Preclinical analyses of the therapeutic potential of allopregnanolone to promote neurogenesis in vitro and in vivo in transgenic mouse model of Alzheimer's disease

Current Alzheimer Research

Volumn 3, Issue 1, 2006, Pages 11-17

  Brinton, Roberta Diaz ^b   Jun, Ming Wang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

Allopregnanolone; Cell cycle genes; Hippocampus; L type calcium channel; Neurogenesis; Therapeutics

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BROXURIDINE; CALCIUM; CALCIUM CHANNEL L TYPE; GREEN FLUORESCENT PROTEIN; PROGESTERONE DERIVATIVE; STEROID; THYMIDINE; TRITIUM; VOLTAGE GATED CALCIUM CHANNEL;

ABSENCE OF SIDE EFFECTS; ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL COUNT; CELL CYCLE; CELL LINEAGE; CELL PROLIFERATION; CONFERENCE PAPER; DATA ANALYSIS; DENTATE GYRUS; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MITOSIS; MOLECULAR WEIGHT; MOUSE STRAIN; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; STEM CELL; STEREOISOMERISM; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; CELL PROLIFERATION; GONADAL STEROID HORMONES; HUMANS; MICE; MICE, TRANSGENIC; NERVE REGENERATION; NEURONS; PREGNANOLONE; RECEPTORS, GABA;

EID: 33645857366     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720506775697160     Document Type: Conference Paper

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