-77.
114. Wolters VM, Wijmenga C . Genetic background of celiac disease and its clinical implications . Am J Gastroenterol 2008; 103: 190-5.
115. Rubio-Tapia A, Kelly DG, Lahr BD et al. Clinical staging and survival in refractory celiac disease: a single center experience . Gastroenterology 2009; 136: 99-107; quiz 352-3.
116. Al-Toma A, Verbeek WH, Hadithi M et al. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience . Gut 2007 ; 56: 1373-8.
117. Book L, Hart A, Black J et al. Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study . Am J Med Genet 2001; 98: 70-4.
118. Wouters J, Weijerman ME, van Furth AM et al. Prospective human leukocyte antigen, endomysium immunoglobulin A antibodies, and transglutaminase antibodies testing for celiac disease in children with Down syndrome . J Pediatr 2009; 154: 239-42.
119. Iddan G, Meron G, Glukhovsky A et al. Wireless capsule endoscopy. Nature 2000; 405: 417.
120. Tennyson CA, Ciaccio EJ, Lewis SK . Video capsule endoscopy in celiac disease . Gastrointest Endosc Clin N Am 2012; 22: 747-58.
121. Chang MS, Rubin M, Lewis SK et al. Diagnosing celiac disease by video capsule endoscopy (VCE) when esophogastroduodenoscopy (EGD) and biopsy is unable to provide a diagnosis: a case series . BMC Gastroenterol 2012; 12: 90.
122. Rokkas T, Niv Y . Th e role of video capsule endoscopy in the diagnosis of celiac disease: a meta-analysis . Eur J Gastroenterol Hepatol 2012; 24: 303-8.
123. Murray JA, Rubio-Tapia A, Van Dyke CT et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment . Clin Gastroenterol Hepatol 2008; 6: 186-93 ; quiz 125.
124. Lidums I, Cummins AG, Teo E . Th e role of capsule endoscopy in suspected celiac disease patients with positive celiac serology . Dig Dis Sci 2011; 56: 499-505.
125. Barret M, Malamut G, Rahmi G et al. Diagnostic yield of capsule endoscopy in refractory celiac disease . Am J Gastroenterol 2012; 107: 1546-53.
126. Culliford A, Daly J, Diamond B et al. The value of wireless capsule endoscopy in patients with complicated celiac disease . Gastrointest Endosc 2005; 62: 55-61.
127. Atlas DS, Rubio-Tapia A, Van Dyke CT et al. Capsule endoscopy in nonresponsive celiac disease . Gastrointest Endosc 2011; 74: 1315-22.
128. Hadithi M, Al-toma A, Oudejans J et al. The value of double-balloon enteroscopy in patients with refractory celiac disease . Am J Gastroenterol 2007; 102: 987-96.
129. Van Weyenberg SJ, Meijerink MR, Jacobs MA et al. MR enteroclysis in refractory celiac disease: proposal and validation of a severity scoring system . Radiology 2011; 259: 151-61.
130. Tennyson CA, Semrad CE . Small bowel imaging in celiac disease. Gastrointest Endosc Clin N Am 2012; 22: 735-46.
131. Fordtran JS, Soergel KH, Ingelfinger FJ . Intestinal absorption of D-xylose in man . N Engl J Med 1962; 267: 274-9.
132. Craig RM, Ehrenpreis ED . D-xylose testing . J Clin Gastroenterol 1999; 29: 143-50.
133. Tveito K, Brunborg C, Bratlie J et al. Intestinal malabsorption of D-xylose: comparison of test modalities in patients with celiac disease . Scand J Gastroenterol 2010; 45: 1289-94.
134. Carroccio A, Iacono G, Montalto G et al. Immunologic and absorptive tests in celiac disease: can they replace intestinal biopsies? Scand J Gastroenterol 1993; 28: 673-6.
135. Heyman M, Abed J, Lebreton C et al. Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis . Gut 2012; 61: 1355-64.
136. Smecuol E, Bai JC, Vazquez H et al. Gastrointestinal permeability in celiac disease . Gastroenterology 1997; 112: 1129-36.
137. Juby LD, Rothwell J, Axon AT . Cellobiose/mannitol sugar test-a sensitive tubeless test for coeliac disease: results on 1010 unselected patients . Gut 1989; 30: 476-80.
