-
1
-
-
0037586498
-
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
-
Anand S, Penrhyn-Lowe S, Venkitaraman AR. 2003. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3: 51-62.
-
(2003)
Cancer Cell
, vol.3
, pp. 51-62
-
-
Anand, S.1
Penrhyn-Lowe, S.2
Venkitaraman, A.R.3
-
2
-
-
34247508923
-
Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer
-
Andre F, Hatzis C, Anderson K, Sotiriou C, Mazouni C, Mejia J, Wang B, Hortobagyi GN, Symmans WF, Pusztai L. 2007. Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer. Clin Cancer Res 13: 2061-2067.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2061-2067
-
-
Andre, F.1
Hatzis, C.2
Anderson, K.3
Sotiriou, C.4
Mazouni, C.5
Mejia, J.6
Wang, B.7
Hortobagyi, G.N.8
Symmans, W.F.9
Pusztai, L.10
-
3
-
-
0344826531
-
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
-
Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM. 2003. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 35: 323-330.
-
(2003)
Nat Genet
, vol.35
, pp. 323-330
-
-
Aoki, K.1
Tamai, Y.2
Horiike, S.3
Oshima, M.4
Taketo, M.M.5
-
4
-
-
74549143568
-
Chromosome 17 polysomy: A unifying hypothesis underlying benefit from adjuvant anthracyclines?
-
Bartlett JM, Desmedt C, Munro A, O'Malley F, Larsimont D, Di Leo A, Cameron D, Isola J, Shepherd L, Twelves C, Pritchard KI. 2009. Chromosome 17 polysomy: A unifying hypothesis underlying benefit from adjuvant anthracyclines? Cancer Res 69 (suppl.2): 11.
-
(2009)
Cancer Res
, vol.69
, Issue.SUPPL.2
, pp. 11
-
-
Bartlett, J.M.1
Desmedt, C.2
Munro, A.3
O'Malley, F.4
Larsimont, D.5
Di Leo, A.6
Cameron, D.7
Isola, J.8
Shepherd, L.9
Twelves, C.10
Pritchard, K.I.11
-
5
-
-
77349118709
-
Predictive markers of anthracycline benefit: A prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601)
-
Bartlett JM, Munro AF, Dunn JA, McConkey C, Jordan S, Twelves CJ, Cameron DA, Thomas J, Campbell FM, Rea DW, Provenzano E, Caldas C, Pharoah P, Hiller L, Earl H, Poole CJ. 2010. Predictive markers of anthracycline benefit: A prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601). Lancet Oncol 11: 266-274.
-
(2010)
Lancet Oncol
, vol.11
, pp. 266-274
-
-
Bartlett, J.M.1
Munro, A.F.2
Dunn, J.A.3
McConkey, C.4
Jordan, S.5
Twelves, C.J.6
Cameron, D.A.7
Thomas, J.8
Campbell, F.M.9
Rea, D.W.10
Provenzano, E.11
Caldas, C.12
Pharoah, P.13
Hiller, L.14
Earl, H.15
Poole, C.J.16
-
6
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castaneda-Soto NJ, Clemens M, Green M, Harvey V, Morales S, Barton C, Ghahramani P. 2005. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 23: 2162-2171.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.J.3
Clemens, M.4
Green, M.5
Harvey, V.6
Morales, S.7
Barton, C.8
Ghahramani, P.9
-
7
-
-
35649022639
-
Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype
-
Bouchet BP, Bertholon J, Falette N, Audoynaud C, Lamblot C, Puisieux A, Galmarini CM. 2007. Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype. Br J Cancer 97: 1218-1224.
-
(2007)
Br J Cancer
, vol.97
, pp. 1218-1224
-
-
Bouchet, B.P.1
Bertholon, J.2
Falette, N.3
Audoynaud, C.4
Lamblot, C.5
Puisieux, A.6
Galmarini, C.M.7
-
8
-
-
65349185446
-
Genotypic intratumoral heterogeneity in breast carcinoma with HER2/neu amplification: Evaluation according to ASCO/CAP criteria
-
Brunelli M, Manfrin E, Martignoni G, Miller K, Remo A, Reghellin D, Bersani S, Gobbo S, Eccher A, Chilosi M, Bonetti F. 2009. Genotypic intratumoral heterogeneity in breast carcinoma with HER2/neu amplification: Evaluation according to ASCO/CAP criteria. Am J Clin Pathol 131: 678-682.
-
(2009)
Am J Clin Pathol
, vol.131
, pp. 678-682
-
-
Brunelli, M.1
Manfrin, E.2
Martignoni, G.3
Miller, K.4
Remo, A.5
Reghellin, D.6
Bersani, S.7
Gobbo, S.8
Eccher, A.9
Chilosi, M.10
Bonetti, F.11
-
9
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature 392: 300-303.
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
Lengauer, C.2
Yu, J.3
Riggins, G.J.4
Willson, J.K.5
Markowitz, S.D.6
Kinzler, K.W.7
Vogelstein, B.8
-
11
-
-
33748286796
-
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
-
Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. 2006. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 38: 1043-1048.
-
(2006)
Nat Genet
, vol.38
, pp. 1043-1048
-
-
Carter, S.L.1
Eklund, A.C.2
Kohane, I.S.3
Harris, L.N.4
Szallasi, Z.5
-
12
-
-
33646409883
-
BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance
-
Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. 2006. BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. Cell Cycle 5(9): 1001-1007.
