메뉴 건너뛰기




Volumn 4, Issue DEC, 2013, Pages

Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes

Author keywords

DNA methylation; Histone modification; Lung cancer; microRNA; RNA editing

Indexed keywords


EID: 84892430346     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00275     Document Type: Review
Times cited : (19)

References (96)
  • 1
    • 84864344679 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
    • doi: 10.1002/hep.25679
    • Au, S. L., Wong, C. C., Lee, J. M., Fan, D. N., Tsang, F. H., Ng, I. O., et al. (2012). Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology 56, 622-631. doi: 10.1002/hep.25679.
    • (2012) Hepatology , vol.56 , pp. 622-631
    • Au, S.L.1    Wong, C.C.2    Lee, J.M.3    Fan, D.N.4    Tsang, F.H.5    Ng, I.O.6
  • 2
    • 13944260434 scopus 로고    scopus 로고
    • Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
    • doi: 10.1261/rna.7240905
    • Baskerville, S., and Bartel, D. P. (2005). Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 11, 241-247. doi: 10.1261/rna.7240905.
    • (2005) RNA , vol.11 , pp. 241-247
    • Baskerville, S.1    Bartel, D.P.2
  • 3
    • 74549118209 scopus 로고    scopus 로고
    • Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach
    • doi: 10.1158/1078-0432.CCR-09-2638
    • Bishop, J. A., Benjamin, H., Cholakh, H., Chajut, A., Clark, D. P., and Westra, W. H. (2010). Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. Clin. Cancer Res. 16, 610-619. doi: 10.1158/1078-0432.CCR-09-2638.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 610-619
    • Bishop, J.A.1    Benjamin, H.2    Cholakh, H.3    Chajut, A.4    Clark, D.P.5    Westra, W.H.6
  • 4
    • 34547458550 scopus 로고    scopus 로고
    • p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • doi: 10.1016/j.cub.2007.06.068
    • Bommer, G. T., Gerin, I., Feng, Y., Kaczorowski, A. J., Kuick, R., Love, R. E., et al. (2007). p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr. Biol. 17, 1298-1307. doi: 10.1016/j.cub.2007.06.068.
    • (2007) Curr. Biol. , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3    Kaczorowski, A.J.4    Kuick, R.5    Love, R.E.6
  • 5
    • 58149145653 scopus 로고    scopus 로고
    • Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
    • doi: 10.1084/jem.20080285
    • Bousquet, M., Quelen, C., Rosati, R., Mansat-De Mas, V., La Starza, R., Bastard, C., et al. (2008). Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J. Exp. Med. 205, 2499-2506. doi: 10.1084/jem.20080285.
    • (2008) J. Exp. Med. , vol.205 , pp. 2499-2506
    • Bousquet, M.1    Quelen, C.2    Rosati, R.3    Mansat-De Mas, V.4    La Starza, R.5    Bastard, C.6
  • 6
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage I lung cancer
    • doi: 10.1056/NEJMoa0706550
    • Brock, M. V., Hooker, C. M., Ota-Machida, E., Han, Y., Guo, M., Ames, S., et al. (2008). DNA methylation markers and early recurrence in stage I lung cancer. N. Engl. J. Med. 358, 1118-1128. doi: 10.1056/NEJMoa0706550.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3    Han, Y.4    Guo, M.5    Ames, S.6
  • 7
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • doi: 10.1073/pnas.242606799
    • Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., et al. (2002). Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. U.S.A. 99, 15524-15529. doi: 10.1073/pnas.242606799.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3    Bichi, R.4    Zupo, S.5    Noch, E.6
  • 8
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • doi: 10.1073/pnas.0307323101
    • Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., et al. (2004). Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl. Acad. Sci. U.S.A. 101, 2999-3004. doi: 10.1073/pnas.0307323101.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3    Hyslop, T.4    Noch, E.5    Yendamuri, S.6
  • 9
    • 1942503942 scopus 로고    scopus 로고
    • The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
    • doi: 10.1016/j.gde.2004.02.001
    • Cao, R., and Zhang, Y. (2004). The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155-164. doi: 10.1016/j.gde.2004.02.001.
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 155-164
    • Cao, R.1    Zhang, Y.2
  • 10
    • 77957280345 scopus 로고    scopus 로고
    • Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
    • doi: 10.1158/1541-7786.MCR-10-0052
    • Ceppi, P., Mudduluru, G., Kumarswamy, R., Rapa, I., Scagliotti, G. V., Papotti, M., et al. (2010). Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol. Cancer Res. 8, 1207-1216. doi: 10.1158/1541-7786.MCR-10-0052.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1207-1216
    • Ceppi, P.1    Mudduluru, G.2    Kumarswamy, R.3    Rapa, I.4    Scagliotti, G.V.5    Papotti, M.6
  • 11
    • 77954658856 scopus 로고    scopus 로고
    • A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia
    • doi: 10.1038/leu.2010.93
    • Chapiro, E., Russell, L. J., Struski, S., Cave, H., Radford-Weiss, I., Valle, V. D., et al. (2010). A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia 24, 1362-1364. doi: 10.1038/leu.2010.93.
    • (2010) Leukemia , vol.24 , pp. 1362-1364
    • Chapiro, E.1    Russell, L.J.2    Struski, S.3    Cave, H.4    Radford-Weiss, I.5    Valle, V.D.6
  • 12
    • 84882658876 scopus 로고    scopus 로고
    • Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer
    • doi: 10.3892/or.2013.2611
    • Chen, Y., Min, L., Zhang, X., Hu, S., Wang, B., Liu, W., et al. (2013). Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer. Oncol. Rep. 30, 1832-1840. doi: 10.3892/or.2013.2611.