138. Juby LD, Rothwell J, Axon AT . Lactulose/mannitol test: an ideal screen for celiac disease . Gastroenterology 1989; 96: 79-85.
139. La Seta F, Buccellato A, Albanese M et al. Radiology and adult celiac disease. Current indications of small bowel barium examinations . Radiol Med 2004; 108: 515-21.
140. Barlow JM, Johnson CD, Stephens DH . Celiac disease: how common is jejunoileal fold pattern reversal found at small-bowel follow-through? Am J Roentgenol 1996; 166: 575-7.
141. Weizman Z, Stringer DA, Durie PR . Radiologic manifestations of malabsorption: a nonspecifi c fi nding . Pediatrics 1984; 74: 530-3.
142. Bonamico M, Ferri M, Nenna R et al. Tissue transglutaminase autoantibody detection in human saliva: a powerful method for celiac disease screening . J Pediatr 2004; 144: 632-6.
143. Bonamico M, Nenna R, Luparia RP et al. Radioimmunological detection of anti-transglutaminase autoantibodies in human saliva: a useful test to monitor coeliac disease follow-up . Aliment Pharmacol Ther 2008; 28: 364-70.
144. Kappler M, Krauss-Etschmann S, Diehl V et al. Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study . BMJ 2006; 332: 213-4.
145. Ludvigsson JF, Leffler DA, Bai JC et al. The Oslo defi nitions for coeliac disease and related terms . Gut 2013; 62: 43-52.
146. Lundin KE, Alaedini A . Non-celiac gluten sensitivity . Gastrointest Endosc Clin N Am 2012; 22: 723-34.
147. Aziz I, Sanders DS . Emerging concepts: from coeliac disease to noncoeliac gluten sensitivity . Proc Nutr Soc 2012; 71: 576-80.
148. Carroccio A, Mansueto P, Iacono G et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity . Am J Gastroenterol 2012; 107: 1898-906.
149. Bao F, Green PH, Bhagat G . An update on celiac disease histopathology and the road ahead . Arch Pathol Lab Med 2012; 136: 735-45.
150. Nasr I, Leffler DA, Ciclitira PJ . Management of celiac disease . Gastrointest Endosc Clin N Am 2012; 22: 695-704.
151. Green PH, Cellier C . Celiac disease . N Engl J Med 2007; 357: 1731-43.
152. Leffler D, Schuppan D, Pallav K et al. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease . Gut 2012 [e-pub ahead of print[.
153. Lahdeaho ML, Maki M, Laurila K et al. Small-bowel mucosal changes and antibody responses aft er low-and moderate-dose gluten challenge in celiac disease . BMC Gastroenterol 2011; 11: 129.
154. Rujner J, Socha J, Romanczuk W et al. [Individual sensitivity of jejunal mucosa to small doses of gluten in coeliac disease] . Wiad Lek 2002; 55: 554-60.
155. Ansaldi N, Tavassoli K, Faussone D et al. Clinico-histological behavior of celiac patients aft er gluten load following the defi nitive diagnosis . Pediatr Med Chir 1988; 10: 3-6.
156. Akobeng AK, Thomas AG . Systematic review: tolerable amount of gluten for people with coeliac disease . Aliment Pharmacol Ther 2008; 27: 1044-52.
157. Ludvigsson JF . Mortality and malignancy in celiac disease . Gastrointest Endosc Clin NAm 2012; 22: 705-22.
158. West J, Logan RF, Smith CJ et al. Malignancy and mortality in people with coeliac disease: population based cohort study . BMJ 2004; 329: 716-9.
159. Askling J, Linet M, Gridley G et al. Cancer incidence in a populationbased cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis . Gastroenterology 2002; 123: 1428-35.
160. Corrao G, Corazza GR, Bagnardi V et al. Mortality in patients with coeliac disease and their relatives: a cohort study . Lancet 2001; 358: 356-61.
161. Bardella MT, Fredella C, Prampolini L et al. Body composition and dietary intakes in adult celiac disease patients consuming a strict gluten-free diet. Am J Clin Nutr 2000; 72: 937-9.
162. Barera G, Mora S, Brambilla P et al. Body composition in children with celiac disease and the Effects of a gluten-free diet: a prospective casecontrol study . Am J Clin Nutr 2000; 72: 71-5.
163. Rea F, Polito C, Marotta A et al. Restoration of body composition in celiac children aft er one year of gluten-free diet . J Pediatr Gastroenterol Nutr 1996; 23: 408-12.
