Neuroactive steroids: An update of their roles in central and peripheral nervous system

Psychoneuroendocrinology

Volumn 34, Issue SUPPL. 1, 2009, Pages

  Melcangi, Roberto Cosimo ^a   Panzica, Giancarlo ^b,c  

^a Pathophysiology   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c National Institute of Neuroscience INN   (Italy)

Author keywords

Brain; Neuroprotection; Neurosteroids; Peripheral nerve; Sex difference; Vitamin D

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANDROSTANOLONE; CALCITRIOL; CANNABINOID 1 RECEPTOR; COLECALCIFEROL; EPIANDROSTERONE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; NEUROACTIVE STEROID; NEUROSTEROID; NUCLEAR RECEPTOR COREPRESSOR; PLACEBO; PRASTERONE; PREGNENOLONE; PROGESTERONE; PROGESTERONE RECEPTOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STEROID HORMONE; STEROID RECEPTOR COACTIVATOR 1; TESTOSTERONE; TETRAHYDROPROGESTERONE; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; EPIGENETICS; HIPPOCAMPUS; HUMAN; MULTIPLE SCLEROSIS; NERVE CRUSH; NERVE DEGENERATION; NEUROENDOCRINE SYSTEM; NEUROPROTECTION; NOCICEPTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCIATIC NEUROPATHY; SEX DIFFERENCE; TRAUMATIC BRAIN INJURY;

ANIMALS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; CHOLECALCIFEROL; HUMANS; MENTAL DISORDERS; NEUROPROTECTIVE AGENTS; NEUROTRANSMITTER AGENTS; PERIPHERAL NERVOUS SYSTEM; SEX CHARACTERISTICS;

EID: 71449125479     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2009.11.001     Document Type: Article

References (103)

