-
1
-
-
13844251076
-
Influence of age and gender on risperidone plasma concentrations
-
W. Aichhorn, U. Weiss, J. Marksteiner, G. Kemmler, T. Walch, G. Zernig, R. Stelzig-Schoeler, C. Stuppaeck, and C. Geretsegger Influence of age and gender on risperidone plasma concentrations J. Psychopharmacol. 19 2005 395 401
-
(2005)
J. Psychopharmacol.
, vol.19
, pp. 395-401
-
-
Aichhorn, W.1
Weiss, U.2
Marksteiner, J.3
Kemmler, G.4
Walch, T.5
Zernig, G.6
Stelzig-Schoeler, R.7
Stuppaeck, C.8
Geretsegger, C.9
-
2
-
-
0019406904
-
Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism
-
M.M. Airaksinen, and I. Kari Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism Med. Biol. 59 1981 21 34
-
(1981)
Med. Biol.
, vol.59
, pp. 21-34
-
-
Airaksinen, M.M.1
Kari, I.2
-
3
-
-
0019776320
-
Beta-Carbolines, psychoactive compounds in the mammalian body. Part II: Effects
-
M.M. Airaksinen, and I. Kari beta-Carbolines, psychoactive compounds in the mammalian body. Part II: effects Med. Biol. 59 1981 190 211
-
(1981)
Med. Biol.
, vol.59
, pp. 190-211
-
-
Airaksinen, M.M.1
Kari, I.2
-
4
-
-
65349188152
-
Effect of pregnancy on the pharmacokinetics of antihypertensive drugs
-
G.D. Anderson, and D.B. Carr Effect of pregnancy on the pharmacokinetics of antihypertensive drugs Clin. Pharmacokinet. 48 2009 159 168
-
(2009)
Clin. Pharmacokinet.
, vol.48
, pp. 159-168
-
-
Anderson, G.D.1
Carr, D.B.2
-
5
-
-
0030858099
-
Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones
-
L.O. Baum, and H.W. Strobel Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones Brain Res. 765 1997 67 73
-
(1997)
Brain Res.
, vol.765
, pp. 67-73
-
-
Baum, L.O.1
Strobel, H.W.2
-
6
-
-
0029812219
-
Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: Effects of xenobiotics and sex steroids
-
A.F. Bergh, and H.W. Strobel Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: effects of xenobiotics and sex steroids Mol. Cell Biochem. 162 1996 31 41
-
(1996)
Mol. Cell Biochem.
, vol.162
, pp. 31-41
-
-
Bergh, A.F.1
Strobel, H.W.2
-
7
-
-
70749145658
-
The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study
-
E. Bromek, A. Haduch, and W.A. Daniel The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study Eur. J. Pharmacol. 626 2010 171 178
-
(2010)
Eur. J. Pharmacol.
, vol.626
, pp. 171-178
-
-
Bromek, E.1
Haduch, A.2
Daniel, W.A.3
-
8
-
-
80051784500
-
Cytochrome P450 mediates dopamine formation in the brain in vivo
-
E. Bromek, A. Haduch, K. Golembiowska, and W.A. Daniel Cytochrome P450 mediates dopamine formation in the brain in vivo J. Neurochem. 118 2011 806 815
-
(2011)
J. Neurochem.
, vol.118
, pp. 806-815
-
-
Bromek, E.1
Haduch, A.2
Golembiowska, K.3
Daniel, W.A.4
-
9
-
-
34547909937
-
The progression of Parkinson disease: A hypothesis
-
W.J. Burke The progression of Parkinson disease: a hypothesis Neurology 69 710-711 2007 711
-
(2007)
Neurology
, vol.69
, Issue.710-711
, pp. 711
-
-
Burke, W.J.1
-
10
-
-
84859762000
-
Genomics of dementia: APOE- and CYP2D6-Related Pharmacogenetics
-
R. Cacabelos, R. Martinez, L. Fernandez-Novoa, J.C. Carril, V. Lombardi, I. Carrera, L. Corzo, I. Tellado, J. Leszek, A. McKay, and M. Takeda Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics Int. J. Alzheimers Dis. 2012 2012 518901
-
(2012)
Int. J. Alzheimers Dis.
, vol.2012
, pp. 518901
-
-
Cacabelos, R.1
Martinez, R.2
Fernandez-Novoa, L.3
Carril, J.C.4
Lombardi, V.5
Carrera, I.6
Corzo, L.7
Tellado, I.8
Leszek, J.9
McKay, A.10
Takeda, M.11
-
11
-
-
18044371666
-
Presence of splice variant forms of cytochrome P4502D1 in rat brain but not in liver
-
S.J. Chinta, H.V. Pai, and V. Ravindranath Presence of splice variant forms of cytochrome P4502D1 in rat brain but not in liver Brain Res. Mol. Brain Res. 135 2005 81 92
-
(2005)
Brain Res. Mol. Brain Res.
, vol.135
, pp. 81-92
-
-
Chinta, S.J.1
Pai, H.V.2
Ravindranath, V.3
-
12
-
-
0032911164
-
Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver
-
T. Chow, S. Imaoka, T. Hiroi, and Y. Funae Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver Drug Metab. Dispos. 27 1999 188 192
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 188-192
-
-
Chow, T.1
Imaoka, S.2
Hiroi, T.3
Funae, Y.4
-
13
-
-
33646107162
-
Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking
-
C. de Graaf, C. Oostenbrink, P.H. Keizers, T. van der Wijst, A. Jongejan, and N.P. Vermeulen Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking J. Med. Chem. 49 2006 2417 2430
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2417-2430
-
-
De Graaf, C.1
Oostenbrink, C.2
Keizers, P.H.3
Van Der Wijst, T.4
Jongejan, A.5
Vermeulen, N.P.6
-
14
-
-
33845985993
-
Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6
-
C. de Graaf, C. Oostenbrink, P.H. Keizers, B.M. van Vugt-Lussenburg, R.A. van Waterschoot, R.A. Tschirret-Guth, J.N. Commandeur, and N.P. Vermeulen Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6 Curr. Drug. Metab. 8 2007 59 77
-
(2007)
Curr. Drug. Metab.