    • (2013) Oncol. Rep. , vol.30 , pp. 1832-1840
    • Chen, Y.1    Min, L.2    Zhang, X.3    Hu, S.4    Wang, B.5    Liu, W.6
  • 13
    • 84868629163 scopus 로고    scopus 로고
    • Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells
    • doi: 10.1172/JCI62925
    • Choudhury, Y., Tay, F. C., Lam, D. H., Sandanaraj, E., Tang, C., Ang, B. T., et al. (2012). Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J. Clin. Invest. 122, 4059-4076. doi: 10.1172/JCI62925.
    • (2012) J. Clin. Invest. , vol.122 , pp. 4059-4076
    • Choudhury, Y.1    Tay, F.C.2    Lam, D.H.3    Sandanaraj, E.4    Tang, C.5    Ang, B.T.6
  • 14
    • 49749150980 scopus 로고    scopus 로고
    • A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    • doi: 10.1158/1541-7786.MCR-07-2102
    • Cole, K. A., Attiyeh, E. F., Mosse, Y. P., Laquaglia, M. J., Diskin, S. J., Brodeur, G. M., et al. (2008). A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol. Cancer Res. 6, 735-742. doi: 10.1158/1541-7786.MCR-07-2102.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 735-742
    • Cole, K.A.1    Attiyeh, E.F.2    Mosse, Y.P.3    Laquaglia, M.J.4    Diskin, S.J.5    Brodeur, G.M.6
  • 15
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • doi: 10.1158/0008-5472.CAN-07-1585
    • Corney, D. C., Flesken-Nikitin, A., Godwin, A. K., Wang, W., and Nikitin, A. Y. (2007). MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67, 8433-8438. doi: 10.1158/0008-5472.CAN-07-1585.
    • (2007) Cancer Res. , vol.67 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Y.5
  • 16
    • 48949115082 scopus 로고    scopus 로고
    • MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines
    • doi: 10.1016/j.bbrc.2008.06.090
    • Crawford, M., Brawner, E., Batte, K., Yu, L., Hunter, M. G., Otterson, G. A., et al. (2008). MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem. Biophys. Res. Commun. 373, 607-612. doi: 10.1016/j.bbrc.2008.06.090.
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 607-612
    • Crawford, M.1    Brawner, E.2    Batte, K.3    Yu, L.4    Hunter, M.G.5    Otterson, G.A.6
  • 17
    • 79959954361 scopus 로고    scopus 로고
    • Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    • doi: 10.1002/cncr.25907
    • Donnem, T., Lonvik, K., Eklo, K., Berg, T., Sorbye, S. W., Al-Shibli, K., et al. (2011). Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival. Cancer 117, 3193-3200. doi: 10.1002/cncr.25907.
    • (2011) Cancer , vol.117 , pp. 3193-3200
    • Donnem, T.1    Lonvik, K.2    Eklo, K.3    Berg, T.4    Sorbye, S.W.5    Al-Shibli, K.6
  • 18
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • doi: 10.1073/pnas.0707628104
    • Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N., Callegari, E., et al. (2007). MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U.S.A. 104, 15805-15810. doi: 10.1073/pnas.0707628104.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3    Liu, Z.4    Zanesi, N.5    Callegari, E.6
  • 19
    • 70849087385 scopus 로고    scopus 로고
    • miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer
    • doi: 10.1093/carcin/bgp219
    • Gallardo, E., Navarro, A., Vinolas, N., Marrades, R. M., Diaz, T., Gel, B., et al. (2009). miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis 30, 1903-1909. doi: 10.1093/carcin/bgp219.
    • (2009) Carcinogenesis , vol.30 , pp. 1903-1909
    • Gallardo, E.1    Navarro, A.2    Vinolas, N.3    Marrades, R.M.4    Diaz, T.5    Gel, B.6
  • 20
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    • doi: 10.1182/blood-2008-07-170589
    • Garzon, R., Liu, S., Fabbri, M., Liu, Z., Heaphy, C. E., Callegari, E., et al. (2009). MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113, 6411-6418. doi: 10.1182/blood-2008-07-170589.
    • (2009) Blood , vol.113 , pp. 6411-6418
    • Garzon, R.1    Liu, S.2    Fabbri, M.3    Liu, Z.4    Heaphy, C.E.5    Callegari, E.6
  • 21
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • doi: 10.1038/ncb1722
    • Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., et al. (2008). The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10, 593-601. doi: 10.1038/ncb1722.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5    Farshid, G.6
  • 22
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • doi: 10.1038/nature03120
    • Gregory, R. I., Yan, K. P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., et al. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240. doi: 10.1038/nature03120.
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3    Chendrimada, T.4    Doratotaj, B.5    Cooch, N.6
  • 23
    • 84861798830 scopus 로고    scopus 로고
    • Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues
    • doi: 10.1186/1756-9966-31-54
    • Guan, P., Yin, Z., Li, X., Wu, W., and Zhou, B. (2012). Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues. J. Exp. Clin. Cancer Res. 31, 54. doi: 10.1186/1756-9966-31-54.
