Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

Journal of Comparative Neurology

Volumn 435, Issue 4, 2001, Pages 406-417

  Cameron, Heather A ^a   Mckay, Ronald D G ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Bromodeoxyuridine; Cell cycle; Hippocampus; Mitosis; Neurons; Thymidine

Indexed keywords

BROXURIDINE; CELL MARKER; THYMIDINE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL DIVISION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; GRANULE CELL; MALE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIMETABOLITES; BROMODEOXYURIDINE; CELL CYCLE; CELL SURVIVAL; DENTATE GYRUS; MALE; RATS; TISSUE FIXATION;

EID: 0035833068     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.1040     Document Type: Article

References (69)

1. The effects of 5-bromodeoxyuridine on fusion of the cranial neural folds in the mouse embryo
2. The cellular effect of 5-bromodeoxyuridine on the mammalian embryo
3. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
4. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats
5. Local homogeneity of cell cycle length in developing mouse cortex
6. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
7. Stem cells and neurogenesis in the adult brain
8. Restoring production of hippocampal neurons in old age
9. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
10. Regulation of adult neurogenesis by NMDA receptor activation
11. Adrenal steroids and NMDA receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway
12. Postnatal neurogenesis in the cerebellum of the cat and tritiated thymidine autoradiography
13. Opiates inhibit neurogenesis in the adult rat hippocampus
14. Neurogenesis in the adult human hippocampus
15. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
16. Hippocampal neurogenesis in adult Old World primates
17. Learning enhances adult neurogenesis in the hippocampal formation
18. Quantification without pontification: Choosing a method for counting objects in sectioned tissues
19. Rapid extension of axons into the CA3 region by adult-generated granule cells
20. Exploiting the dynamics of S-phase tracers in developing brain: Interkinetic nuclear migration for cells entering versus leaving the S-phase
21. Cerebral blood flow and metabolism during exercise
22. Ontogeny and phylogeny of the blood-brain barrier
23. Proliferation of subependymal cells in the adult primate CNS: Differential uptake of DNA labelled precursors
24. Experience-induced neurogenesis in the senescent dentate gyrus
25. Embryonic and postnatal injections of bromodeoxyuridine produce age-dependent morphological and behavioral abnormalities
26. Continuation of neurogenesis in the hippocampus of the adult macaque monkey
27. Unscheduled DNA synthesis in various types of cells of the mouse brain in vivo
28. X-ray dose-effect relationship on unscheduled DNA synthesis and spontaneous unscheduled DNA synthesis in mouse brain cells studied in vivo
29. Kinetics of cell proliferation in the postnatal rat dentate gyrus
30. Late DNA synthesis in heterochromatin
31. Developmental changes in membrane properties and postsynaptic currents of granule cells in rat dentate gyrus
32. Defective transport of thymidine by cultured cells resistant to 5-bromodeoxyuridine
33. Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system
34. Early postmitotic neurons transiently express TOAD-64, a neural specific protein
35. Histogenesis and dependent glutamine synthetase inducibility in embryonic neural retina. Irreversible inhibition of differentiation by 5-bromodeoxyuridine
36. Neuron numbers in the presubiculum, parasubiculum, and entorhinal area of the rat
37. Effects of prenatal exposure to 5-bromo-2′-deoxyuridine on the developing brain and reproductive function in male mouse offspring
38. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population
39. Expression of EGFR-, p75NGFR-, and PSTAIR (cdc2)-like immunoreactivity by proliferating cells in the adult rat hippocampal formation and forebrain
40. Influence of sex on the blood brain barrier permeability during bicuculline-induced seizures
41. Incorporation of thymidine and its analogue, bromodeoxyuridine, into embryos and maternal tissues of the mouse
42. Vascular niche for adult hippocampal neurogenesis
43. Early and transient increase of rat hippocampal blood-brain barrier permeability to amino acids during kainic acid-induced seizures
44. Human neuroblastoma cell culture: Effect of 5-bromodeoxyuridine on morphological differentiation and levels of neural enzymes
45. A family of proteins implicated in axon guidance and outgrowth
46. An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat
47. Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain
48. Age-related production of new granule cells in the adult dentate gyrus
49. Statistical confirmation that immunofluorescent detection of DNA repair in human fibroblasts by measurement of bromodeoxyuridine incorporation is stoichiometric and sensitive
50. Validation of a flow cytometric in vitro DNA repair (UDS) assay in rat hepatocytes
51. Nucleoside transport in choroid plexus: Mechanism and specificity
52. Localization and mechanism of thymidine transport in the central nervous system
53. Specificity and sodium dependence of the active nucleoside transport system in choroid plexus
54. Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
55. BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone
56. The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall
57. Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat
58. Apoptosis and its relation to the cell cycle in the developing cerebral cortex
59. Saturation kinetics, specificity and NBMPR sensitivity of thymidine entry into the central nervous system
60. Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers
61. 3H]thymidine in the anaesthetized rabbit
62. Running enhances neurogenesis, learning, and long-term potentiation in mice
63. Heterogenous properties of dentate granule neurons in the adult rat
64. Effect of fluorodeoxyuridine, colcemid, and bromodeoxyuridine on developing neocortex of the mouse
65. New stereological methods for counting neurons
66. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
67. A developmental study of the quantitative distribution of LHRH neurons within the central nervous system of postnatal male and female rats
68. Delay of oligodendrocyte differentiation by 5-bromodeoxyuridine (BUdR)