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Volumn 373, Issue , 2013, Pages 69-86

Central tolerance induction

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NUCLEAR RECEPTOR NUR77; T LYMPHOCYTE RECEPTOR;

EID: 84892187191     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2013-321     Document Type: Article
Times cited : (19)

References (100)
  • 1
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • doi:10.1038/ng1297-399
    • Aaltonen J (1997) An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17(4):399-403. doi:10.1038/ng1297-399
    • (1997) Nat Genet , vol.17 , Issue.4 , pp. 399-403
    • Aaltonen, J.1
  • 2
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • doi:10.1016/j.cell.2009.12.030, S0092- 8674(09 01616-X [pii]
    • Abramson J, Giraud M, Benoist C, Mathis D (2010) Aire's partners in the molecular control of immunological tolerance. Cell 140(1):123-135. doi:10.1016/j.cell.2009.12.030, S0092- 8674(09)01616-X [pii]
    • (2010) Cell , vol.140 , Issue.1 , pp. 123
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 6
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I, Sarukhan A, Klein L, von Boehmer H (2002) Origin of regulatory T cells with known specificity for antigen. Nat Immunol 3:756-763
    • (2002) Nat Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 8
    • 22344450566 scopus 로고    scopus 로고
    • The timing of TCR alpha expression critically influences T cell development and selection
    • doi:10.1084/jem.20050359, jem.20050359 [pii]
    • Baldwin TA, Sandau MM, Jameson SC, Hogquist KA (2005) The timing of TCR alpha expression critically influences T cell development and selection. J Exp Med 202(1):111-121. doi:10.1084/jem.20050359, jem.20050359 [pii]
    • (2005) J Exp Med , vol.202 , Issue.1 , pp. 111-121
    • Baldwin, T.A.1    Sandau, M.M.2    Jameson, S.C.3    Hogquist, K.A.4
  • 11
    • 0041884736 scopus 로고    scopus 로고
    • Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR
    • Boehm T, Scheu S, Pfeffer K, Bleul CC (2003) Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med 198:757-769
    • (2003) J Exp Med , vol.198 , pp. 757-769
    • Boehm, T.1    Scheu, S.2    Pfeffer, K.3    Bleul, C.C.4
  • 16
    • 0003996006 scopus 로고
    • The clonal selection theory of acquired immunity
    • University Press, Nashville
    • Burnet F (1958) The clonal selection theory of acquired immunity. Vanderbilt University Press, Nashville
    • (1958) Vanderbilt
    • Burnet, F.1
  • 17
    • 0028807837 scopus 로고
    • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
    • Calnan BJ, Szychowski S, Chan FK, Cado D, Winoto A (1995) A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3(3):273-282
    • (1995) Immunity , vol.3 , Issue.3 , pp. 273-282
    • Calnan, B.J.1    Szychowski, S.2    Chan, F.K.3    Cado, D.4    Winoto, A.5
  • 20
    • 27544446622 scopus 로고    scopus 로고
    • Development and function of agonist-induced CD25+ Foxp3+regulatory T cells in the absence of interleukin 2 signaling
    • D'Cruz LM, Klein L (2005) Development and function of agonist-induced CD25+ Foxp3+regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6:1152-1159
    • (2005) Nat Immunol , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 23
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • doi:10.1084/jem.20050471, jem.20050471 [pii]
    • Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, Hergenhahn M, Peltonen L, Walter J, Kyewski B (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 202(1):33-45. doi:10.1084/jem.20050471, jem.20050471 [pii]
    • (2005) J Exp Med , vol.202 , Issue.1 , pp. 33-45
    • Derbinski, J.1    Gabler, J.2    Brors, B.3    Tierling, S.4    Jonnakuty, S.5    Hergenhahn, M.6    Peltonen, L.7    Walter, J.8    Kyewski, B.9
  • 24
    • 38649131259 scopus 로고    scopus 로고
    • Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
    • doi:10.1073/pnas.0707486105 0707486105-[ii]
    • Derbinski J, Pinto S, Rosch S, Hexel K, Kyewski B (2008) Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci USA 105(2):657-662. doi:10.1073/pnas.0707486105, 0707486105 [pii]
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.2 , pp. 657-662
    • Derbinski, J.1    Pinto, S.2    Rosch, S.3    Hexel, K.4    Kyewski, B.5
  • 25
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • doi:10.1038/ni723ni723, ni723 [pii]
