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Volumn 122, Issue 4, 2012, Pages 1138-1143

Chromosomal instability and cancer: A complex relationship with therapeutic potential

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; ARTICLE; CANCER PROGNOSIS; CHROMOSOMAL INSTABILITY; CHROMOSOME LOSS; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; DISEASE ASSOCIATION; HUMAN; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

EID: 84859726409     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59954     Document Type: Article
Times cited : (204)

References (84)
  • 1
    • 0017167185 scopus 로고
    • Clonal evolution of tumor-cell populations
    • Nowell PC. Clonal evolution of tumor-cell populations. Science. 1976;194(4260):23-28.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 2
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • DOI 10.1038/386623a0
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997; 386(6625):623-627. (Pubitemid 27175430)
    • (1997) Nature , vol.386 , Issue.6625 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 3
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • DOI 10.1038/25292
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998; 396(6712):643-649. (Pubitemid 29003936)
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 4
    • 51649083703 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation, aneuploidy, and cancer
    • Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta. 2008; 1786(1):32-40.
    • (2008) Biochim Biophys Acta , vol.1786 , Issue.1 , pp. 32-40
    • Cimini, D.1
  • 5
    • 40849096242 scopus 로고    scopus 로고
    • Examining the link between chromosomal instability and aneuploidy in human cells
    • DOI 10.1083/jcb.200712029
    • Thompson SL, Compton DA. Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol. 2008;180(4):665-672. (Pubitemid 351397764)
    • (2008) Journal of Cell Biology , vol.180 , Issue.4 , pp. 665-672
    • Thompson, S.L.1    Compton, D.A.2
  • 6
    • 74049135504 scopus 로고    scopus 로고
    • Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
    • Boveri T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci. 2008;121 suppl 1:1-84.
    • (2008) J Cell Sci , vol.121 , Issue.SUPPL. 1 , pp. 1-84
    • Boveri, T.1
  • 7
    • 9644252828 scopus 로고    scopus 로고
    • Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia
    • DOI 10.1016/j.anngen.2004.08.004, PII S0003399504000784
    • Receveur A, et al. Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia. Ann Genet. 2004; 47(4):423-427. (Pubitemid 39575623)
    • (2004) Annales de Genetique , vol.47 , Issue.4 , pp. 423-427
    • Receveur, A.1    Ong, J.2    Merlin, L.3    Azgui, Z.4    Merle-Bral, H.5    Berger, R.6    Nguyen-Khac, F.7
  • 9
    • 0000082786 scopus 로고    scopus 로고
    • Hierarchical cytogenetic classification is highly predictive of outcome in AML arising at all ages: Analysis of 4225 cases entered in the UK MRC leukaemia trials
    • Grimwade D, et al. Hierarchical cytogenetic classification is highly predictive of outcome in AML arising at all ages: Analysis of 4225 cases entered in the UK MRC leukaemia trials. Blood. 2000;96:825a.
    • (2000) Blood , vol.96
    • Grimwade, D.1
  • 10
    • 77349083266 scopus 로고    scopus 로고
    • Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia
    • Gulley ML, Shea TC, Fedoriw Y. Genetic tests to evaluate prognosis and predict therapeutic response in acute myeloid leukemia. J Mol Diagn. 2010; 12(1):3-16.
