Allopregnanolone analogs that positively modulate GABAA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice

Epilepsia

Volumn 45, Issue 7, 2004, Pages 864-867

  Kaminski, Rafal M ^a   Livingood, Matthew R ^a,b   Rogawski, Michael A ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

6 Hz model; Allopregnanolone; Clonazepam; GABA A receptor modulation; Ganaxolone; Mouse; Neuroactive steroid; Seizure

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; CLONAZEPAM; GANAXOLONE; NEUROPROTECTIVE AGENT; PENTETRAZOLE; STEROID;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; AUTOMATISM; CONTROLLED STUDY; CORNEA SURGERY; DISEASE MODEL; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; ELECTROSTIMULATION; ELECTROSTIMULATION THERAPY; EPILEPTIC FOCUS; FOCAL EPILEPSY; IMMOBILIZATION; IN VIVO STUDY; LIMBIC CORTEX; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; STRUCTURE ANALYSIS;

ANIMALS; ANTICONVULSANTS; CLONAZEPAM; CORNEA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EPILEPSIES, PARTIAL; GABA MODULATORS; HUMANS; MALE; MICE; PREGNANOLONE; RECEPTORS, GABA; SEIZURES; STEROIDS;

EID: 3042816099     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0013-9580.2004.04504.x     Document Type: Article

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