164. Kemppainen T, Kroger H, Janatuinen E et al. Osteoporosis in adult patients with celiac disease . Bone 1999; 24: 249-55.
165. Meyer D, Stavropolous S, Diamond B et al. Osteoporosis in a North American adult population with celiac disease . Am J Gastroenterol 2001; 96: 112-9.
166. Kalayci AG, Kansu A, Girgin N et al. Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics 2001; 108: e89.
167. Sategna-Guidetti C, Grosso SB, Grosso S et al. The Effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients . Aliment Pharmacol Ther 2000; 14: 35-43.
168. Valdimarsson T, Lofman O, Toss G et al. Reversal of osteopenia with diet in adult coeliac disease . Gut 1996; 38: 322-7.
169. Bernstein CN, Leslie WD, Leboff MS . AGA technical review on osteoporosis in gastrointestinal diseases . Gastroenterology 2003; 124: 795-841.
170. Fickling WE, McFarlane XA, Bhalla AK et al. The clinical impact of metabolic bone disease in coeliac disease . Postgrad Med J 2001; 77: 33-6.
171. Vasquez H, Mazure R, Gonzalez D et al. Risk of fractures in celiac disease patients: a cross-sectional, case-control study . Am J Gastroenterol 2000; 95: 183-9.
172. West J, Logan RF, Card TR et al. Fracture risk in people with celiac disease: a population-based cohort study . Gastroenterology 2003; 125: 429-36.
173. Ciacci C, Maurelli L, Klain M et al. Effects of dietary treatment on bone mineral density in adults with celiac disease: factors predicting response. Am J Gastroenterol 1997; 92: 992-6.
174. Mustalahti K, Collin P, Sievanen H et al. Osteopenia in patients with clinically silent coeliac disease warrants screening . Lancet 1999; 354: 744-5.
175. McFarlane XA, Bhalla AK, Robertson DA . Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease . Gut 1996; 39: 180-4.
176. Mora S, Barera G, Beccio S et al. A prospective, longitudinal study of the long-term Effect of treatment on bone density in children with celiac disease . J Pediatr 2001; 139: 516-21.
177. Choi JM, Lebwohl B, Wang J et al. Increased prevalence of celiac disease in patients with unexplained infertility in the United States . J Reprod Med 2011; 56: 199-203.
178. Ciacci C, Cirillo M, Auriemma G et al. Celiac disease and pregnancy outcome . Am J Gastroenterol 1996; 91: 718-22.
179. Norgard B, Fonager K, Sorensen HT et al. Birth outcomes of women with celiac disease: a nationwide historical cohort study . Am J Gastroenterol 1999; 94: 2435-40.
180. Ludvigsson JF, Montgomery SM, Ekbom A . Celiac disease and risk of adverse fetal outcome: a population-based cohort study . Gastroenterology 2005; 129: 454-63.
181. Khashan AS, Henriksen TB, Mortensen PB et al. The impact of maternal celiac disease on birthweight and preterm birth: a Danish populationbased cohort study . Hum Reprod 2010; 25: 528-34.
182. Kemppainen TA, Heikkinen MT, Ristikankare MK et al. Nutrient intakes during diets including unkilned and large amounts of oats in celiac disease . Eur J Clin Nutr 2010; 64: 62-7.
183. Sey MS, Parfitt J, Gregor J . Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease . J Parenter Enteral Nutr 2011; 35: 459-64.
184. Koskinen O, Villanen M, Korponay-Szabo I et al. Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. J Pediatr Gastroenterol Nutr 2009; 48: 559-65.
185. Kemppainen TA, Heikkinen MT, Ristikankare MK et al. Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study . Scand J Gastroenterol 2008; 43: 1094-101.
186. Guttormsen V, Lovik A, Bye A et al. No induction of anti-avenin IgA by oats in adult, diet-treated coeliac disease . Scand J Gastroenterol 2008; 43: 161-5.
187. Maglio M, Mazzarella G, Barone MV et al. Immunogenicity of two oat varieties, in relation to their safety for celiac patients . Scand J Gastroenterol 2011; 46: 1194-205.
188. Rashid M, Butzner D, Burrows V et al. Consumption of pure oats by individuals with celiac disease: a position statement by the Canadian Celiac Association . Can J Gastroenterol 2007; 21: 649-51.
189. Janatuinen EK, Kemppainen TA, Julkunen RJ et al. No harm from fi ve year ingestion of oats in coeliac disease . Gut 2002; 50: 332-5.
190. Hogberg L, Laurin P, Falth-Magnusson K et al. Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut 2004; 53: 649-54.
191. Koerner TB, Cleroux C, Poirier C et al. Gluten contamination in the Canadian commercial oat supply . Food Addit Contam Part A Chem Anal Control Expos Risk Assess 2011; 28: 705-10.
192. Thompson T . Gluten contamination of commercial oat products in the United States . N Engl J Med 2004; 351: 2021-2.
193. Silano M, Dessi M, De Vincenzi M et al. In vitro tests indicate that certain varieties of oats may be harmful to patients with coeliac disease. J Gastroenterol Hepatol 2007; 22: 528-31.
194. Comino I, Real A, de Lorenzo L et al. Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease . Gut 2011; 60: 915-22.
195. Anson O, Weizman Z, Zeevi N . Celiac disease: parental knowledge and attitudes of dietary compliance . Pediatrics 1990; 85: 98-103.
196. Jackson PT, Glasgow JF, Th om R . Parents ' understanding of coeliac disease and diet . Arch Dis Child 1985; 60: 672-4.
197. Lamontagne P, West GE, Galibois I . Quebecers with celiac disease: analysis of dietary problems . Can J Diet Pract Res 2001; 62: 175-81.
198. Haapalahti M, Kulmala P, Karttunen TJ et al. Nutritional status in adolescents and young adults with screen-detected celiac disease . J Pediatr Gastroenterol Nutr 2005; 40: 566-70.
199. Botero-Lopez JE, Araya M, Parada A et al. Micronutrient defi ciencies in patients with typical and atypical celiac disease . J Pediatr Gastroenterol Nutr 2011; 53: 265-70.
200. Mody RJ, Brown PI, Wechsler DS . Refractory iron defi ciency anemia as the primary clinical manifestation of celiac disease . J Pediatr Hematol Oncol 2003; 25: 169-72.
201. Corazza GR, Valentini RA, Andreani ML et al. Subclinical coeliac disease is a frequent cause of iron-defi ciency anaemia . Scand J Gastroenterol 1995; 30: 153-6.
202. Bottaro G, Cataldo F, Rotolo N et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases . Am J Gastroenterol 1999; 94: 691-6.
203. Howard MR, Turnbull AJ, Morley P et al. A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defi ned iron and folate defi ciency . J Clin Pathol 2002; 55: 754-7.
204. Tikkakoski S, Savilahti E, Kolho KL . Undiagnosed coeliac disease and nutritional defi ciencies in adults screened in primary health care . Scand J Gastroenterol 2007; 42: 60-5.
205. Dickey W . Low serum vitamin B12 is common in coeliac disease and is not due to autoimmune gastritis . Eur J Gastroenterol Hepatol 2002; 14: 425-7.
206. Dahele A, Ghosh S . Vitamin B12 defi ciency in untreated celiac disease. Am J Gastroenterol 2001; 96: 745-50.
207. Reinken L, Zieglauer H . Vitamin B-6 absorption in children with acute celiac disease and in control subjects . J Nutr 1978; 108: 1562-5.
208. Halfdanarson TR, Kumar N, Hogan WJ et al. Copper defi ciency in celiac disease . J Clin Gastroenterol 2009; 43: 162-4.
209. Lerner A, Gruener N, Iancu TC . Serum carnitine concentrations in coeliac disease . Gut 1993; 34: 933-5.
210. Hallert C, Grant C, Grehn S et al. Evidence of poor vitamin status in coeliac patients on a gluten-free diet for 10 years . Aliment Pharmacol Ther 2002; 16: 1333-9.
211. Hallert C, Svensson M, Tholstrup J et al. Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet . Aliment Pharmacol Ther 2009; 29: 811-6.
212. Pietzak MM . Follow-up of patients with celiac disease: achieving compliance with treatment . Gastroenterology 2005; 128: S135-41.
213. Herman ML, Rubio-Tapia A, Lahr BD et al. Patients with celiac disease are not followed up adequately . Clin Gastroenterol Hepatol 2012; 10 : 893-9, e1.