-
(2006)
Cell Cycle
, vol.5
, Issue.9
, pp. 1001-1007
-
-
Chabalier, C.1
Lamare, C.2
Racca, C.3
Privat, M.4
Valette, A.5
Larminat, F.6
-
13
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
Di Leo A, Gomez HL, Aziz Z, Zvirbule Z, Bines J, Arbushites MC, Guerrera SF, Koehler M, Oliva C, Stein SH, Williams LS, Dering J, Finn RS, Press MF. 2008. Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol 26: 5544-5552.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
Aziz, Z.3
Zvirbule, Z.4
Bines, J.5
Arbushites, M.C.6
Guerrera, S.F.7
Koehler, M.8
Oliva, C.9
Stein, S.H.10
Williams, L.S.11
Dering, J.12
Finn, R.S.13
Press, M.F.14
-
14
-
-
55949096605
-
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
-
Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R. 2008. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci USA 105: 16719-16724.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 16719-16724
-
-
Diaz-Rodriguez, E.1
Sotillo, R.2
Schvartzman, J.M.3
Benezra, R.4
-
15
-
-
77951139631
-
Genome remodelling in a basal-like breast cancer metastasis and xenograft
-
Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, Kalicki J, Zhang Q, Chen L, Lin L, Wendl MC, McMichael JF, Magrini VJ, Cook L, McGrath SD, Vickery TL, Appelbaum E, Deschryver K, Davies S, Guintoli T, Crowder R, Tao Y, Snider JE, Smith SM, Dukes AF, Sanderson GE, Pohl CS, Delehaunty KD, Fronick CC, Pape KA, Reed JS, Robinson JS, Hodges JS, Schierding W, Dees ND, Shen D, Locke DP, Wiechert ME, Eldred JM, Peck JB, Oberkfell BJ, Lolofie JT, Du F, Hawkins AE, O'Laughlin MD, Bernard KE, Cunningham M, Elliott G, Mason MD, Thompson DM, Jr., Ivanovich JL, Goodfellow PJ, Perou CM, Weinstock GM, Aft R, Watson M, Ley TJ, Wilson RK, Mardis ER. 2010. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464: 999-1005.
-
(2010)
Nature
, vol.464
, pp. 999-1005
-
-
Ding, L.1
Ellis, M.J.2
Li, S.3
Larson, D.E.4
Chen, K.5
Wallis, J.W.6
Harris, C.C.7
McLellan, M.D.8
Fulton, R.S.9
Fulton, L.L.10
Abbott, R.M.11
Hoog, J.12
Dooling, D.J.13
Koboldt, D.C.14
Schmidt, H.15
Kalicki, J.16
Zhang, Q.17
Chen, L.18
Lin, L.19
Wendl, M.C.20
McMichael, J.F.21
Magrini, V.J.22
Cook, L.23
McGrath, S.D.24
Vickery, T.L.25
Appelbaum, E.26
Deschryver, K.27
Davies, S.28
Guintoli, T.29
Crowder, R.30
Tao, Y.31
Snider, J.E.32
Smith, S.M.33
Dukes, A.F.34
Sanderson, G.E.35
Pohl, C.S.36
Delehaunty, K.D.37
Fronick, C.C.38
Pape, K.A.39
Reed, J.S.40
Robinson, J.S.41
Hodges, J.S.42
Schierding, W.43
Dees, N.D.44
Shen, D.45
Locke, D.P.46
Wiechert, M.E.47
Eldred, J.M.48
Peck, J.B.49
Oberkfell, B.J.50
Lolofie, J.T.51
Du, F.52
Hawkins, A.E.53
O'Laughlin, M.D.54
Bernard, K.E.55
Cunningham, M.56
Elliott, G.57
Mason, M.D.58
Thompson Jr, D.M.59
Ivanovich, J.L.60
Goodfellow, P.J.61
Perou, C.M.62
Weinstock, G.M.63
Aft, R.64
Watson, M.65
Ley, T.J.66
Wilson, R.K.67
Mardis, E.R.68
more..
-
16
-
-
0034687650
-
Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalysed by aneuploidy
-
Duesberg P, Stindl R, Hehlmann R. 2000. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalysed by aneuploidy. Proc Natl Acad Sci USA 97: 14295-14300.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 14295-14300
-
-
Duesberg, P.1
Stindl, R.2
Hehlmann, R.3
-
18
-
-
54949147687
-
Amplification of HER2 is a marker for global genomic instability
-
Ellsworth RE, Ellsworth DL, Patney HL, Deyarmin B, Love B, Hooke JA, Shriver CD. 2008. Amplification of HER2 is a marker for global genomic instability. BMC Cancer 8: 297.
-
(2008)
BMC Cancer
, vol.8
, pp. 297
-
-
Ellsworth, R.E.1
Ellsworth, D.L.2
Patney, H.L.3
Deyarmin, B.4
Love, B.5
Hooke, J.A.6
Shriver, C.D.7
-
19
-
-
67649467032
-
A mechanism linking extra centrosomes to chromosomal instability
-
Ganem NJ, Godinho SA, Pellman D. 2009. A mechanism linking extra centrosomes to chromosomal instability. Nature 460(7252): 278-282.
-
(2009)
Nature
, vol.460
, Issue.7252
, pp. 278-282
-
-
Ganem, N.J.1
Godinho, S.A.2
Pellman, D.3
-
20
-
-
33846477245
-
Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer
-
Gasparini G, Gion M, Mariani L, Papaldo P, Crivellari D, Filippelli G, Morabito A, Silingardi V, Torino F, Spada A, Zancan M, De Sio L, Caputo A, Cognetti F, Lambiase A, Amadori D. 2007. Randomized phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer. Breast Cancer Res Treat 101: 355-365.
-
(2007)
Breast Cancer Res Treat
, vol.101
, pp. 355-365
-
-
Gasparini, G.1
Gion, M.2
Mariani, L.3
Papaldo, P.4
Crivellari, D.5
Filippelli, G.6
Morabito, A.7
Silingardi, V.8
Torino, F.9
Spada, A.10
Zancan, M.11
De Sio, L.12
Caputo, A.13
Cognetti, F.14
Lambiase, A.15
Amadori, D.16
-
22
-
-
38049103907
-
HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
-
Gennari A, Sormani MP, Pronzato P, Puntoni M, Colozza M, Pfeffer U, Bruzzi P. 2008. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials. J Natl Cancer Inst 100: 14-20.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 14-20
-
-
Gennari, A.1
Sormani, M.P.2
Pronzato, P.3
Puntoni, M.4
Colozza, M.5
Pfeffer, U.6
Bruzzi, P.7
-
23
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, Doval DC, Chavez MA, Ang PC, Aziz Z, Nag S, Ng C, Franco SX, Chow LW, Arbushites MC, Casey MA, Berger MS, Stein SH, Sledge GW. 2008. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 26: 2999-3005.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
Chavez, M.A.3
Ang, P.C.4
Aziz, Z.5
Nag, S.6
Ng, C.7
Franco, S.X.8
Chow, L.W.9
Arbushites, M.C.10
Casey, M.A.11
Berger, M.S.12
Stein, S.H.13
Sledge, G.W.14
-
24
-
-
61449083794
-
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
-
Habermann JK, Doering J, Hautaniemi S, Roblick UJ, Bundgen NK, Nicorici D, Kronenwett U, Rathnagiriswaran S, Mettu RK, Ma Y, Kruger S, Bruch HP, Auer G, Guo NL, Ried T. 2009. The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome. Int J Cancer 124: 1552-1564.
-
(2009)
Int J Cancer
, vol.124
, pp. 1552-1564
-
-
Habermann, J.K.1
Doering, J.2
Hautaniemi, S.3
Roblick, U.J.4
Bundgen, N.K.5
Nicorici, D.6
Kronenwett, U.7
Rathnagiriswaran, S.8
Mettu, R.K.9
Ma, Y.10
Kruger, S.11
Bruch, H.P.12
Auer, G.13
Guo, N.L.14
Ried, T.15
-
25
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. 2003. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161: 281-294.
-
(2003)
J Cell Biol
, vol.161
, pp. 281-294
-
-
Hauf, S.1
Cole, R.W.2
LaTerra, S.3
Zimmer, C.4
Schnapp, G.5
Walter, R.6
Heckel, A.7
van Meel, J.8
Rieder, C.L.9
Peters, J.M.10
-
26
-
-
35248895346
-
HER2 and response to paclitaxel in node-positive breast cancer
-
Hayes DF, Thor AD, Dressler LG, Weaver D, Edgerton S, Cowan D, Broadwater G, Goldstein LJ, Martino S, Ingle JN, Henderson IC, Norton L, Winer EP, Hudis CA, Ellis MJ, Berry DA. 2007. HER2 and response to paclitaxel in node-positive breast cancer. N Engl J Med 357: 1496-1506.
-
(2007)
N Engl J Med
, vol.357
, pp. 1496-1506
-
-
Hayes, D.F.1
Thor, A.D.2
Dressler, L.G.3
Weaver, D.4
Edgerton, S.5
Cowan, D.6
Broadwater, G.7
Goldstein, L.J.8
Martino, S.9
Ingle, J.N.10
Henderson, I.C.11
Norton, L.12
Winer, E.P.13
Hudis, C.A.14
Ellis, M.J.15
Berry, D.A.16
-
27
-
-
34347395733
-
Trastuzumab-Mechanism of action and use in clinical practice
-
Hudis CA. 2007. Trastuzumab-Mechanism of action and use in clinical practice. N Engl J Med 357: 39-51.
-
(2007)
N Engl J Med
, vol.357
, pp. 39-51
-
-
Hudis, C.A.1
-
28
-
-
0001887732
-
Amplification of topoisomerase II alpha is a strong predictor of response to epirubicin-based chemotherapy in HER-2/neu positive metastatic breast cancer
-
Abstract 31.
-
Isola J, Tanner M, Holli Kea. 2000. Amplification of topoisomerase II alpha is a strong predictor of response to epirubicin-based chemotherapy in HER-2/neu positive metastatic breast cancer. Breast Cancer Res Treat 64 (S15): Abstract 31.
-
(2000)
Breast Cancer Res Treat
, vol.64
, Issue.SUPPL. 15
-
-
Isola, J.1
Tanner, M.2
Holli, K.3
-
29
-
-
24644466501
-
Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis
-
Jin J, Woodgett JR. 2005. Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis. Oncogene 24: 5459-5470.
-
(2005)
Oncogene
, vol.24
, pp. 5459-5470
-
-
Jin, J.1
Woodgett, J.R.2
-
30
-
-
78049304375
-
A genomic-profile derived summary measure of chromosomal breakpoints predicts response to treatment with the DNA-damaging agent cisplatin
-
San Antonio: SABCS.
-
Juul N, Wang Y, Kim J-Y, Eklund AC, Li Q, Carlton VEH, Gerlinger M, Swanton C, Garber JE, Silver DP, Faham M, Richardson AL, Szallasi Z, Wang ZC. 2009. A genomic-profile derived summary measure of chromosomal breakpoints predicts response to treatment with the DNA-damaging agent cisplatin. San Antonio: SABCS.
-
(2009)
-
-
Juul, N.1
Wang, Y.2
Kim, J.3
Eklund, A.C.4
Li, Q.5
Carlton, V.E.H.6
Gerlinger, M.7
Swanton, C.8
Garber, J.E.9
Silver, D.P.10
Faham, M.11
Richardson, A.L.12
Szallasi, Z.13
Wang, Z.C.14
-
31
-
-
77950341123
-
Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: A retrospective analysis of five clinical trials
-
Juul N, Szallasi Z, Eklund AC, Li Q, Burrell RA, Gerlinger M, Valero V, Andreopoulou E, Esteva FJ, Symmans WF, Desmedt C, Haibe-Kains B, Sotiriou C, Pusztai L, Swanton C. 2010. Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: A retrospective analysis of five clinical trials. Lancet Oncol 11(4): 358-365.
-
(2010)
Lancet Oncol
, vol.11
, Issue.4
, pp. 358-365
-
-
Juul, N.1
Szallasi, Z.2
Eklund, A.C.3
Li, Q.4
Burrell, R.A.5
Gerlinger, M.6
Valero, V.7
Andreopoulou, E.8
Esteva, F.J.9
Symmans, W.F.10
Desmedt, C.11
Haibe-Kains, B.12
Sotiriou, C.13
Pusztai, L.14
Swanton, C.15
-
32
-
-
32944475493
-
retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group
-
Knoop AS, Knudsen H, Balslev E, Rasmussen BB, Overgaard J, Nielsen KV, Schonau A, Gunnarsdottir K, Olsen KE, Mouridsen H, Ejlertsen B. 2005. retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J Clin Oncol 23: 7483-7490.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7483-7490
-
-
Knoop, A.S.1
Knudsen, H.2
Balslev, E.3
Rasmussen, B.B.4
Overgaard, J.5
Nielsen, K.V.6
Schonau, A.7
Gunnarsdottir, K.8
Olsen, K.E.9
Mouridsen, H.10
Ejlertsen, B.11
-
33
-
-
10744224424
-
Improved grading of breast adenocarcinomas based on genomic instability
-
Kronenwett U, Huwendiek S, Ostring C, Portwood N, Roblick UJ, Pawitan Y, Alaiya A, Sennerstam R, Zetterberg A, Auer G. 2004. Improved grading of breast adenocarcinomas based on genomic instability. Cancer Res 64: 904-909.
-
(2004)
Cancer Res
, vol.64
, pp. 904-909
-
-
Kronenwett, U.1
Huwendiek, S.2
Ostring, C.3
Portwood, N.4
Roblick, U.J.5
Pawitan, Y.6
Alaiya, A.7
Sennerstam, R.8
Zetterberg, A.9
Auer, G.10
-
34
-
-
12544250381
-
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
-
Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC, Jr. 2005. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 280: 2092-2104.
-
(2005)
J Biol Chem
, vol.280
, pp. 2092-2104
-
-
Le, X.F.1
Lammayot, A.2
Gold, D.3
Lu, Y.4
Mao, W.5
Chang, T.6
Patel, A.7
Mills, G.B.8
Bast Jr, R.C.9
-
35
-
-
33747868707
-
Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway
-
Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC, Jr. 2006. Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway. Cell Cycle 5: 1654-1661.
-
(2006)
Cell Cycle
, vol.5
, pp. 1654-1661
-
-
Le, X.F.1
Bedrosian, I.2
Mao, W.3
Murray, M.4
Lu, Z.5
Keyomarsi, K.6
Lee, M.H.7
Zhao, J.8
Bast Jr, R.C.9
-
36
-
-
0037108866
-
Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells
-
Lee S, Yang W, Lan KH, Sellappan S, Klos K, Hortobagyi G, Hung MC, Yu D. 2002. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer Res 62: 5703-5710.
-
(2002)
Cancer Res
, vol.62
, pp. 5703-5710
-
-
Lee, S.1
Yang, W.2
Lan, K.H.3
Sellappan, S.4
Klos, K.5
Hortobagyi, G.6
Hung, M.C.7
Yu, D.8
-
37
-
-
23044475881
-
Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining
-
Lewis JT, Ketterling RP, Halling KC, Reynolds C, Jenkins RB, Visscher DW. 2005. Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining. Am J Clin Pathol 124: 273-281.
-
(2005)
Am J Clin Pathol
, vol.124
, pp. 273-281
-
-
Lewis, J.T.1
Ketterling, R.P.2
Halling, K.C.3
Reynolds, C.4
Jenkins, R.B.5
Visscher, D.W.6
-
38
-
-
61449191698
-
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors
-
Li L, Dutra A, Pak E, Labrie JE III, Gerstein RM, Pandolfi PP, Recht LD, Ross AH. 2009. EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors. Neuro Oncol 11: 9-21.
-
(2009)
Neuro Oncol
, vol.11
, pp. 9-21
-
-
Li, L.1
Dutra, A.2
Pak, E.3
Labrie III, J.E.4
Gerstein, R.M.5
Pandolfi, P.P.6
Recht, L.D.7
Ross, A.H.8
-
39
-
-
0037133211
-
Centrosome amplification drives chromosomal instability in breast tumor development
-
Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL. 2002. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA 99: 1978-1983.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1978-1983
-
-
Lingle, W.L.1
Barrett, S.L.2
Negron, V.C.3
D'Assoro, A.B.4
Boeneman, K.5
Liu, W.6
Whitehead, C.M.7
Reynolds, C.8
Salisbury, J.L.9
-
40
-
-
68849111431
-
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis
-
Marchio C, Lambros MB, Gugliotta P, Di Cantogno LV, Botta C, Pasini B, Tan DS, Mackay A, Fenwick K, Tamber N, Bussolati G, Ashworth A, Reis-Filho JS, Sapino A. 2009. Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis. J Pathol 219: 16-24.
-
(2009)
J Pathol
, vol.219
, pp. 16-24
-
-
Marchio, C.1
Lambros, M.B.2
Gugliotta, P.3
Di Cantogno, L.V.4
Botta, C.5
Pasini, B.6
Tan, D.S.7
Mackay, A.8
Fenwick, K.9
Tamber, N.10
Bussolati, G.11
Ashworth, A.12
Reis-Filho, J.S.13
Sapino, A.14
-
42
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, Snyder R, Mauriac L, Tubiana-Hulin M, Chan S, Grimes D, Anton A, Lluch A, Kennedy J, O'Byrne K, Conte P, Green M, Ward C, Mayne K, Extra JM. 2005. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 23: 4265-4274.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
Snyder, R.4
Mauriac, L.5
Tubiana-Hulin, M.6
Chan, S.7
Grimes, D.8
Anton, A.9
Lluch, A.10
Kennedy, J.11
O'Byrne, K.12
Conte, P.13
Green, M.14
Ward, C.15
Mayne, K.16
Extra, J.M.17
-
43
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. 2007. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447: 966-971.
-
(2007)
Nature
, vol.447
, pp. 966-971
-
-
Maser, R.S.1
Choudhury, B.2
Campbell, P.J.3
Feng, B.4
Wong, K.K.5
Protopopov, A.6
O'Neil, J.7
Gutierrez, A.8
Ivanova, E.9
Perna, I.10
Lin, E.11
Mani, V.12
Jiang, S.13
McNamara, K.14
Zaghlul, S.15
Edkins, S.16
Stevens, C.17
Brennan, C.18
Martin, E.S.19
Wiedemeyer, R.20
Kabbarah, O.21
Nogueira, C.22
Histen, G.23
Aster, J.24
Mansour, M.25
Duke, V.26
Foroni, L.27
Fielding, A.K.28
Goldstone, A.H.29
Rowe, J.M.30
Wang, Y.A.31
Look, A.T.32
Stratton, M.R.33
Chin, L.34
Futreal, P.A.35
DePinho, R.A.36
more..
-
44
-
-
70350244838
-
Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy
-
McClelland SE, Burrell RA, Swanton C. 2009. Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy. Cell Cycle 8: 3262-3266.
-
(2009)
Cell Cycle
, vol.8
, pp. 3262-3266
-
-
McClelland, S.E.1
Burrell, R.A.2
Swanton, C.3
-
45
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira AM, Martin SA, Brough R, McCarthy A, Taylor JR, Kim JS, Waldman T, Lord CJ, Ashworth A. 2009. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 1: 315-322.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
Martin, S.A.2
Brough, R.3
McCarthy, A.4
Taylor, J.R.5
Kim, J.S.6
Waldman, T.7
Lord, C.J.8
Ashworth, A.9
-
46
-
-
0035905811
-
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
-
Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. 2001. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409: 355-359.
-
(2001)
Nature
, vol.409
, pp. 355-359
-
-
Michel, L.S.1
Liberal, V.2
Chatterjee, A.3
Kirchwegger, R.4
Pasche, B.5
Gerald, W.6
Dobles, M.7
Sorger, P.K.8
Murty, V.V.9
Benezra, R.10
-
47
-
-
36849043530
-
Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: Tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome
-
Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. 2007. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: Tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J Clin Oncol 25: 5418-5425.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5418-5425
-
-
Moeder, C.B.1
Giltnane, J.M.2
Harigopal, M.3
Molinaro, A.4
Robinson, A.5
Gelmon, K.6
Huntsman, D.7
Camp, R.L.8
Rimm, D.L.9
-
48
-
-
74849138869
-
Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification
-
Moelans CB, de Weger RA, van Diest PJ. 2009. Absence of chromosome 17 polysomy in breast cancer: Analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification. Breast Cancer Res Treat 120(1): 1-7.
-
(2009)
Breast Cancer Res Treat
, vol.120
, Issue.1
, pp. 1-7
-
-
Moelans, C.B.1
de Weger, R.A.2
van Diest, P.J.3
-
49
-
-
85047696060
-
Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu
-
Montagna C, Andrechek ER, Padilla-Nash H, Muller WJ, Ried T. 2002. Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 21: 890-898.
-
(2002)
Oncogene
, vol.21
, pp. 890-898
-
-
Montagna, C.1
Andrechek, E.R.2
Padilla-Nash, H.3
Muller, W.J.4
Ried, T.5
-
50
-
-
65549158566
-
Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy
-
O'Malley FP, Chia S, Tu D, Shepherd LE, Levine MN, Bramwell VH, Andrulis IL, Pritchard KI. 2009. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J Natl Cancer Inst 101: 644-650.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 644-650
-
-
O'Malley, F.P.1
Chia, S.2
Tu, D.3
Shepherd, L.E.4
Levine, M.N.5
Bramwell, V.H.6
Andrulis, I.L.7
Pritchard, K.I.8
-
51
-
-
0037837441
-
Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma
-
Ott K, Vogelsang H, Mueller J, Becker K, Muller M, Fink U, Siewert JR, Hofler H, Keller G. 2003. Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatin-based chemotherapy in gastric carcinoma. Clin Cancer Res 9: 2307-2315.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2307-2315
-
-
Ott, K.1
Vogelsang, H.2
Mueller, J.3
Becker, K.4
Muller, M.5
Fink, U.6
Siewert, J.R.7
Hofler, H.8
Keller, G.9
-
52
-
-
10744229645
-
Simultaneous suppression of epidermal growth factor receptor and c-erbB-2 reverses aneuploidy and malignant phenotype of a human ovarian carcinoma cell line
-
Pack SD, Alper OM, Stromberg K, Augustus M, Ozdemirli M, Miermont AM, Klus G, Rusin M, Slack R, Hacker NF, Ried T, Szallasi Z, Alper O. 2004. Simultaneous suppression of epidermal growth factor receptor and c-erbB-2 reverses aneuploidy and malignant phenotype of a human ovarian carcinoma cell line. Cancer Res 64: 789-794.
-
(2004)
Cancer Res
, vol.64
, pp. 789-794
-
-
Pack, S.D.1
Alper, O.M.2
Stromberg, K.3
Augustus, M.4
Ozdemirli, M.5
Miermont, A.M.6
Klus, G.7
Rusin, M.8
Slack, R.9
Hacker, N.F.10
Ried, T.11
Szallasi, Z.12
Alper, O.13
-
53
-
-
33646681444
-
HER2 and responsiveness of breast cancer to adjuvant chemotherapy
-
Pritchard KI, Shepherd LE, O'Malley FP, Andrulis IL, Tu D, Bramwell VH, Levine MN. 2006. HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N Engl J Med 354: 2103-2111.
-
(2006)
N Engl J Med
, vol.354
, pp. 2103-2111
-
-
Pritchard, K.I.1
Shepherd, L.E.2
O'Malley, F.P.3
Andrulis, I.L.4
Tu, D.5
Bramwell, V.H.6
Levine, M.N.7
-
54
-
-
39149126730
-
HER-2 and topoisomerase II as predictors of response to chemotherapy
-
Pritchard KI, Messersmith H, Elavathil L, Trudeau M, O'Malley F, Dhesy-Thind B. 2008. HER-2 and topoisomerase II as predictors of response to chemotherapy. J Clin Oncol 26: 736-744.
-
(2008)
J Clin Oncol
, vol.26
, pp. 736-744
-
-
Pritchard, K.I.1
Messersmith, H.2
Elavathil, L.3
Trudeau, M.4
O'Malley, F.5
Dhesy-Thind, B.6
-
55
-
-
38749089490
-
Markers predicting clinical benefit in breast cancer from microtubule-targeting agents
-
Pusztai L. 2007. Markers predicting clinical benefit in breast cancer from microtubule-targeting agents. Ann Oncol 18 (Suppl 12): xii15-xii20.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 12
-
-
Pusztai, L.1
-
56
-
-
34247355517
-
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
-
Reddy SK, Rape M, Margansky WA, Kirschner MW. 2007. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446: 921-925.
-
(2007)
Nature
, vol.446
, pp. 921-925
-
-
Reddy, S.K.1
Rape, M.2
Margansky, W.A.3
Kirschner, M.W.4
-
57
-
-
0025014597
-
Development of polyploidization in taxol-resistant human leukemia cells in vitro
-
Roberts JR, Allison DC, Donehower RC, Rowinsky EK. 1990. Development of polyploidization in taxol-resistant human leukemia cells in vitro. Cancer Res 50: 710-716.
-
(1990)
Cancer Res
, vol.50
, pp. 710-716
-
-
Roberts, J.R.1
Allison, D.C.2
Donehower, R.C.3
Rowinsky, E.K.4
-
58
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Jr., Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N. 2005. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353: 1673-1684.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer Jr, C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
Yothers, G.17
Jenkins, R.B.18
Brown, A.M.19
Dakhil, S.R.20
Mamounas, E.P.21
Lingle, W.L.22
Klein, P.M.23
Ingle, J.N.24
Wolmark, N.25
more..
-
59
-
-
25144447723
-
Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability
-
Roschke AV, Kirsch IR. 2005. Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability. Cell Cycle 4: 679-682.
-
(2005)
Cell Cycle
, vol.4
, pp. 679-682
-
-
Roschke, A.V.1
Kirsch, I.R.2
-
60
-
-
0347951257
-
Karyotypic complexity of the NCI-60 drug-screening panel
-
Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN, Kirsch IR. 2003. Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63: 8634-8647.
-
(2003)
Cancer Res
, vol.63
, pp. 8634-8647
-
-
Roschke, A.V.1
Tonon, G.2
Gehlhaus, K.S.3
McTyre, N.4
Bussey, K.J.5
Lababidi, S.6
Scudiero, D.A.7
Weinstein, J.N.8
Kirsch, I.R.9
-
61
-
-
14544308364
-
Karyotypic "state" as a potential determinant for anticancer drug discovery
-
Roschke AV, Lababidi S, Tonon G, Gehlhaus KS, Bussey K, Weinstein JN, Kirsch IR. 2005. Karyotypic "state" as a potential determinant for anticancer drug discovery. Proc Natl Acad Sci USA 102: 2964-2969.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2964-2969
-
-
Roschke, A.V.1
Lababidi, S.2
Tonon, G.3
Gehlhaus, K.S.4
Bussey, K.5
Weinstein, J.N.6
Kirsch, I.R.7
-
62
-
-
30944452440
-
Ablation of the spindle assembly checkpoint by a compound targeting Mps1
-
Schmidt M, Budirahardja Y, Klompmaker R, Medema RH. 2005. Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep 6: 866-872.
-
(2005)
EMBO Rep
, vol.6
, pp. 866-872
-
-
Schmidt, M.1
Budirahardja, Y.2
Klompmaker, R.3
Medema, R.H.4
-
63
-
-
0142059072
-
Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression
-
Schneeweiss A, Sinn HP, Ehemann V, Khbeis T, Neben K, Krause U, Ho AD, Bastert G, Kramer A. 2003. Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression. Int J Cancer 107: 346-352.
-
(2003)
Int J Cancer
, vol.107
, pp. 346-352
-
-
Schneeweiss, A.1
Sinn, H.P.2
Ehemann, V.3
Khbeis, T.4
Neben, K.5
Krause, U.6
Ho, A.D.7
Bastert, G.8
Kramer, A.9
-
64
-
-
70349969478
-
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
-
Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A, Delaney A, Gelmon K, Guliany R, Senz J, Steidl C, Holt RA, Jones S, Sun M, Leung G, Moore R, Severson T, Taylor GA, Teschendorff AE, Tse K, Turashvili G, Varhol R, Warren RL, Watson P, Zhao Y, Caldas C, Huntsman D, Hirst M, Marra MA, Aparicio S. 2009. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461: 809-813.
-
(2009)
Nature
, vol.461
, pp. 809-813
-
-
Shah, S.P.1
Morin, R.D.2
Khattra, J.3
Prentice, L.4
Pugh, T.5
Burleigh, A.6
Delaney, A.7
Gelmon, K.8
Guliany, R.9
Senz, J.10
Steidl, C.11
Holt, R.A.12
Jones, S.13
Sun, M.14
Leung, G.15
Moore, R.16
Severson, T.17
Taylor, G.A.18
Teschendorff, A.E.19
Tse, K.20
Turashvili, G.21
Varhol, R.22
Warren, R.L.23
Watson, P.24
Zhao, Y.25
Caldas, C.26
Huntsman, D.27
Hirst, M.28
Marra, M.A.29
Aparicio, S.30
more..
-
65
-
-
33749595041
-
Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray
-
Shin SJ, Hyjek E, Early E, Knowles DM. 2006. Intratumoral heterogeneity of her-2/neu in invasive mammary carcinomas using fluorescence in-situ hybridization and tissue microarray. Int J Surg Pathol 14: 279-284.
-
(2006)
Int J Surg Pathol
, vol.14
, pp. 279-284
-
-
Shin, S.J.1
Hyjek, E.2
Early, E.3
Knowles, D.M.4
-
66
-
-
70350464164
-
Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: A Brown University Oncology Group Study
-
Sikov WM, Dizon DS, Strenger R, Legare RD, Theall KP, Graves TA, Gass JS, Kennedy TA, Fenton MA. 2009. Frequent pathologic complete responses in aggressive stages II to III breast cancers with every-4-week carboplatin and weekly paclitaxel with or without trastuzumab: A Brown University Oncology Group Study. J Clin Oncol 27: 4693-4700.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4693-4700
-
-
Sikov, W.M.1
Dizon, D.S.2
Strenger, R.3
Legare, R.D.4
Theall, K.P.5
Graves, T.A.6
Gass, J.S.7
Kennedy, T.A.8
Fenton, M.A.9
-
67
-
-
78049244591
-
-
BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC → T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC → TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients. 29th Annual SABCS 2006 General Session 2 Abstract 52.
-
Slamon D. 2006. BCIRG 006: 2nd interim analysis phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC → T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC → TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients. 29th Annual SABCS 2006 General Session 2 Abstract 52.
-
(2006)
-
-
Slamon, D.1
-
68
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. 1987. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
69
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J, Norton L. 2001. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344: 783-792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
70
-
-
0033971807
-
Correlations among p53, Her-2/neu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: Evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas
-
Smith CA, Pollice AA, Gu LP, Brown KA, Singh SG, Janocko LE, Johnson R, Julian T, Hyams D, Wolmark N, Sweeney L, Silverman JF, Shackney SE. 2000. Correlations among p53, Her-2/neu, and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: Evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas. Clin Cancer Res 6: 112-126.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 112-126
-
-
Smith, C.A.1
Pollice, A.A.2
Gu, L.P.3
Brown, K.A.4
Singh, S.G.5
Janocko, L.E.6
Johnson, R.7
Julian, T.8
Hyams, D.9
Wolmark, N.10
Sweeney, L.11
Silverman, J.F.12
Shackney, S.E.13
-
71
-
-
77949773695
-
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
-
Sotillo R, Schvartzman JM, Socci ND, Benezra R. 2010. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464: 436-440.
-
(2010)
Nature
, vol.464
, pp. 436-440
-
-
Sotillo, R.1
Schvartzman, J.M.2
Socci, N.D.3
Benezra, R.4
-
72
-
-
72949119310
-
Complex landscapes of somatic rearrangement in human breast cancer genomes
-
Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerod A, Russnes HE, Foekens JA, Reis-Filho JS, van't Veer L, Richardson AL, Borresen-Dale AL, Campbell PJ, Futreal PA, Stratton MR. 2009. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462: 1005-1010.
-
(2009)
Nature
, vol.462
, pp. 1005-1010
-
-
Stephens, P.J.1
McBride, D.J.2
Lin, M.L.3
Varela, I.4
Pleasance, E.D.5
Simpson, J.T.6
Stebbings, L.A.7
Leroy, C.8
Edkins, S.9
Mudie, L.J.10
Greenman, C.D.11
Jia, M.12
Latimer, C.13
Teague, J.W.14
Lau, K.W.15
Burton, J.16
Quail, M.A.17
Swerdlow, H.18
Churcher, C.19
Natrajan, R.20
Sieuwerts, A.M.21
Martens, J.W.22
Silver, D.P.23
Langerod, A.24
Russnes, H.E.25
Foekens, J.A.26
Reis-Filho, J.S.27
van't Veer, L.28
Richardson, A.L.29
Borresen-Dale, A.L.30
Campbell, P.J.31
Futreal, P.A.32
Stratton, M.R.33
more..
-
73
-
-
1942474378
-
Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint
-
Sudo T, Nitta M, Saya H, Ueno NT. 2004. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 64: 2502-2508.
-
(2004)
Cancer Res
, vol.64
, pp. 2502-2508
-
-
Sudo, T.1
Nitta, M.2
Saya, H.3
Ueno, N.T.4
-
74
-
-
34249828179
-
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
-
Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. 2007. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 11: 498-512.
