Integration of early physiological responses predicts later illness severity in preterm infants

Science Translational Medicine

Volumn 2, Issue 48, 2010, Pages

  Saria, Suchi ^a   Rajani, Anand K ^b   Gould, Jeffrey ^b   Koller, Daphne ^a   Penn, Anna A ^b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APGAR SCORE; ARTICLE; AUTOANALYSIS; BIRTH WEIGHT; BREATHING RATE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DATA EXTRACTION; DISEASE SEVERITY; FEMALE; GESTATIONAL AGE; HEART RATE; HUMAN; INFANT; INFANT MORTALITY; INFECTION COMPLICATION; INSTRUMENT VALIDATION; INTERMETHOD COMPARISON; LUNG DISEASE; MACHINE LEARNING; MALE; NEWBORN ASSESSMENT; NEWBORN MORBIDITY; NON INVASIVE MEASUREMENT; PHYSISCORE; PREMATURITY; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SCORING SYSTEM; SIGNAL DETECTION; ALGORITHM; HOSPITALIZATION; MORBIDITY; NEWBORN; NEWBORN INTENSIVE CARE; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR;

ALGORITHMS; APGAR SCORE; BIRTH WEIGHT; CARDIOVASCULAR DISEASES; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INTENSIVE CARE UNITS, NEONATAL; MORBIDITY; PREGNANCY; RISK FACTORS; ROC CURVE; SEVERITY OF ILLNESS INDEX;

EID: 77956583100     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001304     Document Type: Article

References (29)

