Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy

Biochemical Pharmacology

Volumn 75, Issue 8, 2008, Pages 1677-1687

  Dickmann, Leslie J ^a   Tay, Suzanne ^a   Senn, Tauri D ^a   Zhang, Huixia ^a   Visone, Anthony ^a   Unadkat, Jashvant D ^a   Hebert, Mary F ^a   Isoherranen, Nina ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cyp2c; Cyp2d; Liver; Metabolism; Pregnancy

Indexed keywords

CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 2C12; CYTOCHROME P450 2C19; CYTOCHROME P450 2C6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DICLOFENAC; DRUG METABOLIZING ENZYME; HEPATIC NUCLEAR FACTOR 1; HEPATIC NUCLEAR FACTOR 3 BETA; HEPATIC NUCLEAR FACTOR 4 ALPHA; MESSENGER RNA; NUCLEAR FACTOR; O NORTRAMADOL; PREGNANE X RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYP2D2 GENE; CYP2D4 GENE; DEMETHYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; LIVER; MICROSOMES, LIVER; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TRETINOIN;

EID: 40949100350     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.01.012     Document Type: Article

References (38)

1. Anderson G.D. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 44 10 (2005) 989-1008
2. Bernus I., et al. Effects of pregnancy on various pathways of human antiepileptic drug metabolism. Clin Neuropharmacol 20 1 (1997) 13-21
3. Tracy T.S., et al. Temporal changes in drug metabolism (CYP1A2. CYP2D6 and CYP3A Activity) during pregnancy. Am J Obstet Gynecol 192 2 (2005) 633-639
4. Evans W.E., and Relling M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286 5439 (1999) 487-491
5. Caccia S. Metabolism of the newer antidepressants, An overview of the pharmacological and pharmacokinetic implications. Clin Pharmacokinet 34 4 (1998) 281-302
6. Dickinson R.G., et al. The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin. Br J Clin Pharmacol 28 1 (1989) 17-27
7. Tomson T., et al. Disposition of carbamazepine and phenytoin in pregnancy. Epilepsia 35 1 (1994) 131-135
8. Lander C.M., and Eadie M.J. Plasma antiepileptic drug concentrations during pregnancy. Epilepsia 32 2 (1991) 257-266
9. McGready R., et al. The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria. Eur J Clin Pharmacol 59 7 (2003) 545-552
10. Hogstedt S., et al. Pregnancy-induced increase in metoprolol metabolism. Clin Pharmacol Ther 37 6 (1985) 688-692
11. Wadelius M., et al. Induction of CYP2D6 in pregnancy. Clin Pharmacol Ther 62 4 (1997) 400-407
12. National Institutes of Health Guide for the Care and Use of Laboratory Animals (1985), National Institutes of Health Publication pp. 23-85
13. Estabrook R.W., and Werringloer J. The measurement of difference spectra: application to the cytochromes of microsomes. Methods Enzymol 52 (1978) 212-220
14. Phillips A.H., and Langdon R.G. The influence of thyroxine and other hormones on hepatic TPN-cytochrome reductase activity. Biochim Biophys Acta 19 2 (1956) 380-382
15. Kimura H., et al. Alternative splicing mechanism in a cytochrome P-450 (P-450PB-1) gene generates the two mRNAs coding for proteins of different functions. J Biol Chem 264 4 (1989) 2338-2342
16. Tomson T., et al. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 48 6 (2007) 1111-1116
17. Borlakoglu J.T., et al. Alterations in rat hepatic drug metabolism during pregnancy and lactation. Biochem Pharmacol 46 1 (1993) 29-36
18. Dean M.E., and Stock B.H. The influence of phenobarbital administration on hepatic monooxygenase activity at various stages of gestation in the rat. Drug Metab Dispos 17 5 (1989) 579-581
19. He X.J., et al. Effects of pregnancy on CYPs protein expression in rat liver. Exp Mol Pathol 78 1 (2005) 64-70
20. Feuer G., and Kardish R. Hormonal regulation of drug metabolism during pregnancy. Int J Clin Pharmacol Biopharm 11 4 (1975) 366-374
21. Guarino A.M., et al. Alterations in kinetic constants for hepatic microsomal aniline hydroxylase and ethylmorphine N-demethylase associated with pregnancy in rats. J Pharmacol Exp Ther 168 2 (1969) 224-228
22. Kobayashi K., et al. Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem Pharmacol 63 5 (2002) 889-896
23. Duncan S.A., et al. Regulation of a transcription factor network required for differentiation and metabolism. Science 281 5377 (1998) 692-695
24. Cheung C., et al. Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. Biochem Pharmacol 66 10 (2003) 2011-2020
25. Jacob A., Budhiraja S., and Reichel R.R. The HNF-3alpha transcription factor is a primary target for retinoic acid action. Exp Cell Res 250 1 (1999) 1-9
26. Czerniak R. Gender-based differences in pharmacokinetics in laboratory animal models. Int J Toxicol 20 3 (2001) 161-163
27. Mahnke A., et al. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch Biochem Biophys 337 1 (1997) 62-68
28. Robertson G.R., Farrell G.C., and Liddle C. Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth hormone. Biochem Biophys Res Commun 242 1 (1998) 57-60
29. Hlavica P., and Lewis D.F. Allosteric phenomena in cytochrome P450-catalyzed monooxygenations. Eur J Biochem 268 18 (2001) 4817-4832
30. Omata Y., and Friedman F.K. The effect of dilauroyl-l-3-phosphatidylcholine on the interaction between cytochrome P-450 1A1 and benzo[a]pyrene. FEBS Lett 309 3 (1992) 249-252
31. Yun C.H., Song M., and Kim H. Conformational change of cytochrome P450 1A2 induced by phospholipids and detergents. J Biol Chem 272 32 (1997) 19725-19730
32. Symons A.M., Turcan R.G., and Parke D.V. Hepatic microsomal drug metabolism in the pregnant rat. Xenobiotica 12 6 (1982) 365-374
33. Turcan R.G., et al. Drug metabolism, cytochrome P450 spin state, and phospholipid changes during pregnancy in the rat. Biochem Pharmacol 30 11 (1981) 1223-1225
34. Tang C., et al. Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding. Drug Metab Dispos 30 6 (2002) 648-654
35. Zhou Q., et al. The comparative interaction of human and bovine serum albumins with CYP2C9 in human liver microsomes. Life Sci 75 18 (2004) 2145-2155
36. Kishi R., et al. Effects of pregnancy, age and sex in the metabolism of styrene in rat liver in relation to the regulation of cytochrome P450 enzymes. J Occup Health 47 1 (2005) 49-55
37. Nakajima T., et al. Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. J Pharmacol Exp Ther 261 3 (1992) 869-874
38. Tabei T., and Heinrichs W.L. Hepatic steroid hydroxylase and aminopyrine N-demethylase activities in pregnant rats and rabbits, and the effect of phenobarbital. Biochem Pharmacol 25 18 (1976) 2099-2101