    • (2010) J Mol Diagn , vol.12 , Issue.1 , pp. 3-16
    • Gulley, M.L.1    Shea, T.C.2    Fedoriw, Y.3
  • 11
    • 15744373806 scopus 로고    scopus 로고
    • Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated with Down syndrome
    • DOI 10.1016/j.cancergencyto.2004.08.036
    • Kobayashi K, Usami I, Kubota M, Nishio T, Kakazu N. Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated with Down syndrome. Cancer Genet Cytogenet. 2005;158(2):184-187. (Pubitemid 40417702)
    • (2005) Cancer Genetics and Cytogenetics , vol.158 , Issue.2 , pp. 184-187
    • Kobayashi, K.-I.1    Usami, I.2    Kubota, M.3    Nishio, T.4    Kakazu, N.5
  • 13
    • 33644872564 scopus 로고    scopus 로고
    • Cancer incidence of persons with Down syndrome in Finland: A population-based study
    • DOI 10.1002/ijc.21518
    • Patja K, Pukkala E, Sund R, Iivanainen M, Kaski M. Cancer incidence of persons with Down syndrome in Finland: A population-based study. Int J Cancer. 2006;118(7):1769-1772. (Pubitemid 43376441)
    • (2006) International Journal of Cancer , vol.118 , Issue.7 , pp. 1769-1772
    • Patja, K.1    Pukkala, E.2    Sund, R.3    Iivanainen, M.4    Kaski, M.5
  • 14
    • 0042266900 scopus 로고    scopus 로고
    • High risk of malignancy in mosaic variegated aneuploidy syndrome [6]
    • Hunter A. High risk of malignancy in mosaic variegated aneuploidy syndrome. Am J Med Genet A. 2003;117A(2):199. (Pubitemid 37064020)
    • (2003) American Journal of Medical Genetics , vol.117 A , Issue.2 , pp. 199
    • Hunter, A.1
  • 17
    • 33846853947 scopus 로고    scopus 로고
    • Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes
    • DOI 10.1016/j.patbio.2006.04.007, PII S036981140600068X
    • Paulsson K, Johansson B. Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris). 2007;55(1):37-48. (Pubitemid 46217945)
    • (2007) Pathologie Biologie , vol.55 , Issue.1 , pp. 37-48
    • Paulsson, K.1    Johansson, B.2
  • 18
    • 0033782853 scopus 로고    scopus 로고
    • Spindle assembly in animal cells
    • Compton DA. Spindle assembly in animal cells. Annu Rev Biochem. 2000;69:95-114.
    • (2000) Annu Rev Biochem , vol.69 , pp. 95-114
    • Compton, D.A.1
  • 19
    • 10944236258 scopus 로고    scopus 로고
    • The dynamic kinetochore-microtubule interface
    • DOI 10.1242/jcs.01536
    • Maiato H, DeLuca J, Salmon ED, Earnshaw WC. The dynamic kinetochore-microtubule interface. J Cell Sci. 2004;117(pt 23):5461-5477. (Pubitemid 40012194)
    • (2004) Journal of Cell Science , vol.117 , Issue.23 , pp. 5461-5477
    • Maiato, H.1    DeLuca, J.2    Salmon, E.D.3    Earnshaw, W.C.4
  • 21
    • 51349147655 scopus 로고    scopus 로고
    • Overexpression of Separase induces aneuploidy and mammary tumorigenesis
    • Pati D, et al. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008;105(35):13033-13038.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.35 , pp. 13033-13038
    • Pati, D.1
  • 22
    • 38349169905 scopus 로고    scopus 로고
    • Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
    • Di Leonardo A, Lentini L, Amato A, Schillaci T. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer. 2007;7:212.
    • (2007) BMC Cancer , vol.7 , pp. 212
    • Di Leonardo, A.1    Lentini, L.2    Amato, A.3    Schillaci, T.4
  • 23
    • 68749084849 scopus 로고    scopus 로고
    • Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
    • Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PloS One. 2009; 4(8):e6564.
    • (2009) PloS One , vol.4 , Issue.8
    • Silkworth, W.T.1    Nardi, I.K.2    Scholl, L.M.3    Cimini, D.4
  • 24
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009;460(7252):278-282.
    • (2009) Nature , vol.460 , Issue.7252 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 27
    • 77949773695 scopus 로고    scopus 로고
    • Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    • Sotillo R, Schvartzman JM, Socci ND, Benezra R. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature. 2010;464(7287):436-440.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 436-440
    • Sotillo, R.1    Schvartzman, J.M.2    Socci, N.D.3    Benezra, R.4
  • 28
    • 55949096605 scopus 로고    scopus 로고
    • Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
    • Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci U S A. 2008;105(43):16719-16724.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.43 , pp. 16719-16724
    • Diaz-Rodriguez, E.1    Sotillo, R.2    Schvartzman, J.M.3    Benezra, R.4
  • 29
    • 58149334818 scopus 로고    scopus 로고
    • Genome stability is ensured by temporal control of kinetochore- microtubule dynamics
    • Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol. 2009;11(1):27-35.
    • (2009) Nat Cell Biol , vol.11 , Issue.1 , pp. 27-35
    • Bakhoum, S.F.1    Thompson, S.L.2    Manning, A.L.3    Compton, D.A.4
  • 30
    • 70450176266 scopus 로고    scopus 로고
    • Deviant kinetochore microtubule dynamics underlie chromosomal instability
    • Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol. 2009; 19(22):1937-1942.