, vol.8
, pp. 59-77
-
-
De Graaf, C.1
Oostenbrink, C.2
Keizers, P.H.3
Van Vugt-Lussenburg, B.M.4
Van Waterschoot, R.A.5
Tschirret-Guth, R.A.6
Commandeur, J.N.7
Vermeulen, N.P.8
-
15
-
-
84881427177
-
Parkinson disease: From pathology to molecular disease mechanisms
-
D.T. Dexter, and P. Jenner Parkinson disease: from pathology to molecular disease mechanisms Free Radic. Biol. Med. 62 2013 132 144
-
(2013)
Free Radic. Biol. Med.
, vol.62
, pp. 132-144
-
-
Dexter, D.T.1
Jenner, P.2
-
16
-
-
40949100350
-
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy
-
L.J. Dickmann, S. Tay, T.D. Senn, H. Zhang, A. Visone, J.D. Unadkat, M.F. Hebert, and N. Isoherranen Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy Biochem. Pharmacol. 75 2008 1677 1687
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 1677-1687
-
-
Dickmann, L.J.1
Tay, S.2
Senn, T.D.3
Zhang, H.4
Visone, A.5
Unadkat, J.D.6
Hebert, M.F.7
Isoherranen, N.8
-
17
-
-
12544255204
-
The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats
-
M. Djebaili, Q. Guo, E.H. Pettus, S.W. Hoffman, and D.G. Stein The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats J. Neurotrauma 22 2005 106 118
-
(2005)
J. Neurotrauma
, vol.22
, pp. 106-118
-
-
Djebaili, M.1
Guo, Q.2
Pettus, E.H.3
Hoffman, S.W.4
Stein, D.G.5
-
18
-
-
84860686110
-
Can Parkinson's disease pathology be propagated from one neuron to another?
-
C.J.R. Dunning, J.F. Reyes, J.A. Steiner, and P. Brundin Can Parkinson's disease pathology be propagated from one neuron to another? Prog. Neurobiol. 97 2012 205 219
-
(2012)
Prog. Neurobiol.
, vol.97
, pp. 205-219
-
-
Dunning, C.J.R.1
Reyes, J.F.2
Steiner, J.A.3
Brundin, P.4
-
20
-
-
39149106106
-
Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
-
F. Dutheil, P. Beaune, and M.A. Loriot Xenobiotic metabolizing enzymes in the central nervous system: contribution of cytochrome P450 enzymes in normal and pathological human brain Biochimie 90 2008 426 436
-
(2008)
Biochimie
, vol.90
, pp. 426-436
-
-
Dutheil, F.1
Beaune, P.2
Loriot, M.A.3
-
21
-
-
67649392372
-
Xenobiotic-metabolizing enzymes and transporters in the normal human brain: Regional and cellular mapping as a basis for putative roles in cerebral function
-
F. Dutheil, S. Dauchy, M. Diry, V. Sazdovitch, O. Cloarec, L. Mellottee, I. Bieche, M. Ingelman-Sundberg, J.P. Flinois, I. de Waziers, P. Beaune, X. Decleves, C. Duyckaerts, and M.A. Loriot Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function Drug Metab. Dispos. 37 2009 1528 1538
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 1528-1538
-
-
Dutheil, F.1
Dauchy, S.2
Diry, M.3
Sazdovitch, V.4
Cloarec, O.5
Mellottee, L.6
Bieche, I.7
Ingelman-Sundberg, M.8
Flinois, J.P.9
De Waziers, I.10
Beaune, P.11
Decleves, X.12
Duyckaerts, C.13
Loriot, M.A.14
-
22
-
-
77956800050
-
ABC transporters and cytochromes P450 in the human central nervous system: Influence on brain pharmacokinetics and contribution to neurodegenerative disorders
-
F. Dutheil, A. Jacob, S. Dauchy, P. Beaune, J.M. Scherrmann, X. Decleves, and M.A. Loriot ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders Expert Opin. Drug Metab. Toxicol. 6 2010 1161 1174
-
(2010)
Expert Opin. Drug Metab. Toxicol.
, vol.6
, pp. 1161-1174
-
-
Dutheil, F.1
Jacob, A.2
Dauchy, S.3
Beaune, P.4
Scherrmann, J.M.5
Decleves, X.6
Loriot, M.A.7
-
23
-
-
0023196288
-
Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22
-
M. Eichelbaum, M.P. Baur, H.J. Dengler, B.O. Osikowska-Evers, G. Tieves, C. Zekorn, and C. Rittner Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22 Br. J. Clin Pharmacol. 23 1987 455 458
-
(1987)
Br. J. Clin Pharmacol.
, vol.23
, pp. 455-458
-
-
Eichelbaum, M.1
Baur, M.P.2
Dengler, H.J.3
Osikowska-Evers, B.O.4
Tieves, G.5
Zekorn, C.6
Rittner, C.7
-
24
-
-
1442329302
-
CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease
-
A. Elbaz, C. Levecque, J. Clavel, J.S. Vidal, F. Richard, P. Amouyel, A. Alperovitch, M.C. Chartier-Harlin, and C. Tzourio CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease Ann. Neurol. 55 2004 430 434
-
(2004)
Ann. Neurol.
, vol.55
, pp. 430-434
-
-
Elbaz, A.1
Levecque, C.2
Clavel, J.3
Vidal, J.S.4
Richard, F.5
Amouyel, P.6
Alperovitch, A.7
Chartier-Harlin, M.C.8
Tzourio, C.9
-
25
-
-
81755174301
-
Cytochrome P450 enzymes in the brain: Emerging evidence of biological significance
-
C.S. Ferguson, and R.F. Tyndale Cytochrome P450 enzymes in the brain: emerging evidence of biological significance Trends Pharmacol. Sci. 32 2011 708 714
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 708-714
-
-
Ferguson, C.S.1
Tyndale, R.F.2
-
26
-
-
33847366597
-
The endomorphin system and its evolving neurophysiological role
-
J. Fichna, A. Janecka, J. Costentin, and R.J. Do The endomorphin system and its evolving neurophysiological role Pharmacol. Rev. 59 2007 88 123
-
(2007)
Pharmacol. Rev.