1. Abraham I.M., Koszegi Z., Tolod-Kemp E., and Szego E.M. Action of estrogen on survival of basal forebrain cholinergic neurons: promoting amelioration. Psychoneuroendocrinology 34 Suppl. 1 (2009) S104-S112
2. Acs P., Kipp M., Norkute A., Johann S., Clarner T., Braun A., Berente Z., Komoly S., and Beyer C. 17beta-Estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice. Glia 57 (2009) 807-814
3. Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., and Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology 34 Suppl. 1 (2009) S59-S66
4. Allieri F., Spigolon G., Viglietti-Panzica C., Garcia-Falgueras A., Guillamon A., Collado P., and Panzica G.C. The Tfm rat, a model to study the influence of testosterone on the development of limbic vasopressinergci system. Trabajos del Instituto Cajal (2005) 80
5. Aloisi A.M., Aurilio C., Bachiocco V., Biasi G., Fiorenzani P., Pace M.C., Paci V., Pari G., Passavanti G., Ravaioli L., Sindaco G., Vellucci R., and Ceccarelli I. Endocrine consequences of opioid therapy. Psychoneuroendocrinology 34 Suppl. 1 (2009) S162-S168
6. Arnold A.P., and Gorski R.A. Gonadal steroid induction of structural sex differences in the central nervous system. Annu. Rev. Neurosci. 7 (1984) 413-442
7. Atif F., Sayeed I., Ishrat T., and Stein D.G. Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone. Mol. Med. 15 (2009) 328-336
8. Auger A.P., and Jessen H.M. Corepressors, nuclear receptors, and epigenetic factors on DNA: a tail of repression. Psychoneuroendocrinology 34 Suppl. 1 (2009) S39-S47
9. Baulieu E.E., and Robel P. Neurosteroids: a new brain function. J. Steroid Biochem. Mol. Biol. 37 (1990) 395-403
10. Biamonte F., Assenza G., Marino R., D'Amelio M., Panteri R., Caruso D., Scurati S., Yague J.G., Garcia-Segura L.M., Cesa R., Strata P., Melcangi R.C., and Keller F. Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival. Neurobiol. Dis. 36 (2009) 103-115
11. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34 Suppl. 1 (2009) S186-S195
12. Bodo C. A role for the androgen receptor in the sexual differentiation of the olfactory system in mice. Brain Res. Rev. 57 (2008) 321-331
13. Calabrese F., Molteni R., Racagni G., and Riva M.A. Neuronal plasticity: a link between stress and mood disorders. Psychoneuroendocrinology 34 Suppl. 1 (2009) S208-S216
14. Caruso D., Scurati S., Roglio I., Nobbio L., Schenone A., and Melcangi R.C. Neuroactive steroid levels in a transgenic rat model of CMT1A neuropathy. J. Mol. Neurosci. 34 (2008) 249-253
15. Cekic M., Cutler S.M., Vanlandingham J.W., and Stein D.G. Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiol. Aging (2009) doi:10.1016/j.neurobiolaging.2009.04.017
16. Cekic M., Sayeed I., and Stein D.G. Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Front. Neuroendocrinol. 30 (2009) 158-172
17. Charlier T.D. Importance of steroid receptor coactivators in the modulation of steroid action on brain and behavior. Psychoneuroendocrinology 34 Suppl. 1 (2009) S20-S29
18. Chen J.D., and Evans R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377 (1995) 454-457
19. Compagnone N.A. Treatments for spinal cord injury: is there hope in neurosteroids?. J. Steroid Biochem. Mol. Biol. 109 (2008) 307-313
20. Correale J., Ysrraelit M.C., and Gaitan M.I. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain 132 (2009) 1146-1160
21. Craft R.M. Sex differences in behavioral effects of cannabinoids. Life Sci. 77 (2005) 2471-2478
22. Cukier H.N., Perez A.M., Collins A.L., Zhou Z., Zoghbi H.Y., and Botas J. Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet. 4 (2008) e1000179
23. di Michele F., Lekieffre D., Pasini A., Bernardi G., Benavides J., and Romeo E. Increased neurosteroids synthesis after brain and spinal cord injury in rats. Neurosci. Lett. 284 (2000) 65-68
24. Doncarlos L.L., Azcoitia I., and Garcia-Segura L.M. Neuroprotective actions of selective estrogen receptor modulators. Psychoneuroendocrinology 34 Suppl. 1 (2009) S113-S122
25. Duncan K.A., Jimenez P., and Carruth L.L. The selective estrogen receptor-alpha coactivator, RPL7, and sexual differentiation of the songbird brain. Psychoneuroendocrinology 34 Suppl. 1 (2009) S30-S38
