-
1
-
-
0036223831
-
Summary of information on human CYP enzymes: Human P450 metabolism data
-
Rendic S. Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev 2002;34:83-448.
-
(2002)
Drug Metab Rev
, vol.34
, pp. 83-448
-
-
Rendic, S.1
-
2
-
-
12144288241
-
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
-
Riddick DS, Lee C, Bhathena A, et al. Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals. Drug Metab Dispos 2004;32:367-75.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 367-375
-
-
Riddick, D.S.1
Lee, C.2
Bhathena, A.3
-
3
-
-
3042515935
-
Polymorphic cytochrome P450 2D6: Humanized mouse model and endogenous substrates
-
Yu AM, Idle JR, Gonzalez FJ. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev 2004;36:243-77.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 243-277
-
-
Yu, A.M.1
Idle, J.R.2
Gonzalez, F.J.3
-
4
-
-
0742286803
-
Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
-
Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 2004;369:23-37.
-
(2004)
Naunyn Schmiedebergs Arch Pharmacol
, vol.369
, pp. 23-37
-
-
Zanger, U.M.1
Raimundo, S.2
Eichelbaum, M.3
-
5
-
-
0035960638
-
Oxidation of phenethylamine derivatives by cytochrome P450 2D6: The issue of substrate protonation in binding and catalysis
-
Miller GP, Hanna IH, Nishimura Y, et al. Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis. Biochemistry 2001;40:14215-23.
-
(2001)
Biochemistry
, vol.40
, pp. 14215-14223
-
-
Miller, G.P.1
Hanna, I.H.2
Nishimura, Y.3
-
7
-
-
0037342251
-
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6
-
Yu AM, Idle JR, Byrd LG, et al. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics 2003;13:173-81.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 173-181
-
-
Yu, A.M.1
Idle, J.R.2
Byrd, L.G.3
-
8
-
-
0038240578
-
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
-
Yu AM, Idle JR, Herraiz T, et al. Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 2003;13:307-19.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 307-319
-
-
Yu, A.M.1
Idle, J.R.2
Herraiz, T.3
-
9
-
-
0037381219
-
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine
-
Yu AM, Idle JR, Krausz KW, et al. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. J Pharmacol Exp Ther 2003;305:315-22.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 315-322
-
-
Yu, A.M.1
Idle, J.R.2
Krausz, K.W.3
-
10
-
-
0034869539
-
Progesterone oxidation by cytochrome P450 2D isoforms in the brain
-
Hiroi T, Kishimoto W, Chow T, et al. Progesterone oxidation by cytochrome P450 2D isoforms in the brain. Endocrinology 2001;142:3901-8.
-
(2001)
Endocrinology
, vol.142
, pp. 3901-3908
-
-
Hiroi, T.1
Kishimoto, W.2
Chow, T.3
-
11
-
-
0842313073
-
Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain
-
Kishimoto W, Hiroi T, Shiraishi M, et al. Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology 2004;145:699-705.
-
(2004)
Endocrinology
, vol.145
, pp. 699-705
-
-
Kishimoto, W.1
Hiroi, T.2
Shiraishi, M.3
-
12
-
-
0031014344
-
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization
-
Gilham DE, Cairns W, Paine MJ, et al. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization. Xenobiotica 1997;27:111-25.
-
(1997)
Xenobiotica
, vol.27
, pp. 111-125
-
-
Gilham, D.E.1
Cairns, W.2
Paine, M.J.3
-
13
-
-
0026512229
-
-
Suzuki T, Fujita S, Narimatsu S, et al. Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4- tetrahydroisoquinoline in rat liver microsomes. FASEB J 1992;6:771-6.
-
Suzuki T, Fujita S, Narimatsu S, et al. Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4- tetrahydroisoquinoline in rat liver microsomes. FASEB J 1992;6:771-6.
-
-
-
-
15
-
-
0025342558
-
Morphine formation from codeine in rat brain: A possible mechanism of codeine analgesia
-
Chen ZR, Irvine RJ, Bochner F, et al. Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia. Life Sci 1990;46:1067-74.