, vol.59
, pp. 88-123
-
-
Fichna, J.1
Janecka, A.2
Costentin, J.3
Do, R.J.4
-
27
-
-
4644314162
-
CYP2D in the brain
-
Y. Funae, W. Kishimoto, T. Cho, T. Niwa, and T. Hiroi CYP2D in the brain Drug Metab. Pharmacokinet. 18 2003 337 349
-
(2003)
Drug Metab. Pharmacokinet.
, vol.18
, pp. 337-349
-
-
Funae, Y.1
Kishimoto, W.2
Cho, T.3
Niwa, T.4
Hiroi, T.5
-
28
-
-
0023154962
-
Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the da rat polymorphism
-
F.J. Gonzalez, T. Matsunaga, K. Nagata, U.A. Meyer, D.W. Nebert, J. Pastewka, C.A. Kozak, J. Gillette, H.V. Gelboin, and J.P. Hardwick Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism DNA 6 1987 149 161
-
(1987)
DNA
, vol.6
, pp. 149-161
-
-
Gonzalez, F.J.1
Matsunaga, T.2
Nagata, K.3
Meyer, U.A.4
Nebert, D.W.5
Pastewka, J.6
Kozak, C.A.7
Gillette, J.8
Gelboin, H.V.9
Hardwick, J.P.10
-
29
-
-
49949118071
-
Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers
-
I. Gonzalez, E.M. Penas-Lledo, B. Perez, P. Dorado, M. Alvarez, and A. LLerena Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers Pharmacogenomics 9 2008 833 840
-
(2008)
Pharmacogenomics
, vol.9
, pp. 833-840
-
-
Gonzalez, I.1
Penas-Lledo, E.M.2
Perez, B.3
Dorado, P.4
Alvarez, M.5
Llerena, A.6
-
30
-
-
0037072798
-
Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps
-
F.P. Guengerich, G.P. Miller, I.H. Hanna, H. Sato, and M.V. Martin Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps J. Biol. Chem. 277 2002 33711 33719
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33711-33719
-
-
Guengerich, F.P.1
Miller, G.P.2
Hanna, I.H.3
Sato, H.4
Martin, M.V.5
-
31
-
-
0345282980
-
Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6
-
S. Haji-Momenian, J.M. Rieger, T.L. Macdonald, and M.L. Brown Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6 Bioorg. Med. Chem. 11 2003 5545 5554
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 5545-5554
-
-
Haji-Momenian, S.1
Rieger, J.M.2
Macdonald, T.L.3
Brown, M.L.4
-
32
-
-
0030589009
-
The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA
-
N. Hauptmann, J. Grimsby, J.C. Shih, and E. Cadenas The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA Arch Biochem. Biophys. 335 1996 295 304
-
(1996)
Arch Biochem. Biophys.
, vol.335
, pp. 295-304
-
-
Hauptmann, N.1
Grimsby, J.2
Shih, J.C.3
Cadenas, E.4
-
33
-
-
0642282678
-
Are gender differences important for the clinical effects of antidepressants?
-
M.G. Hildebrandt, E.W. Steyerberg, K.B. Stage, J. Passchier, and P. Kragh-Soerensen Are gender differences important for the clinical effects of antidepressants? Am. J. Psychiatry 160 2003 1643 1650
-
(2003)
Am. J. Psychiatry
, vol.160
, pp. 1643-1650
-
-
Hildebrandt, M.G.1
Steyerberg, E.W.2
Stage, K.B.3
Passchier, J.4
Kragh-Soerensen, P.5
-
34
-
-
0034869539
-
Progesterone oxidation by cytochrome P450 2D isoforms in the brain
-
T. Hiroi, W. Kishimoto, T. Chow, S. Imaoka, T. Igarashi, and Y. Funae Progesterone oxidation by cytochrome P450 2D isoforms in the brain Endocrinology 142 2001 3901 3908
-
(2001)
Endocrinology
, vol.142
, pp. 3901-3908
-
-
Hiroi, T.1
Kishimoto, W.2
Chow, T.3
Imaoka, S.4
Igarashi, T.5
Funae, Y.6
-
36
-
-
85047683695
-
Alterations in drug disposition during pregnancy: Implications for drug therapy
-
L.S. Hodge, and T.S. Tracy Alterations in drug disposition during pregnancy: implications for drug therapy Expert Opin. Drug Metab. Toxicol. 3 2007 557 571
-
(2007)
Expert Opin. Drug Metab. Toxicol.
, vol.3
, pp. 557-571
-
-
Hodge, L.S.1
Tracy, T.S.2
-
37
-
-
0015696661
-
The occurrence of tryptamine in rat brain and its pharmacological manipulation
-
A.S. Horn, and S.R. Snodgrass The occurrence of tryptamine in rat brain and its pharmacological manipulation Br. J. Pharmacol. 47 1973 646P
-
(1973)
Br. J. Pharmacol.
, vol.47
-
-
Horn, A.S.1
Snodgrass, S.R.2
-
38
-
-
68149149465
-
CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection
-
N. Hosono, M. Kato, K. Kiyotani, T. Mushiroda, S. Takata, H. Sato, H. Amitani, Y. Tsuchiya, K. Yamazaki, T. Tsunoda, H. Zembutsu, Y. Nakamura, and M. Kubo CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection Clin. Chem. 55 2009 1546 1554
-
(2009)
Clin. Chem.
