Reactive dopamine metabolites and neurotoxicity: Implications for Parkinson's disease

Advances in Experimental Medicine and Biology

Volumn 387, Issue , 1996, Pages 97-106

  Hastings, Teresa G ^a   Lewis, David A ^a   Zigmond, Michael J ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; ANTIOXIDANT; ASCORBIC ACID; BRAIN PROTEIN; CATECHOL DERIVATIVE; CYSTEINE DERIVATIVE; DOPAMINE; GLUTATHIONE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DOPAMINE METABOLISM; MALE; METABOLITE; NEOSTRIATUM; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

EID: 0029759598     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9480-9_13     Document Type: Conference Paper

References (43)

1. Agid Y., Ruberg M., Javoy-Agid R., Hirsch E., Raisman-Vozari R., Vyas S., Baucheux B., Michel P., Kastner A., Blanchard B., Damier P., Villares J. and Zhang, P. (1993) Are dopaminergic neurons selectively vulnerable to Parkinson's disease? In: Narabayashi H., Ngatsu T., Yanagisawa N. and Mizuno, Y. (eds.), Advances in Neurology, Vol. 60, pp 148-164.
2. Barr G.A., Eckenrode T.C. and Murray M. (1987) Normal development and effects of early deafferentation on choline acetyltransferase, substance P and serotonin-like immunoreactivity in the interpeduncular nucleus. Brain Res. 418, 301-313.
3. Bernheimer H., Birkmayer W., Hornykiewicz O., Jellinger K. and Seitelberger, F. (1973) Brain dopamine and the syndromes of Parkinson and Huntington: Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20, 415-455
4. Bradford M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye-binding. Anal. Biochem. 72, 248-254.
5. Carstam R., Brinck C., Fornstedt B., Rorsman H. and Rosengren E. (1990) 5-S-Cysteinyldopac in human urine. Acta Derm. Venereol. (Stockh). 70, 373-377.
6. Cohen G. (1983) The pathobiology of Parkinson's disease: Biochemical aspects of dopamine neuron senescence. J. Neural Transm. 19 (Suppl), 89-103.
7. Dexter D.T., Carter C.J., Wells F.R., Javoy-Agid F., Lees A., Jenner P. and Marsden C.D. (1989) Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J. Neurochem. 52, 381-389.
8. Dexter D.T., Holley A.E., Flitter W.D., Slater T.F., Wells F.R., Daniel S.E., Lees A.J., Jenner P. and Marsden C.D. (1994) Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Movement Disorders 9, 92-97.
9. Filloux F. and Townsend J.J. (1993) Pre- and post-synaptic neurotoxic effects of dopamine demonstrated by intrastriatal injection. Exp. Neurol. 119, 79-88.
10. Fornstedt B., Bergh I., Rosengren E. and Carlsson, A. (1990a) An improved HPLC-electrochemical detection method for measuring brain levels of 5-S-cysteinyldopamine, 5-S-cysteinyl-3,4-dihydroxyphenylalanine, and 5-S-cysteinyl-3,4-dihydroxyphenylacetic acid. J. Neurochem. 54, 578-586.
11. Fornstedt B., Brum A., Rosengren E. and Carlsson A. (1989) The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra. J. Neural Transm. 1, 279-295.
12. Fornstedt B., Pileblad E. and Carlsson A. (1990b) In vivo autoxidation of dopamine in guinea pig striatum increases with age. J. Neurochem. 55, 655-659.
13. Fornstedt B. and Carlsson A. (1991) Vitamin C deficiency facilitates 5-S-cysteinyldopamine formation in guinea pig striatum. J. Neurochem. 56, 407-414.
14. Glantz L.A. and Lewis D.A. (1994) Synaptophysin and not Rab3A immunoreactivity is specifically reduced in the prefrontal cortex of schizophrenic subjects. Soc. Neurosci. Abstr. 20, 622.
15. Graham D.G., Tiffany S.M., Bell W.R. Jr. and Gutknecht W.F. (1978) Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol. Pharmacol. 14, 644-653.
16. Graham D.G. (1978) Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol. Pharmacol. 14, 633-643.
17. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
18. Hastings T.G., Lewis D.A. and Zigmond M.J. (1994) Intrastriatally administered dopamine: Evidence of selective neurotoxicity associated with dopamine oxidation. Soc. Neurosci. Abstr. 20, 413.
