-
1
-
-
34249653574
-
Cause of death and drug use pattern in deceased drug addicts in sweden 2002-2003
-
Jönsson, A.K., Holmgren, P., Druid, H. & Ahlner, J. Cause of death and drug use pattern in deceased drug addicts in sweden, 2002-2003. Forensic Sci. Int. 169, 101-107 (2007).
-
(2007)
Forensic Sci. Int.
, vol.169
, pp. 101-107
-
-
Jönsson, A.K.1
Holmgren, P.2
Druid, H.3
Ahlner, J.4
-
2
-
-
0026506140
-
Pronounced diferences between native Chinese and swedish populations in the polymorphic hydroxylations of debrisoquin and s-mephenytoin
-
Bertilsson, L. et al. Pronounced diferences between native Chinese and swedish populations in the polymorphic hydroxylations of debrisoquin and s-mephenytoin. Clin. Pharmacol. Ther. 51, 388-397 (1992).
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 388-397
-
-
Bertilsson, L.1
-
3
-
-
0030860004
-
Polymorphism of the cytochrome p450 CYp2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
-
Marez, D. et al. Polymorphism of the cytochrome p450 CYp2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 7, 193-202 (1997).
-
(1997)
Pharmacogenetics
, vol.7
, pp. 193-202
-
-
Marez, D.1
-
4
-
-
0031038038
-
Cytochrome p450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse, C., Brockmöller, J., Bauer, S. & Roots, I. Cytochrome p450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60, 284-295 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmöller, J.2
Bauer, S.3
Roots, I.4
-
5
-
-
0031960093
-
Correctness of prediction of the CYp2D6 phenotype confrmed by genotyping 47 intermediate and poor metabolizers of debrisoquine
-
Sachse, C., Brockmoller, J., Hildebrand, M., Muller, K. & Roots, I. Correctness of prediction of the CYp2D6 phenotype confrmed by genotyping 47 intermediate and poor metabolizers of debrisoquine. Pharmacogenetics 8, 181-185 (1998).
-
(1998)
Pharmacogenetics
, vol.8
, pp. 181-185
-
-
Sachse, C.1
Brockmoller, J.2
Hildebrand, M.3
Muller, K.4
Roots, I.5
-
6
-
-
0026610576
-
Analysis of the CYp2D6 gene in relation to debrisoquin and desipramine hydroxylation in a swedish population
-
Dahl, M.L., Johansson, I., Palmertz, M.P., Ingelman-sundberg, M. & Sjöqvist, F. Analysis of the CYp2D6 gene in relation to debrisoquin and desipramine hydroxylation in a swedish population. Clin. Pharmacol. Ther. 51, 12-17 (1992).
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 12-17
-
-
Dahl, M.L.1
Johansson, I.2
Palmertz, M.P.3
Ingelman-Sundberg, M.4
Sjöqvist, F.5
-
7
-
-
0029064096
-
Ultrarapid hydroxylation of debrisoquine in a swedish population. Analysis of the molecular genetic basis
-
Dahl, M.L., Johansson, I., Bertilsson, L., Ingelman-sundberg, M. & Sjöqvist, F. Ultrarapid hydroxylation of debrisoquine in a swedish population. Analysis of the molecular genetic basis. J. Pharmacol. Exp. Ther. 274, 516-520 (1995).
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.274
, pp. 516-520
-
-
Dahl, M.L.1
Johansson, I.2
Bertilsson, L.3
Ingelman-Sundberg, M.4
Sjöqvist, F.5
-
8
-
-
0027534276
-
Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
-
Bertilsson, L. et al. Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet 341, 63 (1993).
-
(1993)
Lancet
, vol.341
, pp. 63
-
-
Bertilsson, L.1
-
9
-
-
51449102329
-
Respiratory depression with tramadol in a patient with renal impairment and CYp2D6 gene duplication
-
Stamer, U.M., Stuber, F., Muders, T. & Musshof, F. Respiratory depression with tramadol in a patient with renal impairment and CYp2D6 gene duplication. Anesth. Analg. 107, 926-929 (2008).
-
(2008)
Anesth. Analg.
, vol.107
, pp. 926-929
-
-
Stamer, U.M.1
Stuber, F.2
Muders, T.3
Musshof, F.4
-
10
-
-
38349163777
-
Efects of the CYp2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
-
Kirchheiner, J., Keulen, J.T., Bauer, S., Roots, I. & Brockmoller, J. Efects of the CYp2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J. Clin. Psychopharmacol. 28, 78-83 (2008).