26. Eyles D.W., Feron F., Cui X., Kesby J.P., Harms L.H., Ko P., McGrath J.J., and Burne T.H. Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology 34 Suppl. 1 (2009) S247-S257
27. Farhang B., Diaz S., Tang S.L., and Wagner E.J. Sex differences in the cannabinoid regulation of energy homeostasis. Psychoneuroendocrinology 34 Suppl. 1 (2009) S237-S246
28. Fattore L., Fadda P., and Fratta W. Sex differences in the self-administration of cannabinoids and other drugs of abuse. Psychoneuroendocrinology 34 Suppl. 1 (2009) S227-S236
29. Fernandes de Abreu D.A., Eyles D., and Feron F. Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 34 Suppl. 1 (2009) S265-S277
30. Fester L., Zhou L., Voets C., Ossig C., Disteldorf E., Peters C., Blaute F., Prange-Kiel J., Dudzinski D., Jarry H., and Rune G.M. The opposing roles of estradiol on synaptic protein expression in hippocampal cultures. Psychoneuroendocrinology 34 Suppl. 1 (2009) S123-S129
31. Frye C.A. Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions. Psychoneuroendocrinology 34 Suppl. 1 (2009) S143-S161
32. Gallagher P., Reid K.S., and Ferrier I.N. Neuropsychological functioning in health and mood disorder: modulation by glucocorticoids and their receptors. Psychoneuroendocrinology 34 Suppl. 1 (2009) S196-S207
33. Garay L., Gonzalez Deniselle M.C., Gierman L., Meyer M., Lima A., Roig P., and De Nicola A.F. Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis. Neuroimmunomodulation 15 (2008) 76-83
34. Garay L., Deniselle M.C., Meyer M., Costa J.J., Lima A., Roig P., and Denicola A.F. Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis. Brain Res. 1283 (2009) 177-185
35. Garcia-Segura L.M., and Balthazart J. Steroids and neuroprotection: new advances. Front. Neuroendocrinol. 30 (2009) v-ix
36. Giatti S., D'Intino G., Maschi O., Pesaresi M., Garcia-Segura L.M., Calza L., Caruso D., and Melcangi R.C. Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels. Neurochem. Int. (2009) doi:10.1016/j.neuint.2009.09.009
37. Giatti S., Pesaresi M., Cavaletti G., Bianchi R., Carozzi V., Lombardi R., Maschi O., Lauria G., Garcia-Segura L.M., Caruso D., and Melcangi R.C. Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy. Neuroscience 164 (2009) 520-529
38. Gore A.C. Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. Front. Neuroendocrinol. 29 (2008) 358-374
39. Grecksch G., Ruthrich H., Hollt V., and Becker A. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats. Psychoneuroendocrinology 34 Suppl. 1 (2009) S258-S264
40. Greenstein B.D. The role of hormone receptors in development and puberty. J. Reprod. Fertil. 52 (1978) 419-426
41. Handa R.J., Pak T.R., Kudwa A.E., Lund T.D., and Hinds L. An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol. Horm. Behav. 53 (2008) 741-752
42. Jevtovic-Todorovic V., Covey D.F., and Todorovic S.M. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?. Psychoneuroendocrinology 34 Suppl. 1 (2009) S178-S185
43. Jordan C.L., and Doncarlos L. Androgens in health and disease: an overview. Horm. Behav. 53 (2008) 589-595
44. Ke L., and Lukas R.J. Effects of steroid exposure on ligand binding and functional activities of diverse nicotinic acetylcholine receptor subtypes. J. Neurochem. 67 (1996) 1100-1112
45. Lambert J.J., Cooper M.A., Simmons R.D., Weir C.J., and Belelli D. Neurosteroids: endogenous allosteric modulators of GABA(A) receptors. Psychoneuroendocrinology 34 Suppl. 1 (2009) S48-S58
46. Lavinsky R.M., Jepsen K., Heinzel T., Torchia J., Mullen T.M., Schiff R., Del-Rio A.L., Ricote M., Ngo S., Gemsch J., Hilsenbeck S.G., Osborne C.K., Glass C.K., Rosenfeld M.G., and Rose D.W. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2920-2925
47. Lee E.S., Sidoryk M., Jiang H., Yin Z., and Aschner M. Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J. Neurochem. 110 (2009) 530-544
48. Liu Z., Auboeuf D., Wong J., Chen J.D., Tsai S.Y., Tsai M.J., and O'Malley B.W. Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 7940-7944
49. Maccarrone M. CB2 receptors in reproduction. Br. J. Pharmacol. 153 (2008) 189-198
50. Maguire J., and Mody I. Steroid hormone fluctuations and GABA(A)R plasticity. Psychoneuroendocrinology 34 Suppl. 1 (2009) S84-S90
