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Volumn 10, Issue 7, 2009, Pages 1111-1120

Relation between CYP2D6 genotype, personality, neurocognition and overall psychopathology in healthy volunteers

Author keywords

CANTAB ; CYP2D6; Impulsivity; KSP; Personality; Pharmacogenetics; Pharmacogenomics; SCL 90 R; TCI R

Indexed keywords

CYTOCHROME P450 2D6; DOPAMINE; SEROTONIN;

EID: 70449516166     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.75     Document Type: Conference Paper
Times cited : (46)

References (40)
  • 1
    • 0028207482 scopus 로고
    • Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism
    • Mikus G, Bochner F, Eichelbaum M, Horak P, Somogyi AA, Spector S: Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism. J. Pharmacol. Exp. Ther. 268(2), 546-551 (1994).
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , Issue.2 , pp. 546-551
    • Mikus, G.1    Bochner, F.2    Eichelbaum, M.3    Horak, P.4    Somogyi, A.A.5    Spector, S.6
  • 2
    • 62649122990 scopus 로고    scopus 로고
    • Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity
    • LLerena A, Dorado P, Peñas-LLedó EM: Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity. Pharmacogenomics 10(1), 17-28 (2009).
    • (2009) Pharmacogenomics , vol.10 , Issue.1 , pp. 17-28
    • Llerena, A.1    Dorado, P.2    Peñas-LLedó, E.M.3
  • 3
    • 33845333337 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs
    • Dorado P, Berecz R, Peñas-LLedó EM, Cáceres MC, LLerena A: Clinical implications of CYP2D6 genetic polymorphism during treatment with antipsychotic drugs. Curr. Drug Targets 7(12), 1671-1680 (2006).
    • (2006) Curr. Drug Targets , vol.7 , Issue.12 , pp. 1671-1680
    • Dorado, P.1    Berecz, R.2    Peñas-LLedó, E.M.3    Cáceres, M.C.4    Llerena, A.5
  • 4
    • 0036874345 scopus 로고    scopus 로고
    • Drug-metabolizing cytochrome P450s in the brain
    • Miksys SL, Tyndale RF: Drug-metabolizing cytochrome P450s in the brain. J. Psychiatry Neurosci. 27(6), 406-415 (2002).
    • (2002) J. Psychiatry Neurosci. , vol.27 , Issue.6 , pp. 406-415
    • Miksys, S.L.1    Tyndale, R.F.2
  • 5
    • 0037342251 scopus 로고    scopus 로고
    • Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6
    • DOI 10.1097/00008571-200303000-00007
    • Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ: Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics 13(3), 173-181 (2003). (Pubitemid 36324247)
    • (2003) Pharmacogenetics , vol.13 , Issue.3 , pp. 173-181
    • Yu, A.-M.1    Idle, J.R.2    Byrd, L.G.3    Krausz, K.W.4    Kupfer, A.5    Gonzalez, F.J.6
  • 6
    • 3042515935 scopus 로고    scopus 로고
    • Polymorphic cytochrome P450 2D6: Humanized mouse model and endogenous substrates
    • This in vivo study shows that the polymorphic CYP2D6 may play an important role in the interconversions of psychoactive tryptamines, including a crucial step in a serotonin-melatonin cycle
    • Yu AM, Idle JR, Gonzalez FJ: Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab. Rev. 36(2), 243-277 (2004). ■■ This in vivo study shows that the polymorphic CYP2D6 may play an important role in the interconversions of psychoactive tryptamines, including a crucial step in a serotonin-melatonin cycle.
    • (2004) Drug Metab. Rev. , vol.36 , Issue.2 , pp. 243-277
    • Yu, A.M.1    Idle, J.R.2    Gonzalez, F.J.3
  • 7
    • 37349090515 scopus 로고    scopus 로고
    • CYP2D6 polymorphism: Implications for antipsychotic drug response, schizophrenia and personality traits
    • DOI 10.2217/14622416.8.11.1597
    • Dorado P, Peñas-LLedó EM, LLerena A: CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits. Pharmacogenomics 8(11), 1597-1608 (2007). (Pubitemid 350286402)
    • (2007) Pharmacogenomics , vol.8 , Issue.11 , pp. 1597-1608
    • Dorado, P.1    Penas-Lledo, E.M.2    Llerena, A.3
  • 8
    • 34247229036 scopus 로고    scopus 로고
    • CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited
    • Suggests that CYP2D6 genetic variation may potentially influence pharmacodynamic tissue sensitivity in the brain through disposition of an endogenous substrate
    • Ozdemir V, Bertilsson L, Miura J et al.: CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited. Pharmacogenet. Genomics 17(5), 339-347 (2007). ■■ Suggests that CYP2D6 genetic variation may potentially influence pharmacodynamic tissue sensitivity in the brain through disposition of an endogenous substrate.
    • (2007) Pharmacogenet. Genomics , vol.17 , Issue.5 , pp. 339-347
    • Ozdemir, V.1    Bertilsson, L.2    Miura, J.3
  • 9
    • 37349117305 scopus 로고    scopus 로고
    • CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine
    • DOI 10.1097/FPC.0b013e3282f01aa3, PII 0121301120071100000009
    • Aklillu E, Kalow W, Endrenyi L, Harper P, Miura J, Ozdemir V: CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet. Genomics 17(11), 989-993 (2007). (Pubitemid 350293798)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.11 , pp. 989-993
    • Aklillu, E.1    Kalow, W.2    Endrenyi, L.3    Harper, P.4    Miura, J.5    Ozdemir, V.6
  • 11
    • 0024412185 scopus 로고
    • Debrisoquine hydroxylation phenotypes in healthy volunteers
    • LLerena A, Cobaleda J, Benítez J: Debrisoquine hydroxylation phenotypes in healthy volunteers. Lancet 1(8651), 1398 (1989).
    • (1989) Lancet , vol.1 , Issue.8651 , pp. 1398
    • Llerena, A.1    Cobaleda, J.2    Benítez, J.3
  • 12
    • 49949118071 scopus 로고    scopus 로고
    • Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers
    • First study that replicated the study of LLerena et al. (1993) [14] in a similar population of healthy volunteers but in a different country (Cuba) showing very similar personality differences (Karolinska Scales of Personality) with regard to different degrees of CYP2D6 activity (debrisoquine hydroxylation phenotype)
    • González I, Peñas-LLedó EM, Pérez B, Dorado P, Alvarez M, LLerena A: Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics 9(7), 833-840 (2008). ■■ First study that replicated the study of LLerena et al. (1993) [14] in a similar population of healthy volunteers but in a different country (Cuba) showing very similar personality differences (Karolinska Scales of Personality) with regard to different degrees of CYP2D6 activity (debrisoquine hydroxylation phenotype).
    • (2008) Pharmacogenomics , vol.9 , Issue.7 , pp. 833-840
    • González, I.1    Peñas-LLedó, E.M.2    Pérez, B.3    Dorado, P.4    Alvarez, M.5    Llerena, A.6
  • 13
    • 0011578981 scopus 로고
    • Debrisoquine hydroxylation polymorphism and personality
    • First study that explored the relationship between personality traits with the Karolinska Scales of Personality and debrisoquine hydroxylation phenotype (poor metabolizers vs extensive metablizers) in a Swedish population of healthy volunteers
    • Bertilsson L, Alm C, de las Carreras C, Widen J, Edman G, Schalling D: Debrisoquine hydroxylation polymorphism and personality. Lancet 1(8637), 555 (1989). ■■ First study that explored the relationship between personality traits with the Karolinska Scales of Personality and debrisoquine hydroxylation phenotype (poor metabolizers vs extensive metablizers) in a Swedish population of healthy volunteers.
    • (1989) Lancet , vol.1 , Issue.8637 , pp. 555
    • Bertilsson, L.1    Alm, C.2    De Las Carreras, C.3    Widen, J.4    Edman, G.5    Schalling, D.6
  • 14
    • 0027464041 scopus 로고
    • Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P-4502D6
    • First study in a large sample of healthy volunteers in Spain showing personality differences (Karolinska Scales of Personality) with regard to different degrees of CYP2D6 activity (debrisoquine hydroxylation phenotype)
