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Volumn 351, Issue 24, 2004, Pages 2498-2508

Levodopa and the progression of parkinson’s disease

(138)  Fahn, S a   Oakes, D an   Shoulson, I an   Kieburtz, K b   Rudolph, A c   Marek, K an   Seibyl, J d   Lang, A e   Olanow, C W f   Tanner, C g   Schifitto, G c   Zhao, H c   Reyes, L a   Shinaman, A c   Comella, C h   Goetz, C h   Blasucci, L h   Samanta, J i   Stacy, M i   Williamson, K i   more..


Author keywords

[No Author keywords available]

Indexed keywords

2BETA CARBOXYMETHOXY 3BETA (4 IODOPHENYL)TROPANE I 123; IODINE 123; LEVODOPA; PLACEBO; UNCLASSIFIED DRUG;

EID: 19744378296     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa033447     Document Type: Article
Times cited : (1612)

References (35)
  • 1
    • 0017082987 scopus 로고
    • Time course of nigrostriatal degeneration in Parkinson’s disease: A detailed study of influential factors in human brain amine analysis
    • Riederer P, Wuketich S. Time course of nigrostriatal degeneration in Parkinson’s disease: a detailed study of influential factors in human brain amine analysis. J Neural Transm 1976;38:277-301.
    • (1976) J Neural Transm , vol.38 , pp. 277-301
    • Riederer, P.1    Wuketich, S.2
  • 2
    • 0027200457 scopus 로고
    • Practice parameters: Initial therapy of Parkinson’s disease (summary statement): Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Practice parameters: initial therapy of Parkinson’s disease (summary statement): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1993;43:1296-7.
    • (1993) Neurology , vol.43 , pp. 1296-1297
  • 3
    • 0032890731 scopus 로고    scopus 로고
    • Parkinson disease, the effect of levodopa, and the ELLDOPA trial
    • Fahn S. Parkinson disease, the effect of levodopa, and the ELLDOPA trial. Arch Neurol 1999;56:529-35.
    • (1999) Arch Neurol , vol.56 , pp. 529-535
    • Fahn, S.1
  • 4
    • 0030815243 scopus 로고    scopus 로고
    • Levodopa-induced neurotoxicity: Does it represent a problem for the treatment of Parkinson’s disease?
    • Fahn S. Levodopa-induced neurotoxicity: does it represent a problem for the treatment of Parkinson’s disease? CNS Drugs 1997;8:376-93.
    • (1997) CNS Drugs , vol.8 , pp. 376-393
    • Fahn, S.1
  • 6
    • 0034844226 scopus 로고    scopus 로고
    • Is there a rationale for neuroprotection against dopamine toxicity in Parkinson’s disease?
    • Barzilai A, Melamed E, Shirvan A. Is there a rationale for neuroprotection against dopamine toxicity in Parkinson’s disease? Cell Mol Neurobiol 2001;21:215-35.
    • (2001) Cell Mol Neurobiol , vol.21 , pp. 215-235
    • Barzilai, A.1    Melamed, E.2    Shirvan, A.3
  • 7
    • 0037309436 scopus 로고    scopus 로고
    • Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress
    • Mytilineou C, Walker RH, JnoBaptiste R, Olanow CW. Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress. J Pharmacol Exp Ther 2003;304:792-800.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 792-800
    • Mytilineou, C.1    Walker, R.H.2    Jnobaptiste, R.3    Olanow, C.W.4
  • 8
    • 0031899713 scopus 로고    scopus 로고
    • Levodopa: Is toxicity a myth?
    • Agid Y. Levodopa: is toxicity a myth? Neurology 1998;50:858-63.
    • (1998) Neurology , vol.50 , pp. 858-863
    • Agid, Y.1
  • 9
    • 0031968959 scopus 로고    scopus 로고
    • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
    • Murer MG, Dziewczapolski G, Menalled LB, et al. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Ann Neurol 1998; 43:561-75.
    • (1998) Ann Neurol , vol.43 , pp. 561-575
    • Murer, M.G.1    Dziewczapolski, G.2    Menalled, L.B.3
  • 10
    • 0035353737 scopus 로고    scopus 로고
    • DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl (3) nigrostriatal lesions
    • Datla KP, Blunt SB, Dexter DT. Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl (3) nigrostriatal lesions. Mov Disord 2001;16:424-34.
    • (2001) Mov Disord , vol.16 , pp. 424-434
    • Datla, K.P.1    Blunt, S.B.2    Dexter, D.T.3    Chronic, L.4
  • 11
    • 0022946382 scopus 로고
    • Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period
    • Quinn N, Parkes D, Janota I, Marsden CD. Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period. Mov Disord 1986;1:65-8.
    • (1986) Mov Disord , vol.1 , pp. 65-68
    • Quinn, N.1    Parkes, D.2    Janota, I.3    Marsden, C.D.4
  • 13