    • (2012) J. Exp. Clin. Cancer Res. , vol.31 , pp. 54
    • Guan, P.1    Yin, Z.2    Li, X.3    Wu, W.4    Zhou, B.5
  • 24
    • 27544495514 scopus 로고    scopus 로고
    • A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    • doi: 10.1158/0008-5472.CAN-05-2352
    • Hayashita, Y., Osada, H., Tatematsu, Y., Yamada, H., Yanagisawa, K., Tomida, S., et al. (2005). A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 65, 9628-9632. doi: 10.1158/0008-5472.CAN-05-2352.
    • (2005) Cancer Res. , vol.65 , pp. 9628-9632
    • Hayashita, Y.1    Osada, H.2    Tatematsu, Y.3    Yamada, H.4    Yanagisawa, K.5    Tomida, S.6
  • 25
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • doi: 10.1038/nature05939
    • He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature 447, 1130-1134. doi: 10.1038/nature05939.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3    De Stanchina, E.4    Xuan, Z.5    Liang, Y.6
  • 26
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • doi: 10.1038/nature03552
    • He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., Goodson, S., et al. (2005). A microRNA polycistron as a potential human oncogene. Nature 435, 828-833. doi: 10.1038/nature03552.
    • (2005) Nature , vol.435 , pp. 828-833
    • He, L.1    Thomson, J.M.2    Hemann, M.T.3    Hernando-Monge, E.4    Mu, D.5    Goodson, S.6
  • 27
    • 84858239830 scopus 로고    scopus 로고
    • Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
    • doi: 10.1158/1078-0432.CCR-11-2450
    • Heller, G., Weinzierl, M., Noll, C., Babinsky, V., Ziegler, B., Altenberger, C., et al. (2012). Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers. Clin. Cancer Res. 18, 1619-1629. doi: 10.1158/1078-0432.CCR-11-2450.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1619-1629
    • Heller, G.1    Weinzierl, M.2    Noll, C.3    Babinsky, V.4    Ziegler, B.5    Altenberger, C.6
  • 28
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • doi: 10.1056/NEJMra023075
    • Herman, J. G., and Baylin, S. B. (2003). Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042-2054. doi: 10.1056/NEJMra023075.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 29
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • doi: 10.1038/cdd.2009.56
    • Hermeking, H. (2010). The miR-34 family in cancer and apoptosis. Cell Death Differ. 17, 193-199. doi: 10.1038/cdd.2009.56.
    • (2010) Cell Death Differ. , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 30
    • 67749129007 scopus 로고    scopus 로고
    • DICER1 mutations in familial pleuropulmonary blastoma
    • doi: 10.1126/science.1174334
    • Hill, D. A., Ivanovich, J., Priest, J. R., Gurnett, C. A., Dehner, L. P., Desruisseau, D., et al. (2009). DICER1 mutations in familial pleuropulmonary blastoma. Science 325, 965. doi: 10.1126/science.1174334.
    • (2009) Science , vol.325 , pp. 965
    • Hill, D.A.1    Ivanovich, J.2    Priest, J.R.3    Gurnett, C.A.4    Dehner, L.P.5    Desruisseau, D.6
  • 31
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • doi: 10.1126/science.1062961
    • Hutvagner, G., Mclachlan, J., Pasquinelli, A. E., Balint, E., Tuschl, T., and Zamore, P. D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838. doi: 10.1126/science.1062961.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    Mclachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 32
    • 84857998198 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer
    • doi: 10.1002/cncr.26441
    • Huqun, Ishikawa, R., Zhang, J., Miyazawa, H., Goto, Y., Shimizu, Y., et al. (2012). Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer. Cancer 118, 1599-1606. doi: 10.1002/cncr.26441.
    • (2012) Cancer , vol.118 , pp. 1599-1606
    • Huqun Ishikawa, R.1    Zhang, J.2    Miyazawa, H.3    Goto, Y.4    Shimizu, Y.5
  • 33
    • 84858777556 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-212 expression in lung cancer
    • doi: 10.1371/journal.pone.0027722
    • Incoronato, M., Urso, L., Portela, A., Laukkanen, M. O., Soini, Y., Quintavalle, C., et al. (2011). Epigenetic regulation of miR-212 expression in lung cancer. PLoS ONE 6:e27722. doi: 10.1371/journal.pone.0027722 .
    • (2011) PLoS ONE , vol.6
    • Incoronato, M.1    Urso, L.2    Portela, A.3    Laukkanen, M.O.4    Soini, Y.5    Quintavalle, C.6
  • 34
    • 84859434875 scopus 로고    scopus 로고
    • Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer
    • doi: 10.1016/j.lungcan.2011.10.012
    • Jeon, H. S., Lee, S. Y., Lee, E. J., Yun, S. C., Cha, E. J., Choi, E., et al. (2012). Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer. Lung Cancer 76, 171-176. doi: 10.1016/j.lungcan.2011.10.012.
    • (2012) Lung Cancer , vol.76 , pp. 171-176
    • Jeon, H.S.1    Lee, S.Y.2    Lee, E.J.3    Yun, S.C.4    Cha, E.J.5    Choi, E.6
  • 35
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • doi: 10.1016/j.cell.2005.01.014
    • Johnson, S. M., Grosshans, H., Shingara, J., Byrom, M., Jarvis, R., Cheng, A., et al. (2005). RAS is regulated by the let-7 microRNA family. Cell 120, 635-647. doi: 10.1016/j.cell.2005.01.014.