-
(2008)
J. Clin. Psychopharmacol.
, vol.28
, pp. 78-83
-
-
Kirchheiner, J.1
Keulen, J.T.2
Bauer, S.3
Roots, I.4
Brockmoller, J.5
-
11
-
-
34250345279
-
Apnea in a child after oral codeine: A genetic variant-an ultra-rapid metabolizer
-
Voronov, P., Przybylo, H.J. & Jagannathan, N. Apnea in a child after oral codeine: a genetic variant-an ultra-rapid metabolizer. Paediatr. Anaesth. 17, 684-687 (2007).
-
(2007)
Paediatr. Anaesth.
, vol.17
, pp. 684-687
-
-
Voronov, P.1
Przybylo, H.J.2
Jagannathan, N.3
-
12
-
-
0029812804
-
Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry
-
Brosen, K. Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry. Ther. Drug Monit. 18, 393-396 (1996).
-
(1996)
Ther. Drug Monit.
, vol.18
, pp. 393-396
-
-
Brosen, K.1
-
13
-
-
0036001244
-
Change from the CYp2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion
-
Güzey, C., Norström, A. & Spigset, O. Change from the CYp2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion. Ther. Drug Monit. 24, 436-437 (2002).
-
(2002)
Ther. Drug Monit.
, vol.24
, pp. 436-437
-
-
Güzey, C.1
Norström, A.2
Spigset, O.3
-
14
-
-
0034751517
-
Inhibition of cytochrome p4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test
-
Laine, K. et al. Inhibition of cytochrome p4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test. Clin. Pharmacol. Ther. 70, 327-335 (2001).
-
(2001)
Clin. Pharmacol. Ther.
, vol.70
, pp. 327-335
-
-
Laine, K.1
-
15
-
-
0029587180
-
Use of omeprazole as a probe drug for CYp2C19 phenotype in swedish Caucasians: Comparison with s-mephenytoin hydroxylation phenotype and CYp2C19 genotype
-
Chang, M., Dahl, M.L., Tybring, G., Gotharson, E. & Bertilsson, L. Use of omeprazole as a probe drug for CYp2C19 phenotype in swedish Caucasians: comparison with s-mephenytoin hydroxylation phenotype and CYp2C19 genotype. Pharmacogenetics 5, 358-363 (1995).
-
(1995)
Pharmacogenetics
, vol.5
, pp. 358-363
-
-
Chang, M.1
Dahl, M.L.2
Tybring, G.3
Gotharson, E.4
Bertilsson, L.5
-
16
-
-
0025572192
-
Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
-
Alvan, G., Bechtel, P., Iselius, L. & Gundert-Remy, U. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur. J. Clin. Pharmacol. 39, 533-537 (1990).
-
(1990)
Eur. J. Clin. Pharmacol.
, vol.39
, pp. 533-537
-
-
Alvan, G.1
Bechtel, P.2
Iselius, L.3
Gundert-Remy, U.4
-
17
-
-
30344457586
-
A common novel CYp2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
-
Sim, S.C. et al. A common novel CYp2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin. Pharmacol. Ther. 79, 103-113 (2006).
-
(2006)
Clin. Pharmacol. Ther.
, vol.79
, pp. 103-113
-
-
Sim, S.C.1
-
18
-
-
8744248219
-
Fatal intoxication cases: Cytochrome p450 2D6 and 2C19 genotype distributions
-
Zackrisson, A.L., Holmgren, P., Gladh, A.B., Ahlner, J. & Lindblom, B. Fatal intoxication cases: cytochrome p450 2D6 and 2C19 genotype distributions. Eur. J. Clin. Pharmacol. 60, 547-552 (2004).
-
(2004)
Eur. J. Clin. Pharmacol.
, vol.60
, pp. 547-552
-
-
Zackrisson, A.L.1
Holmgren, P.2
Gladh, A.B.3
Ahlner, J.4
Lindblom, B.5
-
19
-
-
1242269894
-
Increased incidence of CYp2D6 gene duplication in patients with persistent mood disorders: Ultrarapid metabolism of antidepressants as a cause of nonresponse
-
Kawanishi, C., Lundgren, S, Agren, H. & Bertilsson, L. Increased incidence of CYp2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study. Eur. J. Clin. Pharmacol. 59, 803-807 (2004).
-
(2004)
A Pilot Study. Eur. J. Clin. Pharmacol.
