Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise

Progress in Neurobiology

Volumn 113, Issue , 2014, Pages 40-55

  Irwin, Ronald W ^a   Brinton, Roberta Diaz ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Neurogenesis; Neurosteroid; Pharmacodynamics; Pharmacokinetics; Regenerative medicine; Treatment regimen

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; CHOLESTEROL; NEUROSTEROID;

AGING; ALZHEIMER DISEASE; AMNESIA; AREA UNDER THE CURVE; BRAIN DEVELOPMENT; CELL PROLIFERATION; CHOLESTEROL METABOLISM; CLINICAL STUDY; CLINICAL TRIAL (TOPIC); COGNITION; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG SAFETY; ENZYME ACTIVITY; IN VIVO STUDY; LONG TERM CARE; MEMORY; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NEURAL STEM CELL; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; PREVENTION AND CONTROL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; STATE DEPENDENT LEARNING; STEROIDOGENESIS; SYSTEMS BIOLOGY; THERAPY EFFECT; TRANSLATIONAL RESEARCH; WHITE MATTER;

2-HYDROXYPROPYL Β-CYCLODEXTRIN; 3-HYDROXY-3-METHYL-GLUTARYL-COA-REDUCTASE; 3XTGAD; 3Α-HSD; 3Α-HYDROXYSTEROID DEHYDROGENASE; 3Β-HSD; 3Β-HYDROXYSTEROID DEHYDROGENASE; 5Α-DHP; 5Α-DIHYDROPROGESTERONE; 5Α-R; 5Α-REDUCTASE; ABAD; AD; ADENINE NUCLEOTIDE TRANSPORTER PROTEIN; ALLO; ALLOPREGNANOLONE; ALZHEIMER'S DISEASE; AMYLOID-BETA BINDING ALCOHOL DEHYDROGENASE; ANT; AREA UNDER THE CURVE; AUC; AΒ; CGMP; CHEMISTRY, MANUFACTURING, AND CONTROLS; CMC; CYP3A; CYP450SCC; CYTOCHROME P450 3A; CYTOCHROME P450 SIDE-CHAIN CLEAVAGE; EMA; EUROPEAN MEDICINES AGENCY; FDA; GLP; GOOD LABORATORY PRACTICES; GOOD MANUFACTURING PRACTICES; HMG-COA-R; HΒCD; IM; IN; IND; INTRAMUSCULAR; INTRANASAL; INTRAVENOUS; INVESTIGATIONAL NEW DRUG; IV; LIVER-X-RECEPTOR; LXR; MAXIMUM TOLERATED DOSE; MED; MINIMAL EFFECTIVE DOSE; MTD; NEUROGENESIS; NEUROSTEROID; NON-TRANSGENIC; NONTG; PHARMACODYNAMICS; PHARMACOKINETICS; PKA; PKCE; PREGNANE-X-RECEPTOR; PROTEIN KINASE A; PROTEIN KINASE C EPSILON; PXR; REGENERATIVE MEDICINE; SBEΒCD; SC; SGZ; STAR; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SUBCUTANEOUS; SUBGRANULAR ZONE; SUBVENTRICULAR ZONE; SULFOBUTYL ETHER Β-CYCLODEXTRIN; SVZ; TD; TRANSDERMAL; TRANSLOCATOR PROTEIN; TREATMENT REGIMEN; TRIPLE TRANSGENIC MOUSE MODEL OF AD; TSPO; UNITED STATES FOOD AND DRUG ADMINISTRATION; VDAC; VOLTAGE-DEPENDENT ANION CHANNEL PROTEIN; Β-AMYLOID;

ALZHEIMER DISEASE; ANIMALS; BRAIN; HUMANS; NEUROPROTECTIVE AGENTS; PREGNANOLONE;

EID: 84892885865     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.08.004     Document Type: Review

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