51. Maninger N., Wolkowitz O.M., Reus V.I., Epel E.S., and Mellon S.H. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front. Neuroendocrinol. 30 (2009) 65-91
52. 3 in embryonic hippocampal cells. Hippocampus (2009) doi: 10.1002/hipo.20670
53. Martini M., Di Sante G., Collado P., Pinos H., Guillamon A., and Panzica G.C. Androgen receptors are required for full masculinization of nitric oxide synthase system in rat limbic-hypothalamic region. Horm. Behav. 54 (2008) 557-564
54. Marx C.E., Keefe R.S., Buchanan R.W., Hamer R.M., Kilts J.D., Bradford D.W., Strauss J.L., Naylor J.C., Payne V.M., Lieberman J.A., Savitz A.J., Leimone L.A., Dunn L., Porcu P., Morrow A.L., and Shampine L.J. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 34 (2009) 1885-1903
55. McCarthy M.M., and Konkle A.T.M. When is a sex difference not a sex difference?. Front. Neuroendocrinol. 26 (2005) 85-102
56. McCarthy M.M. Estradiol and the developing brain. Physiol. Rev. 88 (2008) 91-134
57. McCarthy M.M., Auger A.P., Bale T.L., De Vries G.J., Dunn G.A., Forger N.G., Murray E.K., Nugent B.M., Schwarz J.M., and Wilson M.E. The epigenetics of sex differences in the brain. J. Neurosci. 29 (2009) 12815-12823
58. Meffre D., Pianos A., Liere P., Eychenne B., Cambourg A., Schumacher M., Stein D.G., and Guennoun R. Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry. Endocrinology 148 (2007) 2505-2517
59. Melcangi R.C., and Panzica G.C. Neuroactive Steroids in the Third Millenium vol. 37 (2001), Elsevier
60. Melcangi R.C., and Panzica G.C. Neuroactive steroids: old players in a new game. Neuroscience 138 (2006) 733-739
61. Melcangi R.C., and Garcia-Segura L.M. Sex-specific therapeutic strategies based on neuroactive steroids: In search for innovative tools for neuroprotection. Horm. Behav. (2009) doi:10.1016/j.yhbeh.2009.06.001
62. Mellon S.H., Gong W., and Schonemann M.D. Endogenous and synthetic neurosteroids in treatment of Niemann-Pick Type C disease. Brain Res. Rev. 57 (2008) 410-420
63. Mensah-Nyagan A.G., Meyer L., Schaeffer V., Kibaly C., and Patte-Mensah C. Evidence for a key role of steroids in the modulation of pain. Psychoneuroendocrinology 34 Suppl. 1 (2009) S169-S177
64. Moore F.L., Orchinik M., and Lowry C. Functional studies on corticosterone receptors in neuronal membranes. Receptor 5 (1995) 21-28
65. Morissette M., and Di Paolo T. Effect of estradiol on striatal dopamine activity of female hemiparkinsonian monkeys. J. Neurosci. Res. 87 (2009) 1634-1644
66. Mostallino M.C., Sanna E., Concas A., Biggio G., and Follesa P. Plasticity and function of extrasynaptic GABA(A) receptors during pregnancy and after delivery. Psychoneuroendocrinology 34 Suppl. 1 (2009) S74-S83
67. Naftolin F., and Stanbury M.G. Phytoestrogens: are they really estrogen mimics?. Fertil. Steril. 77 (2002) 15-17
68. Orchinik M., Murray T.F., and Moore F.L. A corticosteroid receptor in neuronal membranes. Science 252 (1991) 1848-1851
69. Panzica G.C., Viglietti-Panzica C., and Ottinger M.A. Introduction: neurobiological impact of environmental estrogens. Brain Res. Bull. 65 (2005) 187-191
70. Panzica G.C., Viglietti-Panzica C., Mura E., Quinn Jr. M.J., Palanza P., and Ottinger M.A. Effects of xenoestrogens on the differentiation of behaviorally relevant neural circuits. Front. Neuroendocrinol. 28 (2007) 179-200
71. Panzica G.C., and Melcangi R.C. The endocrine nervous system: source and target for neuroactive steroids. Brain Res. Rev. 57 (2008) 271-276
72. Paul S.M., and Purdy R.H. Neuroactive steroids. FASEB J. 6 (1992) 2311-2322
73. Peng H.Y., Chen G.D., Lee S.D., Lai C.Y., Chiu C.H., Cheng C.L., Chang Y.S., Hsieh M.C., Tung K.C., and Lin T.B. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABA(A) receptor subtypes. Pain 143 (2009) 12-20
74. Pesaresi M., Maschi O., Giatti S., Garcia-Segura L.M., Caruso D., and Melcangi R.C. Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. Horm. Behav. (2009) doi:10.1016/j.yhbeh.2009.04.008
75. Pfaff D.W., and Levine J.E. Reconciling molecular neuroendocrine signals and the scientists who study them. Front. Neuroendocrinol. 29 (2008) 167-168