, vol.59
, pp. 803-807
-
-
Kawanishi, C.1
Lundgren, S.2
Agren, H.3
Bertilsson, L.4
-
20
-
-
0011578981
-
Debrisoquine hydroxylation polymorphism and personality
-
Bertilsson, L., Alm, C., De Las Carreras, C., Widen, J., Edman, G. & Schalling, D. Debrisoquine hydroxylation polymorphism and personality. Lancet 1, 555 (1989).
-
(1989)
Lancet
, vol.1
, pp. 555
-
-
Bertilsson, L.1
Alm, C.2
De Las Carreras, C.3
Widen, J.4
Edman, G.5
Schalling, D.6
-
21
-
-
0027464041
-
Relationship between personality and debrisoquine hydroxylation capacity. suggestion of an endogenous neuroactive substrate or product of the cytochrome p4502D6
-
Llerena, A., Edman, G., Cobaleda, J., Benitez, J., Schalling, D. & Bertilsson, L. Relationship between personality and debrisoquine hydroxylation capacity. suggestion of an endogenous neuroactive substrate or product of the cytochrome p4502D6. Acta Psychiatr. Scand. 87, 23-28 (1993).
-
(1993)
Acta Psychiatr. Scand.
, vol.87
, pp. 23-28
-
-
Llerena, A.1
Edman, G.2
Cobaleda, J.3
Benitez, J.4
Schalling, D.5
Bertilsson, L.6
-
22
-
-
2942577455
-
Relationship between type A and B personality and debrisoquine hydroxylation capacity
-
Gan, S.H., Ismail, R., Wan Adnan, W.A., Zulmi, W., Kumaraswamy, N. & Larmie, E.T. Relationship between type A and B personality and debrisoquine hydroxylation capacity. Br. J. Clin. Pharmacol. 57, 785-789 (2004).
-
(2004)
Br. J. Clin. Pharmacol.
, vol.57
, pp. 785-789
-
-
Gan, S.H.1
Ismail, R.2
Wan Adnan, W.A.3
Zulmi, W.4
Kumaraswamy, N.5
Larmie, E.T.6
-
23
-
-
2142642298
-
Association between cytochrome p450 2D6 genotype and harm avoidance
-
Roberts, R.L., Luty, S.E., Mulder, R.T., Joyce, P.R. & Kennedy, M.A. Association between cytochrome p450 2D6 genotype and harm avoidance. Am. J. Med. Genet. B Neuropsychiatr. Genet. 127, 90-93 (2004).
-
(2004)
Am. J. Med. Genet. B Neuropsychiatr. Genet.
, vol.127
, pp. 90-93
-
-
Roberts, R.L.1
Luty, S.E.2
Mulder, R.T.3
Joyce, P.R.4
Kennedy, M.A.5
-
24
-
-
49949118071
-
Relation between CYp2D6 phenotype and genotype and personality in healthy volunteers
-
González, I., Peñas-Lledó, E.M., Pérez, B., Dorado, P., Alvarez, M. & LLerena, A. Relation between CYp2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics 9, 833-840 (2008).
-
(2008)
Pharmacogenomics
, vol.9
, pp. 833-840
-
-
González, I.1
Peñas-Lledó, E.M.2
Pérez, B.3
Dorado, P.4
Alvarez, M.5
Llerena, A.6
-
25
-
-
0037672477
-
Cytochrome p450 2D6 polymorphism and character traits
-
Suzuki, E., Kitao, Y., Ono, Y., Iijima, Y. & Inada, T. Cytochrome p450 2D6 polymorphism and character traits. Psychiatr. Genet. 13, 111-113 (2003).
-
(2003)
Psychiatr. Genet.
, vol.13
, pp. 111-113
-
-
Suzuki, E.1
Kitao, Y.2
Ono, Y.3
Iijima, Y.4
Inada, T.5
-
26
-
-
33746923412
-
Association of CYp2D6 genotypes and personality traits in healthy individuals
-
Kirchheiner, J., Lang, U., Stamm, T., Sander, T. & Gallinat, J. Association of CYp2D6 genotypes and personality traits in healthy individuals. J. Clin. Psychopharmacol. 26, 440-442 (2006).
-
(2006)
J. Clin. Psychopharmacol.
, vol.26
, pp. 440-442
-
-
Kirchheiner, J.1
Lang, U.2
Stamm, T.3
Sander, T.4
Gallinat, J.5
-
27
-
-
0035049437
-
Cellular localization and regional distribution of CYp2D6 mRN and protein expression in human brain
-
Siegle, I., Fritz, P., Eckhardt, K., Zanger, U.M. & Eichelbaum, M. Cellular localization and regional distribution of CYp2D6 mRN and protein expression in human brain. Pharmacogenetics 11, 237-245 (2001).