-
(1990)
Life Sci
, vol.46
, pp. 1067-1074
-
-
Chen, Z.R.1
Irvine, R.J.2
Bochner, F.3
-
16
-
-
0028876877
-
Dextromethorphan O-demethylase activity in rat brain microsomes
-
Jolivalt C, Minn A, Vincent-Viry M, et al. Dextromethorphan O-demethylase activity in rat brain microsomes. Neurosci Lett 1995;187:65-8.
-
(1995)
Neurosci Lett
, vol.187
, pp. 65-68
-
-
Jolivalt, C.1
Minn, A.2
Vincent-Viry, M.3
-
17
-
-
0032809128
-
Characterization of cytochrome P-450 2D1 activity in rat brain: High-affinity kinetics for dextromethorphan
-
Tyndale RF, Li Y, Li NY, et al. Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Drug Metab Dispos 1999;27:924-30.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 924-930
-
-
Tyndale, R.F.1
Li, Y.2
Li, N.Y.3
-
18
-
-
0026731379
-
Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy) methamphetamine by rat brain microsomes
-
Lin LY, Kumagai Y, Cho AK. Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy) methamphetamine by rat brain microsomes. Chem Res Toxicol 1992;5:401-6.
-
(1992)
Chem Res Toxicol
, vol.5
, pp. 401-406
-
-
Lin, L.Y.1
Kumagai, Y.2
Cho, A.K.3
-
19
-
-
0036736195
-
Regional and cellular expression of CYP2D6 in human brain: Higher levels in alcoholics
-
Miksys S, Rao Y, Hoffmann E, et al. Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. J Neurochem 2002;82:1376-87.
-
(2002)
J Neurochem
, vol.82
, pp. 1376-1387
-
-
Miksys, S.1
Rao, Y.2
Hoffmann, E.3
-
20
-
-
0037198965
-
Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain
-
Chinta SJ, Pai HV, Upadhya SC, et al. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res Mol Brain Res 2002;103:49-61.
-
(2002)
Brain Res Mol Brain Res
, vol.103
, pp. 49-61
-
-
Chinta, S.J.1
Pai, H.V.2
Upadhya, S.C.3
-
21
-
-
0035049437
-
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
-
Siegle I, Fritz P, Eckhardt K, et al. Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 2001;11:237-45.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 237-245
-
-
Siegle, I.1
Fritz, P.2
Eckhardt, K.3
-
22
-
-
0032520750
-
Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain
-
McFayden MC, Melvin WT, Murray GI. Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. Biochem Pharmacol 1998;55:825-30.
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 825-830
-
-
McFayden, M.C.1
Melvin, W.T.2
Murray, G.I.3
-
23
-
-
0025779409
-
Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): Potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6
-
Tyndale RF, Sunahara R, Inaba T, et al. Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Mol Pharmacol 1991;40:63-8.
-
(1991)
Mol Pharmacol
, vol.40
, pp. 63-68
-
-
Tyndale, R.F.1
Sunahara, R.2
Inaba, T.3
-
24
-
-
0034645927
-
Cytochrome P-450 activities in human and rat brain microsomes
-
Voirol P, Jonzier-Perey M, Porchet F, et al. Cytochrome P-450 activities in human and rat brain microsomes. Brain Res 2000; 855:235-43.
-
(2000)
Brain Res
, vol.855
, pp. 235-243
-
-
Voirol, P.1
Jonzier-Perey, M.2
Porchet, F.3
-
25
-
-
0026685066
-
Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes
-
Britto MR, Wedlund PJ. Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes. Drug Metab Dispos 1992;20:446-50.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 446-450
-
-
Britto, M.R.1
Wedlund, P.J.2
-
26
-
-
3042519581
-
The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics
-
Miksys S, Tyndale RF. The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. Drug Metab Rev 2004;36:313-33.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 313-333
-
-
Miksys, S.1
Tyndale, R.F.2
-
27
-
-
28344457549
-
Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: Sources of variability and predictors of adverse effects in 419 healthy subjects
-
Funck-Brentano C, Boelle PY, Verstuyft C, et al. Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. Eur J Clin Pharmacol 2005;61:821-9.
