Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4- phenylpyridinium toxicity in SH-SY5Y neuronal cells

European Journal of Neuroscience

Volumn 31, Issue 7, 2010, Pages 1185-1193

  Mann, Amandeep ^a   Tyndale, Rachel F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

AMMC; Cytochrome P450 2D6; Cytochrome P450 3A; MPP+; MPTP; Parkinson's disease; SH SY5Y human neuroblastoma cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; KETOCONAZOLE; METOPROLOL; PROPRANOLOL; QUINIDINE; TIMOLOL;

ARTICLE; BRAIN CELL; CANCER CELL CULTURE; CELL DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ACETAMIDES; CELL LINE, TUMOR; COUMARINS; CYTOCHROME P-450 CYP2D6; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; NEUROBLASTOMA; NEURONS; NEUROTOXINS; PYRIDAZINES; QUATERNARY AMMONIUM COMPOUNDS;

EID: 77950419280     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2010.07142.x     Document Type: Article

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