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3    Byrom, M.4    Jarvis, R.5    Cheng, A.6
  • 36
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • doi: 10.1038/nrg816
    • Jones, P. A., and Baylin, S. B. (2002). The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428. doi: 10.1038/nrg816.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 37
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones, P. A., and Takai, D. (2001). The role of DNA methylation in mammalian epigenetics. Science 293, 1068-1070.
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 38
    • 84866653610 scopus 로고    scopus 로고
    • let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non-small-cell lung cancer
    • doi: 10.1371/journal.pone.0045577
    • Jusufovic, E., Rijavec, M., Keser, D., Korosec, P., Sodja, E., Iljazovic, E., et al. (2012). let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non-small-cell lung cancer. PLoS ONE 7:e45577. doi: 10.1371/journal.pone.0045577.
    • (2012) PLoS ONE , vol.7
    • Jusufovic, E.1    Rijavec, M.2    Keser, D.3    Korosec, P.4    Sodja, E.5    Iljazovic, E.6
  • 39
    • 20144373433 scopus 로고    scopus 로고
    • Reduced expression of Dicer associated with poor prognosis in lung cancer patients
    • Karube, Y., Tanaka, H., Osada, H., Tomida, S., Tatematsu, Y., Yanagisawa, K., et al. (2005). Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci. 96, 111-115.
    • (2005) Cancer Sci. , vol.96 , pp. 111-115
    • Karube, Y.1    Tanaka, H.2    Osada, H.3    Tomida, S.4    Tatematsu, Y.5    Yanagisawa, K.6
  • 40
    • 52649128795 scopus 로고    scopus 로고
    • Frequency and fate of microRNA editing in human brain
    • doi: 10.1111/j.1349-7006.2005.00015.x
    • Kawahara, Y., Megraw, M., Kreider, E., Iizasa, H., Valente, L., Hatzigeorgiou, A. G., et al. (2008). Frequency and fate of microRNA editing in human brain. Nucleic Acids Res. 36, 5270-5280. doi: 10.1111/j.1349-7006.2005.00015.x.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5270-5280
    • Kawahara, Y.1    Megraw, M.2    Kreider, E.3    Iizasa, H.4    Valente, L.5    Hatzigeorgiou, A.G.6
  • 41
    • 33847317017 scopus 로고    scopus 로고
    • Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    • doi: 10.1093/nar/gkn479
    • Kawahara, Y., Zinshteyn, B., Sethupathy, P., Iizasa, H., Hatzigeorgiou, A. G., and Nishikura, K. (2007). Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315, 1137-1140. doi: 10.1093/nar/gkn479.
    • (2007) Science , vol.315 , pp. 1137-1140
    • Kawahara, Y.1    Zinshteyn, B.2    Sethupathy, P.3    Iizasa, H.4    Hatzigeorgiou, A.G.5    Nishikura, K.6
  • 42
    • 81855166206 scopus 로고    scopus 로고
    • CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer
    • doi: 10.1126/science.1138050
    • Kitano, K., Watanabe, K., Emoto, N., Kage, H., Hamano, E., Nagase, T., et al. (2011). CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer. Cancer Sci. 102, 2126-2131. doi: 10.1126/science.1138050.
    • (2011) Cancer Sci. , vol.102 , pp. 2126-2131
    • Kitano, K.1    Watanabe, K.2    Emoto, N.3    Kage, H.4    Hamano, E.5    Nagase, T.6
  • 43
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • doi: 10.1111/j.1349-7006.2011.02101.x
    • Kondo, Y., Shen, L., Cheng, A. S., Ahmed, S., Boumber, Y., Charo, C., et al. (2008). Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat. Genet. 40, 741-750. doi: 10.1111/j.1349-7006.2011.02101.x.
    • (2008) Nat. Genet. , vol.40 , pp. 741-750
    • Kondo, Y.1    Shen, L.2    Cheng, A.S.3    Ahmed, S.4    Boumber, Y.5    Charo, C.6
  • 44
    • 42049104107 scopus 로고    scopus 로고
    • Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
    • doi: 10.1038/ng.159
    • Kozaki, K., Imoto, I., Mogi, S., Omura, K., and Inazawa, J. (2008). Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res. 68, 2094-2105. doi: 10.1038/ng.159.
    • (2008) Cancer Res. , vol.68 , pp. 2094-2105
    • Kozaki, K.1    Imoto, I.2    Mogi, S.3    Omura, K.4    Inazawa, J.5
  • 45
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • doi: 10.1158/0008-5472.CAN-07-5194
    • Kumar, M. S., Lu, J., Mercer, K. L., Golub, T. R., and Jacks, T. (2007). Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39, 673-677. doi: 10.1158/0008-5472.CAN-07-5194.
    • (2007) Nat. Genet. , vol.39 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 46
    • 77949877527 scopus 로고    scopus 로고
    • Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches
    • doi: 10.1038/ng2003
    • Kusakabe, M., Kutomi, T., Watanabe, K., Emoto, N., Aki, N., Kage, H., et al. (2010). Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int. J. Cancer 126, 1895-1902. doi: 10.1038/ng2003.
