GPI1046 prevents dopaminergic dysfunction by activating glutathione system in the mouse striatum

Neuroscience Letters

Volumn 321, Issue 1-2, 2002, Pages 45-48

  Tanaka, Ken ichi ^a   Yoshioka, Michiyo ^a   Miyazaki, Ikuko ^a   Fujita, Naoko ^a   Ogawa, Norio ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

6 Hydroxydopamine; Antioxidant; FK506 binding protein; Neuroimmunophilin; Non immunosuppressive immunophilin ligands; Tacrolimus

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; CATALASE; GLUTATHIONE; OXIDOPAMINE; SUPEROXIDE DISMUTASE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; LIPID PEROXIDATION; MALE; METABOLITE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TOXICITY;

ANIMALS; ANTIOXIDANTS; CATALASE; DOPAMINE; DOPAMINE AGENTS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED ICR; NEOSTRIATUM; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; OXIDOPAMINE; PARKINSON DISEASE; PYRROLIDINES; SUPEROXIDE DISMUTASE; TACROLIMUS;

EID: 0037087049     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02547-2     Document Type: Article

References (20)

1. Monoamine oxidase, hydrogen peroxide, and Parkinson's disease
2. Multiple roles of glutathione in the central nervous system
3. A novel immunophilin ligands: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease
4. The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells
5. Neuroimmunophilin ligands: Evaluation of their therapeutic potential for the treatment of neurological disorders
6. A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration
7. Analysis of the neurotrophic effects of GPI1046 on neuron survival and regeneration in culture and in vivo
8. Immunophilin ligands as a novel treatment for neurological disorders
9. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist
10. Oxidative stress and the pathogenesis of Parkinson's disease
11. Degeneration of dopaminergic neurons and free radicals: Possible participation of levodopa
12. The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia
13. The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats
14. Neural actions of immunophilin ligands
15. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
16. 2-induced apoptotic cell death by increasing glutathione levels in Neuro 2A neuroblastoma cells
17. Effects of immunophilin ligands on hydrogen peroxide-induced apoptosis in C6 glioma cells
18. 2-induced cell damage by increasing glutathione levels in NG108-15 cells
19. Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist
20. The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle