Intratumoral heterogeneity in breast carcinoma revealed by laser- microdissection and comparative genomic hybridization

Cancer Genetics and Cytogenetics

Volumn 110, Issue 2, 1999, Pages 94-102

  Aubele, Michaela ^a   Mattis, Anita ^b   Zitzelsberger, Horst ^a,c   Walch, Axel ^a   Kremer, Markus ^b   Hutzler, Peter ^a   Höfler, Heinz ^a,b   Werner, Martin ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; BREAST CANCER; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; DISSECTION; DNA PRIMERS; DNA, NEOPLASM; FEMALE; GENETIC HETEROGENEITY; HISTOCYTOLOGICAL PREPARATION TECHNIQUES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; IN SITU HYBRIDIZATION, FLUORESCENCE; LASERS; LOSS OF HETEROZYGOSITY; LYMPHATIC METASTASIS; MICROSATELLITE REPEATS; POLYMERASE CHAIN REACTION;

EID: 0033560868     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(98)00205-2     Document Type: Article

References (27)

1. Sandberg A.A. The Chromosomes in Human Cancer and Leukemia. 2nd ed:1990;Elsevier Publishing, New York.
2. Kallioniemi A., Kallioniemi O.-P., Sudar D., Rutovit D., Gray J.W., Waldman F., Pinkel D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science. 258:1992;818-821.
3. duManoir S., Speicher M.R., Joos S., Schröck E., Popp S., Dohner H., Kovacs G., Robert-Nicoud M., Lichter P., Cremer T. Detection of complete and partial chromosome gains and losses by comparative genomic hybridization. Hum Genet. 90:1993;590-610.
4. Isola J.J., Kallioniemi O.-P., Chu L.W., Fuqua S.A.W., Hilsenbeck S.G., Osborne C.K., Waldman F.M. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer. Am J Pathol. 147:1995;905-911.
5. Kallioniemi A., Kallioniemi O.-P., Piper J., Tanner M., Stokke T., Chen L., Smith H.S., Pinkel D., Gray J.W., Waldman F.M. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA. 91:1994;2156-2160.
6. Schröck E., Thiel G., Lozanova T., duManoir S., Meffert M.-C., Jauch A., Speicher M.R., Nürnberg P., Vogel S., Jänisch W., Donis-Keller H., Ried T., Witkowski R., Cremer T. Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses. Am J Pathol. 144:1994;1203-1218.
7. Ried T., Just K.E., Holtgreve-Grez H., duManoir S., Speicher M.R., Schröck E., Latham C., Blegen H., Zetterberg A., Cremer T., Auer G. Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors revealed different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res. 15:1995;5415-5420.
8. Zitzelsberger H., Lehmann L., Werner M., Bauchinger M. Comparative genomic hybridization for the analysis of chromosomal imbalances in solid tumours and haematological malignancies. Histochem Cell Biol. 108:1997;403-417.
9. Ghazvini S., Char D.H., Kroll S., Waldman F.M., Pinkel D. Comparative genomic hybridization analysis of archival formalin-fixed paraffin-embedded uveal melanomas. Cancer Genet Cytogenet. 90:1996;95-101.
10. Speicher M.R., duManoir S., Schröck E., Holtgreve-Grez H., Schoell B., Lengauer C., Cremer T., Ried T. Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification. Hum Mol Genetics. 2:1993;1907-1914.
11. Isola J., DeVries S., Chu L., Ghazvini S., Waldman F. Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. Am J Pathol. 145:1994;1301-1308.
12. Kuukasjärvi T., Karhu R., Tanner M., Kähkönen M., Schäffer A., Nupponen N., Pennanen S., Kallioniemi A., Kallioniemi O.-P., Isola J. Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res. 57:1997;1597-1604.
13. Mertens F., Johansson B., Höglund M., Mitelman F. Chromosomal imbalance maps of malignant solid tumors. a cytogenetic survey of 3185 neoplasms Cancer Res. 57:1997;2765-2780.
14. Tanner M.M., Tirkkonen M., Kallioniemi A., Collins C., Stokke T., Karhu R., Kowbel D., Shadravan F., Hintz M., Kuo W.-L., Waldman F.M., Isola J.J., Gray J.W., Kallioniemi O.-P. Increased copy number at 20q13 in breast cancer. defining the critical region and exclusion of candidate genes Cancer Res. 54:1994;4257-4260.
15. Kallioniemi O.-P., Kallioniemi A., Piper J., Isola J., Waldman F.M., Gray J.W., Pinkel D. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chrom Cancer. 10:1994;231-243.
16. Becker I., Becker K.F., Röhrl M.H., Schütze K., Minkus G., Höfler H. Single-cell mutation analysis from stained histological slides. Lab Invest. 75:1996;801-807.
17. Guan X.-Y., Trent J.M., Meltzer P.S. Generation of band-specific painting probes from a single microdissected chromosome. Hum Mol Genet. 2:1993;1117-1121.
18. Telenius H., Carter N.C., Bebb C.E., Nordenskjöld M., Ponder B.A.J., Tunnacliffe A. Degenerate oligonucleotide-primed PCR. general amplification of target DNA by a single degenerate primer Genomics. 13:1992;718-725.
19. Lehmann L., Greulich K.M., Zitzelsberger H., Negele T., Spelsberg F., Bauchinger M., Weier H.U. Cytogenetic and molecular genetic characterization of a chromosome 2 rearrangement in a case of human papillary thyroid carcinoma with radiation history. Cancer Genet Cytogenet. 96:1997;30-36.
20. Aubele M., Zitzelsberger H., Szücs S., Werner M., Braselmann H., Hutzler P., Rodenacker K., Lehmann L., Minkus G., Höfler H. Comparative FISH analysis of numerical chromosome 7 abnormalities in 5 μm and 15 μm paraffin-embedded tissue sections from prostatic carcinoma. Histochem Cell Biol. 107:1997;121-126.
21. Zitzelsberger H., Szücs S., Weier H.U., Lehmann L., Braselmann H., Enders S., Schilling A., Breul J., Höfler H., Bauchinger M. Numerical abnormalities of chromosome 7 in human prostate cancer detected by fluorescence in situ hybridization (FISH) on paraffin-embedded tissue sections with centromere-specific DNA probes. J Pathol. 172:1994;325-335.
22. Beckmann M.W., Picard F., An H.X., vanRoeyen C.R., Dominik S.I., Mosny D.S., Schnurch H.G., Bender H.G., Niederacher D. Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer. Br J Cancer. 73:1996;1220-1226.
23. Hainsworth P.J., Raphael K.L., Stillwell R.G., Bennett R.C., Garson O.M. Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features. Br J Cancer. 66:1992;131-135.
24. Anzick S.L., Kononen J., Walker R.L., Azorsa D.O., Tanner M.M., Guan X.-Y., Sauter G., Kallioniemi O.-P., Trent J.M., Meltzer P.S. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 277:1997;965-968.
25. Tanner M.M., Tirkkonen M., Kallioniemi A., Isola J., Kuukasjärvi T., Collins C., Kowbel D., Guan X.-Y., Trent J., Gray J.W., Meltzer P., Kallioniemi O.-P. Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res. 56:1996;3441-3445.
26. Guan X.-Y., Xu J., Anzick S.L., Zhang H., Trent J.M., Meltzer P.S. Hybrid selection of transcribed sequences from microdissected DNA. isolation of genes within an amplified region at 20q11-20q13.2 in breast cancer Cancer Res. 56:1996;3446-3450.
27. Koreth J., Bethwaite P.B., McGee O.D. Mutation at chromosome 11q23 in human non-familial breast cancer. a microdissection microsatellite analysis J Pathol. 176:1995;11-18.