-
(2005)
Eur J Clin Pharmacol
, vol.61
, pp. 821-829
-
-
Funck-Brentano, C.1
Boelle, P.Y.2
Verstuyft, C.3
-
28
-
-
0027190772
-
The chronic administration of nicotine induces cytochrome P450 in rat brain
-
Anandatheerthavarada HK, Williams JF, Wecker L. The chronic administration of nicotine induces cytochrome P450 in rat brain. J Neurochem 1993;60:1941-4.
-
(1993)
J Neurochem
, vol.60
, pp. 1941-1944
-
-
Anandatheerthavarada, H.K.1
Williams, J.F.2
Wecker, L.3
-
29
-
-
0034017040
-
Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment
-
Miksys S, Hoffmann E, Tyndale RF. Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment. Biochem Pharmacol 2000;59:1501-11.
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 1501-1511
-
-
Miksys, S.1
Hoffmann, E.2
Tyndale, R.F.3
-
30
-
-
0027213570
-
Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1
-
Anandatheerthavarada HK, Williams JF, Wecker L. Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1. Biochem Biophys Res Commun 1993;194: 312-8.
-
(1993)
Biochem Biophys Res Commun
, vol.194
, pp. 312-318
-
-
Anandatheerthavarada, H.K.1
Williams, J.F.2
Wecker, L.3
-
31
-
-
0037739660
-
Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics
-
Howard LA, Miksys S, Hoffmann E, et al. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. Br J Pharmacol 2003;138:1376-86.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1376-1386
-
-
Howard, L.A.1
Miksys, S.2
Hoffmann, E.3
-
32
-
-
33645109957
-
Induction and recovery time course of rat brain CYP2E1 after nicotine treatment
-
Joshi M, Tyndale RF. Induction and recovery time course of rat brain CYP2E1 after nicotine treatment. Drug Metab Dispos 2006;34: 647-52.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 647-652
-
-
Joshi, M.1
Tyndale, R.F.2
-
33
-
-
0033947897
-
Regional and cellular distribution of CYP2D subfamily members in rat brain
-
Miksys S, Rao Y, Sellers EM, et al. Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica 2000;30:547-64.
-
(2000)
Xenobiotica
, vol.30
, pp. 547-564
-
-
Miksys, S.1
Rao, Y.2
Sellers, E.M.3
-
34
-
-
0034756293
-
Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver
-
Howard LA, Micu AL, Sellers EM, et al. Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. J Pharmacol Exp Ther 2001;299:542-50.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 542-550
-
-
Howard, L.A.1
Micu, A.L.2
Sellers, E.M.3
-
35
-
-
0029073965
-
Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6
-
Cribb A, Nuss C, Wang R. Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6. Drug Metab Dispos 1995;23:671-5.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 671-675
-
-
Cribb, A.1
Nuss, C.2
Wang, R.3
-
36
-
-
0033431747
-
Long-term effects of a single course of nicotine treatment in acute ulcerative colitis: Remission maintenance in a 12-month follow-up study
-
Guslandi M. Long-term effects of a single course of nicotine treatment in acute ulcerative colitis: remission maintenance in a 12-month follow-up study. Int J Colorectal Dis 1999;14:261-2.
-
(1999)
Int J Colorectal Dis
, vol.14
, pp. 261-262
-
-
Guslandi, M.1
-
37
-
-
0032893921
-
Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
-
White HK, Levin ED. Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. Psychopharmacology (Berl) 1999;143:158-65.
-
(1999)
Psychopharmacology (Berl)
, vol.143
, pp. 158-165
-
-
White, H.K.1
Levin, E.D.2
-
38
-
-
0033842094
-
Smoking and Parkinson's and Alzheimer's disease: Review of the epidemiological studies
-
Fratiglioni L, Wang HX. Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies. Behav Brain Res 2000;113:117-20.