19. 3H-dopamine: Impact of ascorbic acid and glutathione. J. Neurochem. 63, 1126-1132.
20. Hastings T.G. (1995) Enzymatic oxidation of dopamine: The role of prostaglandin H synthase. J. Neurochem. 64, 919-924.
21. Hirsch E., Graybiel A.M. and Agid Y.A. (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334, 345-348.
22. Ito S., Kato T. and Fujita K. (1988) Covalent binding of catechols to proteins through the sulphydryl group. Biochem. Pharmacol. 37, 1707-1710.
23. Kastner A., Hirsch E.C., Lejeune O., Javoy-Agid F., Rascol O. and Agid Y. (1992) Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J. Neurochem. 59, 1080-1089.
24. Kato T., Ito S. and Fujita K. (1986) Tyrosinase-catalyzed binding of 3,4-dihydroxyphenylalanine with proteins through the sulfhydryl group. Biochim. Biophys. Acta 881, 415-421.
25. Kish S.J., Morito C. and Hornykiewicz O. (1985) Glutathione peroxidase activity in Parkinson's disease brain. Neurosci. Lett. 58, 343-346.
26. Lewis D.A., Melchitzky D.S., Haycock J.W. (1994) Expression and distribution of two isoforms of tyrosine hydroxylase in macaque monkey brain. Brain Res. 656, 1-13.
27. 3H]norepinephrine with particulate fractions of cells responsive to catecholamines. Mol. Pharmacol. 10, 563-581.
28. Mann V.M., Cooper J.M., Daniel S.E., Srai K., Jenner P., Marsden C.D. and Schapira A.H.V. (1994) Complex I, iron, and ferritin in Parkinson's disease substantia nigra. Ann. Neurol. 36, 876-881.
29. Martilla R.J., Lorentz H., Rinne U.K. (1988) Oxygen toxicity protecting enzymes in Parkinson's disease. J. Neurol. Sci. 86, 321-31.
30. McLean J.H. and M.T. Shipley (1987) Serotonergic afferents to the rat olfactory bulb: I. Origins and laminar specificity of serotonergic inputs in the adult rat. J. Neurosci. 7, 3016-3028.
31. Michel P.P. and Hefti F. (1990) Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture. J. Neurosci. Res. 26, 428-435.
32. Perry T.L., Godin D.V. and Hansen S. (1982) Parkinson's disease: A disorder due to nigral glutathione deficiency? Neurosci. Lett. 33, 305-310.
33. Rosengren E., Linder-Eliasson E. and Carlsson A. (1985) Detection of 5-S-cysteinyldopamine in human brain. J. Neural Transm. 63, 247-253.
34. Rotman A., Daly J.W. and Creveling C.R. (1976) Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and related compounds with proteins in vitro: A model for cytotoxicity. Mol. Pharmacol. 12, 887-899.
35. Saggu H., Cooksey J., Dexter D., Wells F.R., Lees A., Penner P. and Marsden C.D. (1989) A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra. J. Neurochem. 53, 692-697.
36. Saner A. and Thoenen H. (1971) Model experiments on the molecular mechanism of action of 6-hydroxydopamine. Mol. Pharmacol. 7, 147-154.
37. Scheulen M., Wollenberg P., Bolt H.M., Kappus H. and Remmer H. (1975) Irreversible binding of dopa and dopamine metabolites to protein by rat liver microsomes. Biochem. Biophys. Res. Commun. 66, 1396-1400.
38. Schmidt D.J., Ritter J.K., Sonsalla P.K., Hanson R. and Gibb J.W. (1985) Role of dopamine in the neurotoxic effects of methamphetamine. J. Pharmacol. Exp. Ther. 233, 539-544.
39. Sofie E., Paulus W., Jellinger K., Reiderer P. and Youdim M.B.H. (1991) Selective increase of iron in substantia nigra zona compacta of Parkinsonian brains. J. Neurochem. 56, 978-982.
40. Tse D.C.S., McCreery R.L. and Adams R.N. (1976) Potential oxidative pathways of brain catecholamines. J. Med. Chem. 19, 37-40.
41. Weinberger J., Nieves-Rosa J. and Cohen G. (1985) Nerve terminal damage in cerebral ischemia: Protective effect of alpha-methyl-para-tyrosine. Stroke 16, 864-870.
42. Zigmond M.J., Acheson A.L., Stachowiak M.K. and Stricker E.M. (1984) Neurochemical compensation after nigrostriatal injury in an animal model of preclinical Parkinsonism. Arch Neurol. 41, 856-890.
43. Zigmond M.J., Hastings T.G. and Abercrombie, E.D. (1992) Neurochemical responses to 6-hydroxydopamine and L-DOPA therapy: Implications for Parkinson's disease. Ann. NY Acad. Sci. 648, 71-86.