    • (2010) Int. J. Cancer , vol.126 , pp. 1895-1902
    • Kusakabe, M.1    Kutomi, T.2    Watanabe, K.3    Emoto, N.4    Aki, N.5    Kage, H.6
  • 47
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • doi: 10.1126/science.1064921
    • Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs. Science 294, 853-858. doi: 10.1126/science.1064921.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 48
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • doi: 10.1126/science.1065062
    • Lau, N. C., Lim, L. P., Weinstein, E. G., and Bartel, D. P. (2001). An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862. doi: 10.1126/science.1065062.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 49
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • doi: 10.1126/science.1065329
    • Lee, R. C., and Ambros, V. (2001). An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864. doi: 10.1126/science.1065329.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 50
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • doi: 10.1016/0092-8674(93)90529-Y
    • Lee, R. C., Feinbaum, R. L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854. doi: 10.1016/0092-8674(93)90529-Y.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 51
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • doi: 10.1038/sj.emboj.7600385
    • Lee, Y., Kim, M., Han, J., Yeom, K. H., Lee, S., Baek, S. H., et al. (2004). MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051-4060. doi: 10.1038/sj.emboj.7600385.
    • (2004) EMBO J. , vol.23 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3    Yeom, K.H.4    Lee, S.5    Baek, S.H.6
  • 52
    • 84862829792 scopus 로고    scopus 로고
    • The mechanism involved in the loss of PTEN expression in NSCLC tumor cells
    • doi: 10.1016/j.bbrc.2012.01.065
    • Li, G., Zhao, J., Peng, X., Liang, J., Deng, X., and Chen, Y. (2012). The mechanism involved in the loss of PTEN expression in NSCLC tumor cells. Biochem. Biophys. Res. Commun. 418, 547-552. doi: 10.1016/j.bbrc.2012.01.065.
    • (2012) Biochem. Biophys. Res. Commun. , vol.418 , pp. 547-552
    • Li, G.1    Zhao, J.2    Peng, X.3    Liang, J.4    Deng, X.5    Chen, Y.6
  • 53
    • 84886716989 scopus 로고    scopus 로고
    • Epigenetic therapy in lung cancer
    • doi: 10.3389/fonc.2013.00135
    • Liu, S. V., Fabbri, M., Gitlitz, B. J., and Laird-Offringa, I. A. (2013). Epigenetic therapy in lung cancer. Front. Oncol. 3:135. doi: 10.3389/fonc.2013.00135.
    • (2013) Front. Oncol. , vol.3 , pp. 135
    • Liu, S.V.1    Fabbri, M.2    Gitlitz, B.J.3    Laird-Offringa, I.A.4
  • 54
    • 66049084202 scopus 로고    scopus 로고
    • MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo
    • doi: 10.1016/j.lungcan.2009.01.010
    • Liu, B., Peng, X. C., Zheng, X. L., Wang, J., and Qin, Y. W. (2009). MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 66, 169-175. doi: 10.1016/j.lungcan.2009.01.010.
    • (2009) Lung Cancer , vol.66 , pp. 169-175
    • Liu, B.1    Peng, X.C.2    Zheng, X.L.3    Wang, J.4    Qin, Y.W.5
  • 55
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • doi: 10.4161/cc.7.16.6533
    • Lodygin, D., Tarasov, V., Epanchintsev, A., Berking, C., Knyazeva, T., Korner, H., et al. (2008). Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7, 2591-2600. doi: 10.4161/cc.7.16.6533.
    • (2008) Cell Cycle , vol.7 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3    Berking, C.4    Knyazeva, T.5    Korner, H.6
  • 56
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • doi: 10.1038/nature03702
    • Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., et al. (2005). MicroRNA expression profiles classify human cancers. Nature 435, 834-838. doi: 10.1038/nature03702.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3    Alvarez-Saavedra, E.4    Lamb, J.5    Peck, D.6
  • 58
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • doi: 10.1158/0008-5472.CAN-06-4218
    • Lujambio, A., Ropero, S., Ballestar, E., Fraga, M. F., Cerrato, C., Setien, F., et al. (2007). Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 67, 1424-1429. doi: 10.1158/0008-5472.CAN-06-4218.
    • (2007) Cancer Res. , vol.67 , pp. 1424-1429
    • Lujambio, A.1    Ropero, S.2    Ballestar, E.3    Fraga, M.F.4    Cerrato, C.5    Setien, F.6
  • 59
    • 0347988235 scopus 로고    scopus 로고
    • Nuclear export of microRNA precursors
    • doi: 10.1126/science.1090599
    • Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E., and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303, 95-98. doi: 10.1126/science.1090599.
    • (2004) Science , vol.303 , pp. 95-98
    • Lund, E.1    Guttinger, S.2    Calado, A.3    Dahlberg, J.E.4    Kutay, U.5
  • 60
    • 0035807807 scopus 로고    scopus 로고
    • Underediting of glutamate receptor GluR-B mRNA in malignant gliomas
    • doi: 10.1073/pnas.251531398
    • Maas, S., Patt, S., Schrey, M., and Rich, A. (2001). Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc. Natl. Acad. Sci. U.S.A. 98, 14687-14692. doi: 10.1073/pnas.251531398.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 14687-14692
    • Maas, S.1    Patt, S.2    Schrey, M.3    Rich, A.4
  • 61
    • 68749113985 scopus 로고    scopus 로고
    • Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
    • doi: 10.1016/j.cell.2009.06.016
    • Mayr, C., and Bartel, D. P. (2009). Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138, 673-684. doi: 10.1016/j.cell.2009.06.016.
    • (2009) Cell , vol.138 , pp. 673-684
    • Mayr, C.1    Bartel, D.P.2
  • 62
    • 33947431322 scopus 로고    scopus 로고
    • Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    • doi: 10.1126/science.1137999
    • Mayr, C., Hemann, M. T., and Bartel, D. P. (2007). Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315, 1576-1579. doi: 10.1126/science.1137999.