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression and mortality
    • Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-42.
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 14
    • 0000224448 scopus 로고
    • UPDRS Development Committee. The Unified Parkinson’s Disease Rating Scale
    • In Fahn S, Marsden CD, Calne DB, Goldstein M, eds., Florham Park, N.J.: Macmillan Healthcare Information
    • Fahn S, Elton RL, UPDRS Development Committee. The Unified Parkinson’s Disease Rating Scale. In Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Recent developments in Parkinson’s disease. Vol. 2. Florham Park, N.J.: Macmillan Healthcare Information, 1987:153-163, 293-304.
    • (1987) Recent Developments in Parkinson’s Disease , vol.2
    • Fahn, S.1    Elton, R.L.2
  • 15
    • 0014208039 scopus 로고
    • Aromatic amino acids and modification of parkinsonism
    • Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of parkinsonism. N Engl J Med 1967;276: 374-9.
    • (1967) N Engl J Med , vol.276 , pp. 374-379
    • Cotzias, G.C.1    Van Woert, M.H.2    Schiffer, L.M.3
  • 16
    • 0034106361 scopus 로고    scopus 로고
    • Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson’s disease
    • Hauser RA, Koller WC, Hubble JP, Malapira T, Busenbark K, Olanow CW. Time course of loss of clinical benefit following withdrawal of levodopa/carbidopa and bromocriptine in early Parkinson’s disease. Mov Disord 2000;15:485-9.
    • (2000) Mov Disord , vol.15 , pp. 485-489
    • Hauser, R.A.1    Koller, W.C.2    Hubble, J.P.3    Malapira, T.4    Busenbark, K.5    Olanow, C.W.6
  • 17
    • 0028858370 scopus 로고
    • The effect of deprenyl and levodopa on the progression of Parkinson’s disease
    • Olanow CW, Hauser RA, Gauger L, et al. The effect of deprenyl and levodopa on the progression of Parkinson’s disease. Ann Neurol 1995;38:771-7.
    • (1995) Ann Neurol , vol.38 , pp. 771-777
    • Olanow, C.W.1    Hauser, R.A.2    Gauger, L.3
  • 18
    • 0035846468 scopus 로고    scopus 로고
    • 123I]b-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression
    • Marek K, Innis R, van Dyck C, et al. [123I]b-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression. Neurology 2001;57:2089-94.
    • (2001) Neurology , vol.57 , pp. 2089-2094
    • Marek, K.1    Innis, R.2    Van Dyck, C.3
  • 19
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease
    • Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. N Engl J Med 1993;328:176-83.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 20
    • 0029094141 scopus 로고
    • Decreased single-photon emission computed tomographic [123I ]beta-CIT striatal uptake correlates with symptom severity in Parkinson’s disease
    • Seibyl JP, Marek KL, Quinlan D, et al. Decreased single-photon emission computed tomographic [123I ]beta-CIT striatal uptake correlates with symptom severity in Parkinson’s disease. Ann Neurol 1995;38: 589-98.
    • (1995) Ann Neurol , vol.38 , pp. 589-598
    • Seibyl, J.P.1    Marek, K.L.2    Quinlan, D.3
  • 21
    • 10044273613 scopus 로고    scopus 로고
    • B-CIT scans without evidence of dopaminergic deficit (SWEDD) in the ELLDOPA-CIT and CALM-CIT study: Longterm imaging assessment
    • Parkinson Study Group
    • Marek K, Seibyl J, Parkinson Study Group. b-CIT scans without evidence of dopaminergic deficit (SWEDD) in the ELLDOPA-CIT and CALM-CIT study: longterm imaging assessment. Neurology 2003; 60:Suppl 1:A298. abstract.
    • (2003) Neurology , vol.60
    • Marek, K.1    Seibyl, J.2
  • 22
    • 0036764810 scopus 로고    scopus 로고
    • Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson’s disease
    • Hauser RA, Holford NHG. Quantitative description of loss of clinical benefit following withdrawal of levodopa-carbidopa and bromocriptine in early Parkinson’s disease. Mov Disord 2002;17:961-8.
    • (2002) Mov Disord , vol.17 , pp. 961-968
    • Hauser, R.A.1    Holford, N.H.G.2
  • 23
    • 0015043830 scopus 로고
    • L-dopa therapy of Parkinson’s disease: Plasma L-dopa concentration, therapeutic response, and side effects
    • Muenter MD, Tyce GM. L-dopa therapy of Parkinson’s disease: plasma L-dopa concentration, therapeutic response, and side effects. Mayo Clin Proc 1971;46:231-9.
    • (1971) Mayo Clin Proc , vol.46 , pp. 231-239
    • Muenter, M.D.1    Tyce, G.M.2
  • 24
    • 0035849532 scopus 로고    scopus 로고