    • (2009) Curr Biol , vol.19 , Issue.22 , pp. 1937-1942
    • Bakhoum, S.F.1    Genovese, G.2    Compton, D.A.3
  • 31
    • 84055163537 scopus 로고    scopus 로고
    • Merotelic attachment of single kinetochores to microtubules from opposite poles is not detected by the mitotic spindle checkpoint and induces chromosome loss during mitosis
    • Cimini D, Howell BJ, Degrassi F, Salmon ED. Merotelic attachment of single kinetochores to microtubules from opposite poles is not detected by the mitotic spindle checkpoint and induces chromosome loss during mitosis. Mol Biol Cell. 2000; 11:430a.
    • (2000) Mol Biol Cell , vol.11
    • Cimini, D.1    Howell, B.J.2    Degrassi, F.3    Salmon, E.D.4
  • 32
    • 0035972237 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
    • Cimini D, Howell B, Maddox P, Khodjakov A, Degrassi F, Salmon ED. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol. 2001; 153(3):517-527. (Pubitemid 34280139)
    • (2001) Journal of Cell Biology , vol.152 , Issue.3 , pp. 517-527
    • Cimini, D.1    Howell, B.2    Maddox, P.3    Khodjakov, A.4    Degrassi, F.5    Salmon, E.D.6
  • 33
    • 80051985198 scopus 로고    scopus 로고
    • The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly
    • Khodjakov A, Magidson V, O'Connell CB, Loncarek J, Paul R, Mogilner A. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly. Cell. 2011;146(4):555-567.
    • (2011) Cell , vol.146 , Issue.4 , pp. 555-567
    • Khodjakov, A.1    Magidson, V.2    O'Connell, C.B.3    Loncarek, J.4    Paul, R.5    Mogilner, A.6
  • 36
    • 37549071893 scopus 로고    scopus 로고
    • Molecular architecture of the kinetochore-microtubule interface
    • Cheeseman IM, Desai A. Molecular architecture of the kinetochore- microtubule interface. Nat Rev Mol Cell Biol. 2008;9(1):33-46.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.1 , pp. 33-46
    • Cheeseman, I.M.1    Desai, A.2
  • 38
    • 33751227843 scopus 로고    scopus 로고
    • Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1
    • DOI 10.1016/j.cell.2006.09.047, PII S0092867406014085
    • DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell. 2006;127(5):969-982. (Pubitemid 44792254)
    • (2006) Cell , vol.127 , Issue.5 , pp. 969-982
    • DeLuca, J.G.1    Gall, W.E.2    Ciferri, C.3    Cimini, D.4    Musacchio, A.5    Salmon, E.D.6
  • 39
    • 68249133956 scopus 로고    scopus 로고
    • Cancer: CINful centrosomes
    • Bakhoum SF, Compton DA. Cancer: CINful centrosomes. Curr Biol. 2009;19(15):R642-R645.
    • (2009) Curr Biol , vol.19 , Issue.15
    • Bakhoum, S.F.1    Compton, D.A.2
  • 42
    • 12344266713 scopus 로고    scopus 로고
    • The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments
    • DOI 10.1038/ncb1208
    • Lampson MA, Kapoor TM. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat Cell Biol. 2005;7(1):93-98. (Pubitemid 40123388)
    • (2005) Nature Cell Biology , vol.7 , Issue.1 , pp. 93-98
    • Lampson, M.A.1    Kapoor, T.M.2
  • 43
    • 34247333444 scopus 로고    scopus 로고
    • The spindle-assembly checkpoint in space and time
    • DOI 10.1038/nrm2163, PII NRM2163
    • Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8(5):379-393. (Pubitemid 46643240)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 379-393
    • Musacchio, A.1    Salmon, E.D.2
  • 44
    • 77958478983 scopus 로고    scopus 로고
    • CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity
    • Manning AL, Bakhoum SF, Maffini S, Correia- Melo C, Maiato H, Compton DA. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J. 2010; 29(20):3531-3543.
    • (2010) EMBO J , vol.29 , Issue.20 , pp. 3531-3543
    • Manning, A.L.1    Bakhoum, S.F.2    Maffini, S.3    Correia- Melo, C.4    Maiato, H.5    Compton, D.A.6
  • 45
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • DOI 10.1038/nature04217, PII N04217
    • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature. 2005;437(7061):1043-1047. (Pubitemid 41486987)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 46
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Campbell PJ, et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 2011;144(1):27-40.