    • (2007) Science , vol.315 , pp. 1576-1579
    • Mayr, C.1    Hemann, M.T.2    Bartel, D.P.3
  • 63
    • 77957940475 scopus 로고    scopus 로고
    • A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells
    • doi: 10.1016/j.ccr.2010.09.007
    • Melo, S. A., Moutinho, C., Ropero, S., Calin, G. A., Rossi, S., Spizzo, R., et al. (2010). A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18, 303-315. doi: 10.1016/j.ccr.2010.09.007.
    • (2010) Cancer Cell , vol.18 , pp. 303-315
    • Melo, S.A.1    Moutinho, C.2    Ropero, S.3    Calin, G.A.4    Rossi, S.5    Spizzo, R.6
  • 64
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
    • doi: 10.1038/ng.317
    • Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., et al. (2009). A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat. Genet. 41, 365-370. doi: 10.1038/ng.317.
    • (2009) Nat. Genet. , vol.41 , pp. 365-370
    • Melo, S.A.1    Ropero, S.2    Moutinho, C.3    Aaltonen, L.A.4    Yamamoto, H.5    Calin, G.A.6
  • 65
    • 58049213696 scopus 로고    scopus 로고
    • Dicer, Drosha, and outcomes in patients with ovarian cancer
    • doi: 10.1056/NEJMoa0803785
    • Merritt, W. M., Lin, Y. G., Han, L. Y., Kamat, A. A., Spannuth, W. A., Schmandt, R., et al. (2008). Dicer, Drosha, and outcomes in patients with ovarian cancer. N. Engl. J. Med. 359, 2641-2650. doi: 10.1056/NEJMoa0803785.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2641-2650
    • Merritt, W.M.1    Lin, Y.G.2    Han, L.Y.3    Kamat, A.A.4    Spannuth, W.A.5    Schmandt, R.6
  • 66
    • 70350596499 scopus 로고    scopus 로고
    • MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
    • doi: 10.1016/j.ejca.2009.09.014
    • Muniyappa, M. K., Dowling, P., Henry, M., Meleady, P., Doolan, P., Gammell, P., et al. (2009). MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines. Eur. J. Cancer 45, 3104-3118. doi: 10.1016/j.ejca.2009.09.014.
    • (2009) Eur. J. Cancer , vol.45 , pp. 3104-3118
    • Muniyappa, M.K.1    Dowling, P.2    Henry, M.3    Meleady, P.4    Doolan, P.5    Gammell, P.6
  • 67
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • doi: 10.1101/gad.1640608
    • Park, S. M., Gaur, A. B., Lengyel, E., and Peter, M. E. (2008). The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22, 894-907. doi: 10.1101/gad.1640608.
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 68
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • doi: 10.1038/35040556
    • Pasquinelli, A. E., Reinhart, B. J., Slack, F., Martindale, M. Q., Kuroda, M. I., Maller, B., et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408, 86-89. doi: 10.1038/35040556.
    • (2000) Nature , vol.408 , pp. 86-89
    • Pasquinelli, A.E.1    Reinhart, B.J.2    Slack, F.3    Martindale, M.Q.4    Kuroda, M.I.5    Maller, B.6
  • 69
    • 0032481315 scopus 로고    scopus 로고
    • Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA
    • doi: 10.1093/emboj/17.4.1120
    • Paul, M. S., and Bass, B. L. (1998). Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J. 17, 1120-1127. doi: 10.1093/emboj/17.4.1120.
    • (1998) EMBO J. , vol.17 , pp. 1120-1127
    • Paul, M.S.1    Bass, B.L.2
  • 70
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • doi: 10.1038/35002607
    • Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., et al. (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901-906. doi: 10.1038/35002607.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3    Pasquinelli, A.E.4    Bettinger, J.C.5    Rougvie, A.E.6
  • 71
    • 84885730364 scopus 로고    scopus 로고
    • Epigenetic therapy in lung cancer-role of microRNAs
    • doi: 10.3389/fonc.2013.00158
    • Rothschild, S. I. (2013). Epigenetic therapy in lung cancer-role of microRNAs. Front. Oncol. 3:158. doi: 10.3389/fonc.2013.00158 .
    • (2013) Front. Oncol. , vol.3 , pp. 158
    • Rothschild, S.I.1
  • 72
    • 84866541922 scopus 로고    scopus 로고
    • MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma
    • doi: 10.1038/onc.2011.578
    • Rothschild, S. I., Tschan, M. P., Federzoni, E. A., Jaggi, R., Fey, M. F., Gugger, M., et al. (2012). MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. Oncogene 31, 4221-4232. doi: 10.1038/onc.2011.578.
    • (2012) Oncogene , vol.31 , pp. 4221-4232
    • Rothschild, S.I.1    Tschan, M.P.2    Federzoni, E.A.3    Jaggi, R.4    Fey, M.F.5    Gugger, M.6
  • 73
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • doi: 10.1016/j.ccr.2006.04.020
    • Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., et al. (2006). Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9, 435-443. doi: 10.1016/j.ccr.2006.04.020.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3    Friedman, J.M.4    Chuang, J.C.5    Coetzee, G.A.6
  • 74
    • 84863360077 scopus 로고    scopus 로고
    • Preclinical rationale for combining an EGFR antibody with cisplatin/gemcitabine for the treatment of NSCLC
    • Samakoglu, S., Deevi, D. S., Li, H., Wang, S., Murphy, M., Bao, C., et al. (2012). Preclinical rationale for combining an EGFR antibody with cisplatin/gemcitabine for the treatment of NSCLC. Cancer Genomics Proteomics 9, 77-92.
