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Volumn 111, Issue 4, 2010, Pages 782-790

Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer

Author keywords

Breast cancer; CEP17; Chromosomal instability; Drug resistance; HER2; Microtubule; Tumour heterogeneity

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; LAPATINIB; PACLITAXEL; TRASTUZUMAB;

EID: 78049261497     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22781     Document Type: Article
Times cited : (41)

References (86)
  • 1
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand S, Penrhyn-Lowe S, Venkitaraman AR. 2003. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3: 51-62.
    • (2003) Cancer Cell , vol.3 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 2
    • 34247508923 scopus 로고    scopus 로고
    • Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer
    • Andre F, Hatzis C, Anderson K, Sotiriou C, Mazouni C, Mejia J, Wang B, Hortobagyi GN, Symmans WF, Pusztai L. 2007. Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer. Clin Cancer Res 13: 2061-2067.
    • (2007) Clin Cancer Res , vol.13 , pp. 2061-2067
    • Andre, F.1    Hatzis, C.2    Anderson, K.3    Sotiriou, C.4    Mazouni, C.5    Mejia, J.6    Wang, B.7    Hortobagyi, G.N.8    Symmans, W.F.9    Pusztai, L.10
  • 3
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    • Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM. 2003. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 35: 323-330.
    • (2003) Nat Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3    Oshima, M.4    Taketo, M.M.5
  • 7
    • 35649022639 scopus 로고    scopus 로고
    • Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype
    • Bouchet BP, Bertholon J, Falette N, Audoynaud C, Lamblot C, Puisieux A, Galmarini CM. 2007. Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype. Br J Cancer 97: 1218-1224.
    • (2007) Br J Cancer , vol.97 , pp. 1218-1224
    • Bouchet, B.P.1    Bertholon, J.2    Falette, N.3    Audoynaud, C.4    Lamblot, C.5    Puisieux, A.6    Galmarini, C.M.7
  • 11
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. 2006. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 38: 1043-1048.
    • (2006) Nat Genet , vol.38 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 12
    • 33646409883 scopus 로고    scopus 로고
    • BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance
    • Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. 2006. BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. Cell Cycle 5(9): 1001-1007.
    • (2006) Cell Cycle , vol.5 , Issue.9 , pp. 1001-1007
    • Chabalier, C.1    Lamare, C.2    Racca, C.3    Privat, M.4    Valette, A.5    Larminat, F.6
  • 14
    • 55949096605 scopus 로고    scopus 로고
    • Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
    • Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R. 2008. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci USA 105: 16719-16724.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16719-16724
    • Diaz-Rodriguez, E.1    Sotillo, R.2    Schvartzman, J.M.3    Benezra, R.4
  • 16
    • 0034687650 scopus 로고    scopus 로고
    • Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalysed by aneuploidy
    • Duesberg P, Stindl R, Hehlmann R. 2000. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalysed by aneuploidy. Proc Natl Acad Sci USA 97: 14295-14300.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 14295-14300
    • Duesberg, P.1    Stindl, R.2    Hehlmann, R.3
  • 17
    • 40749137815 scopus 로고    scopus 로고
    • Integrative genomic analysis of aneuploidy in uveal melanoma
    • Ehlers JP, Worley L, Onken MD, Harbour JW. 2008. Integrative genomic analysis of aneuploidy in uveal melanoma. Clin Cancer Res 14: 115-122.
    • (2008) Clin Cancer Res , vol.14 , pp. 115-122
    • Ehlers, J.P.1    Worley, L.2    Onken, M.D.3    Harbour, J.W.4
  • 19
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D. 2009. A mechanism linking extra centrosomes to chromosomal instability. Nature 460(7252): 278-282.
    • (2009) Nature , vol.460 , Issue.7252 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 22
    • 38049103907 scopus 로고    scopus 로고
    • HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
    • Gennari A, Sormani MP, Pronzato P, Puntoni M, Colozza M, Pfeffer U, Bruzzi P. 2008. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials. J Natl Cancer Inst 100: 14-20.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 14-20
    • Gennari, A.1    Sormani, M.P.2    Pronzato, P.3    Puntoni, M.4    Colozza, M.5    Pfeffer, U.6    Bruzzi, P.7
  • 25
    • 0038746733 scopus 로고    scopus 로고
    • The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    • Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. 2003. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161: 281-294.
    • (2003) J Cell Biol , vol.161 , pp. 281-294
    • Hauf, S.1    Cole, R.W.2    LaTerra, S.3    Zimmer, C.4    Schnapp, G.5    Walter, R.6    Heckel, A.7    van Meel, J.8    Rieder, C.L.9    Peters, J.M.10
  • 27
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-Mechanism of action and use in clinical practice
    • Hudis CA. 2007. Trastuzumab-Mechanism of action and use in clinical practice. N Engl J Med 357: 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 28
    • 0001887732 scopus 로고    scopus 로고
    • Amplification of topoisomerase II alpha is a strong predictor of response to epirubicin-based chemotherapy in HER-2/neu positive metastatic breast cancer
    • Abstract 31.