    • (2011) Cell , vol.144 , Issue.1 , pp. 27-40
    • Campbell, P.J.1
  • 47
    • 78650964769 scopus 로고    scopus 로고
    • Cancer genomes evolve by pulverizing single chromosomes
    • Meyerson M, Pellman D. Cancer genomes evolve by pulverizing single chromosomes. Cell. 2011;144(1):9-10.
    • (2011) Cell , vol.144 , Issue.1 , pp. 9-10
    • Meyerson, M.1    Pellman, D.2
  • 48
    • 84055176499 scopus 로고    scopus 로고
    • Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma
    • Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA. Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma. Clin Cancer Res. 2011;17(24):7704-7711.
    • (2011) Clin Cancer Res , vol.17 , Issue.24 , pp. 7704-7711
    • Bakhoum, S.F.1    Danilova, O.V.2    Kaur, P.3    Levy, N.B.4    Compton, D.A.5
  • 50
    • 46349086833 scopus 로고    scopus 로고
    • Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis
    • DOI 10.1136/gut.2007.135004
    • Walther A, Houlston R, Tomlinson I. Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis. Gut. 2008;57(7):941-950. (Pubitemid 351919529)
    • (2008) Gut , vol.57 , Issue.7 , pp. 941-950
    • Walther, A.1    Houlston, R.2    Tomlinson, I.3
  • 51
    • 41849120477 scopus 로고    scopus 로고
    • Chromosomal instability in bladder cancer
    • Florl AR, Schulz WA. Chromosomal instability in bladder cancer. Arch Toxicol. 2008;82(3):173-182.
    • (2008) Arch Toxicol , vol.82 , Issue.3 , pp. 173-182
    • Florl, A.R.1    Schulz, W.A.2
  • 52
    • 77951962238 scopus 로고    scopus 로고
    • JC human polyomavirus is associated to chromosomal instability in peripheral blood lymphocytes of Hodgkin's lymphoma patients and poor clinical outcome
    • M'kacher R, et al. JC human polyomavirus is associated to chromosomal instability in peripheral blood lymphocytes of Hodgkin's lymphoma patients and poor clinical outcome. Ann Oncol. 2010; 21(4):826-832.
    • (2010) Ann Oncol , vol.21 , Issue.4 , pp. 826-832
    • M'kacher, R.1
  • 53
    • 34548548519 scopus 로고    scopus 로고
    • Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma
    • DOI 10.1158/0008-5472.CAN-07-1666
    • Knudson CM, van de Wetering CI. Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma. Cancer Res. 2007;67(17):8081-8088. (Pubitemid 47395142)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8081-8088
    • Van De, W.C.I.1    Knudson, C.M.2
  • 55
    • 75149140916 scopus 로고    scopus 로고
    • Mitotic chromosomal instability and cancer: Mouse modelling of the human disease
    • Schvartzman JM, Sotillo R, Benezra R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer. 2010; 10(2):102-115.
    • (2010) Nat Rev Cancer , vol.10 , Issue.2 , pp. 102-115
    • Schvartzman, J.M.1    Sotillo, R.2    Benezra, R.3
  • 56
    • 33846065784 scopus 로고    scopus 로고
    • Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
    • DOI 10.1016/j.ccr.2006.12.003, PII S1535610806003680
    • Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 2007; 11(1):25-36. (Pubitemid 46070223)
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 25-36
    • Weaver, B.A.A.1    Silk, A.D.2    Montagna, C.3    Verdier-Pinard, P.4    Cleveland, D.W.5
  • 57
    • 79958733630 scopus 로고    scopus 로고
    • Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition
    • Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell. 2011;19(6):701-714.
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 701-714
    • Schvartzman, J.M.1    Duijf, P.H.2    Sotillo, R.3    Coker, C.4    Benezra, R.5
  • 58
    • 76349126361 scopus 로고    scopus 로고
    • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
    • Thompson SL, Compton DA. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol. 2010;188(3):369-381.