1. R. Behrman, A. Butler, Eds., Preterm Birth: Causes, Consequences and Prevention (National Academies Press, Washington, DC, 2007).
2. P. A. Robertson, S. H. Sniderman, R. K. Laros Jr., R. Cowan, D. Heilbron, R. L. Goldenberg, J. D. Iams, R. K. Creasy, Neonatal morbidity according to gestational age and birth weight from five tertiary care centers in the United States, 1983 through 1986. Am. J. Obstet. Gynecol. 166, 1629-1641 (1992).
3. J. E. Tyson, N. A. Parikh, J. Langer, C. Green, R. D. Higgins; National Institute of Child Health and Human Development Neonatal Research Network, Intensive care for extreme prematurity - moving beyond gestational age. N. Engl. J. Med. 358, 1672-1681 (2008).
4. D. K. Richardson, J. E. Gray, M. C. McCormick, K. Workman, D. A. Goldmann, Score for Neonatal Acute Physiology: A physiologic severity index for neonatal intensive care. Pediatrics 91, 617-623 (1993).
5. D. K. Richardson, J. D. Corcoran, G. J. Escobar, S. K. Lee, SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores. J. Pediatr. 138, 92-100 (2001).
6. The International Neonatal Network, The CRIB (Clinical Risk Index for Babies) score: A tool for assessing initial risk and comparing performance of neonatal intensive care units. Lancet 342, 193-198 (1993).
7. V. Schulte-Frohlinde, Y. Ashkenazy, A. L. Goldberger, P. Ivanov, M. Costa, A. Morley-Davies, H. E. Stanley, L. Glass, Complex patterns of abnormal heartbeats. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 66, 031901 (2002).
8. H. Tsuji, F. J. Venditti Jr., E. S. Manders, J. C. Evans, M. G. Larson, C. L. Feldman, D. Levy, Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 90, 878-883 (1994).
9. M. P. Griffin, D. E. Lake, J. R. Moorman, Heart rate characteristics and laboratory tests in neonatal sepsis. Pediatrics 115, 937-941 (2005).
10. K. P. Williams, F. Galerneau, Intrapartum fetal heart rate patterns in the prediction of neonatal acidemia. Am. J. Obstet. Gynecol. 188, 820-823 (2003).
11. B. M. Casey, D. D. McIntire, K. J. Leveno, The continuing value of the Apgar score for the assessment of newborn infants. N. Engl. J. Med. 344, 467-471 (2001).
12. E. R. DeLong, D. M. DeLong, D. L. Clarke-Pearson, Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics 44, 837-845 (1988).
13. K. P. Williams, F. Galerneau, Intrapartum influences on cesarean delivery in multiple gestation. Acta Obstet. Gynecol. Scand. 82, 241-245 (2003).
14. V. Tuzcu, S. Nas, U. Ulusar, A. Ugur, J. R. Kaiser, Altered heart rhythm dynamics in very low birth weight infants with impending intraventricular hemorrhage. Pediatrics 123, 810-815 (2009).
15. R. M. Rangayyan, Biomedical Image Analysis. Biomedical Engineering Series (CRC Press, Boca Raton, FL, 2005).
16. H. J. McCrea, L. R. Ment, The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin. Perinatol. 35, 777-792, (2008).
17. P. Vannemreddy, C. Notarianni, K. Yanamandra, D. Napper, J. Bocchini, Is an endothelial nitric oxide synthase gene mutation a risk factor in the origin of intraventricular hemorrhage? Neurosurg. Focus 28, E11 (2010).
18. The American Recovery and Reinvestment Act of 2009 (Public Law 111-5) official text (Government Institutes/Bernan Press, Lanham, MD, 2009).
19. R. A. Ehrenkranz, M. C. Walsh, B. R. Vohr, A. H. Jobe, L. L. Wright, A. A. Fanaroff, L. A. Wrage, K. Poole; National Institutes of Child Health and Human Development Neonatal Research Network, Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 116, 1353-1360 (2005).
20. International Committee for the Classification of Retinopathy of Prematurity, The International Classification of Retinopathy of Prematurity revisited. Arch. Ophthalmol. 123, 991-999 (2005).
21. R. M. Kliegman, M. C. Walsh, Neonatal necrotizing enterocolitis: Pathogenesis, classification, and spectrum of illness. Curr. Probl. Pediatr. 17, 213-288 (1987).
22. L. A. Papile, J. Burstein, R. Burstein, H. Koffler, Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gm. J. Pediatr. 92, 529-534 (1978).
23. S. Saria, D. Koller, A. Penn, Discovering shared and individual latent structure in multiple time series. arXiv:1008.2028v1 [stat.ML] (2010).
24. G. Whitlock, S. Lewington, P. Sherliker, R. Clarke, J. Emberson, J. Halsey, N. Qizilbash, R. Collins, R. Peto, Body-mass index and cause-specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies. Lancet 373, 1083-1096 (2009).
25. R. B. Schnabel, L. M. Sullivan, D. Levy, M. J. Pencina, J. M. Massaro, R. B. D'Agostino Sr., C. Newton-Cheh, J. F. Yamamoto, J. W. Magnani, T. M. Tadros, W. B. Kannel, T. J. Wang, P. T. Ellinor, P. A. Wolf, R. S. Vasan, E. J. Benjamin, Development of a risk score for atrial fibrillation (Framingham Heart Study): A community-based cohort study. Lancet 373, 739-745 (2009).
26. S. M. Ross, Introduction to Probability and Statistics for Engineers and Scientists (Elsevier Academic Press, Amsterdam, ed. 3, 2004).
27. T. Hastie, R. Tibshirani, J. H. Friedman, The Elements of Statistical Learning: Data Mining, Inference, and Prediction (Springer, New York, 2001).
28. J. Zhu, T. Hastie, Classification of gene microarrays by penalized logistic regression. Biostatistics 5, 427-443 (2004).
29. Acknowledgments: We thank E. Helfenbein (Phillips Healthcare) for help in setting up a monitor data capture system; N. Llerena for data extraction; A. Pasca for figure production; D. Vickrey for insightful discussions; J. Hall, B. Kogut, P. Hartsell, and A. White for data annotation; and P. Prasad and Clinical Technology and Biomedical Engineering at Stanford for technical support. Funding: S.S. is a Rambus Fellow in Computer Science. A.K.R. is a Susan and Lynn Orr Fellow in Neonatology. This work was supported by the Stanford University Department of Computer Science pilot project funds. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author contributions: S.S., D.K., and A.A.P. conceived the study. All authors contributed to study design. S.S. and D.K. designed the methods and performed the analysis. A.K.R. extracted the medical annotations from the medical records. S.S. implemented the model and generated the figures. All authors contributed to the preparation of the manuscript and approved the final version. Competing interests: The authors declare that they have no competing interests.