Tolerability of isradipine in early Parkinson's disease: A pilot dose escalation study

Movement Disorders

Volumn 25, Issue 16, 2010, Pages 2863-2866

  Simuni, Tanya ^a   Borushko, Emily ^a   Avram, Michael J ^a   Miskevics, Scott ^b   Martel, Audrey ^a   Zadikoff, C ^a   Videnovic, Aleksandar ^a   Weaver, Frances M ^b   Williams, Karen ^a   Surmeier, D James ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b HINES VA HOSPITAL   (United States)

Author keywords

Clinical trial; Dihydropyridine calcium channel blockers; Parkinson's disease

Indexed keywords

ISRADIPINE;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED DRUG RELEASE; DIZZINESS; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HUMAN; LEG EDEMA; MALE; MOTOR DYSFUNCTION; PARKINSON DISEASE; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; CALCIUM CHANNEL BLOCKERS; HUMANS; ISRADIPINE; MIDDLE AGED; PARKINSON DISEASE; PILOT PROJECTS; TREATMENT OUTCOME;

EID: 78650183301     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23308     Document Type: Article

References (11)

1. Chan CS, Guzman JN, Ilijic E, et al. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 2007; 447: 1081-1086.
2. Becker C, Jick SS, Meier CR. Use of antihypertensives and the risk of Parkinson disease. Neurology 2008; 70 (Part 2): 1438-1444.
3. Ritz B, Rhodes SL, Qian L, et al. L-type calcium channel blockers and Parkinson disease in Denmark. Ann Neurol 2010; 67: 600-606.
4. Goetz CG, Stebbins GT, Chmura TA, et al. Teaching tape for the motor section of the unified Parkinson's disease rating scale. Mov Disord 1995; 10: 263-266.
5. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967; 17: 427-442.
6. Schwab RS, England A. Projection technique for evaluating surgery in Parkinson's disease. Gillingham FJ, DI, editors. Presented at the 3rd Symposium on Parkinson's Disease, Edinburgh, Scotland: E& S Livingstone; 1969. pp 152-157.
7. Folstein MF, Folstein SE, Mchugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
8. Pahwa R, Wilkinson S, Smith D, Lyons K, Miyawaki E, Koller WC. High-frequency stimulation of the globus pallidus for the treatment of Parkinson's disease. Neurology 1997; 49: 249-253.
9. Physician desk reference PDR: Accessed 12 June 2010.
10. Weir MR, Rosenberger C, Fink JC. Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists. Am J Hypertens 2001; 14 (Part 1): 963-968.
11. NINDS NET-PD Investigators. A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. Neurology 2006; 66: 664-671.