214. Haines ML, Anderson RP, Gibson PR . Systematic review: the evidence base for long-term management of coeliac disease . Aliment Pharmacol Ther 2008; 28: 1042-66.
215. Gerrard JW, Ross CA, Smellie JM . Coeliac disease; results of late treatment with gluten-free wheat diet . Lancet 1955; 268: 587-9.
216. Bebb JR, Lawson A, Knight T et al. Long-term follow-up of coeliac disease-what do coeliac patients want? Aliment Pharmacol Ther 2006; 23: 827-31.
217. Kurppa K, Lauronen O, Collin P et al. Factors associated with dietary adherence in celiac disease: a nationwide study . Digestion 2012; 86 : 309-14.
218. Leffler DA, Dennis M, Hyett B et al. Etiologies and predictors of diagnosis in nonresponsive celiac disease . Clin Gastroenterol Hepatol 2007; 5 : 445-50.
219. Abdulkarim AS, Burgart LJ, See J et al. Etiology of nonresponsive celiac disease: results of a systematic approach . Am J Gastroenterol 2002; 97: 2016-21.
220. Simpson S, Thompson T . Nutrition assessment in celiac disease . Gastrointest Endosc Clin N Am 2012; 22: 797-809.
221. Nachman F, Sugai E, Vazquez H et al. Serological tests for celiac disease as indicators of long-term compliance with the gluten-free diet . Eur J Gastroenterol Hepatol 2011; 23: 473-80.
222. Koop I, Ilchmann R, Izzi L et al. Detection of autoantibodies against tissue transglutaminase in patients with celiac disease and dermatitis herpetiformis . Am J Gastroenterol 2000; 95: 2009-14.
223. Kaukinen K, Sulkanen S, Maki M et al. IgA-class transglutaminase antibodies in evaluating the effi cacy of gluten-free diet in coeliac disease. Eur J Gastroenterol Hepatol 2002; 14: 311-5.
224. Lanzini A, Lanzarotto F, Villanacci V et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet . Aliment Pharmacol Ther 2009; 29: 1299-308.
225. Leffler DA, Dennis M, Edwards George JB et al. A simple validated gluten-free diet adherence survey for adults with celiac disease . Clin Gastroenterol Hepatol 2009; 7: 530-6, 536 e1-2.
226. Biagi F, Andrealli A, Bianchi PI et al. A gluten-free diet score to evaluate dietary compliance in patients with coeliac disease . Br J Nutr 2009; 102: 882-7.
227. Biagi F, Bianchi PI, Marchese A et al. A score that verifi es adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life . Br J Nutr 2012; 108: 1884-8.
228. Lebwohl B, Granath F, Ekbom A et al. Mucosal healing and mortality in celiac disease . Aliment Pharmacol Ther 2013; 37: 332-9.
229. Dewar DH, Donnelly SC, McLaughlin SD et al. Celiac disease: management of persistent symptoms in patients on a gluten-free diet . World J Gastroenterol 2012; 18: 1348-56.
230. Wahab PJ, Meijer JW, Mulder CJ . Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. Am J Clin Pathol 2002; 118: 459-63.
231. Kaukinen K, Peraaho M, Lindfors K et al. Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease . Aliment Pharmacol Ther 2007; 25: 1237-45.
232. Elfstrom P, Granath F, Ekstrom Smedby K et al. Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease . J Natl Cancer Inst 2011; 103: 436-44.
233. Lebwohl B, Granath F, Ekbom A et al. Mucosal healing and mortality in coeliac disease . Aliment Pharmacol Ther 2013; 37: 332-9.
234. Dipper CR, Maitra S, Thomas R et al. Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease . Aliment Pharmacol Ther 2009; 30: 236-44.
235. Saez LR, Alvarez DF, Martinez IP et al. Refractory iron-defi ciency anemia and gluten intolerance-response to gluten-free diet . Rev Esp Enferm Dig 2011; 103: 349-54.
236. Halfdanarson TR, Litzow MR, Murray JA . Hematologic manifestations of celiac disease . Blood 2007; 109: 412-21.
237. Patterson SK, Green PH, Tennyson CA et al. Copper levels in patients with celiac neuropathy . J Clin Neuromuscul Dis 2012; 14: 11-6.
238. Bai JC, Gonzalez D, Mautalen C et al. Long-term Effect of gluten restriction on bone mineral density of patients with coeliac disease . Aliment Pharmacol Ther 1997; 11: 157-64.