, vol.55
, pp. 1546-1554
-
-
Hosono, N.1
Kato, M.2
Kiyotani, K.3
Mushiroda, T.4
Takata, S.5
Sato, H.6
Amitani, H.7
Tsuchiya, Y.8
Yamazaki, K.9
Tsunoda, T.10
Zembutsu, H.11
Nakamura, Y.12
Kubo, M.13
-
39
-
-
0025180083
-
Tryptamine may couple dopaminergic and serotonergic transmission in the brain
-
A.V. Juorio, and I.A. Paterson Tryptamine may couple dopaminergic and serotonergic transmission in the brain Gen Pharmacol. 21 1990 613 616
-
(1990)
Gen Pharmacol.
, vol.21
, pp. 613-616
-
-
Juorio, A.V.1
Paterson, I.A.2
-
40
-
-
84863437931
-
Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice
-
J. Jurica, R. Bartecek, A. Zourkova, E. Pindurova, A. Sulcova, T. Kasparek, and O. Zendulka Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice J. Clin. Pharm. Ther. 37 2012 486 490
-
(2012)
J. Clin. Pharm. Ther.
, vol.37
, pp. 486-490
-
-
Jurica, J.1
Bartecek, R.2
Zourkova, A.3
Pindurova, E.4
Sulcova, A.5
Kasparek, T.6
Zendulka, O.7
-
41
-
-
0028902652
-
CDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily
-
H. Kawashima, and H.W. Strobel cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily Biochem. Biophys. Res. Commun. 209 1995 535 540
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.209
, pp. 535-540
-
-
Kawashima, H.1
Strobel, H.W.2
-
42
-
-
0842313073
-
Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain
-
W. Kishimoto, T. Hiroi, M. Shiraishi, M. Osada, S. Imaoka, S. Kominami, T. Igarashi, and Y. Funae Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain Endocrinology 145 2004 699 705
-
(2004)
Endocrinology
, vol.145
, pp. 699-705
-
-
Kishimoto, W.1
Hiroi, T.2
Shiraishi, M.3
Osada, M.4
Imaoka, S.5
Kominami, S.6
Igarashi, T.7
Funae, Y.8
-
43
-
-
70349568746
-
CYP2D6: Novel genomic structures and alleles
-
W.E. Kramer, D.L. Walker, D.J. O'Kane, D.A. Mrazek, P.K. Fisher, B.A. Dukek, J.K. Bruflat, and J.L. Black CYP2D6: novel genomic structures and alleles Pharmacogenet Genomics 19 2009 813 822
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 813-822
-
-
Kramer, W.E.1
Walker, D.L.2
O'Kane, D.J.3
Mrazek, D.A.4
Fisher, P.K.5
Dukek, B.A.6
Bruflat, J.K.7
Black, J.L.8
-
44
-
-
0034986838
-
Role of biotransformation in conceptal toxicity of drugs and other chemicals
-
A.P. Kulkarni Role of biotransformation in conceptal toxicity of drugs and other chemicals Curr. Pharm Des. 7 2001 833 857
-
(2001)
Curr. Pharm Des.
, vol.7
, pp. 833-857
-
-
Kulkarni, A.P.1
-
45
-
-
0027330416
-
Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease
-
M.C. Kurth, and J.H. Kurth Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease Am. J. Med. Genet. 48 1993 166 168
-
(1993)
Am. J. Med. Genet.
, vol.48
, pp. 166-168
-
-
Kurth, M.C.1
Kurth, J.H.2
-
46
-
-
0042315387
-
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms
-
A.J. Lee, M.X. Cai, P.E. Thomas, A.H. Conney, and B.T. Zhu Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms Endocrinology 144 2003 3382 3398
-
(2003)
Endocrinology
, vol.144
, pp. 3382-3398
-
-
Lee, A.J.1
Cai, M.X.2
Thomas, P.E.3
Conney, A.H.4
Zhu, B.T.5
-
47
-
-
0027464041
-
Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
-
A. Llerena, G. Edman, J. Cobaleda, J. Benitez, D. Schalling, and L. Bertilsson Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6 Acta. Psychiatr. Scand. 87 1993 23 28
-
(1993)
Acta. Psychiatr. Scand.
, vol.87
, pp. 23-28
-
-
Llerena, A.1
Edman, G.2
Cobaleda, J.3
Benitez, J.4
Schalling, D.5
Bertilsson, L.6
-
48
-
-
54049130764
-
Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment
-
A. Mann, S. Miksys, A. Lee, D.C. Mash, and R.F. Tyndale Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment Neuropharmacology 55 2008 1147 1155
-
(2008)
Neuropharmacology
, vol.55
, pp. 1147-1155
-
-
Mann, A.1
Miksys, S.2
Lee, A.3
Mash, D.C.4
Tyndale, R.F.5
-
49
-
-
84859065441
-
The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients
-
A. Mann, S.L. Miksys, A. Gaedigk, S.J. Kish, D.C. Mash, and R.F. Tyndale The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients Neurobiol. Aging 33 2012 2160 2171
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2160-2171
-
-
Mann, A.1
Miksys, S.L.2
Gaedigk, A.3
Kish, S.J.4
Mash, D.C.5
Tyndale, R.F.6
-
50
-
-
77950419280
-
Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4- phenylpyridinium toxicity in SH-SY5Y neuronal cells
-
A. Mann, and R.F. Tyndale Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells Eur. J. Neurosci. 31 2010 1185 1193
-
(2010)
Eur. J. Neurosci.
, vol.31
, pp. 1185-1193
-
-
Mann, A.1
Tyndale, R.F.2
-
51
-
-
38849189514
-
Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition
-
K.J. Mantione, P. Cadet, W. Zhu, R.M. Kream, M. Sheehan, G.L. Fricchione, Y. Goumon, T. Esch, and G.B. Stefano Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition Addict Biol. 13 2008 118 123
-
(2008)
Addict Biol.