    • LLerena A, Edman G, Cobaleda J, Benítez J, Schalling D, Bertilsson L: Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P-4502D6. Acta Psychiatr. Scand. 87(1), 23-28 (1993). ■■ First study in a large sample of healthy volunteers in Spain showing personality differences (Karolinska Scales of Personality) with regard to different degrees of CYP2D6 activity (debrisoquine hydroxylation phenotype).
    • (1993) Acta Psychiatr. Scand. , vol.87 , Issue.1 , pp. 23-28
    • Llerena, A.1    Edman, G.2    Cobaleda, J.3    Benítez, J.4    Schalling, D.5    Bertilsson, L.6
  • 17
    • 33746923412 scopus 로고    scopus 로고
    • Association of CYP2D6 genotypes and personality traits in healthy individuals [9]
    • DOI 10.1097/01.jcp.0000229484.52955.22, PII 0000471420060800000024
    • Kirchheiner J, Lang U, Stamm T, Sander T, Gallinat J: Association of CYP2D6 genotypes and personality traits in healthy individuals. J. Clin. Psychopharmacol. 26(4), 440-442 (2006). (Pubitemid 44187657)
    • (2006) Journal of Clinical Psychopharmacology , vol.26 , Issue.4 , pp. 440-442
    • Kirchheiner, J.1    Lang, U.2    Stamm, T.3    Sander, T.4    Gallinat, J.5
  • 19
    • 0037672477 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 polymorphism and character traits
    • DOI 10.1097/00041444-200306000-00010
    • Suzuki E, Kitao Y, Ono Y, Iijima Y, Inada T: Cytochrome P450 2D6 polymorphism and character traits. Psychiatr. Genet. 13, 111-113 (2003). (Pubitemid 36724541)
    • (2003) Psychiatric Genetics , vol.13 , Issue.2 , pp. 111-113
    • Suzuki, E.1    Kitao, Y.2    Ono, Y.3    Iijima, Y.4    Inada, T.5
  • 21
    • 0025790337 scopus 로고
    • Volunteers for biomedical research. Recruitment and screening of normal controls
    • Shtasel DL, Gur RE, Mozley PD et al.: Volunteers for biomedical research. Recruitment and screening of normal controls. Arch. Gen. Psychiatry. 48, 1022-1025 (1991).
    • (1991) Arch. Gen. Psychiatry , vol.48 , pp. 1022-1025
    • Shtasel, D.L.1    Gur, R.E.2    Mozley, P.D.3
  • 23
    • 15544389022 scopus 로고    scopus 로고
    • High prevalence of personality disorders among healthy volunteers for research: Implications for control group bias
    • Bunce SC, Noblett KL, McCloskey MS, Coccaro EF: High prevalence of personality disorders among healthy volunteers for research: implications for control group bias. J. Psychiatr. Res. 39, 421-430 (2005).
    • (2005) J. Psychiatr. Res. , vol.39 , pp. 421-430
    • Bunce, S.C.1    Noblett, K.L.2    McCloskey, M.S.3    Coccaro, E.F.4
  • 24
    • 37549022670 scopus 로고    scopus 로고
    • Serotoninergic regulation of emotional and behavioural control processes
    • DOI 10.1016/j.tics.2007.10.011, PII S1364661307003051
    • Cools R, Roberts AC, Robbins TW: Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn. Sci. 12, 31-40 (2008). (Pubitemid 50012215)
    • (2008) Trends in Cognitive Sciences , vol.12 , Issue.1 , pp. 31-40
    • Cools, R.1    Roberts, A.C.2    Robbins, T.W.3
  • 25
    • 47549083266 scopus 로고    scopus 로고
    • Role of dopamine in the motivational and cognitive control of behavior
    • Cools R: Role of dopamine in the motivational and cognitive control of behavior. Neuroscientist 14, 381-395 (2008).
    • (2008) Neuroscientist , vol.14 , pp. 381-395
    • Cools, R.1
  • 26
    • 32944476961 scopus 로고    scopus 로고
    • Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use
    • Dorado P, Caceres MC, Pozo-Guisado E, Wong ML, Licinio J, LLerena A: Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use. Biotechniques 39(4), 571-574 (2005).
    • (2005) Biotechniques , vol.39 , Issue.4 , pp. 571-574
    • Dorado, P.1    Caceres, M.C.2    Pozo-Guisado, E.3    Wong, M.L.4    Licinio, J.5    Llerena, A.6
  • 27
    • 0023394266 scopus 로고
    • Markers for vulnerability to psychopathology: Temperament traits associated with platelet MAO activity
    • Schalling D, Asberg M, Edman G, Oreland L: Markers for vulnerability to psychopathology: temperament traits associated with platelet MAO activity. Acta Psychiatr. Scand. 76(2), 172-182 (1987).