    • (2010) J Cell Biol , vol.188 , Issue.3 , pp. 369-381
    • Thompson, S.L.1    Compton, D.A.2
  • 59
    • 77955138739 scopus 로고    scopus 로고
    • Transcriptomic profiling of human oocytes: Association of meiotic aneuploidy and altered oocyte gene expression
    • Fragouli E, et al. Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression. Mol Hum Reprod. 2010;16(8):570-582.
    • (2010) Mol Hum Reprod , vol.16 , Issue.8 , pp. 570-582
    • Fragouli, E.1
  • 60
    • 3543110316 scopus 로고    scopus 로고
    • Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome
    • Yaspo ML, et al. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res. 2004; 14(7):1258-1267.
    • (2004) Genome Res , vol.14 , Issue.7 , pp. 1258-1267
    • Yaspo, M.L.1
  • 61
    • 70749158525 scopus 로고    scopus 로고
    • Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
    • Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell. 2009;16(6):475-486.
    • (2009) Cancer Cell , vol.16 , Issue.6 , pp. 475-486
    • Baker, D.J.1    Jin, F.2    Jeganathan, K.B.3    Van Deursen, J.M.4
  • 62
    • 80053364894 scopus 로고    scopus 로고
    • Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    • Janssen A, van der Burg M, Szuhai K, Kops GJPL, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science. 2011;333(6051):1895-1898.
    • (2011) Science , vol.333 , Issue.6051 , pp. 1895-1898
    • Janssen, A.1    Van Der Burg, M.2    Szuhai, K.3    Kops, G.J.P.L.4    Medema, R.H.5
  • 63
    • 56849125516 scopus 로고    scopus 로고
    • The aneuploidy paradox in cell growth and tumorigenesis
    • Weaver BA, Cleveland DW. The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 2008;14(6):431-433.
    • (2008) Cancer Cell , vol.14 , Issue.6 , pp. 431-433
    • Weaver, B.A.1    Cleveland, D.W.2
  • 64
    • 73149101630 scopus 로고    scopus 로고
    • Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
    • Janssen A, Kops GJ, Medema RH. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A. 2009; 106(45):19108-19113.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.45 , pp. 19108-19113
    • Janssen, A.1    Kops, G.J.2    Medema, R.H.3
  • 65
    • 74949088096 scopus 로고    scopus 로고
    • Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
    • Galimberti F, et al. Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe. Clin Cancer Res. 2010; 16(1):109-120.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 109-120
    • Galimberti, F.1
  • 68
    • 0032127258 scopus 로고    scopus 로고
    • Reductive evolution of resident genomes
    • DOI 10.1016/S0966-842X(98)01312-2, PII S0966842X98013122
    • Andersson SGE, Kurland CG. Reductive evolution of resident genomes. Trends Microbiol. 1998; 6(7):263-268. (Pubitemid 28343306)
    • (1998) Trends in Microbiology , vol.6 , Issue.7 , pp. 263-268
    • Andersson, S.G.E.1    Kurland, C.G.2
  • 69
    • 52449132715 scopus 로고    scopus 로고
    • Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression
    • Weaver BA, Silk AD, Cleveland DW. Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol. 2008;30(5):453.
    • (2008) Cell Oncol , vol.30 , Issue.5 , pp. 453
    • Weaver, B.A.1    Silk, A.D.2    Cleveland, D.W.3
  • 70
    • 79959243434 scopus 로고    scopus 로고
    • Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes
    • Smid M, et al. Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes. Breast Cancer Res Treat. 2011; 128(1):23-30.
    • (2011) Breast Cancer Res Treat , vol.128 , Issue.1 , pp. 23-30
    • Smid, M.1
  • 71
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • DOI 10.1038/ng1861, PII NG1861
    • Szallasi Z, Carter SL, Eklund AC, Kohane IS, Harris LN. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet. 2006;38(9):1043-1048. (Pubitemid 44325930)
    • (2006) Nature Genetics , vol.38 , Issue.9 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 72
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • Li R, et al. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature. 2010;468(7321):321-325.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 321-325
    • Li, R.1
  • 74
    • 79956160582 scopus 로고    scopus 로고
    • Paradoxical relationship between chromosomal instability and survival outcome in cancer
    • Birkbak NJ, et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res. 2011;71(10):3447-3452.