    • (2012) Cancer Genomics Proteomics , vol.9 , pp. 77-92
    • Samakoglu, S.1    Deevi, D.S.2    Li, H.3    Wang, S.4    Murphy, M.5    Bao, C.6
  • 75
    • 34250196272 scopus 로고    scopus 로고
    • A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer
    • doi: 10.1038/sj.onc.1210483
    • Sano, A., Kage, H., Sugimoto, K., Kitagawa, H., Aki, N., Goto, A., et al. (2007). A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer. Oncogene 26, 6518-6525. doi: 10.1038/sj.onc.1210483.
    • (2007) Oncogene , vol.26 , pp. 6518-6525
    • Sano, A.1    Kage, H.2    Sugimoto, K.3    Kitagawa, H.4    Aki, N.5    Goto, A.6
  • 76
    • 84864881089 scopus 로고    scopus 로고
    • Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer
    • doi: 10.1038/bjc.2012.330
    • Sasahira, T., Kurihara, M., Bhawal, U. K., Ueda, N., Shimomoto, T., Yamamoto, K., et al. (2012). Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer. Br. J. Cancer 107, 700-706. doi: 10.1038/bjc.2012.330.
    • (2012) Br. J. Cancer , vol.107 , pp. 700-706
    • Sasahira, T.1    Kurihara, M.2    Bhawal, U.K.3    Ueda, N.4    Shimomoto, T.5    Yamamoto, K.6
  • 77
    • 84877868296 scopus 로고    scopus 로고
    • Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells
    • doi: 10.1158/0008-5472.CAN-12-4136
    • Shien, K., Toyooka, S., Yamamoto, H., Soh, J., Jida, M., Thu, K. L., et al. (2013). Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells. Cancer Res. 73, 3051-3061. doi: 10.1158/0008-5472.CAN-12-4136.
    • (2013) Cancer Res. , vol.73 , pp. 3051-3061
    • Shien, K.1    Toyooka, S.2    Yamamoto, H.3    Soh, J.4    Jida, M.5    Thu, K.L.6
  • 78
    • 0035829691 scopus 로고    scopus 로고
    • Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis
    • doi: 10.1038/sj.onc.1204940
    • Takai, D., Yagi, Y., Wakazono, K., Ohishi, N., Morita, Y., Sugimura, T., et al. (2001). Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis. Oncogene 20, 7505-7513. doi: 10.1038/sj.onc.1204940.
    • (2001) Oncogene , vol.20 , pp. 7505-7513
    • Takai, D.1    Yagi, Y.2    Wakazono, K.3    Ohishi, N.4    Morita, Y.5    Sugimura, T.6
  • 79
    • 2542626605 scopus 로고    scopus 로고
    • Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    • doi: 10.1158/0008-5472.CAN-04-0637
    • Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., et al. (2004). Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64, 3753-3756. doi: 10.1158/0008-5472.CAN-04-0637.
    • (2004) Cancer Res. , vol.64 , pp. 3753-3756
    • Takamizawa, J.1    Konishi, H.2    Yanagisawa, K.3    Tomida, S.4    Osada, H.5    Endoh, H.6
  • 80
    • 84858006067 scopus 로고    scopus 로고
    • Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer
    • doi: 10.1016/j.lungcan.2011.10.002
    • Tanaka, N., Toyooka, S., Soh, J., Kubo, T., Yamamoto, H., Maki, Y., et al. (2012). Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. Lung Cancer 76, 32-38. doi: 10.1016/j.lungcan.2011.10.002.
    • (2012) Lung Cancer , vol.76 , pp. 32-38
    • Tanaka, N.1    Toyooka, S.2    Soh, J.3    Kubo, T.4    Yamamoto, H.5    Maki, Y.6
  • 81
    • 38049115129 scopus 로고    scopus 로고
    • Endogenous human microRNAs that suppress breast cancer metastasis
    • doi: 10.1038/nature06487
    • Tavazoie, S. F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P. D., et al. (2008). Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147-152. doi: 10.1038/nature06487.
    • (2008) Nature , vol.451 , pp. 147-152
    • Tavazoie, S.F.1    Alarcon, C.2    Oskarsson, T.3    Padua, D.4    Wang, Q.5    Bos, P.D.6
  • 82
    • 79954576652 scopus 로고    scopus 로고
    • EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells
    • doi: 10.1158/0008-5472.CAN-10-3035
    • Tellez, C. S., Juri, D. E., Do, K., Bernauer, A. M., Thomas, C. L., Damiani, L. A., et al. (2011). EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 71, 3087-3097. doi: 10.1158/0008-5472.CAN-10-3035.
    • (2011) Cancer Res. , vol.71 , pp. 3087-3097
    • Tellez, C.S.1    Juri, D.E.2    Do, K.3    Bernauer, A.M.4    Thomas, C.L.5    Damiani, L.A.6
  • 83
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • doi: 10.1158/0008-5472.CAN-08-0325
    • Toyota, M., Suzuki, H., Sasaki, Y., Maruyama, R., Imai, K., Shinomura, Y., et al. (2008). Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 68, 4123-4132. doi: 10.1158/0008-5472.CAN-08-0325.