-
(2007)
Cancer Cell
, vol.11
, pp. 498-512
-
-
Swanton, C.1
Marani, M.2
Pardo, O.3
Warne, P.H.4
Kelly, G.5
Sahai, E.6
Elustondo, F.7
Chang, J.8
Temple, J.9
Ahmed, A.A.10
Brenton, J.D.11
Downward, J.12
Nicke, B.13
-
75
-
-
66649137945
-
Chromosomal instability determines taxane response
-
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. 2009. Chromosomal instability determines taxane response. Proc Natl Acad Sci USA 106(21): 8671-8676.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.21
, pp. 8671-8676
-
-
Swanton, C.1
Nicke, B.2
Schuett, M.3
Eklund, A.C.4
Ng, C.5
Li, Q.6
Hardcastle, T.7
Lee, A.8
Roy, R.9
East, P.10
Kschischo, M.11
Endesfelder, D.12
Wylie, P.13
Kim, S.N.14
Chen, J.G.15
Howell, M.16
Ried, T.17
Habermann, J.K.18
Auer, G.19
Brenton, J.D.20
Szallasi, Z.21
Downward, J.22
more..
-
76
-
-
0028848397
-
ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer
-
Szollosi J, Balazs M, Feuerstein BG, Benz CC, Waldman FM. 1995. ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res 55: 5400-5407.
-
(1995)
Cancer Res
, vol.55
, pp. 5400-5407
-
-
Szollosi, J.1
Balazs, M.2
Feuerstein, B.G.3
Benz, C.C.4
Waldman, F.M.5
-
77
-
-
18444379938
-
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis
-
Tan M, Jing T, Lan KH, Neal CL, Li P, Lee S, Fang D, Nagata Y, Liu J, Arlinghaus R, Hung MC, Yu D. 2002. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell 9: 993-1004.
-
(2002)
Mol Cell
, vol.9
, pp. 993-1004
-
-
Tan, M.1
Jing, T.2
Lan, K.H.3
Neal, C.L.4
Li, P.5
Lee, S.6
Fang, D.7
Nagata, Y.8
Liu, J.9
Arlinghaus, R.10
Hung, M.C.11
Yu, D.12
-
78
-
-
69849084891
-
Outcome of patients with early-stage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status
-
Tubbs R, Barlow WE, Budd GT, Swain E, Porter P, Gown A, Yeh IT, Sledge G, Shapiro C, Ingle J, Haskell C, Albain KS, Livingston R, Hayes DF. 2009. Outcome of patients with early-stage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status. J Clin Oncol 27: 3881-3886.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3881-3886
-
-
Tubbs, R.1
Barlow, W.E.2
Budd, G.T.3
Swain, E.4
Porter, P.5
Gown, A.6
Yeh, I.T.7
Sledge, G.8
Shapiro, C.9
Ingle, J.10
Haskell, C.11
Albain, K.S.12
Livingston, R.13
Hayes, D.F.14
-
79
-
-
34447306848
-
Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
-
Valabrega G, Montemurro F, Aglietta M. 2007. Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 18: 977-984.
-
(2007)
Ann Oncol
, vol.18
, pp. 977-984
-
-
Valabrega, G.1
Montemurro, F.2
Aglietta, M.3
-
80
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M, Shak S, Stewart SJ, Press M. 2002. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20: 719-726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
Press, M.13
-
81
-
-
46349086833
-
Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis
-
Walther A, Houlston R, Tomlinson I. 2008. Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis. Gut 57: 941-950.
-
(2008)
Gut
, vol.57
, pp. 941-950
-
-
Walther, A.1
Houlston, R.2
Tomlinson, I.3
-
82
-
-
19944427982
-
Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling
-
Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X. 2004. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem 279: 54590-54598.
-
(2004)
J Biol Chem
, vol.279
, pp. 54590-54598
-
-
Wang, H.1
Hu, X.2
Ding, X.3
Dou, Z.4
Yang, Z.5
Shaw, A.W.6
Teng, M.7
Cleveland, D.W.8
Goldberg, M.L.9
Niu, L.10
Yao, X.11
-
83
-
-
33751085368
-
Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation
-
Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, Deng CX. 2006. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 25: 7148-7158.
-
(2006)
Oncogene
, vol.25
, pp. 7148-7158
-
-
Wang, X.1
Zhou, Y.X.2
Qiao, W.3
Tominaga, Y.4
Ouchi, M.5
Ouchi, T.6
Deng, C.X.7
-
84
-
-
22244478043
-
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
-
Weaver BA, Cleveland DW. 2005. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 8: 7-12.
-
(2005)
Cancer Cell
, vol.8
, pp. 7-12
-
-
Weaver, B.A.1
Cleveland, D.W.2
-
85
-
-
69549124028
-
Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event
-
Yeh IT, Martin MA, Robetorye RS, Bolla AR, McCaskill C, Shah RK, Gorre ME, Mohammed MS, Gunn SR. 2009. Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event. Mod Pathol 22: 1169-1175.
-
(2009)
Mod Pathol
, vol.22
, pp. 1169-1175
-
-
Yeh, I.T.1
Martin, M.A.2
Robetorye, R.S.3
Bolla, A.R.4
McCaskill, C.5
Shah, R.K.6
Gorre, M.E.7
Mohammed, M.S.8
Gunn, S.R.9
-
86
-
-
0032214980
-
Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
-
Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ, Hung MC. 1998. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell 2: 581-591.
-
(1998)
Mol Cell
, vol.2
, pp. 581-591
-
-
Yu, D.1
Jing, T.2
Liu, B.3
Yao, J.4
Tan, M.5
McDonnell, T.J.6
Hung, M.C.7
|