    • (2011) Cancer Res , vol.71 , Issue.10 , pp. 3447-3452
    • Birkbak, N.J.1
  • 75
    • 33646262907 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma with overexpression of cyclin E substantiates poor standard treatment response and inferior outcome
    • Tzankov A, et al. Diffuse large B-cell lymphoma with overexpression of cyclin E substantiates poor standard treatment response and inferior outcome. Clin Cancer Res. 2006;12(7 pt 1):2125-2132.
    • (2006) Clin Cancer Res , vol.12 , Issue.7 PART 1 , pp. 2125-2132
    • Tzankov, A.1
  • 76
    • 33751232957 scopus 로고    scopus 로고
    • The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore
    • DOI 10.1016/j.cell.2006.09.039, PII S0092867406013456
    • Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell. 2006;127(5):983-997. (Pubitemid 44792248)
    • (2006) Cell , vol.127 , Issue.5 , pp. 983-997
    • Cheeseman, I.M.1    Chappie, J.S.2    Wilson-Kubalek, E.M.3    Desai, A.4
  • 77
    • 33750612373 scopus 로고    scopus 로고
    • Aurora Kinase Promotes Turnover of Kinetochore Microtubules to Reduce Chromosome Segregation Errors
    • DOI 10.1016/j.cub.2006.07.022, PII S0960982206018537
    • Cimini D, Wan XH, Hirel CB, Salmon ED. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol. 2006;16(17):1711-1718. (Pubitemid 44691779)
    • (2006) Current Biology , vol.16 , Issue.17 , pp. 1711-1718
    • Cimini, D.1    Wan, X.2    Hirel, C.B.3    Salmon, E.D.4
  • 78
    • 62149111407 scopus 로고    scopus 로고
    • Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates
    • Liu D, Vader G, Vromans MJ, Lampson MA, Lens SM. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009;323(5919):1350-1353.
    • (2009) Science , vol.323 , Issue.5919 , pp. 1350-1353
    • Liu, D.1    Vader, G.2    Vromans, M.J.3    Lampson, M.A.4    Lens, S.M.5
  • 79
    • 81155132604 scopus 로고    scopus 로고
    • AT9283, a novel pan- Aurora/ JAK-2 kinase inhibitor suppresses tumor growth in aggressive B-cell non-Hodgkin's lymphoma
    • abstract
    • Mahadevan D, Liu X, Persky DO, Miller TP, Squires MS, Wenqing Q. AT9283, a novel pan- Aurora/ JAK-2 kinase inhibitor suppresses tumor growth in aggressive B-cell non-Hodgkin's lymphoma [abstract]. Blood. 2010;116:3930.
    • (2010) Blood , vol.116 , pp. 3930
    • Mahadevan, D.1    Liu, X.2    Persky, D.O.3    Miller, T.P.4    Squires, M.S.5    Wenqing, Q.6
  • 80
    • 79251556865 scopus 로고    scopus 로고
    • Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors
    • Schellens JH, et al. Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors. Ann Oncol. 2011; 22(2):431-437.
    • (2011) Ann Oncol , vol.22 , Issue.2 , pp. 431-437
    • Schellens, J.H.1
  • 81
    • 78649971294 scopus 로고    scopus 로고
    • Preclinical evaluation of AMG 900, a novel potent and highly selective panaurora kinase inhibitor with activity in taxane- resistant tumor cell lines
    • Payton M, et al. Preclinical evaluation of AMG 900, a novel potent and highly selective panaurora kinase inhibitor with activity in taxane- resistant tumor cell lines. Cancer Res. 2010; 70(23):9846-9854.
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9846-9854
    • Payton, M.1
  • 82
    • 80052100694 scopus 로고    scopus 로고
    • A Phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia
    • Tsuboi K, et al. A Phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia. Leuk Res. 2011;35(10):1384-1389.
    • (2011) Leuk Res , vol.35 , Issue.10 , pp. 1384-1389
    • Tsuboi, K.1
  • 83
    • 80053536086 scopus 로고    scopus 로고
    • Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer
    • Roylance R, et al. Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer. Cancer Epidemiol Biomarkers Prev. 2011;20(10):2183-2194.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , Issue.10 , pp. 2183-2194
    • Roylance, R.1
  • 84
    • 84856424908 scopus 로고    scopus 로고
    • DNA breaks and chromosome pulverization from errors in mitosis
    • Crasta K, et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012; 482(7383):53-58.
    • (2012) Nature , vol.482 , Issue.7383 , pp. 53-58
    • Crasta, K.1


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