    • (1987) Acta Psychiatr. Scand. , vol.76 , Issue.2 , pp. 172-182
    • Schalling, D.1    Asberg, M.2    Edman, G.3    Oreland, L.4
  • 29
    • 17144436638 scopus 로고    scopus 로고
    • Temperament and Character Inventory Revised (TCI-R). Standardization and normative data in a general population sample
    • Gutiérrez-Zotes JA, Bayón C, Montserrat C et al.: [Temperament and Character Inventory Revised (TCI-R). Standardization and normative data in a general population sample]. Actas Esp. Psiquiatr. 32, 8-15 (2004).
    • (2004) Actas Esp. Psiquiatr. , vol.32 , pp. 8-15
    • Gutiérrez-Zotes, J.A.1    Bayón, C.2    Montserrat, C.3
  • 31
    • 0037812887 scopus 로고    scopus 로고
    • Comparison of the GHQ-36, the GHQ-12 and the SCL-90 as psychiatric screening instruments in the Finnish population
    • DOI 10.1080/08039480310001418
    • Holi MM, Marttunen M, Aalberg V: Comparison of the GHQ-36, the GHQ-12 and the SCL-90 as psychiatric screening instruments in the Finnish population. Nord. J. Psychiatry. 57(3), 233-238 (2003). (Pubitemid 36805997)
    • (2003) Nordic Journal of Psychiatry , vol.57 , Issue.3 , pp. 233-238
    • Holi, M.M.1    Marttunen, M.2    Aalberg, V.3
  • 32
    • 32044475043 scopus 로고    scopus 로고
    • SCL-90-R: Aplicación y análisis de las propiedades psicométricas en una muestra de sujetos clínicos españoles
    • Robles JI, Andreu JM, Peña ME: SCL-90-R: Aplicación y análisis de las propiedades psicométricas en una muestra de sujetos clínicos españoles. Psicopatología clínica, legal y forense 2, 1-19 (2002).
    • (2002) Psicopatología Clínica, Legal Y Forense , vol.2 , pp. 1-19
    • Robles, J.I.1    Andreu, J.M.2    Peña, M.E.3
  • 35
    • 33750203592 scopus 로고    scopus 로고
    • The cognitive genetics of attention deficit hyperactivity disorder (ADHD): Sustained attention as a candidate phenotype
    • Bellgrove MA, Hawi Z, Gill M, Robertson IH: The cognitive genetics of attention deficit hyperactivity disorder (ADHD): Sustained attention as a candidate phenotype. Cortex 42(6), 838-845 (2006). (Pubitemid 46768738)
    • (2006) Cortex , vol.42 , Issue.6 , pp. 838-845
    • Bellgrove, M.A.1    Hawi, Z.2    Gill, M.3    Robertson, I.H.4
  • 36
    • 33745738412 scopus 로고    scopus 로고
    • The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance
    • DOI 10.1007/s00213-006-0410-7
    • Silber BY, Croft RJ, Papafotiou K, Stough C: The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance. Psychopharmacology 187(2), 154-169 (2006). (Pubitemid 44015610)
    • (2006) Psychopharmacology , vol.187 , Issue.2 , pp. 154-169
    • Silber, B.Y.1    Croft, R.J.2    Papafotiou, K.3    Stough, C.4
  • 38
    • 2442586760 scopus 로고    scopus 로고
    • Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory
    • DOI 10.1177/0269881104040215
    • Matrenza C, Hughes JM, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ: Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. J. Psychopharmacol. 18(1), 21-31 (2004). (Pubitemid 38623090)
    • (2004) Journal of Psychopharmacology , vol.18 , Issue.1 , pp. 21-31
    • Matrenza, C.1    Hughes, J.-M.2    Kemp, A.H.3    Wesnes, K.A.4    Harrison, B.J.5    Nathan, P.J.6
  • 39
    • 36549047439 scopus 로고    scopus 로고
    • Low frequency of CYP2D6 poor metabolizers among schizophrenia patients
    • DOI 10.1038/sj.tpj.6500439, PII 6500439
    • LLerena A, Dorado P, Peñas-LLedó EM, Cáceres MC, De la Rubia A: Low frequency of CYP2D6 poor metabolizers among schizophrenia patients. Pharmacogenomics J. 7(6), 408-410 (2007). (Pubitemid 350187452)
    • (2007) Pharmacogenomics Journal , vol.7 , Issue.6 , pp. 408-410
    • Llerena, A.1    Dorado, P.2    Penas-LLedo, E.M.3    Caceres, M.C.4    De La Rubia, A.5
  • 40
    • 70449479917 scopus 로고    scopus 로고
    • Cambridge Cognition Ltd: CANTAB®
    • Cambridge Cognition Ltd: CANTAB® www.cantab.com


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