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Volumn 11, Issue 1, 2014, Pages 6-23

Pathogenesis-Targeted, Disease-Modifying Therapies in Parkinson Disease

Author keywords

Clinical trials; disease modification; neuroprotection; Parkinson disease; pathogenesis

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; ALPHA SYNUCLEIN; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; CALCIUM CHANNEL BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ERYTHROPOIETIN; EXENDIN 4; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; LEVODOPA; NICOTINE; PHOSPHOTRANSFERASE INHIBITOR;

EID: 84893071526     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-013-0218-1     Document Type: Review
Times cited : (122)

References (184)
  • 1
    • 78149299057 scopus 로고    scopus 로고
    • Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future
    • Lang AE. Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future. Nat Med 2010;16: 1223-1226.
    • (2010) Nat Med , vol.16 , pp. 1223-1226
    • Lang, A.E.1
  • 3
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • Alam ZI, Jenner A, Daniel SE, et al. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 1997;69: 1196-1203.
    • (1997) J Neurochem , vol.69 , pp. 1196-1203
    • Alam, Z.I.1    Jenner, A.2    Daniel, S.E.3
  • 4
    • 0028091176 scopus 로고
    • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    • Dexter DT, Sian J, Rose S, et al. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol 1994;35: 38-44.
    • (1994) Ann Neurol , vol.35 , pp. 38-44
    • Dexter, D.T.1    Sian, J.2    Rose, S.3
  • 5
    • 0029759598 scopus 로고    scopus 로고
    • Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease
    • Hastings TG, Lewis DA, Zigmond MJ. Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease. Adv Exp Med Biol 1996;387: 97-106.
    • (1996) Adv Exp Med Biol , vol.387 , pp. 97-106
    • Hastings, T.G.1    Lewis, D.A.2    Zigmond, M.J.3
  • 6
    • 0024456653 scopus 로고
    • Effect of deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group
    • The Parkinson Study Group. Effect of deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1989;321: 1364-1371.
    • (1989) N Engl J Med , vol.321 , pp. 1364-1371
  • 7
    • 0028858370 scopus 로고
    • The effect of deprenyl and levodopa on the progression of signs and symptoms in Parkinson's disease
    • Olanow CW, Hauser RA, Gauger L, et al. The effect of deprenyl and levodopa on the progression of signs and symptoms in Parkinson's disease. Ann Neurol 1995;38: 771-777.
    • (1995) Ann Neurol , vol.38 , pp. 771-777
    • Olanow, C.W.1    Hauser, R.A.2    Gauger, L.3
  • 8
    • 33646686620 scopus 로고    scopus 로고
    • Selegiline slows the progression of the symptoms of Parkinson disease
    • Pålhagen S, Heinonen E, Hägglund J, et al. Selegiline slows the progression of the symptoms of Parkinson disease. Neurology 2006;66: 1200-1206.
    • (2006) Neurology , vol.66 , pp. 1200-1206
    • Pålhagen, S.1    Heinonen, E.2    Hägglund, J.3
  • 9
    • 75949114175 scopus 로고    scopus 로고
    • The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline
    • Bar-Am O, Weinreb O, Amit T, Youdim MB. The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline. J Neurochem 2010;112: 1131-1137.
    • (2010) J Neurochem , vol.112 , pp. 1131-1137
    • Bar-Am, O.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.4
  • 10
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • Parkinson Study Group
    • Parkinson Study Group. A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol 2004;61: 561-566.
    • (2004) Arch Neurol , vol.61 , pp. 561-566
  • 11
    • 70349456475 scopus 로고    scopus 로고
    • A double-blind, delayed start trial of rasagiline in Parkinson's disease
    • Olanow CW, Rascol O, Hauser R, et al. A double-blind, delayed start trial of rasagiline in Parkinson's disease. N Engl J Med 2009;361: 1268-1278.
    • (2009) N Engl J Med , vol.361 , pp. 1268-1278
    • Olanow, C.W.1    Rascol, O.2    Hauser, R.3
  • 12
    • 79954706259 scopus 로고    scopus 로고
    • A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes
    • Rascol O, Fitzer-Attas CJ, Hauser R et al. A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol 2011;10: 415-423.
    • (2011) Lancet Neurol , vol.10 , pp. 415-423
    • Rascol, O.1    Fitzer-Attas, C.J.2    Hauser, R.3
  • 13
    • 81955167502 scopus 로고    scopus 로고
    • Explaining ADAGIO: a critical review of the biological basis for the clinical effects of rasagiline
    • Jenner P, Langston JW. Explaining ADAGIO: a critical review of the biological basis for the clinical effects of rasagiline. Mov Disord 2011;26: 2316-2323.
    • (2011) Mov Disord , vol.26 , pp. 2316-2323
    • Jenner, P.1    Langston, J.W.2
  • 14
    • 79952693640 scopus 로고
    • Mitophagy and Parkinson's disease: the PINK1-parkin link
    • Deas E, Wood NW, Plun-Favreau H. Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta 2011;1813: 623-633.
    • (1813) Biochim Biophys Acta , vol.2011 , pp. 623-633
    • Deas, E.1    Wood, N.W.2    Plun-Favreau, H.3
  • 16
    • 0025254401 scopus 로고
    • Mitochondrial complex I deficiency in Parkinson's disease
    • Schapira AHV, Cooper JM, Dexter D, et al. Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 1990;54: 823-827.
    • (1990) J Neurochem , vol.54 , pp. 823-827
    • Schapira, A.H.V.1    Cooper, J.M.2    Dexter, D.3
  • 17
    • 0024330311 scopus 로고
    • Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease
    • Mizuno Y, Ohta S, Tanaka M, et al. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 1989;163: 1450-1455.
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 1450-1455
    • Mizuno, Y.1    Ohta, S.2    Tanaka, M.3
  • 18
    • 0037379314 scopus 로고    scopus 로고
    • Bioenergetic approaches for neuroprotection in Parkinson's disease
    • Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann Neurol 2003;53: S39-S47.
    • (2003) Ann Neurol , vol.53
    • Beal, M.F.1
  • 19
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
    • Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59: 1541-1550.
    • (2002) Arch Neurol , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3
  • 20
    • 84893089340 scopus 로고    scopus 로고
    • Effects of Coenzyme Q10 (CoQ) in Parkinson Disease (QE3). Clinicaltrials. gov. Available at, Accessed August 16, 2013
    • Effects of Coenzyme Q10 (CoQ) in Parkinson Disease (QE3). Clinicaltrials. gov. Available at: www. http://clinicaltrials. gov/ct2/show/NCT00740714. Accessed August 16, 2013.
  • 21
    • 77955792985 scopus 로고    scopus 로고
    • A double-blind, placebo controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease- modifying therapy in Parkinson's disease
    • Snow BJ, Rolfe FL, Lockhart MM, et al. A double-blind, placebo controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease- modifying therapy in Parkinson's disease. Mov Disord 2010;25: 1670-1674.
    • (2010) Mov Disord , vol.25 , pp. 1670-1674
    • Snow, B.J.1    Rolfe, F.L.2    Lockhart, M.M.3
  • 22
    • 0032914740 scopus 로고    scopus 로고
    • Creatine and cyclocreatine attenuate MPTP neurotoxicity
    • Matthews RT, Ferrante RJ, Klivenyi P, et al. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol 1999;157: 142-149.