76. Pierman S., Sica M., Allieri F., Viglietti-Panzica C., Panzica G.C., and Bakker J. Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene. Horm. Behav. 54 (2008) 98-106
77. Plumari L., Viglietti-Panzica C., Allieri F., Honda S., Harada N., Absil P., Balthazar J., and Panzica G.C. Changes in the arginine-vasopressin immunoreactive systems in male mice lacking a functional aromatase gene. J. Neuroendocrinol. 14 (2002) 971-978
78. Ramirez V.D., and Zheng J. Membrane sex-steroid receptors in the brain. Front. Neuroendocrinol. 17 (1996) 402-439
79. Reddy D.S. The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy. Epilepsy Res. 85 (2009) 1-30
80. Roglio I., Bianchi R., Gotti S., Scurati S., Giatti S., Pesaresi M., Caruso D., Panzica G.C., and Melcangi R.C. Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience 155 (2008) 673-685
81. Roglio I., Bianchi R., Camozzi F., Carozzi V., Cervellini I., Crippa D., Lauria G., Cavaletti G., and Melcangi R.C. Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model. J. Peripher. Nerv. Syst. 14 (2009) 36-44
82. Rupprecht R., and Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci. 22 (1999) 410-416
83. Rupprecht R., di Michele F., Hermann B., Strohle A., Lancel M., Romeo E., and Holsboer F. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res. Rev. 37 (2001) 59-67
84. Sayeed I., and Stein D.G. Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. Prog. Brain Res. 175 (2009) 219-237
85. Schumacher M. Rapid membrane effects of steroid hormones: an emerging concept in neuroendocrinology. Trends Neurosci. 13 (1990) 359-362
86. Shepard K.N., Michopoulos V., Toufexis D.J., and Wilson M.E. Genetic, epigenetic and environmental impact on sex differences in social behavior. Physiol. Behav. 97 (2009) 157-170
87. Skinner M.K., Anway M.D., Savenkova M.I., Gore A.C., and Crews D. Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS One 3 (2008) e3745
88. Smith C.C., Vedder L.C., and McMahon L.L. Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses. Psychoneuroendocrinology 34 Suppl. 1 (2009) S130-S142
89. Smith S.S., Aoki C., and Shen H. Puberty, steroids and GABA(A) receptor plasticity. Psychoneuroendocrinology 34 Suppl. 1 (2009) S91-S103
90. Tetel M.J. Nuclear receptor coactivators in neuroendocrine function. J. Neuroendocrinol. 12 (2000) 927-932
91. Tetel M.J. Nuclear receptor coactivators: essential players for steroid hormone action in the brain and in behaviour. J. Neuroendocrinol. 21 (2009) 229-237
92. Tetel M.J. Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators. Psychoneuroendocrinology 34 Suppl. 1 (2009) S9-S19
93. Tsai M.J., and O'Malley B.W. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63 (1994) 451-486
94. Tuohimaa P., Keisala T., Minasyan A., Cachat J., and Kalueff A. Vitamin D, nervous system and aging. Psychoneuroendocrinology 34 Suppl. 1 (2009) S278-S286
95. Valera S., Ballivet M., and Bertrand D. Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 9949-9953
96. Viveros M.P., Llorente R., Lopez-Gallardo M., Suarez J., Bermudez-Silva F., De la Fuente M., Rodriguez de Fonseca F., and Garcia-Segura L.M. Sex-dependent alterations in response to maternal deprivation in rats. Psychoneuroendocrinology 34 Suppl. 1 (2009) S217-S226
97. Wang C., Dehghani B., Li Y., Kaler L.J., Proctor T., Vandenbark A.A., and Offner H. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J. Immunol. 182 (2009) 3294-3303
98. Wang C., Dehghani B., Li Y., Kaler L.J., Vandenbark A.A., and Offner H. Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1. Immunology 126 (2009) 329-335
99. Williams-Ashman H.G., and Reddi A.H. Actions of vertebrate sex hormones. Annu. Rev. Physiol. 33 (1971) 31-82
100. Yague J.G., Garcia-Segura L.M., and Azcoitia I. Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells. Endocrine 35 (2009) 252-261
101. Yoon H.G., and Wong J. The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. Mol. Endocrinol. 20 (2006) 1048-1060
102. Zheleznova N.N., Sedelnikova A., and Weiss D.S. Function and modulation of δ-containing GABAa receptors. Psychoneuroendocrinology 34 Suppl. 1 (2009) S67-S73
103. Zheng P. Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog. Neurobiol. 89 (2009) 134-152