-
(2001)
Pharmacogenetics
, vol.11
, pp. 237-245
-
-
Siegle, I.1
Fritz, P.2
Eckhardt, K.3
Zanger, U.M.4
Eichelbaum, M.5
-
28
-
-
0037198965
-
Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome p4502D in human brain
-
Chinta, S.J., Pai, H.V., Upadhya, S.C., Boyd, M.R. & Ravindranath, V. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome p4502D in human brain. Brain Res. Mol. Brain Res. 103, 49-61 (2002).
-
(2002)
Brain Res. Mol. Brain Res.
, vol.103
, pp. 49-61
-
-
Chinta, S.J.1
Pai, H.V.2
Upadhya, S.C.3
Boyd, M.R.4
Ravindranath, V.5
-
29
-
-
0034869539
-
Progesterone oxidation by cytochrome p450 2D isoforms in the brain
-
Hiroi, T., Kishimoto, W., Chow, T., Imaoka, S., Igarashi, T. & Funae, Y. Progesterone oxidation by cytochrome p450 2D isoforms in the brain. Endocrinology 142, 3901-3908 (2001).
-
(2001)
Endocrinology
, vol.142
, pp. 3901-3908
-
-
Hiroi, T.1
Kishimoto, W.2
Chow, T.3
Imaoka, S.4
Igarashi, T.5
Funae, Y.6
-
30
-
-
4644295005
-
Efect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYp2D6
-
Niwa, T. et al. Efect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYp2D6. Brain Res. Mol. Brain Res. 129, 117-123 (2004).
-
(2004)
Brain Res. Mol. Brain Res.
, vol.129
, pp. 117-123
-
-
Niwa, T.1
-
31
-
-
3042515935
-
Polymorphic cytochrome p450 2D6: Humanized mouse model and endogenous substrates
-
Yu, A.M., Idle, J.R. & Gonzalez, F.J. polymorphic cytochrome p450 2D6: humanized mouse model and endogenous substrates. Drug Metab. Rev. 36, 243-277 (2004).
-
(2004)
Drug Metab. Rev.
, vol.36
, pp. 243-277
-
-
Yu, A.M.1
Idle, J.R.2
Gonzalez, F.J.3
-
32
-
-
0030432585
-
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYp2D6 alleles
-
Aklillu, E., Persson, I., Bertilsson, L., Johansson, I., Rodrigues, F. & Ingelman-sundberg, M. Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYp2D6 alleles. J. Pharmacol. Exp. Ther. 278, 441-446 (1996).
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, pp. 441-446
-
-
Aklillu, E.1
Persson, I.2
Bertilsson, L.3
Johansson, I.4
Rodrigues, F.5
Ingelman-Sundberg, M.6
-
33
-
-
0242637084
-
Identifcation of CYp2D6 alleles by single nucleotide polymorphism analysis using pyrosequencing
-
Zackrisson, A.L. & Lindblom, B. Identifcation of CYp2D6 alleles by single nucleotide polymorphism analysis using pyrosequencing. Eur. J. Clin. Pharmacol. 59, 521-526 (2003).
-
(2003)
Eur. J. Clin. Pharmacol.
, vol.59
, pp. 521-526
-
-
Zackrisson, A.L.1
Lindblom, B.2
-
34
-
-
14544294868
-
Determination of CYp2D6 gene copy number by pyrosequencing
-
Söderbäck, E., Zackrisson, A.L., Lindblom, B. & Alderborn, A. Determination of CYp2D6 gene copy number by pyrosequencing. Clin. Chem. 51, 522-531 (2005).
-
(2005)
Clin. Chem.
, vol.51
, pp. 522-531
-
-
Söderbäck, E.1
Zackrisson, A.L.2
Lindblom, B.3
Alderborn, A.4
-
35
-
-
0042843050
-
Cytochrome p450 genotyping by multiplexed real-time dna sequencing with pyrosequencing technology
-
Eriksson, S., Berg, L.M., Wadelius, M. & Alderborn, A. Cytochrome p450 genotyping by multiplexed real-time dna sequencing with pyrosequencing technology. Assay Drug Dev. Technol. 1, 49-59 (2002).
-
(2002)
Assay Drug Dev. Technol.
, vol.1
, pp. 49-59
-
-
Eriksson, S.1
Berg, L.M.2
Wadelius, M.3
Alderborn, A.4
|