    • (1999) Exp Neurol , vol.157 , pp. 142-149
    • Matthews, R.T.1    Ferrante, R.J.2    Klivenyi, P.3
  • 23
    • 33749835508 scopus 로고    scopus 로고
    • Creatine supplementation in Parkinson disease: a placebo controlled randomized pilot trial
    • Bender A, Koch W, Elstner M, et al. Creatine supplementation in Parkinson disease: a placebo controlled randomized pilot trial. Neurology 2006;67: 1262-1264.
    • (2006) Neurology , vol.67 , pp. 1262-1264
    • Bender, A.1    Koch, W.2    Elstner, M.3
  • 24
    • 33645894705 scopus 로고    scopus 로고
    • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease
    • NINDS NET-PD Investigators
    • NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 2006;66: 664-671.
    • (2006) Neurology , vol.66 , pp. 664-671
  • 25
    • 84867693278 scopus 로고    scopus 로고
    • Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1
    • NINDS NET-PD Investigators
    • Elm JJ; NINDS NET-PD Investigators. Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. Mov Disord 2012;27: 1513-1521.
    • (2012) Mov Disord , vol.27 , pp. 1513-1521
    • Elm, J.J.1
  • 26
    • 0031716026 scopus 로고    scopus 로고
    • Dopamine agonists and neuroprotection in Parkinson's disease
    • Olanow CW, Jenner P, Brooks D. Dopamine agonists and neuroprotection in Parkinson's disease. Ann Neurol 1998;44: 167-174.
    • (1998) Ann Neurol , vol.44 , pp. 167-174
    • Olanow, C.W.1    Jenner, P.2    Brooks, D.3
  • 27
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET study
    • Whone A, Watts R, Stoessl J, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET study: Ann Neurol 2003;54: 93-101.
    • (2003) Ann Neurol , vol.54 , pp. 93-101
    • Whone, A.1    Watts, R.2    Stoessl, J.3
  • 28
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of Pramipexole vs levodopa Parkinson disease progression
    • Parkinson Study Group
    • Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of Pramipexole vs levodopa Parkinson disease progression. JAMA 2002;287: 1653-1661.
    • (2002) Jama , vol.287 , pp. 1653-1661
  • 29
    • 19944432710 scopus 로고    scopus 로고
    • The role of radiotracer imaging in Parkinson disease
    • Ravina B, Eidelberg D, Ahlskog JE, et al. The role of radiotracer imaging in Parkinson disease. Neurology 2005;64: 208-215.
    • (2005) Neurology , vol.64 , pp. 208-215
    • Ravina, B.1    Eidelberg, D.2    Ahlskog, J.E.3
  • 30
    • 4644314827 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson's disease: current controversies
    • Olanow CW, Agid Y, Mizuno Y, et al. Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord 2004;19: 997-1005.
    • (2004) Mov Disord , vol.19 , pp. 997-1005
    • Olanow, C.W.1    Agid, Y.2    Mizuno, Y.3
  • 31
    • 0029775677 scopus 로고    scopus 로고
    • Is levodopa toxic?
    • Fahn S. Is levodopa toxic? Neurology 1996;47: S184-195.
    • (1996) Neurology , vol.47
    • Fahn, S.1
  • 32
    • 0034844226 scopus 로고    scopus 로고
    • Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?
    • Barzilai A, Melamed E, Shirvan A. Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease? Cell Mol Neurobiol 2001;21: 215-235.
    • (2001) Cell Mol Neurobiol , vol.21 , pp. 215-235
    • Barzilai, A.1    Melamed, E.2    Shirvan, A.3
  • 33
    • 0031968959 scopus 로고    scopus 로고
    • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
    • Murer MG, Dziewczapolski G, Menalled LB et al. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol 1998;43: 561-575.
    • (1998) Ann Neurol , vol.43 , pp. 561-575
    • Murer, M.G.1    Dziewczapolski, G.2    Menalled, L.B.3
  • 34
    • 0035353737 scopus 로고    scopus 로고
    • Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions
    • Datla KP, Blunt SB, Dexter DT. Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions. Mov Disord 2001;16: 424-434.
    • (2001) Mov Disord , vol.16 , pp. 424-434
    • Datla, K.P.1    Blunt, S.B.2    Dexter, D.T.3
  • 35
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson's disease
    • Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med 2004;351: 2498-2508.
    • (2004) N Engl J Med , vol.351 , pp. 2498-2508
    • Fahn, S.1    Oakes, D.2    Shoulson, I.3
  • 36
    • 20544431978 scopus 로고    scopus 로고
    • Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy
    • Olanow CW, Jankovic J. Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy. Mov Disord 2005;20: S3-10.
    • (2005) Mov Disord , vol.20 , pp. 3-10
    • Olanow, C.W.1    Jankovic, J.2
  • 37
    • 84880329276 scopus 로고    scopus 로고
    • Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial
    • Schapira AH, McDermott MP, Barone P, et al. Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial. Lancet Neurol 2013;12: 747-755.
    • (2013) Lancet Neurol , vol.12 , pp. 747-755
    • Schapira, A.H.1    McDermott, M.P.2    Barone, P.3
  • 38
    • 0033762265 scopus 로고    scopus 로고
    • Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra
    • Howells DW, Porritt MJ, Wong JY, et al. Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp Neurol 2000;166: 127-135.
    • (2000) Exp Neurol , vol.166 , pp. 127-135
    • Howells, D.W.1    Porritt, M.J.2    Wong, J.Y.3
  • 39
    • 0034959811 scopus 로고    scopus 로고
    • Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain
    • Chauhan NB, Siegel GJ, Lee JM. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J Chem Neuroanat 2001;21: 277-288.
    • (2001) J Chem Neuroanat , vol.21 , pp. 277-288
    • Chauhan, N.B.1    Siegel, G.J.2    Lee, J.M.3
  • 40
    • 0033597983 scopus 로고    scopus 로고
    • Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
    • Mogi M, Togari A, Kondo T, et al. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci Lett 1999;270: 45-48.
    • (1999) Neurosci Lett , vol.270 , pp. 45-48
    • Mogi, M.1    Togari, A.2    Kondo, T.3
  • 41
    • 0032563356 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice
    • Cheng FC, Ni DR, Wu MC, Kuo JS, Chia LG. Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. Neurosci Lett 1998;252: 87-90.
    • (1998) Neurosci Lett , vol.252 , pp. 87-90
    • Cheng, F.C.1    Ni, D.R.2    Wu, M.C.3    Kuo, J.S.4    Chia, L.G.5
  • 42
    • 0035970762 scopus 로고    scopus 로고
    • Neuroprotective effects of GDNF against 6-OHDA in young and aged rats
    • Fox CM, Gash DM, Smoot MK, Cass WA. Neuroprotective effects of GDNF against 6-OHDA in young and aged rats. Brain Res 2001;896: 56-63.
    • (2001) Brain Res , vol.896 , pp. 56-63
    • Fox, C.M.1    Gash, D.M.2    Smoot, M.K.3    Cass, W.A.4
  • 44
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill SS, Patel NK, Hotton GR, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003;9: 589-595.
    • (2003) Nat Med , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3
  • 45
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang AE, Gill S, Patel NK, et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 2006;59: 459-466.