    • Isola J, Tanner M, Holli Kea. 2000. Amplification of topoisomerase II alpha is a strong predictor of response to epirubicin-based chemotherapy in HER-2/neu positive metastatic breast cancer. Breast Cancer Res Treat 64 (S15): Abstract 31.
    • (2000) Breast Cancer Res Treat , vol.64 , Issue.SUPPL. 15
    • Isola, J.1    Tanner, M.2    Holli, K.3
  • 29
    • 24644466501 scopus 로고    scopus 로고
    • Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis
    • Jin J, Woodgett JR. 2005. Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis. Oncogene 24: 5459-5470.
    • (2005) Oncogene , vol.24 , pp. 5459-5470
    • Jin, J.1    Woodgett, J.R.2
  • 32
    • 32944475493 scopus 로고    scopus 로고
    • retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
    • Knoop AS, Knudsen H, Balslev E, Rasmussen BB, Overgaard J, Nielsen KV, Schonau A, Gunnarsdottir K, Olsen KE, Mouridsen H, Ejlertsen B. 2005. retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 23: 7483-7490.
    • (2005) J Clin Oncol , vol.23 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3    Rasmussen, B.B.4    Overgaard, J.5    Nielsen, K.V.6    Schonau, A.7    Gunnarsdottir, K.8    Olsen, K.E.9    Mouridsen, H.10    Ejlertsen, B.11
  • 34
    • 12544250381 scopus 로고    scopus 로고
    • Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
    • Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC, Jr. 2005. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 280: 2092-2104.
    • (2005) J Biol Chem , vol.280 , pp. 2092-2104
    • Le, X.F.1    Lammayot, A.2    Gold, D.3    Lu, Y.4    Mao, W.5    Chang, T.6    Patel, A.7    Mills, G.B.8    Bast Jr, R.C.9
  • 36
    • 0037108866 scopus 로고    scopus 로고
    • Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells
    • Lee S, Yang W, Lan KH, Sellappan S, Klos K, Hortobagyi G, Hung MC, Yu D. 2002. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer Res 62: 5703-5710.
    • (2002) Cancer Res , vol.62 , pp. 5703-5710
    • Lee, S.1    Yang, W.2    Lan, K.H.3    Sellappan, S.4    Klos, K.5    Hortobagyi, G.6    Hung, M.C.7    Yu, D.8
  • 37
    • 23044475881 scopus 로고    scopus 로고
    • Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining
    • Lewis JT, Ketterling RP, Halling KC, Reynolds C, Jenkins RB, Visscher DW. 2005. Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining. Am J Clin Pathol 124: 273-281.
    • (2005) Am J Clin Pathol , vol.124 , pp. 273-281
    • Lewis, J.T.1    Ketterling, R.P.2    Halling, K.C.3    Reynolds, C.4    Jenkins, R.B.5    Visscher, D.W.6
  • 41
    • 59549083317 scopus 로고    scopus 로고
    • Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer
    • Mariani G, Fasolo A, De Benedictis E, Gianni L. 2009. Trastuzumab as adjuvant systemic therapy for HER2-positive breast cancer. Nat Clin Pract Oncol 6: 93-104.
    • (2009) Nat Clin Pract Oncol , vol.6 , pp. 93-104
    • Mariani, G.1    Fasolo, A.2    De Benedictis, E.3    Gianni, L.4
  • 44
    • 70350244838 scopus 로고    scopus 로고
    • Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy
    • McClelland SE, Burrell RA, Swanton C. 2009. Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy. Cell Cycle 8: 3262-3266.
    • (2009) Cell Cycle , vol.8 , pp. 3262-3266
    • McClelland, S.E.1    Burrell, R.A.2    Swanton, C.3
  • 47
    • 36849043530 scopus 로고    scopus 로고
    • Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: Tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome
    • Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. 2007. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: Tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J Clin Oncol 25: 5418-5425.
    • (2007) J Clin Oncol , vol.25 , pp. 5418-5425
    • Moeder, C.B.1    Giltnane, J.M.2    Harigopal, M.3    Molinaro, A.4    Robinson, A.5    Gelmon, K.6    Huntsman, D.7    Camp, R.L.8    Rimm, D.L.9
  • 48
    • 74849138869 scopus 로고    scopus 로고
    • Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification
    • Moelans CB, de Weger RA, van Diest PJ. 2009. Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification. Breast Cancer Res Treat 120(1): 1-7.
    • (2009) Breast Cancer Res Treat , vol.120 , Issue.1 , pp. 1-7
    • Moelans, C.B.1    de Weger, R.A.2    van Diest, P.J.3
  • 49
    • 85047696060 scopus 로고    scopus 로고
    • Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu
    • Montagna C, Andrechek ER, Padilla-Nash H, Muller WJ, Ried T. 2002. Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 21: 890-898.
    • (2002) Oncogene , vol.21 , pp. 890-898
    • Montagna, C.1    Andrechek, E.R.2    Padilla-Nash, H.3    Muller, W.J.4    Ried, T.5
  • 51
    • 0037837441 scopus 로고    scopus 로고
    • Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma
    • Ott K, Vogelsang H, Mueller J, Becker K, Muller M, Fink U, Siewert JR, Hofler H, Keller G. 2003. Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma. Clin Cancer Res 9: 2307-2315.
    • (2003) Clin Cancer Res , vol.9 , pp. 2307-2315
    • Ott, K.1    Vogelsang, H.2    Mueller, J.3    Becker, K.4    Muller, M.5    Fink, U.6    Siewert, J.R.7    Hofler, H.8    Keller, G.9
  • 55
    • 38749089490 scopus 로고    scopus 로고
    • Markers predicting clinical benefit in breast cancer from microtubule-targeting agents
    • Pusztai L. 2007. Markers predicting clinical benefit in breast cancer from microtubule-targeting agents. Ann Oncol 18 (Suppl 12): xii15-xii20.
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 12
    • Pusztai, L.1
  • 56
    • 34247355517 scopus 로고    scopus 로고
    • Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
    • Reddy SK, Rape M, Margansky WA, Kirschner MW. 2007. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446: 921-925.
    • (2007) Nature , vol.446 , pp. 921-925
    • Reddy, S.K.1    Rape, M.2    Margansky, W.A.3    Kirschner, M.W.4
  • 57
    • 0025014597 scopus 로고
    • Development of polyploidization in taxol-resistant human leukemia cells in vitro
    • Roberts JR, Allison DC, Donehower RC, Rowinsky EK. 1990. Development of polyploidization in taxol-resistant human leukemia cells in vitro. Cancer Res 50: 710-716.
    • (1990) Cancer Res , vol.50 , pp. 710-716
    • Roberts, J.R.1    Allison, D.C.2    Donehower, R.C.3    Rowinsky, E.K.4
  • 59
    • 25144447723 scopus 로고    scopus 로고
    • Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability
    • Roschke AV, Kirsch IR. 2005. Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability. Cell Cycle 4: 679-682.
    • (2005) Cell Cycle , vol.4 , pp. 679-682
    • Roschke, A.V.1    Kirsch, I.R.2
  • 62
    • 30944452440 scopus 로고    scopus 로고
    • Ablation of the spindle assembly checkpoint by a compound targeting Mps1
    • Schmidt M, Budirahardja Y, Klompmaker R, Medema RH. 2005. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep 6: 866-872.
    • (2005) EMBO Rep , vol.6 , pp. 866-872
    • Schmidt, M.1    Budirahardja, Y.2    Klompmaker, R.3    Medema, R.H.4
  • 63
    • 0142059072 scopus 로고    scopus 로고
    • Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression
    • Schneeweiss A, Sinn HP, Ehemann V, Khbeis T, Neben K, Krause U, Ho AD, Bastert G, Kramer A. 2003. Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression. Int J Cancer 107: 346-352.
    • (2003) Int J Cancer , vol.107 , pp. 346-352
    • Schneeweiss, A.1    Sinn, H.P.2    Ehemann, V.3    Khbeis, T.4    Neben, K.5    Krause, U.6    Ho, A.D.7    Bastert, G.8    Kramer, A.9
  • 65
    • 33749595041 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray
    • Shin SJ, Hyjek E, Early E, Knowles DM. 2006. Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray. Int J Surg Pathol 14: 279-284.
    • (2006) Int J Surg Pathol , vol.14 , pp. 279-284
    • Shin, S.J.1    Hyjek, E.2    Early, E.3    Knowles, D.M.4
  • 66
    • 70350464164 scopus 로고    scopus 로고
    • Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: A Brown University Oncology Group Study
    • Sikov WM, Dizon DS, Strenger R, Legare RD, Theall KP, Graves TA, Gass JS, Kennedy TA, Fenton MA. 2009. Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: A Brown University Oncology Group Study. J Clin Oncol 27: 4693-4700.
    • (2009) J Clin Oncol , vol.27 , pp. 4693-4700
    • Sikov, W.M.1    Dizon, D.S.2    Strenger, R.3    Legare, R.D.4    Theall, K.P.5    Graves, T.A.6    Gass, J.S.7    Kennedy, T.A.8    Fenton, M.A.9
  • 67
    • 78049244591 scopus 로고    scopus 로고
    • BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC → T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC → TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients. 29th Annual SABCS 2006 General Session 2 Abstract 52.
    • Slamon D. 2006. BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC → T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC → TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients. 29th Annual SABCS 2006 General Session 2 Abstract 52.
    • (2006)
    • Slamon, D.1
  • 68
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. 1987. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 70
    • 0033971807 scopus 로고    scopus 로고
    • Correlations among p53, Her-2/neu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: Evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas
    • Smith CA, Pollice AA, Gu LP, Brown KA, Singh SG, Janocko LE, Johnson R, Julian T, Hyams D, Wolmark N, Sweeney L, Silverman JF, Shackney SE. 2000. Correlations among p53, Her-2/neu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: Evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas. Clin Cancer Res 6: 112-126.
    • (2000) Clin Cancer Res , vol.6 , pp. 112-126
    • Smith, C.A.1    Pollice, A.A.2    Gu, L.P.3    Brown, K.A.4    Singh, S.G.5    Janocko, L.E.6    Johnson, R.7    Julian, T.8    Hyams, D.9    Wolmark, N.10    Sweeney, L.11    Silverman, J.F.12    Shackney, S.E.13
  • 71
    • 77949773695 scopus 로고    scopus 로고
    • Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    • Sotillo R, Schvartzman JM, Socci ND, Benezra R. 2010. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464: 436-440.
    • (2010) Nature , vol.464 , pp. 436-440
    • Sotillo, R.1    Schvartzman, J.M.2    Socci, N.D.3    Benezra, R.4
  • 73
    • 1942474378 scopus 로고    scopus 로고
    • Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint
    • Sudo T, Nitta M, Saya H, Ueno NT. 2004. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 64: 2502-2508.
    • (2004) Cancer Res , vol.64 , pp. 2502-2508
    • Sudo, T.1    Nitta, M.2    Saya, H.3    Ueno, N.T.4
  • 76
    • 0028848397 scopus 로고
    • ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer
    • Szollosi J, Balazs M, Feuerstein BG, Benz CC, Waldman FM. 1995. ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res 55: 5400-5407.
    • (1995) Cancer Res , vol.55 , pp. 5400-5407
    • Szollosi, J.1    Balazs, M.2    Feuerstein, B.G.3    Benz, C.C.4    Waldman, F.M.5
  • 77
    • 18444379938 scopus 로고    scopus 로고
    • Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis
    • Tan M, Jing T, Lan KH, Neal CL, Li P, Lee S, Fang D, Nagata Y, Liu J, Arlinghaus R, Hung MC, Yu D. 2002. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell 9: 993-1004.
    • (2002) Mol Cell , vol.9 , pp. 993-1004
    • Tan, M.1    Jing, T.2    Lan, K.H.3    Neal, C.L.4    Li, P.5    Lee, S.6    Fang, D.7    Nagata, Y.8    Liu, J.9    Arlinghaus, R.10    Hung, M.C.11    Yu, D.12
  • 79
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • Valabrega G, Montemurro F, Aglietta M. 2007. Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 18: 977-984.
    • (2007) Ann Oncol , vol.18 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 81
    • 46349086833 scopus 로고    scopus 로고
    • Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis
    • Walther A, Houlston R, Tomlinson I. 2008. Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis. Gut 57: 941-950.
    • (2008) Gut , vol.57 , pp. 941-950
    • Walther, A.1    Houlston, R.2    Tomlinson, I.3
  • 83
    • 33751085368 scopus 로고    scopus 로고
    • Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
    • Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, Deng CX. 2006. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25: 7148-7158.
    • (2006) Oncogene , vol.25 , pp. 7148-7158
    • Wang, X.1    Zhou, Y.X.2    Qiao, W.3    Tominaga, Y.4    Ouchi, M.5    Ouchi, T.6    Deng, C.X.7
  • 84
    • 22244478043 scopus 로고    scopus 로고
    • Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
    • Weaver BA, Cleveland DW. 2005. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 8: 7-12.
    • (2005) Cancer Cell , vol.8 , pp. 7-12
    • Weaver, B.A.1    Cleveland, D.W.2
  • 86
    • 0032214980 scopus 로고    scopus 로고
    • Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
    • Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ, Hung MC. 1998. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell 2: 581-591.
    • (1998) Mol Cell , vol.2 , pp. 581-591
    • Yu, D.1    Jing, T.2    Liu, B.3    Yao, J.4    Tan, M.5    McDonnell, T.J.6    Hung, M.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.