    • Influence of L-dopa and pramipexole on striatal dopamine trans-porter in early PD
    • Guttman M, Stewart D, Hussey D, Wilson A, Houle S, Kish S. Influence of L-dopa and pramipexole on striatal dopamine trans-porter in early PD. Neurology 2001;56:1559-64.
    • (2001) Neurology , vol.56 , pp. 1559-1564
    • Guttman, M.1    Stewart, D.2    Hussey, D.3    Wilson, A.4    Houle, S.5    Kish, S.6
  • 25
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression
    • Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA 2002;287: 1653-61.
    • (2002) JAMA , vol.287 , pp. 1653-1661
  • 26
    • 0033408426 scopus 로고    scopus 로고
    • Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter SPECT imaging with [123I]beta-CIT
    • Innis RB, Marek KL, Sheff K, et al. Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter SPECT imaging with [123I]beta-CIT. Mov Disord 1999;14:436-42.
    • (1999) Mov Disord , vol.14 , pp. 436-442
    • Innis, R.B.1    Marek, K.L.2    Sheff, K.3
  • 27
    • 0033756440 scopus 로고    scopus 로고
    • Reproducibility and effect of levodopa on dopamine transporter function measurements: A [F-18]CFT PET study
    • Nurmi E, Bergman J, Eskola O, et al. Reproducibility and effect of levodopa on dopamine transporter function measurements: a [F-18]CFT PET study. J Cereb Blood Flow Metab 2000;20:1604-9.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1604-1609
    • Nurmi, E.1    Bergman, J.2    Eskola, O.3
  • 28
    • 0027362832 scopus 로고
    • Toxic and protective effects of L-DOPA on mesencephalic cell cultures
    • Mytilineou C, Han SK, Cohen G. Toxic and protective effects of L-DOPA on mesencephalic cell cultures. J Neurochem 1993; 61:1470-8.
    • (1993) J Neurochem , vol.61 , pp. 1470-1478
    • Mytilineou, C.1    Han, S.K.2    Cohen, G.3
  • 29
    • 0030880246 scopus 로고    scopus 로고
    • Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms
    • Mena MA, Casarejos MJ, Carazo A, Paino CL, Garcia de Yebenes J. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms. J Neural Transm 1997;104:317-28.
    • (1997) J Neural Transm , vol.104 , pp. 317-328
    • Mena, M.A.1    Casarejos, M.J.2    Carazo, A.3    Paino, C.L.4    Garcia De Yebenes, J.5
  • 30
    • 0030931665 scopus 로고    scopus 로고
    • Neurotrophic effects of L-DOPA in postnatal midbrain dopamine neuron/cortical astrocyte cocultures
    • Mena MA, Davila V, Sulzer D. Neurotrophic effects of L-DOPA in postnatal midbrain dopamine neuron/cortical astrocyte cocultures. J Neurochem 1997;69:1398-408.
    • (1997) J Neurochem , vol.69 , pp. 1398-1408
    • Mena, M.A.1    Davila, V.2    Sulzer, D.3
  • 31
    • 0029990439 scopus 로고    scopus 로고
    • Astrocytes protect neurons from hydrogen peroxide toxicity
    • Desagher S, Glowinski J, Premont J. Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci 1996;16:2553-62.
    • (1996) J Neurosci , vol.16 , pp. 2553-2562
    • Desagher, S.1    Glowinski, J.2    Premont, J.3
  • 32
    • 0030059868 scopus 로고    scopus 로고
    • L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress
    • Han SK, Mytilineou C, Cohen G. L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J Neurochem 1996;66:501-10.
    • (1996) J Neurochem , vol.66 , pp. 501-510
    • Han, S.K.1    Mytilineou, C.2    Cohen, G.3
  • 33
    • 0022375650 scopus 로고
    • A neuroleptic malignantlike syndrome due to levodopa therapy withdrawal
    • Friedman JH, Feinberg SS, Feldman RG. A neuroleptic malignantlike syndrome due to levodopa therapy withdrawal. JAMA 1985;254:2792-5.
    • (1985) JAMA , vol.254 , pp. 2792-2795
    • Friedman, J.H.1    Feinberg, S.S.2    Feldman, R.G.3
  • 34
    • 0035470411 scopus 로고    scopus 로고
    • Neuroleptic malignant syndrome in advanced Parkinson’s disease
    • Gordon PH, Frucht SJ. Neuroleptic malignant syndrome in advanced Parkinson’s disease. Mov Disord 2001;16:960-2.
    • (2001) Mov Disord , vol.16 , pp. 960-962
    • Gordon, P.H.1    Frucht, S.J.2
  • 35
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson’s disease with ropinirole versus levodopa: The REALPET study
    • Whone AL, Watts RL, Stoessl AJ, et al. Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REALPET study. Ann Neurol 2003;54:93-101.
    • (2003) Ann Neurol , vol.54 , pp. 93-101
    • Whone, A.L.1    Watts, R.L.2    Stoessl, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.