    • (2006) Ann Neurol , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3
  • 46
    • 84893055988 scopus 로고    scopus 로고
    • AAV2-GDNF for Advanced Parkinson's Disease. Clinicaltrials. gov. Available at
    • AAV2-GDNF for Advanced Parkinson's Disease. Clinicaltrials. gov. Available at: www. http://clinicaltrials. gov/ct2/show/NCT01621581. Accessed August 16, 2013.
  • 47
    • 78349247631 scopus 로고    scopus 로고
    • Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
    • Marks WJ Jr, Bartus RT, Siffert J, et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2010;9: 1164-1172.
    • (2010) Lancet Neurol , vol.9 , pp. 1164-1172
    • Marks Jr., W.J.1    Bartus, R.T.2    Siffert, J.3
  • 48
    • 84893110167 scopus 로고    scopus 로고
    • Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD). Clinicaltrials. gov. Available at, Accessed August 16, 2013
    • Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD). Clinicaltrials. gov. Available at: www. http://clinicaltrials. gov/ct2/show/NCT01060878. Accessed August 16, 2013.
  • 49
    • 0030975605 scopus 로고    scopus 로고
    • Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
    • Steiner JP, Connolly MA, Valentine HL, et al. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 1997;3: 421-428.
    • (1997) Nat Med , vol.3 , pp. 421-428
    • Steiner, J.P.1    Connolly, M.A.2    Valentine, H.L.3
  • 50
    • 0037063708 scopus 로고    scopus 로고
    • The nonimmunosuppressive immunophilin ligand GPI-1046 potently stimulates regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel
    • Khan Z, Ferrari G, Kasper M, et al. The nonimmunosuppressive immunophilin ligand GPI-1046 potently stimulates regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel. Neuroscience 2002;114: 601-609.
    • (2002) Neuroscience , vol.114 , pp. 601-609
    • Khan, Z.1    Ferrari, G.2    Kasper, M.3
  • 51
    • 4244043155 scopus 로고    scopus 로고
    • Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment
    • Zhang C, Steiner JP, Hamilton GS, Hicks TP, Poulter MO. Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment. J Neurosci 2001;21: RC156.
    • (2001) J Neurosci , vol.21
    • Zhang, C.1    Steiner, J.P.2    Hamilton, G.S.3    Hicks, T.P.4    Poulter, M.O.5
  • 52
    • 0037087049 scopus 로고    scopus 로고
    • GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum
    • Tanaka K, Yoshioka M, Miyazaki I, Fujita N, Ogawa N. GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum. Neurosci Lett 2002;321: 45-48.
    • (2002) Neurosci Lett , vol.321 , pp. 45-48
    • Tanaka, K.1    Yoshioka, M.2    Miyazaki, I.3    Fujita, N.4    Ogawa, N.5
  • 53
    • 0037466474 scopus 로고    scopus 로고
    • Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain
    • Tanaka K, Fujita N, Ogawa N. Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain. Brain Res 2003;970: 250-253.
    • (2003) Brain Res , vol.970 , pp. 250-253
    • Tanaka, K.1    Fujita, N.2    Ogawa, N.3
  • 54
    • 4344694987 scopus 로고    scopus 로고
    • Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?
    • Poulter MO, Payne KB, Steiner JP. Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease? Neuroscience 2004;128: 1-6.
    • (2004) Neuroscience , vol.128 , pp. 1-6
    • Poulter, M.O.1    Payne, K.B.2    Steiner, J.P.3
  • 55
    • 0029157640 scopus 로고
    • NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release
    • Mody I, MacDonald JF. NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release. Trends Pharmacol Sci 1995;16: 356-359.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 356-359
    • Mody, I.1    MacDonald, J.F.2
  • 56
    • 0036164536 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease
    • Jankovic J, Hunter C. A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease. Parkinsonism Relat Disord 2002;8: 271-276.
    • (2002) Parkinsonism Relat Disord , vol.8 , pp. 271-276
    • Jankovic, J.1    Hunter, C.2
  • 57
    • 0344373312 scopus 로고    scopus 로고
    • A 2-year multicenter, placebo-controlled, double-blind, parallel group study of the effect of riluzole on Parkinson's disease progression
    • Rascol O, Olanow W, Brooks D, Koch G, Truffinet P, Bejuit R. A 2-year multicenter, placebo-controlled, double-blind, parallel group study of the effect of riluzole on Parkinson's disease progression. Mov Disord 2002;17 (Suppl. 5): A80.
    • (2002) Mov Disord , vol.17 , Issue.SUPPL. 5
    • Rascol, O.1    Olanow, W.2    Brooks, D.3    Koch, G.4    Truffinet, P.5    Bejuit, R.6
  • 58
    • 35148882113 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
    • Parkinson Study Group PRECEPT Investigators
    • Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 2007;69: 1480-1490.
    • (2007) Neurology , vol.69 , pp. 1480-1490
  • 59
    • 33750719088 scopus 로고    scopus 로고
    • TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial
    • Olanow CW, Schapira AH, LeWitt PA, et al. TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2006;5: 1013-1020.
    • (2006) Lancet Neurol , vol.5 , pp. 1013-1020
    • Olanow, C.W.1    Schapira, A.H.2    LeWitt, P.A.3
  • 60
    • 0035871840 scopus 로고    scopus 로고
    • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
    • Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 2001;21: 2580-2588.
    • (2001) J Neurosci , vol.21 , pp. 2580-2588
    • Tikka, T.1    Fiebich, B.L.2    Goldsteins, G.3    Keinanen, R.4    Koistinaho, J.5
  • 61
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 2001;166: 7527-7533.
    • (2001) J Immunol , vol.166 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 62
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y, Ma Z, Lin S, et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A 2001;98: 14669-14674.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3
  • 63
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • He Y, Appel S, Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res 2001;909: 187-193.
    • (2001) Brain Res , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 64
    • 84870949704 scopus 로고    scopus 로고
    • A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients
    • Schneider JS, Gollomp SM, Sendek S, Colcher A, Cambi F, Du W. A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients. J Neurol Sci 2013;324: 140-148.
    • (2013) J Neurol Sci , vol.324 , pp. 140-148
    • Schneider, J.S.1    Gollomp, S.M.2    Sendek, S.3    Colcher, A.4    Cambi, F.5    Du, W.6
  • 65
    • 84873476695 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: limits and relevance to neuroprotection studies
    • Bezard E, Yue Z, Kirik D, Spillantini MG. Animal models of Parkinson's disease: limits and relevance to neuroprotection studies. Mov Disord 2013;57: 61-70.
    • (2013) Mov Disord , vol.57 , pp. 61-70
    • Bezard, E.1    Yue, Z.2    Kirik, D.3    Spillantini, M.G.4
  • 66
    • 70449371718 scopus 로고    scopus 로고
    • Modeling Parkinson's disease
    • Olanow CW, Kordower J. Modeling Parkinson's disease. Ann Neurol 2009;66: 432-436.
    • (2009) Ann Neurol , vol.66 , pp. 432-436
    • Olanow, C.W.1    Kordower, J.2
  • 67
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron 2010;66: 646-661.
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 68
    • 84873473495 scopus 로고    scopus 로고
    • Obstacles to the development of a neuroprotective therapy for Parkinson's disease
    • Stocchi F, Olanow CW. Obstacles to the development of a neuroprotective therapy for Parkinson's disease. Mov Disord 2013;28: 3-7.