-
(2000)
Behav Brain Res
, vol.113
, pp. 117-120
-
-
Fratiglioni, L.1
Wang, H.X.2
-
39
-
-
0034213707
-
The effects of nicotine on Parkinson's disease
-
Kelton MC, Kahn HJ, Conrath CL, et al. The effects of nicotine on Parkinson's disease. Brain Cogn 2000;43:274-82.
-
(2000)
Brain Cogn
, vol.43
, pp. 274-282
-
-
Kelton, M.C.1
Kahn, H.J.2
Conrath, C.L.3
-
40
-
-
0041430939
-
Rat hepatic CYP2E1 is induced by very low nicotine doses: An investigation of induction, time course, dose response, and mechanism
-
Micu AL, Miksys S, Sellers EM, et al. Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism. J Pharmacol Exp Ther 2003;306:941-7.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, pp. 941-947
-
-
Micu, A.L.1
Miksys, S.2
Sellers, E.M.3
-
41
-
-
0032824167
-
Nicotine addiction
-
Benowitz NL. Nicotine addiction. Prim Care 1999;26:611-31.
-
(1999)
Prim Care
, vol.26
, pp. 611-631
-
-
Benowitz, N.L.1
-
42
-
-
0032728209
-
Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2′-(14)C]nicotine
-
Ghosheh O, Dwoskin LP, Li WK, et al. Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2′-(14)C]nicotine. Drug Metab Dispos 1999;27:1448-55.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 1448-1455
-
-
Ghosheh, O.1
Dwoskin, L.P.2
Li, W.K.3
-
43
-
-
0035856770
-
Different pharmacokinetics of nicotine following intravenous administration of nicotine base and nicotine hydrogen tartarate in rats
-
Hwa Jung B, Chul Chung B, Chung SJ, et al. Different pharmacokinetics of nicotine following intravenous administration of nicotine base and nicotine hydrogen tartarate in rats. J Control Release 2001;77:183-90.
-
(2001)
J Control Release
, vol.77
, pp. 183-190
-
-
Hwa Jung, B.1
Chul Chung, B.2
Chung, S.J.3
-
44
-
-
0029959286
-
Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing Imipramine N-demethylation
-
Kawashima H, Sequeira DJ, Nelson DR, et al. Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing Imipramine N-demethylation. J Biol Chem 1996;271:28176-80.
-
(1996)
J Biol Chem
, vol.271
, pp. 28176-28180
-
-
Kawashima, H.1
Sequeira, D.J.2
Nelson, D.R.3
-
45
-
-
0032792189
-
Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression
-
Schulz-Utermoehl T, Bennett AJ, Ellis SW, et al. Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression. Pharmacogenetics 1999;9:357-66.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 357-366
-
-
Schulz-Utermoehl, T.1
Bennett, A.J.2
Ellis, S.W.3
-
46
-
-
0029788829
-
Cytochrome P4502D4 in the brain: Specific neuronal regulation by clozapine and toluene
-
Hedlund E, Wyss A, Kainu T, et al. Cytochrome P4502D4 in the brain: specific neuronal regulation by clozapine and toluene. Mol Pharmacol 1996;50:342-50.
-
(1996)
Mol Pharmacol
, vol.50
, pp. 342-350
-
-
Hedlund, E.1
Wyss, A.2
Kainu, T.3
-
47
-
-
0028118901
-
Effect of ethanol on cytochrome P450 in the rat brain
-
Warner M, Gustafsson JA. Effect of ethanol on cytochrome P450 in the rat brain. Proc Natl Acad Sci U S A 1994;91:1019-23.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 1019-1023
-
-
Warner, M.1
Gustafsson, J.A.2
-
48
-
-
1242332464
-
Regulation of CYP2D expression in rat brain by toluene
-
Mizuno D, Hiroi T, Ng P, et al. Regulation of CYP2D expression in rat brain by toluene. Osaka City Med J 2003;49:49-56.
-
(2003)
Osaka City Med J
, vol.49
, pp. 49-56
-
-
Mizuno, D.1
Hiroi, T.2
Ng, P.3
|