, vol.13
, pp. 118-123
-
-
Mantione, K.J.1
Cadet, P.2
Zhu, W.3
Kream, R.M.4
Sheehan, M.5
Fricchione, G.L.6
Goumon, Y.7
Esch, T.8
Stefano, G.B.9
-
52
-
-
0030951095
-
Tryptamine: A possible endogenous substrate for CYP2D6
-
C. Martinez, J.A. Agundez, G. Gervasini, R. Martin, and J. Benitez Tryptamine: a possible endogenous substrate for CYP2D6 Pharmacogenetics 7 1997 85 93
-
(1997)
Pharmacogenetics
, vol.7
, pp. 85-93
-
-
Martinez, C.1
Agundez, J.A.2
Gervasini, G.3
Martin, R.4
Benitez, J.5
-
53
-
-
0027157983
-
Pharmacokinetics of endogenous substances: Some problems and some solutions
-
A. Marzo, and A. Rescigno Pharmacokinetics of endogenous substances: some problems and some solutions Eur. J. Drug Metab. Pharmacokinet. 18 1993 77 88
-
(1993)
Eur. J. Drug Metab. Pharmacokinet.
, vol.18
, pp. 77-88
-
-
Marzo, A.1
Rescigno, A.2
-
54
-
-
0345602167
-
Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells
-
N. Matoh, S. Tanaka, M. Takehashi, M. Banasik, T. Stedeford, E. Masliah, S. Suzuki, Y. Nishimura, and K. Ueda Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells Gene. Expr. 11 2003 117 124
-
(2003)
Gene. Expr.
, vol.11
, pp. 117-124
-
-
Matoh, N.1
Tanaka, S.2
Takehashi, M.3
Banasik, M.4
Stedeford, T.5
Masliah, E.6
Suzuki, S.7
Nishimura, Y.8
Ueda, K.9
-
55
-
-
0031472072
-
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: A case-control study and meta-analysis
-
S.J. McCann, S.M. Pond, K.M. James, and D.G. Le Couteur The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis J. Neurol. Sci. 153 1997 50 53
-
(1997)
J. Neurol. Sci.
, vol.153
, pp. 50-53
-
-
McCann, S.J.1
Pond, S.M.2
James, K.M.3
Le Couteur, D.G.4
-
56
-
-
77952513532
-
A role for CYP in the drug-hormone crosstalk of the brain
-
R.P. Meyer, and M. Gehlhaus A role for CYP in the drug-hormone crosstalk of the brain Expert Opin. Drug Metab. Toxicol. 6 2010 675 687
-
(2010)
Expert Opin. Drug Metab. Toxicol.
, vol.6
, pp. 675-687
-
-
Meyer, R.P.1
Gehlhaus, M.2
-
57
-
-
0036736195
-
Regional and cellular expression of CYP2D6 in human brain: Higher levels in alcoholics
-
S. Miksys, Y. Rao, E. Hoffmann, D.C. Mash, and R.F. Tyndale Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics J. Neurochem. 82 2002 1376 1387
-
(2002)
J. Neurochem.
, vol.82
, pp. 1376-1387
-
-
Miksys, S.1
Rao, Y.2
Hoffmann, E.3
Mash, D.C.4
Tyndale, R.F.5
-
58
-
-
0033947897
-
Regional and cellular distribution of CYP2D subfamily members in rat brain
-
S. Miksys, Y. Rao, E.M. Sellers, M. Kwan, D. Mendis, and R.F. Tyndale Regional and cellular distribution of CYP2D subfamily members in rat brain Xenobiotica 30 2000 547 564
-
(2000)
Xenobiotica
, vol.30
, pp. 547-564
-
-
Miksys, S.1
Rao, Y.2
Sellers, E.M.3
Kwan, M.4
Mendis, D.5
Tyndale, R.F.6
-
59
-
-
3042519581
-
The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics
-
S. Miksys, and R.F. Tyndale The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics Drug Metab. Rev. 36 2004 313 333
-
(2004)
Drug Metab. Rev.
, vol.36
, pp. 313-333
-
-
Miksys, S.1
Tyndale, R.F.2
-
60
-
-
1242332464
-
Regulation of CYP2D expression in rat brain by toluene
-
D. Mizuno, T. Hiroi, P. Ng, W. Kishimoto, S. Imaoka, and Y. Funae Regulation of CYP2D expression in rat brain by toluene Osaka City Med. J. 49 2003 49 56
-
(2003)
Osaka City Med. J.
, vol.49
, pp. 49-56
-
-
Mizuno, D.1
Hiroi, T.2
Ng, P.3
Kishimoto, W.4
Imaoka, S.5
Funae, Y.6
-
61
-
-
79952849578
-
Steroid regulation of drug-metabolizing cytochromes P450
-
K. Monostory, and Z. Dvorak Steroid regulation of drug-metabolizing cytochromes P450 Curr. Drug Metab. 12 2011 154 172
-
(2011)
Curr. Drug Metab.
, vol.12
, pp. 154-172
-
-
Monostory, K.1
Dvorak, Z.2
-
62
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
D.R. Nelson, L. Koymans, T. Kamataki, J.J. Stegeman, R. Feyereisen, D.J. Waxman, M.R. Waterman, O. Gotoh, M.J. Coon, R.W. Estabrook, I.C. Gunsalus, and D.W. Nebert P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature Pharmacogenetics 6 1996 1 42
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
Gunsalus, I.C.11
Nebert, D.W.12
-
63
-
-
4644295005
-
Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6
-
T. Niwa, T. Hiroi, D. Tsuzuki, S. Yamamoto, S. Narimatsu, T. Fukuda, J. Azuma, and Y. Funae Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6 Brain Res. Mol. Brain Res. 129 2004 117 123
-
(2004)
Brain Res. Mol. Brain Res.
, vol.129
, pp. 117-123
-
-
Niwa, T.1
Hiroi, T.2
Tsuzuki, D.3
Yamamoto, S.4
Narimatsu, S.5
Fukuda, T.6
Azuma, J.7
Funae, Y.8
-
64
-
-
41149176900
-
Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain
-
T. Niwa, K. Okada, T. Hiroi, S. Imaoka, S. Narimatsu, and Y. Funae Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain Biol. Pharm. Bull. 31 2008 348 351
-
(2008)
Biol. Pharm. Bull.