    • (2013) Mov Disord , vol.28 , pp. 3-7
    • Stocchi, F.1    Olanow, C.W.2
  • 69
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012;338: 949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 70
    • 33744981624 scopus 로고    scopus 로고
    • Issues in neuroprotection clinical trials in Parkinson's disease
    • Kieburtz K. Issues in neuroprotection clinical trials in Parkinson's disease. Neurology 2006;66: S50-57.
    • (2006) Neurology , vol.66
    • Kieburtz, K.1
  • 71
    • 84873478145 scopus 로고    scopus 로고
    • Trial designs used to study neuroprotective therapy in Parkinson's disease
    • Lang AE, Melamed E, Poewe W, Rascol O. Trial designs used to study neuroprotective therapy in Parkinson's disease. Mov Disord 2013;28: 86-95.
    • (2013) Mov Disord , vol.28 , pp. 86-95
    • Lang, A.E.1    Melamed, E.2    Poewe, W.3    Rascol, O.4
  • 72
    • 0042591659 scopus 로고    scopus 로고
    • The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations
    • The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 2003;18: 738-750.
    • (2003) Mov Disord , vol.18 , pp. 738-750
  • 73
    • 61449165975 scopus 로고    scopus 로고
    • Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results
    • for the Movement Disorder Society UPDRS Revision Task Force
    • Goetz CG, Tilley BC, Shaftman SR, et al., for the Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008;23: 2129-2170.
    • (2008) Mov Disord , vol.23 , pp. 2129-2170
    • Goetz, C.G.1    Tilley, B.C.2    Shaftman, S.R.3
  • 74
    • 2542612292 scopus 로고    scopus 로고
    • Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease
    • Lang AE, Obeso JA. Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease. Ann Neurol 2004;55: 761-765.
    • (2004) Ann Neurol , vol.55 , pp. 761-765
    • Lang, A.E.1    Obeso, J.A.2
  • 75
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • Shi M, Bradner J, Hancock AM, et al. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol 2011;69: 570-580.
    • (2011) Ann Neurol , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3
  • 76
    • 64549093797 scopus 로고    scopus 로고
    • Circulating interleukin-10 and interleukin-12 in Parkinson's disease
    • Rentzos M, Nikolaou C, Andreadou E, et al. Circulating interleukin-10 and interleukin-12 in Parkinson's disease. Acta Neurol Scand 2009;119: 332-337.
    • (2009) Acta Neurol Scand , vol.119 , pp. 332-337
    • Rentzos, M.1    Nikolaou, C.2    Andreadou, E.3
  • 77
    • 84873415220 scopus 로고    scopus 로고
    • Biomarkers for Trials of Neuroprotection in Parkinson's Disease
    • Agarwal PA, Stoessl AJ. Biomarkers for Trials of Neuroprotection in Parkinson's Disease. Mov Disord 2013;28: 71-85.
    • (2013) Mov Disord , vol.28 , pp. 71-85
    • Agarwal, P.A.1    Stoessl, A.J.2
  • 78
    • 78751614807 scopus 로고    scopus 로고
    • An introduction to adaptive designs and adaptation in CNS trials
    • Dragalin V. An introduction to adaptive designs and adaptation in CNS trials. Eur Neuropsychopharmacol. 2011;21: 153-158.
    • (2011) Eur Neuropsychopharmacol. , vol.21 , pp. 153-158
    • Dragalin, V.1
  • 80
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter DT, Wells FR, Lees AJ, et al. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 1989;52: 1830-1836.
    • (1989) J Neurochem , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3
  • 81
    • 84893031420 scopus 로고    scopus 로고
    • Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease (FAIR-PARK-I). Clinicaltrials. gov. Available at
    • Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease (FAIR-PARK-I). Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT00943748. Accessed August 16, 2013.
  • 82
    • 0019787519 scopus 로고
    • Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis
    • Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981;78: 6858-6862.
    • (1981) Proc Natl Acad Sci U S A , vol.78 , pp. 6858-6862
    • Ames, B.N.1    Cathcart, R.2    Schwiers, E.3    Hochstein, P.4
  • 85
  • 86
    • 45149122797 scopus 로고    scopus 로고
    • Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    • Schwarzschild MA, Schwid SR, Marek K, et al. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol 2008;65: 716-723.
    • (2008) Arch Neurol , vol.65 , pp. 716-723
    • Schwarzschild, M.A.1    Schwid, S.R.2    Marek, K.3
  • 88
    • 84893031851 scopus 로고    scopus 로고
    • Safety of Urate Elevation in Parkinson's Disease (SURE-PD). ClinicalTrials. gov. Available at
    • Safety of Urate Elevation in Parkinson's Disease (SURE-PD). ClinicalTrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT00833690. Accessed August 16, 2013.
  • 89
    • 84878450855 scopus 로고    scopus 로고
    • Zonisamide attenuates MPP+-induced oxidative toxicity through modulation of Ca2+ signaling and caspase-3 activity in neuronal PC12 cells
    • Yürekli VA, Gürler S, Nazi{dotless}roǧlu M, Uǧuz AC, Koyuncuoǧlu HR. Zonisamide attenuates MPP+-induced oxidative toxicity through modulation of Ca2+ signaling and caspase-3 activity in neuronal PC12 cells. Cell Mol Neurobiol 2013;33: 205-212.
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 205-212
    • Yürekli, V.A.1    Gürler, S.2    Naziroǧlu, M.3    Uǧuz, A.C.4    Koyuncuoǧlu, H.R.5
  • 90
    • 79953029664 scopus 로고    scopus 로고
    • Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity
    • Choudhury ME, Moritoyo T, Kubo M, et al. Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. Brain Res 2011;1384: 170-178.
    • (2011) Brain Res , vol.1384 , pp. 170-178
    • Choudhury, M.E.1    Moritoyo, T.2    Kubo, M.3
  • 91
    • 84893141659 scopus 로고    scopus 로고
    • Study of Zonisamide in Early Parkinson Disease (ZONIST). ClinicalTrials. gov. Available at, Accessed August 16, 2013
    • Study of Zonisamide in Early Parkinson Disease (ZONIST). ClinicalTrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT01766128. Accessed August 16, 2013.
  • 92
    • 67651148277 scopus 로고    scopus 로고
    • Randomized, doubleblind, pilot evaluation of intravenous glutathione in Parkinson's disease
    • Hauser RA, Lyons KE, McClain T, et al. Randomized, doubleblind, pilot evaluation of intravenous glutathione in Parkinson's disease. Mov Disord 2009;24: 979-983.
    • (2009) Mov Disord , vol.24 , pp. 979-983
    • Hauser, R.A.1    Lyons, K.E.2    McClain, T.3
  • 93
    • 77951941750 scopus 로고    scopus 로고
    • Reply: Based on the available randomized trial patients should say no to glutathione for Parkinson's disease
    • Okun MS, Lang A, Jankovic J. Reply: Based on the available randomized trial patients should say no to glutathione for Parkinson's disease. Mov Disord. 2010;25: 961-962.
    • (2010) Mov Disord. , vol.25 , pp. 961-962
    • Okun, M.S.1    Lang, A.2    Jankovic, J.3
  • 94
    • 84893084688 scopus 로고    scopus 로고
    • Intranasal Glutathione in Parkinson's Disease (inGSH in PD). ClinicalTrials. gov. Available at, Accessed August 16, 2013
    • Intranasal Glutathione in Parkinson's Disease (inGSH in PD). ClinicalTrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT01398748. Accessed August 16, 2013.
