Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults

Journal of the American Geriatrics Society

Volumn 50, Issue 11, 2002, Pages 1789-1795

  Rajan, Suparna ^a,b   Wallace, Jeffrey I ^c   Brodkin, Kayla I ^a,b   Beresford, Shirley A ^d   Allen, Robert H ^c   Stabler, Sally P ^c  

^a Veterans Puget Sound Health Care System   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cobalamin; Methylmalonic acid; Senior's nutrition; Total homocysteine; Vitamin B12 treatment; Vitamin supplements

Indexed keywords

COBALAMIN; CYANOCOBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID;

AGED; AGING; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; DOSE RESPONSE; FEMALE; HUMAN; MALE; NUTRITION; STANDARD; STATISTICAL ANALYSIS; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; AGE FACTORS; AGED; AGED, 80 AND OVER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HOMOCYSTEINE; HUMANS; MALE; METHYLMALONIC ACID; PILOT PROJECTS; TIME FACTORS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 0036843983     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2002.50506.x     Document Type: Article

References (28)

1. Lindenbaum J, Rosenberg IH, Wilson PW et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
2. Pennypacker LC, Allen RH, Kelly JP et al. High prevalence of cobalamin deficiency in elderly populations. J Am Geriatr Soc 1992;40:1197-2004.
3. Stabler SP, Allen RH, Fried LP et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Am J Clin Nutr 1999;70:911-919.
4. Koehler KM, Romero LJ, Stabler PM et al. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Nutr 1996;15:364-376.
5. McRae TD, Freedman ML. Why vitamin B-12 deficiency should be managed aggressively. Geriatrics 1989;44:70-79.
6. Healton EB, Savage DG, Brust JCM et al. Neurologic aspects of cobalamin deficiency. Medicine 1991;70:229-254.
7. Martin DC, Francis J, Protetch J et al. Time dependence of cognitive recovery with cobalamin replacement: Reports of a pilot study. J Am Geriatr Soc 1992;40:168-172.
8. Oakley GP Jr. Let's increase folic acid fortification and include vitamin B-12. Am J Clin Nutr 1997;65:1889-1890.
9. Herbert V, Bigaouette J. Call for endorsement of a petition to the Food and Drug Administration to always add vitamin B-12 to any folate fortification. Am J Clin Nutr 1997;65:572-573
10. Catmel R. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997;66:750-759.
11. Berlin H, Berlin R, Brante G. Oral treatment of pernicious anemia with doses of vitamin B-12 without intrinsic factor. Acta Med Scand 1968;184:247-258.
12. Kuzminski AM, Del Giacco EJ, Allen RH et al. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998;92:1191-1198.
13. Stabler SP, Lindenbaum J, Allen RH. Vitamin B-12 deficiency in the elderly: Current dilemmas. Am J Clin Nutr 1997;66:741-749.
14. 12 serum levels in older people by oral treatment. J Am Geriatr Soc 1997;45:123.
15. Lindenbaum J, Savage DG, Stabler SP et al. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107.
16. Wallace JI, Buchner D, Grothaus L et al. Implementation and effectiveness of a community based health promotion program for older adults. J Gerontol A Biol Sci Med Sci 1998;53A:M301-M306.
17. Green R, Kinsella LJ. Current concepts in the diagnosis of cobalamin deficiency. Neurology 1995;45:1435-1440.
18. Allen RH, Stabler SP, Savage DG et al. Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency. Metabolism 1993;42:978-988.
19. Stabler SP, Marcell PD, Podell ER et al. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest 1986;77:1610-1612.
20. Stabler SP, Lindenbaum J, Savage DG et al. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 1993;81:3104-3113.
21. Stabler SP, Marcell PD, Podell ER et al. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466-474.
22. Cockcraft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
23. Diggie PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data. New York, NY: Oxford University Press, 1994.
24. Naurath HJ, Joosten E, Riezier R et al. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995;345:85-89.
25. Rasmussen K, Moller J, Lyngbak M et al. Age and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem 1996;42:630-636.
26. Rajan S, Wallace JI, Beresford SAA et al. Screening for cobalamin deficiency in geriatric outpatients. J Am Geriatr Soc 2002;50:624-630.
27. Lederle FA. Oral cobalamin for pernicious anemia. JAMA 1993;71:745-750.
28. Henning BF, Tepel M, Riezler R et al. Long-term effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin B12 concentrations. Gerontology 2001;47:30-35.