, vol.31
, pp. 348-351
-
-
Niwa, T.1
Okada, K.2
Hiroi, T.3
Imaoka, S.4
Narimatsu, S.5
Funae, Y.6
-
65
-
-
0031748287
-
Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones
-
T. Niwa, Y. Yabusaki, K. Honma, N. Matsuo, K. Tatsuta, F. Ishibashi, and M. Katagiri Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones Xenobiotica 28 1998 539 547
-
(1998)
Xenobiotica
, vol.28
, pp. 539-547
-
-
Niwa, T.1
Yabusaki, Y.2
Honma, K.3
Matsuo, N.4
Tatsuta, K.5
Ishibashi, F.6
Katagiri, M.7
-
66
-
-
79954997862
-
Understanding the determinants of selectivity in drug metabolism through modeling of dextromethorphan oxidation by cytochrome P450
-
J. Olah, A.J. Mulholland, and J.N. Harvey Understanding the determinants of selectivity in drug metabolism through modeling of dextromethorphan oxidation by cytochrome P450 Proc. Natl. Acad Sci. USA 108 2011 6050 6055
-
(2011)
Proc. Natl. Acad Sci. USA
, vol.108
, pp. 6050-6055
-
-
Olah, J.1
Mulholland, A.J.2
Harvey, J.N.3
-
67
-
-
0018750857
-
Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone
-
W.M. Pardridge, and L.J. Mietus Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone J. Clin. Invest. 64 1979 145 154
-
(1979)
J. Clin. Invest.
, vol.64
, pp. 145-154
-
-
Pardridge, W.M.1
Mietus, L.J.2
-
68
-
-
79959574764
-
High risk of lifetime history of suicide attempts among CYP2D6 ultrarapid metabolizers with eating disorders
-
E.M. Penas-Lledo, P. Dorado, Z. Aguera, M. Gratacos, X. Estivill, F. Fernandez-Aranda, and A. Llerena High risk of lifetime history of suicide attempts among CYP2D6 ultrarapid metabolizers with eating disorders Mol. Psychiatry 16 2011 691 692
-
(2011)
Mol. Psychiatry
, vol.16
, pp. 691-692
-
-
Penas-Lledo, E.M.1
Dorado, P.2
Aguera, Z.3
Gratacos, M.4
Estivill, X.5
Fernandez-Aranda, F.6
Llerena, A.7
-
69
-
-
85027940350
-
CYP2D6 polymorphism in patients with eating disorders
-
E.M. Penas-Lledo, P. Dorado, Z. Aguera, M. Gratacos, X. Estivill, F. Fernandez-Aranda, and A. Llerena CYP2D6 polymorphism in patients with eating disorders Pharmacogenomics J. 12 2012 173 175
-
(2012)
Pharmacogenomics J.
, vol.12
, pp. 173-175
-
-
Penas-Lledo, E.M.1
Dorado, P.2
Aguera, Z.3
Gratacos, M.4
Estivill, X.5
Fernandez-Aranda, F.6
Llerena, A.7
-
70
-
-
70449516166
-
Relation between CYP2D6 genotype, personality, neurocognition and overall psychopathology in healthy volunteers
-
E.M. Penas-LLedo, P. Dorado, R. Pacheco, I. Gonzalez, and A. LLerena Relation between CYP2D6 genotype, personality, neurocognition and overall psychopathology in healthy volunteers Pharmacogenomics 10 2009 1111 1120
-
(2009)
Pharmacogenomics
, vol.10
, pp. 1111-1120
-
-
Penas-Lledo, E.M.1
Dorado, P.2
Pacheco, R.3
Gonzalez, I.4
Llerena, A.5
-
71
-
-
0017891480
-
Evidence for the presence of m-tyramine, p-tyramine, tryptamine, and phenylethylamine in the rat brain and several areas of the human brain
-
S.R. Philips, B. Rozdilsky, and A.A. Boulton Evidence for the presence of m-tyramine, p-tyramine, tryptamine, and phenylethylamine in the rat brain and several areas of the human brain Biol. Psychiatry 13 1978 51 57
-
(1978)
Biol. Psychiatry
, vol.13
, pp. 51-57
-
-
Philips, S.R.1
Rozdilsky, B.2
Boulton, A.A.3
-
73
-
-
0025973816
-
Determination of 5-methoxyindoles in pineal gland and plasma samples by high-performance liquid chromatography with electrochemical detection
-
F. Raynaud, and P. Pevet Determination of 5-methoxyindoles in pineal gland and plasma samples by high-performance liquid chromatography with electrochemical detection J. Chromatogr. 564 1991 103 113
-
(1991)
J. Chromatogr.
, vol.564
, pp. 103-113
-
-
Raynaud, F.1
Pevet, P.2
-
74
-
-
33646092472
-
Crystal structure of human cytochrome P450 2D6
-
P. Rowland, F.E. Blaney, M.G. Smyth, J.J. Jones, V.R. Leydon, A.K. Oxbrow, C.J. Lewis, M.G. Tennant, S. Modi, D.S. Eggleston, R.J. Chenery, and A.M. Bridges Crystal structure of human cytochrome P450 2D6 J. Biol. Chem. 281 2006 7614 7622
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7614-7622
-
-
Rowland, P.1
Blaney, F.E.2
Smyth, M.G.3
Jones, J.J.4
Leydon, V.R.5
Oxbrow, A.K.6
Lewis, C.J.7
Tennant, M.G.8
Modi, S.9
Eggleston, D.S.10
Chenery, R.J.11
Bridges, A.M.12
-
75
-
-
81355138765
-
Finite-time synchronization of coupled neural networks via discontinuous controllers
-
J. Shen, and J. Cao Finite-time synchronization of coupled neural networks via discontinuous controllers Cogn. Neurodyn. 5 2011 373 385
-
(2011)
Cogn. Neurodyn.