  • 95
    • 84893097241 scopus 로고    scopus 로고
    • N-Acetylcysteine for Neuroprotection in Parkinson's Disease (NAC for PD). ClinicalTrials. gov. Available at, Accessed August 16, 2013
    • N-Acetylcysteine for Neuroprotection in Parkinson's Disease (NAC for PD). ClinicalTrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT01470027. Accessed August 16, 2013.
  • 96
    • 36549060678 scopus 로고    scopus 로고
    • Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway
    • Guo S, Yan J, Yang T, Yang X, Bezard E, Zhao B. Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway. Biol Psychiatry 2007;62: 1353-1362.
    • (2007) Biol Psychiatry , vol.62 , pp. 1353-1362
    • Guo, S.1    Yan, J.2    Yang, T.3    Yang, X.4    Bezard, E.5    Zhao, B.6
  • 97
    • 84893067009 scopus 로고    scopus 로고
    • Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients. ClinicalTrials. gov. Available at, Accessed August 16, 2013
    • Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients. ClinicalTrials. gov. Available at: http://www. clinicaltrials. gov/ct2/show/NCT00461942. Accessed August 16, 2013.
  • 98
    • 0034950069 scopus 로고    scopus 로고
    • Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
    • Ascherio A, Zhang SM, Hernan MA, et al. Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 2001;50: 56-63.
    • (2001) Ann Neurol , vol.50 , pp. 56-63
    • Ascherio, A.1    Zhang, S.M.2    Hernan, M.A.3
  • 99
    • 84866293285 scopus 로고    scopus 로고
    • Caffeine and risk of Parkinson's disease in a large cohort of men and women
    • Palacios N, Gao X, McCullough ML, et al. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord 2012;27: 1276-82.
    • (2012) Mov Disord , vol.27 , pp. 1276-1282
    • Palacios, N.1    Gao, X.2    McCullough, M.L.3
  • 101
    • 84874216826 scopus 로고    scopus 로고
    • Novel nondopaminergic targets for motor features of Parkinson's disease: review of recent trials
    • Kalia LV, Brotchie JM, Fox SH. Novel nondopaminergic targets for motor features of Parkinson's disease: review of recent trials. Mov Disord 2013;28: 131-144.
    • (2013) Mov Disord , vol.28 , pp. 131-144
    • Kalia, L.V.1    Brotchie, J.M.2    Fox, S.H.3
  • 102
    • 84893067992 scopus 로고    scopus 로고
    • A Placebo- and Active-Controlled Study of Preladenant in Early Parkinson's Disease (P05664 AM5). ClinicalTrials. gov. Available at
    • A Placebo- and Active-Controlled Study of Preladenant in Early Parkinson's Disease (P05664 AM5). ClinicalTrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT01155479. Accessed August 16, 2013.
  • 103
    • 35348966882 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    • Tansey MG, McCoy MK, Frank-Cannon TC. Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol 2007;208: 1-25.
    • (2007) Exp Neurol , vol.208 , pp. 1-25
    • Tansey, M.G.1    McCoy, M.K.2    Frank-Cannon, T.C.3
  • 104
    • 34548822734 scopus 로고    scopus 로고
    • The role of anti-inflammatory agents in Parkinson's disease
    • McGeer EG, McGeer PL. The role of anti-inflammatory agents in Parkinson's disease. CNS Drugs 2007;21: 789-797.
    • (2007) CNS Drugs , vol.21 , pp. 789-797
    • McGeer, E.G.1    McGeer, P.L.2
  • 105
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38: 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 106
    • 0242384667 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
    • McGeer PL, Schwab C, Parent A, Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine administration. Ann Neurol 2003;54: 599-604.
    • (2003) Ann Neurol , vol.54 , pp. 599-604
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 107
    • 0037402801 scopus 로고    scopus 로고
    • Selective microglial activation in the rat rotenone model of Parkinson's disease
    • Sherer TB, Betarbet R, Kim JH, Greenamyre JT. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci Lett 2003;341: 87-90.
    • (2003) Neurosci Lett , vol.341 , pp. 87-90
    • Sherer, T.B.1    Betarbet, R.2    Kim, J.H.3    Greenamyre, J.T.4
  • 108
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi M, Harada M, Kondo T, et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 1994;180: 147-150.
    • (1994) Neurosci Lett , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3
  • 109
    • 33644903466 scopus 로고    scopus 로고
    • Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease
    • Goldknopf IL, Sheta EA, Bryson J, et al. Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. Biochem Biophys Res Commun 2006;342: 1034-1039.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 1034-1039
    • Goldknopf, I.L.1    Sheta, E.A.2    Bryson, J.3
  • 111
    • 0041653249 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    • Chen H, Zhang SM, Hernan MA, et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Arch Neurol 2003;60: 1059-1064.
    • (2003) Arch Neurol , vol.60 , pp. 1059-1064
    • Chen, H.1    Zhang, S.M.2    Hernan, M.A.3
  • 112
    • 28544451467 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
    • Chen H, Jacobs E, Schwarzschild MA, et al. Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol 2005;58: 963-967.
    • (2005) Ann Neurol , vol.58 , pp. 963-967
    • Chen, H.1    Jacobs, E.2    Schwarzschild, M.A.3
  • 113
    • 33747044127 scopus 로고    scopus 로고
    • Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study
    • Bower JH, Maraganore DM, Peterson BJ, Ahlskog JE, Rocca WA. Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study. Neurology 2006;67: 494-496.
    • (2006) Neurology , vol.67 , pp. 494-496
    • Bower, J.H.1    Maraganore, D.M.2    Peterson, B.J.3    Ahlskog, J.E.4    Rocca, W.A.5
  • 114
    • 33646089430 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease
    • Hernan MA, Logroscino G, Garcia Rodriguez LA. Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease. Neurology 2006;66: 1097-1099.
    • (2006) Neurology , vol.66 , pp. 1097-1099
    • Hernan, M.A.1    Logroscino, G.2    Garcia Rodriguez, L.A.3
  • 115
    • 14944350244 scopus 로고    scopus 로고
    • Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice
    • Selley ML. Simvastatin prevents 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice. Brain Res 2005;1037: 1-6.
    • (2005) Brain Res , vol.1037 , pp. 1-6
    • Selley, M.L.1
  • 116
    • 0036900697 scopus 로고    scopus 로고
    • Statins and stroke: evidence for cholesterol independent effects
    • Di Napoli P, Taccardi AA, Oliver M, De Caterina R. Statins and stroke: evidence for cholesterol independent effects. Eur Heart J 2002;23: 1908-1921.
    • (2002) Eur Heart J , vol.23 , pp. 1908-1921
    • Di Napoli, P.1    Taccardi, A.A.2    Oliver, M.3    De Caterina, R.4
  • 117
    • 34548299453 scopus 로고    scopus 로고
    • Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
    • Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE. Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med 2007;5: 20.
    • (2007) BMC Med , vol.5 , pp. 20
    • Wolozin, B.1    Wang, S.W.2    Li, N.C.3    Lee, A.4    Lee, T.A.5    Kazis, L.E.6
  • 120
    • 34147163966 scopus 로고    scopus 로고
    • Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease
    • Huang X, Chen H, Miller WC, et al. Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord 2007;22: 377-381.