    • (2008) Cancer Res. , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3    Maruyama, R.4    Imai, K.5    Shinomura, Y.6
  • 84
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • doi: 10.1126/science.1165395
    • Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., et al. (2008). Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695-1699. doi: 10.1126/science.1165395.
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3    Shankar, S.4    Wang, X.5    Ateeq, B.6
  • 85
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • doi: 10.1073/pnas.0510565103
    • Volinia, S., Calin, G. A., Liu, C. G., Ambs, S., Cimmino, A., Petrocca, F., et al. (2006). A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U.S.A. 103, 2257-2261. doi: 10.1073/pnas.0510565103.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3    Ambs, S.4    Cimmino, A.5    Petrocca, F.6
  • 86
    • 84876099353 scopus 로고    scopus 로고
    • Meta-analysis of microRNA expression in lung cancer
    • doi: 10.1002/ijc.27981
    • Vosa, U., Vooder, T., Kolde, R., Vilo, J., Metspalu, A., and Annilo, T. (2013). Meta-analysis of microRNA expression in lung cancer. Int. J. Cancer 132, 2884-2893. doi: 10.1002/ijc.27981.
    • (2013) Int. J. Cancer , vol.132 , pp. 2884-2893
    • Vosa, U.1    Vooder, T.2    Kolde, R.3    Vilo, J.4    Metspalu, A.5    Annilo, T.6
  • 87
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • doi: 10.1016/j.devcel.2008.07.002
    • Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., Mcanally, J., Hill, J. A., et al. (2008). The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev. Cell 15, 261-271. doi: 10.1016/j.devcel.2008.07.002.
    • (2008) Dev. Cell , vol.15 , pp. 261-271
    • Wang, S.1    Aurora, A.B.2    Johnson, B.A.3    Qi, X.4    Mcanally, J.5    Hill, J.A.6
  • 88
    • 79952331586 scopus 로고    scopus 로고
    • DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer
    • doi: 10.4161/cbt.11.5.14550
    • Wang, Z., Chen, Z., Gao, Y., Li, N., Li, B., Tan, F., et al. (2011). DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer. Cancer Biol. Ther. 11, 490-496. doi: 10.4161/cbt.11.5.14550.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 490-496
    • Wang, Z.1    Chen, Z.2    Gao, Y.3    Li, N.4    Li, B.5    Tan, F.6
  • 89
    • 84859157171 scopus 로고    scopus 로고
    • Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer
    • doi: 10.1002/ijc.26254
    • Watanabe, K., Emoto, N., Hamano, E., Sunohara, M., Kawakami, M., Kage, H., et al. (2012). Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. Int. J. Cancer 130, 2580-2590. doi: 10.1002/ijc.26254.
    • (2012) Int. J. Cancer , vol.130 , pp. 2580-2590
    • Watanabe, K.1    Emoto, N.2    Hamano, E.3    Sunohara, M.4    Kawakami, M.5    Kage, H.6
  • 90
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • doi: 10.1038/sj.onc.1210293
    • Welch, C., Chen, Y., and Stallings, R. L. (2007). MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26, 5017-5022. doi: 10.1038/sj.onc.1210293.
    • (2007) Oncogene , vol.26 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 91
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C
    • doi: 10.1016/0092-8674(93)90530-4
    • Wightman, B., Ha, I., and Ruvkun, G. (1993). Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862. doi: 10.1016/0092-8674(93)90530-4.
    • (1993) elegans. Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 92
    • 84874631435 scopus 로고    scopus 로고
    • Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis
    • doi: 10.1172/JCI61271
    • Xi, S., Xu, H., Shan, J., Tao, Y., Hong, J. A., Inchauste, S., et al. (2013). Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J. Clin. Invest. 123, 1241-1261. doi: 10.1172/JCI61271.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1241-1261
    • Xi, S.1    Xu, H.2    Shan, J.3    Tao, Y.4    Hong, J.A.5    Inchauste, S.6
  • 93
    • 68049117231 scopus 로고    scopus 로고
    • MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors
    • doi: 10.1158/0008-5472.CAN-08-4517
    • Xu, H., Cheung, I. Y., Guo, H. F., and Cheung, N. K. (2009). MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res. 69, 6275-6281. doi: 10.1158/0008-5472.CAN-08-4517.
    • (2009) Cancer Res. , vol.69 , pp. 6275-6281
    • Xu, H.1    Cheung, I.Y.2    Guo, H.F.3    Cheung, N.K.4
  • 94
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • doi: 10.1016/j.ccr.2006.01.025
    • Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., et al. (2006). Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9, 189-198. doi: 10.1016/j.ccr.2006.01.025.
    • (2006) Cancer Cell , vol.9 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3    Seike, M.4    Kumamoto, K.5    Yi, M.6
  • 95
    • 37349096992 scopus 로고    scopus 로고
    • MicroRNA signature predicts survival and relapse in lung cancer
    • doi: 10.1016/j.ccr.2007.12.008
    • Yu, S. L., Chen, H. Y., Chang, G. C., Chen, C. Y., Chen, H. W., Singh, S., et al. (2008). MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 13, 48-57. doi: 10.1016/j.ccr.2007.12.008.
    • (2008) Cancer Cell , vol.13 , pp. 48-57
    • Yu, S.L.1    Chen, H.Y.2    Chang, G.C.3    Chen, C.Y.4    Chen, H.W.5    Singh, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.