, vol.5
, pp. 373-385
-
-
Shen, J.1
Cao, J.2
-
76
-
-
0035049437
-
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
-
I. Siegle, P. Fritz, K. Eckhardt, U.M. Zanger, and M. Eichelbaum Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain Pharmacogenetics 11 2001 237 245
-
(2001)
Pharmacogenetics
, vol.11
, pp. 237-245
-
-
Siegle, I.1
Fritz, P.2
Eckhardt, K.3
Zanger, U.M.4
Eichelbaum, M.5
-
77
-
-
79960280142
-
CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care
-
U.M. Stamer, E.H. Lee, N.I. Rauers, L. Zhang, M. Kleine-Brueggeney, R. Fimmers, F. Stuber, and F. Musshoff CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care Anesth. Analg. 113 2011 48 54
-
(2011)
Anesth. Analg.
, vol.113
, pp. 48-54
-
-
Stamer, U.M.1
Lee, E.H.2
Rauers, N.I.3
Zhang, L.4
Kleine-Brueggeney, M.5
Fimmers, R.6
Stuber, F.7
Musshoff, F.8
-
78
-
-
47949109211
-
Developmental changes in human liver CYP2D6 expression
-
J.C. Stevens, S.A. Marsh, M.J. Zaya, K.J. Regina, K. Divakaran, M. Le, and R.N. Hines Developmental changes in human liver CYP2D6 expression Drug Metab. Dispos. 36 2008 1587 1593
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 1587-1593
-
-
Stevens, J.C.1
Marsh, S.A.2
Zaya, M.J.3
Regina, K.J.4
Divakaran, K.5
Le, M.6
Hines, R.N.7
-
79
-
-
84855462649
-
Genetic variation in CYP2D6 impacts neural activation during cognitive tasks in humans
-
J.C. Stingl, C. Esslinger, H. Tost, E. Bilek, P. Kirsch, B. Ohmle, R. Viviani, H. Walter, M. Rietschel, and A. Meyer-Lindenberg Genetic variation in CYP2D6 impacts neural activation during cognitive tasks in humans Neuroimage 59 2012 2818 2823
-
(2012)
Neuroimage
, vol.59
, pp. 2818-2823
-
-
Stingl, J.C.1
Esslinger, C.2
Tost, H.3
Bilek, E.4
Kirsch, P.5
Ohmle, B.6
Viviani, R.7
Walter, H.8
Rietschel, M.9
Meyer-Lindenberg, A.10
-
80
-
-
79951813026
-
CYP2D6 in the brain: Impact on suicidality
-
J.C. Stingl, and R. Viviani CYP2D6 in the brain: impact on suicidality Clin. Pharmacol. Ther. 89 2011 352 353
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 352-353
-
-
Stingl, J.C.1
Viviani, R.2
-
81
-
-
25644451318
-
Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers
-
T. Takashima, S. Murase, K. Iwasaki, and K. Shimada Evaluation of dextromethorphan metabolism using hepatocytes from CYP2D6 poor and extensive metabolizers Drug Metab. Pharmacokinet. 20 2005 177 182
-
(2005)
Drug Metab. Pharmacokinet.
, vol.20
, pp. 177-182
-
-
Takashima, T.1
Murase, S.2
Iwasaki, K.3
Shimada, K.4
-
82
-
-
84857705331
-
Pharmacogenomics of CYP2D6: Molecular genetics, interethnic differences and clinical importance
-
L.K. Teh, and L. Bertilsson Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance Drug Metab. Pharmacokinet. 27 2012 55 67
-
(2012)
Drug Metab. Pharmacokinet.
, vol.27
, pp. 55-67
-
-
Teh, L.K.1
Bertilsson, L.2
-
83
-
-
0033846716
-
Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid
-
C.M. Thompson, J.H. Capdevila, and H.W. Strobel Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid J. Pharmacol. Exp. Ther. 294 2000 1120 1130
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.294
, pp. 1120-1130
-
-
Thompson, C.M.1
Capdevila, J.H.2
Strobel, H.W.3
-
84
-
-
13444269471
-
Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy
-
T.S. Tracy, R. Venkataramanan, D.D. Glover, and S.N. Caritis Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy Am. J. Obstet Gynecol. 192 2005 633 639
-
(2005)
Am. J. Obstet Gynecol.
, vol.192
, pp. 633-639
-
-
Tracy, T.S.1
Venkataramanan, R.2
Glover, D.D.3
Caritis, S.N.4
-
86
-
-
23844494772
-
Cytochrome P450-mediated metabolism of estrogens and its regulation in human
-
Y. Tsuchiya, M. Nakajima, and T. Yokoi Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 227 2005 115 124
-
(2005)
Cancer Lett.
, vol.227
, pp. 115-124
-
-
Tsuchiya, Y.1
Nakajima, M.2
Yokoi, T.3
-
87
-
-
0019295039
-
Extraction of pineal and uterine tissue at different pH values: A preliminary report on the occurrence of a few groups of compounds in both tissues
-
C.J. van der Horst, and I. Ebels Extraction of pineal and uterine tissue at different pH values: a preliminary report on the occurrence of a few groups of compounds in both tissues Cytobios 29 1980 191 203
-
(1980)
Cytobios
, vol.29
, pp. 191-203
-
-
Van Der Horst, C.J.1
Ebels, I.2
-
88
-
-
18844426008
-
In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: Prediction of nonstationary pharmacokinetics and drug interaction magnitude
-
K. Venkatakrishnan, and R.S. Obach In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude Drug Metab. Dispos. 33 2005 845 852
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 845-852
-
-
Venkatakrishnan, K.1
Obach, R.S.2
-
89
-
-
33947715346
-
Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes
-
M.M. Verbeek, P.B. Geurtz, M.A. Willemsen, and R.A. Wevers Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes Mol. Genet. Metab. 90 2007 363 369
-
(2007)
Mol. Genet. Metab.