    • (2007) Mov Disord , vol.22 , pp. 377-381
    • Huang, X.1    Chen, H.2    Miller, W.C.3
  • 121
    • 84877949532 scopus 로고    scopus 로고
    • Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?
    • Carta AR, Pisanu A. Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease? Neurotox Res 2013;23: 112-123.
    • (2013) Neurotox Res , vol.23 , pp. 112-123
    • Carta, A.R.1    Pisanu, A.2
  • 122
    • 84893055685 scopus 로고    scopus 로고
    • Pioglitazone in Early Parkinson's Disease. ClinicalTrials. gov. Available at
    • Pioglitazone in Early Parkinson's Disease. ClinicalTrials. gov. Available at: http://www. clinicaltrials. gov/ct2/show/NCT01280123. Accessed August 16, 2013.
  • 123
    • 77953447144 scopus 로고    scopus 로고
    • A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease
    • Chan CS, Gertler TS, Surmeier DJ. A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease. Mov Disord 2010;25: S63-70.
    • (2010) Mov Disord , vol.25
    • Chan, C.S.1    Gertler, T.S.2    Surmeier, D.J.3
  • 125
    • 84859178001 scopus 로고    scopus 로고
    • Dihydropyridine calcium channel blockers and the progression of parkinsonism
    • Marras C, Gruneir A, Rochon P, et al. Dihydropyridine calcium channel blockers and the progression of parkinsonism. Ann Neurol 2012;71: 362-369.
    • (2012) Ann Neurol , vol.71 , pp. 362-369
    • Marras, C.1    Gruneir, A.2    Rochon, P.3
  • 126
    • 78650183301 scopus 로고    scopus 로고
    • Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation study
    • Simuni T, Borushko E, Avram MJ, et al. Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation study. Mov Disord 2010;25: 2863-2866.
    • (2010) Mov Disord , vol.25 , pp. 2863-2866
    • Simuni, T.1    Borushko, E.2    Avram, M.J.3
  • 127
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of α-synuclein: from structure and toxicity to therapeutic target
    • Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 2013;14: 38-48.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3    Masliah, E.4
  • 129
    • 84875415994 scopus 로고    scopus 로고
    • α-Synuclein oligomers and clinical implications for Parkinson disease
    • Kalia LV, Kalia SK, McLean PJ, Lozano AM, Lang AE. α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol 2013;73: 155-169.
    • (2013) Ann Neurol , vol.73 , pp. 155-169
    • Kalia, L.V.1    Kalia, S.K.2    McLean, P.J.3    Lozano, A.M.4    Lang, A.E.5
  • 130
    • 84893143071 scopus 로고    scopus 로고
    • Tolerability and Safety of Subcutaneous Administration of Two Doses of AFFITOPE® PD01A in Early Parkinson's Disease. Clinicaltrials. gov. Available at
    • Tolerability and Safety of Subcutaneous Administration of Two Doses of AFFITOPE® PD01A in Early Parkinson's Disease. Clinicaltrials. gov. Available at: http://clinicaltrials. gov/ct2/show/NCT01568099. Accessed August 16, 2013.
  • 131
    • 1842608890 scopus 로고    scopus 로고
    • Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue
    • Bodles AM, El-Agnaf OM, Greer B, Guthrie DJ, Irvine GB. Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue. Neurosci Lett 2004;359: 89-93.
    • (2004) Neurosci Lett , vol.359 , pp. 89-93
    • Bodles, A.M.1    El-Agnaf, O.M.2    Greer, B.3    Guthrie, D.J.4    Irvine, G.B.5
  • 132
    • 33747607074 scopus 로고    scopus 로고
    • Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders
    • Amer DA, Irvine GB, El-Agnaf OM. Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders. Exp Brain Res 2006;173: 223-233.
    • (2006) Exp Brain Res , vol.173 , pp. 223-233
    • Amer, D.A.1    Irvine, G.B.2    El-Agnaf, O.M.3
  • 133
    • 78649239916 scopus 로고    scopus 로고
    • Molecular chaperones as rational drug targets for Parkinson's disease therapeutics
    • Kalia SK, Kalia LV, McLean PJ. Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets 2010;9: 741-753.
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , pp. 741-753
    • Kalia, S.K.1    Kalia, L.V.2    McLean, P.J.3
  • 134
    • 79955694568 scopus 로고    scopus 로고
    • Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    • Qiao L, Hamamichi S, Caldwell KA, et al. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain 2008;1: 17.
    • (2008) Mol Brain , vol.1 , pp. 17
    • Qiao, L.1    Hamamichi, S.2    Caldwell, K.A.3
  • 135
    • 84865688581 scopus 로고    scopus 로고
    • Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression
    • Yu D, Pendergraff H, Liu J, et al. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 2012;150: 895-908.
    • (2012) Cell , vol.150 , pp. 895-908
    • Yu, D.1    Pendergraff, H.2    Liu, J.3
  • 136
    • 19944432921 scopus 로고    scopus 로고
    • A common LRRK2 mutation in idiopathic Parkinson's disease
    • Gilks WP, Abou-Sleiman PM, Gandhi S, et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 2005;365: 415-416.
    • (2005) Lancet , vol.365 , pp. 415-416
    • Gilks, W.P.1    Abou-Sleiman, P.M.2    Gandhi, S.3
  • 137
    • 50049104725 scopus 로고    scopus 로고
    • Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
    • Healy DG, Falchi M, O'Sullivan SS, et al. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol 2008;7: 583-590.
    • (2008) Lancet Neurol , vol.7 , pp. 583-590
    • Healy, D.G.1    Falchi, M.2    O'Sullivan, S.S.3
  • 138
    • 27644455523 scopus 로고    scopus 로고
    • G2019S LRRK2 mutation in French and North African families with Parkinson's disease
    • Lesage S, Ibanez P, Lohmann E, et al. G2019S LRRK2 mutation in French and North African families with Parkinson's disease. Ann Neurol 2005;58: 784-787.
    • (2005) Ann Neurol , vol.58 , pp. 784-787
    • Lesage, S.1    Ibanez, P.2    Lohmann, E.3
  • 139
    • 31344439221 scopus 로고    scopus 로고
    • LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
    • Ozelius LJ, Senthil G, Saunders-Pullman R, et al. LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N Engl J Med 2006;354: 424-425.
    • (2006) N Engl J Med , vol.354 , pp. 424-425
    • Ozelius, L.J.1    Senthil, G.2    Saunders-Pullman, R.3
  • 140
    • 28044460070 scopus 로고    scopus 로고
    • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
    • West AB, Moore DJ, Biskup S, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 2005;102: 16842-16847.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16842-16847
    • West, A.B.1    Moore, D.J.2    Biskup, S.3
  • 141
    • 33846562487 scopus 로고    scopus 로고
    • Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
    • West AB, Moore DJ, Choi C, et al. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum Mol Genet 2007;16: 223-232.
    • (2007) Hum Mol Genet , vol.16 , pp. 223-232
    • West, A.B.1    Moore, D.J.2    Choi, C.3
  • 142
    • 80054977424 scopus 로고    scopus 로고
    • Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons
    • Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol 2011;6: 1021-1028.
    • (2011) ACS Chem Biol , vol.6 , pp. 1021-1028
    • Ramsden, N.1    Perrin, J.2    Ren, Z.3
  • 143
    • 80053152848 scopus 로고    scopus 로고
    • Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
    • Liu Z, Hamamichi S, Lee BD, et al. Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet 2011;20: 3933-3942.
