Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition

Addiction Biology

Volumn 13, Issue 1, 2008, Pages 118-123

  Mantione, Kirk J ^a   Cadet, Patrick ^a   Zhu, Wei ^a   Kream, Richard M ^b   Sheehan, Melinda ^a   Fricchione, Gregory L ^c   Goumon, Yannick ^d   Esch, Tobias ^e   Stefano, George B ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d INSERM   (France)

^e Department of Electrical Engineering and Computer Science   (Germany)

Author keywords

COMT; CYP2D6; Microarray; Morphine; Nitric oxide; Tyrosine hydroxylase

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450 2D6; DOPAMINE BETA MONOOXYGENASE; ENZYME; GLUCUROSYLTRANSFERASE; MESSENGER RNA; MORPHINE; MORPHINE 6 GLUCURONIDE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; S NITROSO N ACETYL DEXTRO LEVO PENICILLAMINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ANALYTIC METHOD; ARTICLE; AUTOCRINE EFFECT; BLOOD SAMPLING; CHROMAFFIN CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKOCYTE; MICROARRAY ANALYSIS; NEGATIVE FEEDBACK; PARACRINE SIGNALING; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AUTOCRINE COMMUNICATION; CATECHOL O-METHYLTRANSFERASE; CYTOCHROME P-450 CYP2D6; DOWN-REGULATION; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEUKOCYTES; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARACRINE COMMUNICATION; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; S-NITROSO-N-ACETYLPENICILLAMINE; SIGNAL TRANSDUCTION;

EID: 38849189514     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2007.00072.x     Document Type: Article

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