, vol.90
, pp. 363-369
-
-
Verbeek, M.M.1
Geurtz, P.B.2
Willemsen, M.A.3
Wevers, R.A.4
-
91
-
-
70350044889
-
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme
-
B. Wang, L.P. Yang, X.Z. Zhang, S.Q. Huang, M. Bartlam, and S.F. Zhou New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme Drug Metab. Rev. 41 2009 573 643
-
(2009)
Drug Metab. Rev.
, vol.41
, pp. 573-643
-
-
Wang, B.1
Yang, L.P.2
Zhang, X.Z.3
Huang, S.Q.4
Bartlam, M.5
Zhou, S.F.6
-
92
-
-
78649332050
-
Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: The unsolved paradox
-
T. Wassenberg, M.A. Willemsen, P.B. Geurtz, M. Lammens, K. Verrijp, M. Wilmer, W.T. Lee, R.A. Wevers, and M.M. Verbeek Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox Mol. Genet. Metab. 101 2010 349 356
-
(2010)
Mol. Genet. Metab.
, vol.101
, pp. 349-356
-
-
Wassenberg, T.1
Willemsen, M.A.2
Geurtz, P.B.3
Lammens, M.4
Verrijp, K.5
Wilmer, M.6
Lee, W.T.7
Wevers, R.A.8
Verbeek, M.M.9
-
93
-
-
0016424683
-
Levels of follicle-stimulating hormone, luteinizing hormone, oestradiol-17 beta and progesterone, and follicular growth in the pseudopregnant rat
-
R. Welschen, P. Osman, J. Dullaart, W.J. de Greef, J.T. Uilenbroek, and F.H. de Jong Levels of follicle-stimulating hormone, luteinizing hormone, oestradiol-17 beta and progesterone, and follicular growth in the pseudopregnant rat J. Endocrinol. 64 1975 37 47
-
(1975)
J. Endocrinol.
, vol.64
, pp. 37-47
-
-
Welschen, R.1
Osman, P.2
Dullaart, J.3
De Greef, W.J.4
Uilenbroek, J.T.5
De Jong, F.H.6
-
94
-
-
0034782996
-
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: Can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
-
A. Yu, and R.L. Haining Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab. Dispos. 29 2001 1514 1520
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1514-1520
-
-
Yu, A.1
Haining, R.L.2
-
95
-
-
0038240578
-
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
-
A.M. Yu, J.R. Idle, T. Herraiz, A. Kupfer, and F.J. Gonzalez Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase Pharmacogenetics 13 2003 307 319
-
(2003)
Pharmacogenetics
, vol.13
, pp. 307-319
-
-
Yu, A.M.1
Idle, J.R.2
Herraiz, T.3
Kupfer, A.4
Gonzalez, F.J.5
-
96
-
-
0037342251
-
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6
-
A.M. Yu, J.R. Idle, L.G. Byrd, K.W. Krausz, A. Kupfer, and F.J. Gonzalez Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6 Pharmacogenetics 13 2003 173 181
-
(2003)
Pharmacogenetics
, vol.13
, pp. 173-181
-
-
Yu, A.M.1
Idle, J.R.2
Byrd, L.G.3
Krausz, K.W.4
Kupfer, A.5
Gonzalez, F.J.6
-
97
-
-
0037310739
-
The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine
-
A.M. Yu, C.P. Granvil, R.L. Haining, K.W. Krausz, J. Corchero, A. Kupfer, J.R. Idle, and F.J. Gonzalez The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine J. Pharmacol. Exp. Ther. 304 2003 539 546
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 539-546
-
-
Yu, A.M.1
Granvil, C.P.2
Haining, R.L.3
Krausz, K.W.4
Corchero, J.5
Kupfer, A.6
Idle, J.R.7
Gonzalez, F.J.8
-
98
-
-
79953328535
-
Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy)-induced cytochrome P450 2D6 inhibition in humans
-
S. Yubero-Lahoz, R. Pardo, M. Farre, B. O'Mahony, M. Torrens, C. Mustata, C. Perez-Mana, M.L. Carbo, and R. de la Torre Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans Clin. Pharmacokinet. 50 2011 319 329
-
(2011)
Clin. Pharmacokinet.
, vol.50
, pp. 319-329
-
-
Yubero-Lahoz, S.1
Pardo, R.2
Farre, M.3
O'Mahony, B.4
Torrens, M.5
Mustata, C.6
Perez-Mana, C.7
Carbo, M.L.8
De La Torre, R.9
-
99
-
-
39149094615
-
Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: An investigation of induction and time course
-
J. Yue, S. Miksys, E. Hoffmann, and R.F. Tyndale Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course J. Psychiatry Neurosci. 33 2008 54 63
-
(2008)
J. Psychiatry Neurosci.
, vol.33
, pp. 54-63
-
-
Yue, J.1
Miksys, S.2
Hoffmann, E.3
Tyndale, R.F.4
-
100
-
-
77955865554
-
High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases
-
A.L. Zackrisson, B. Lindblom, and J. Ahlner High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases Clin. Pharmacol. Ther. 88 2010 354 359
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 354-359
-
-
Zackrisson, A.L.1
Lindblom, B.2
Ahlner, J.3
-
101
-
-
70249149974
-
Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance
-
P. Zheng Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance Prog. Neurobiol. 89 2009 134 152
-
(2009)
Prog. Neurobiol.
, vol.89
, pp. 134-152
-
-
Zheng, P.1
-
102
-
-
70349387884
-
Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development
-
S.F. Zhou, J.P. Liu, and X.S. Lai Substrate specificity, inhibitors and regulation of human cytochrome P450 2D6 and implications in drug development Curr. Med. Chem. 16 2009 2661 2805
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 2661-2805
-
-
Zhou, S.F.1
Liu, J.P.2
Lai, X.S.3
-
103
-
-
55549134329
-
CYP2D6: A key enzyme in morphine synthesis in animals
-
W. Zhu CYP2D6: a key enzyme in morphine synthesis in animals Med. Sci. Monit. 14 2008 C15 C18
-
(2008)
Med. Sci. Monit.
, vol.14
-
-
Zhu, W.1
|