    • (2011) Hum Mol Genet , vol.20 , pp. 3933-3942
    • Liu, Z.1    Hamamichi, S.2    Lee, B.D.3
  • 144
    • 84878542289 scopus 로고    scopus 로고
    • Exenatide and the treatment of patients with Parkinson's disease
    • May 20 [Epub ahead of print]
    • Aviles-Olmos I, Dickson J, Kefalopoulou Z, et al. Exenatide and the treatment of patients with Parkinson's disease. J Clin Invest 2013 May 20 [Epub ahead of print].
    • (2013) J Clin Invest
    • Aviles-Olmos, I.1    Dickson, J.2    Kefalopoulou, Z.3
  • 145
    • 84893082991 scopus 로고    scopus 로고
    • Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease (NICOPARK2). Clinicaltrials. gov. Available at
    • Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease (NICOPARK2). Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT00873392. Accessed August 16, 2013.
  • 146
    • 84893143983 scopus 로고    scopus 로고
    • Disease-modifying Potential of Transdermal NICotine in Early Parkinson's Disease (NIC-PD). Clinicaltrials. gov. Available at
    • Disease-modifying Potential of Transdermal NICotine in Early Parkinson's Disease (NIC-PD). Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/ NCT01560754. Accessed August 16, 2013.
  • 147
    • 34247862145 scopus 로고    scopus 로고
    • Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease
    • Xue YQ, Zhao LR, Guo WP, Duan WM. Intrastriatal administration of erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson's disease. Neuroscience 2007;146: 1245-1258.
    • (2007) Neuroscience , vol.146 , pp. 1245-1258
    • Xue, Y.Q.1    Zhao, L.R.2    Guo, W.P.3    Duan, W.M.4
  • 148
    • 84856462230 scopus 로고    scopus 로고
    • Use of Cuban recombinant human erythropoietin in Parkinson's disease treatment
    • Pedroso I, Bringas ML, Aguiar A, et al. Use of Cuban recombinant human erythropoietin in Parkinson's disease treatment. MEDICC Rev 2012;14: 11-17.
    • (2012) MEDICC Rev , vol.14 , pp. 11-17
    • Pedroso, I.1    Bringas, M.L.2    Aguiar, A.3
  • 149
    • 77955089797 scopus 로고    scopus 로고
    • Post-MPTP treatment with granulocyte colony-stimulating factor improves nigrostriatal function in the mouse model of Parkinson's disease
    • McCollum M, Ma Z, Cohen E, et al. Post-MPTP treatment with granulocyte colony-stimulating factor improves nigrostriatal function in the mouse model of Parkinson's disease. Mol Neurobiol 2010;41: 410-419.
    • (2010) Mol Neurobiol , vol.41 , pp. 410-419
    • McCollum, M.1    Ma, Z.2    Cohen, E.3
  • 150
    • 84893093996 scopus 로고    scopus 로고
    • Study of the Neuro-protective Effect of Granulocyte-colony Stimulating Factor on Early Stage Parkinson's Disease. Clinicaltrials. gov. Available at
    • Study of the Neuro-protective Effect of Granulocyte-colony Stimulating Factor on Early Stage Parkinson's Disease. Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT01227681. Accessed August 16, 2013.
  • 151
    • 84893028565 scopus 로고    scopus 로고
    • The ParkCycle Study. Clinicaltrials. gov. Available at
    • The ParkCycle Study. Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/ NCT01562496. Accessed August 16, 2013.
  • 152
    • 33646076457 scopus 로고    scopus 로고
    • Practice parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Pahwa R, Factor SA, Lyons KE, et al. Practice parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006;66: 983-995.
    • (2006) Neurology , vol.66 , pp. 983-995
    • Pahwa, R.1    Factor, S.A.2    Lyons, K.E.3
  • 153
    • 80055083817 scopus 로고    scopus 로고
    • The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease
    • Fox SHKR, Lim SY, Ravina B, et al. The Movement Disorder Society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease. Mov Disord 2011;26: S2-S41.
    • (2011) Mov Disord , vol.26
    • Fox, S.H.K.R.1    Lim, S.Y.2    Ravina, B.3
  • 155
    • 77953169733 scopus 로고    scopus 로고
    • Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease
    • Follett KA, Weaver FM, Stern M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010;362: 2077-2091.
    • (2010) N Engl J Med , vol.362 , pp. 2077-2091
    • Follett, K.A.1    Weaver, F.M.2    Stern, M.3
  • 156
    • 0011087583 scopus 로고    scopus 로고
    • Deep brain stimulation for Parkinson's disease: disrupting the disruption
    • Lozano AM, Dostrovsky J, Chen R, Ashby P. Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol 2002;1: 225-231.
    • (2002) Lancet Neurol , vol.1 , pp. 225-231
    • Lozano, A.M.1    Dostrovsky, J.2    Chen, R.3    Ashby, P.4
  • 157
    • 0023262215 scopus 로고
    • Efferent projections of the subthalamic nucleus in the rat: light and electron microscopic analysis with the PHA-L method
    • Kita H., Kitai S. T. Efferent projections of the subthalamic nucleus in the rat: light and electron microscopic analysis with the PHA-L method. J. Comp. Neurol 1987;260: 435-452.
    • (1987) J. Comp. Neurol , vol.260 , pp. 435-452
    • Kita, H.1    Kitai, S.T.2
  • 158
    • 27744448963 scopus 로고    scopus 로고
    • The functional role of the subthalamic nucleus in cognitive and limbic circuits
    • Temel Y, Blokland A, Steinbusch HW, Visser-Vandewalle V. The functional role of the subthalamic nucleus in cognitive and limbic circuits. Prog Neurobiol 2005;76: 393-413.
    • (2005) Prog Neurobiol , vol.76 , pp. 393-413
    • Temel, Y.1    Blokland, A.2    Steinbusch, H.W.3    Visser-Vandewalle, V.4
  • 159
    • 0031696407 scopus 로고    scopus 로고
    • Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection
    • Rodriguez MC, Obeso JA, Olanow CW. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann Neurol 1998;44: S175-S188.
    • (1998) Ann Neurol , vol.44
    • Rodriguez, M.C.1    Obeso, J.A.2    Olanow, C.W.3
  • 160
    • 33750459096 scopus 로고    scopus 로고
    • Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    • Temela Y, Visser-Vandewalle V, Kapland S, et al. Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Res 2006;1120: 100-105.
    • (2006) Brain Res , vol.1120 , pp. 100-105
    • Temela, Y.1    Visser-Vandewalle, V.2    Kapland, S.3
  • 161
    • 84893143934 scopus 로고    scopus 로고
    • Deep Brain Stimulation (DBS) for Early Stage Parkinson's Disease (PD). Clinicaltrials. gov. Available at
    • Deep Brain Stimulation (DBS) for Early Stage Parkinson's Disease (PD). Clinicaltrials. gov. Available at: www. clinicaltrials. gov/ct2/show/NCT00282152. Accessed August 16, 2013.
  • 162
    • 79952740079 scopus 로고    scopus 로고
    • AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
    • LeWitt PA, Rezai AR, Leehey MA, et al. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol 2011;10: 309-319.
    • (2011) Lancet Neurol , vol.10 , pp. 309-319
    • LeWitt, P.A.1    Rezai, A.R.2    Leehey, M.A.3
  • 163
    • 51849088599 scopus 로고    scopus 로고
    • Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease
    • Park HJ, Lee PH, Bang OY, Lee G, Ahn YH. Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's disease. J Neurochem 2008;107: 141-151.