239. Sanchez MI, Mohaidle A, Baistrocchi A et al. Risk of fracture in celiac disease: gender, dietary compliance, or both? World J Gastroenterol 2011; 17: 3035-42.
240. Jafri MR, Nordstrom CW, Murray JA et al. Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota . Dig Dis Sci 2008; 53: 964-71.
241. Ludvigsson JF, Michaelsson K, Ekbom A et al. Coeliac disease and the risk of fractures-a general population-based cohort study . Aliment Pharmacol Ther 2007; 25: 273-85.
242. O ' Mahony S, Howdle PD, Losowsky MS . Review article: management of patients with non-responsive coeliac disease . Aliment Pharmacol Ther 1996; 10: 671-80.
243. Fine KD, Meyer RL, Lee EL . The prevalence and causes of chronic diarrhea in patients with celiac sprue treated with a gluten-free diet. Gastroenterology 1997; 112: 1830-8.
244. Malamut G, Afchain P, Verkarre V et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 2009; 136: 81-90.
245. Roshan B, Leffler DA, Jamma S et al. The incidence and clinical spectrum of refractory celiac disease in a North American referral center . Am J Gastroenterol 2011; 106: 923-8.
246. Cellier C, Delabesse E, Helmer C, et al., French Coeliac Disease Study Group . Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group . Lancet 2000; 356: 203-8.
247. Tursi A, Brandimarte G, Giorgetti G . High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms aft er gluten withdrawal . Am J Gastroenterol 2003; 98: 839-43.
248. Pallav K, Leffler DA, Tariq S et al. Noncoeliac enteropathy: the diff erential diagnosis of villous atrophy in contemporary clinical practice . Aliment Pharmacol Ther 2012; 35: 380-90.
249. Stewart M, Andrews CN, Urbanski S et al. The association of coeliac disease and microscopic colitis: a large population-based study . Aliment Pharmacol Ther 2011; 33: 1340-9.
250. Green PH, Yang J, Cheng J et al. An association between microscopic colitis and celiac disease . Clin Gastroenterol Hepatol 2009; 7: 1210-6.
251. Pardi DS, Kelly CP . Microscopic colitis . Gastroenterology 2011; 140 : 1155-65.
252. Trier JS, Falchuk ZM, Carey MC et al. Celiac sprue and refractory sprue. Gastroenterology 1978; 75: 307-16.
253. Cellier C, Patey N, Mauvieux L et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue . Gastroenterology 1998; 114: 471-81.
254. Daum S, Weiss D, Hummel M et al. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue . Gut 2001; 49: 804-12.
255. Daum S, Ipczynski R, Heine B et al. Therapy with budesonide in patients with refractory sprue . Digestion 2006; 73: 60-8.
256. Brar P, Lee S, Lewis S et al. Budesonide in the treatment of refractory celiac disease . Am J Gastroenterol 2007; 102: 2265-9.
257. Jamma S, Leffler DA, Dennis M et al. Small intestinal release mesalamine for the treatment of refractory celiac disease type I . J Clin Gastroenterol 2011; 45: 30-3.
258. Maurino E, Niveloni S, Chernavsky A et al. Azathioprine in refractory sprue: results from a prospective, open-label study . Am J Gastroenterol 2002; 97: 2595-602.
259. Wahab PJ, Crusius JB, Meijer JW et al. Cyclosporin in the treatment of adults with refractory coeliac disease-an open pilot study . Aliment Pharmacol Ther 2000; 14: 767-74.
260. Tack GJ, Verbeek WH, Al-Toma A et al. Evaluation of Cladribine treatment in refractory celiac disease type II . World J Gastroenterol 2011; 17: 506-13.
261. Abdallah H, Leffler D, Dennis M et al. Refractory celiac disease . Curr Gastroenterol Rep 2007; 9: 401-5.
262. Sieniawski M, Angamuthu N, Boyd K et al. Evaluation of enteropathy associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplant . Blood 2010; 115 : 3664-70.
263. Chandesris MO, Malamut G, Verkarre V et al. Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives . Gastroenterol Clin Biol 2010; 34: 590-605.
264. Camilleri MO, Parkman HP, Shafi MA et al. Clinical guideline: management of gastroparesis . Am J Gastroenterol 2013; 108: 18-37.