    • (2008) J Neurochem , vol.107 , pp. 141-151
    • Park, H.J.1    Lee, P.H.2    Bang, O.Y.3    Lee, G.4    Ahn, Y.H.5
  • 164
    • 67549118438 scopus 로고    scopus 로고
    • Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease
    • Sadan O, Bahat-Stromza M, Barhum Y, et al. Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease. Stem Cells Dev 2009;18: 1179-1190.
    • (2009) Stem Cells Dev , vol.18 , pp. 1179-1190
    • Sadan, O.1    Bahat-Stromza, M.2    Barhum, Y.3
  • 165
    • 0023623403 scopus 로고
    • Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease
    • Brundin P, Strecker RE, Lindvall O, et al. Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease. Ann N Y Acad Sci 1987; 495, 473-496.
    • (1987) Ann N Y Acad Sci , vol.495 , pp. 473-496
    • Brundin, P.1    Strecker, R.E.2    Lindvall, O.3
  • 166
    • 84874046508 scopus 로고    scopus 로고
    • Therapeutic application of stem cell technology toward the treatment of Parkinson's disease
    • Nishimura K, Takahashi J. Therapeutic application of stem cell technology toward the treatment of Parkinson's disease. Biol Pharm Bull 2013;36: 171-175.
    • (2013) Biol Pharm Bull , vol.36 , pp. 171-175
    • Nishimura, K.1    Takahashi, J.2
  • 167
    • 0036120029 scopus 로고    scopus 로고
    • Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases
    • Mendez I, Dagher A, Hong M, et al. Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. J Neurosurg 2002;96: 589-596.
    • (2002) J Neurosurg , vol.96 , pp. 589-596
    • Mendez, I.1    Dagher, A.2    Hong, M.3
  • 168
    • 79956077225 scopus 로고    scopus 로고
    • Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial
    • Gross RE, Watts RL, Hauser RA, et al. Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2011;10: 509-519.
    • (2011) Lancet Neurol , vol.10 , pp. 509-519
    • Gross, R.E.1    Watts, R.L.2    Hauser, R.A.3
  • 169
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed CR, Greene PE, Breeze RE, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001;344: 710-719.
    • (2001) N Engl J Med , vol.344 , pp. 710-719
    • Freed, C.R.1    Greene, P.E.2    Breeze, R.E.3
  • 170
    • 0042837887 scopus 로고    scopus 로고
    • A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    • Olanow CW, Goetz CG, Kordower JH, et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003;54: 403-414.
    • (2003) Ann Neurol , vol.54 , pp. 403-414
    • Olanow, C.W.1    Goetz, C.G.2    Kordower, J.H.3
  • 171
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    • Kriks S, Shim JW, Piao J, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011;480: 547-551.
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1    Shim, J.W.2    Piao, J.3
  • 172
    • 84870892437 scopus 로고    scopus 로고
    • Clinical experience with stem cells and other cell therapies in neurological diseases
    • Karussis D, Petrou P, Kassis I. Clinical experience with stem cells and other cell therapies in neurological diseases. J Neurol Sci 2013;324: 1-9.
    • (2013) J Neurol Sci , vol.324 , pp. 1-9
    • Karussis, D.1    Petrou, P.2    Kassis, I.3
  • 173
    • 1942520420 scopus 로고    scopus 로고
    • Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough
    • Lang AE, Obeso JA. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol 2004;3: 309-316.
    • (2004) Lancet Neurol , vol.3 , pp. 309-316
    • Lang, A.E.1    Obeso, J.A.2
  • 174
    • 72949111183 scopus 로고    scopus 로고
    • Dopaminergic transplantation for Parkinson's disease: current status and future prospects
    • Olanow CW, Kordower JH, Lang AE, Obeso JA. Dopaminergic transplantation for Parkinson's disease: current status and future prospects. Ann Neurol 2009;66: 591-596.
    • (2009) Ann Neurol , vol.66 , pp. 591-596
    • Olanow, C.W.1    Kordower, J.H.2    Lang, A.E.3    Obeso, J.A.4
  • 175
    • 0024343466 scopus 로고
    • The effect of deprenyl (selegiline) on the natural history of Parkinson's disease
    • Tetrud JW, Langston JW. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science 1989;245: 519-522.
    • (1989) Science , vol.245 , pp. 519-522
    • Tetrud, J.W.1    Langston, J.W.2
  • 176
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • The Parkinson Study Group
    • The Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 1993;328: 176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 178
    • 0030042620 scopus 로고    scopus 로고
    • Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP subjects not requiring levodopa
    • Parkinson Study Group
    • Parkinson Study Group. Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP subjects not requiring levodopa. Ann Neurol 1996;39: 29-36.
    • (1996) Ann Neurol , vol.39 , pp. 29-36
  • 179
    • 0345019854 scopus 로고    scopus 로고
    • Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group
    • Pålhagen S, Heinonen EH, Hägglund J, et al. Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group. Neurology 1998;51: 520-525.
    • (1998) Neurology , vol.51 , pp. 520-525
    • Pålhagen, S.1    Heinonen, E.H.2    Hägglund, J.3
  • 180
    • 33846115045 scopus 로고    scopus 로고
    • A randomized clinical trial of coenzyme Q(10) and GPI-1485 in early Parkinson disease
    • NINDS NET-PD Investigators
    • NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q(10) and GPI-1485 in early Parkinson disease. Neurology 2007;68: 20-28.
    • (2007) Neurology , vol.68 , pp. 20-28
  • 181
    • 0034684139 scopus 로고    scopus 로고
    • Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group
    • Parkinson Study Group
    • Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group. JAMA 2000;284: 1931-1938.
    • (2000) JAMA , vol.284 , pp. 1931-1938
  • 182
    • 84893143864 scopus 로고    scopus 로고
    • GPI 1485, a neuroimmunophilin ligand, fails to alter disease progression in mild to moderate Parkinson's disease
    • The GPI 1485 Study Group
    • The GPI 1485 Study Group. GPI 1485, a neuroimmunophilin ligand, fails to alter disease progression in mild to moderate Parkinson's disease. Mov Disord 2006;21: A1009.
    • (2006) Mov Disord , vol.21
  • 183
    • 84873482476 scopus 로고    scopus 로고
    • Evaluation of a potential neurotrophic drug on the progression of Parkinson disease with 18FDOPA
    • Ribeiro MJ, Stoessl AJ, Brooks D, et al. Evaluation of a potential neurotrophic drug on the progression of Parkinson disease with 18FDOPA. J Nucl Med 2009;50(Suppl. 2): A125.
    • (2009) J Nucl Med , vol.50 , Issue.SUPPL. 2
    • Ribeiro, M.J.1    Stoessl, A.J.2    Brooks, D.3
  • 184
    • 77949873306 scopus 로고    scopus 로고
    • GM1 ganglioside in Parkinson's disease: results of a five year open study
    • Schneider JS, Sendek S, Daskalakis C, Cambi F. GM1 ganglioside in Parkinson's disease: results of a five year open study. J Neurol Sci 2010;292: 45-51.
    • (2010) J Neurol Sci , vol.292 , pp. 45-51
    • Schneider, J.S.1    Sendek, S.2    Daskalakis, C.3    Cambi, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.