    • Derbinski J, Schulte A, Kyewski B, Klein L (2001) Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2(11):1032-1039. doi:10.1038/ni723ni723, ni723 [pii]
    • (2001) Nat Immunol , vol.2 , Issue.11 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 27
    • 60549084941 scopus 로고    scopus 로고
    • CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg
    • DiPaolo RJ, Shevach EM (2009) CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur J Immunol 39:234-240
    • (2009) Eur J Immunol , vol.39 , pp. 234-240
    • DiPaolo, R.J.1    Shevach, E.M.2
  • 28
    • 84857989935 scopus 로고    scopus 로고
    • Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
    • doi:10.1073/pnas.1200090109, 1200090109-[ii]
    • Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C (2012) Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci USA 109(10):3891-3896. doi:10.1073/pnas. 1200090109, 1200090109 [pii]
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.10 , pp. 3891-3896
    • Fassett, M.S.1    Jiang, W.2    D'Alise, A.M.3    Mathis, D.4    Benoist, C.5
  • 29
    • 0029065488 scopus 로고
    • Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells
    • doi:10.1038/375795a0
    • Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H (1995) Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 375(6534):795-798. doi:10.1038/375795a0
    • (1995) Nature , vol.375 , Issue.6534 , pp. 795-798
    • Fehling, H.J.1    Krotkova, A.2    Saint-Ruf, C.3    Von Boehmer, H.4
  • 30
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
    • doi:10.1038/ni904, ni904 [pii]
    • Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4(4):330-336. doi:10.1038/ni904, ni904 [pii]
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 32
    • 0023690729 scopus 로고
    • Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage
    • doi:10.1038/334620a0
    • Fowlkes BJ, Schwartz RH, Pardoll DM (1988) Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature 334(6183):620-623. doi:10.1038/334620a0
    • (1988) Nature , vol.334 , Issue.6183 , pp. 620-623
    • Fowlkes, B.J.1    Schwartz, R.H.2    Pardoll, D.M.3
  • 33
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos AM, Bevan MJ (2004) Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200:1039-1049
    • (2004) J Exp Med , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 34
    • 14244262563 scopus 로고    scopus 로고
    • T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes
    • doi:10.1084/jem.20042036, jem.20042036 [pii]
    • Gil D, Schrum AG, Alarcon B, Palmer E (2005) T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J Exp Med 201(4):517-522. doi:10.1084/jem.20042036, jem.20042036 [pii]
    • (2005) J Exp Med , vol.201 , Issue.4 , pp. 517-522
    • Gil, D.1    Schrum, A.G.2    Alarcon, B.3    Palmer, E.4
  • 36
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D (2007) Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204:2521-2528
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 40
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1
  • 41
    • 4143066714 scopus 로고    scopus 로고
    • Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors
    • Hsieh C-S, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY (2004) Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21:267-277
    • (2004) Immunity , vol.21 , pp. 267-277
    • Hsieh, C.-S.1    Liang, Y.2    Tyznik, A.J.3    Self, S.G.4    Liggitt, D.5    Rudensky, A.Y.6
  • 42
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh C-S, Zheng Y, Liang Y, Fontenot JD, Rudensky AY (2006) An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 7:401-410
    • (2006) Nat Immunol , vol.7 , pp. 401-410
    • Hsieh, C.-S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 44
    • 0033136302 scopus 로고    scopus 로고
    • Thymus and autoimmunity: Production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S (1999) Thymus and autoimmunity: Production of CD25+ CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 162:5317-5326
    • (1999) J Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1    Takahashi, T.2    Sakaguchi, N.3    Kuniyasu, Y.4    Shimizu, J.5    Otsuka, F.6    Sakaguchi, S.7
  • 47
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • 0092-8674 8790568-X [ii]
    • Kappler JW, Roehm N, Marrack P (1987) T cell tolerance by clonal elimination in the thymus. Cell 49(2):273-280, 0092-8674(87)90568-X [pii]
    • (1987) Cell , vol.49 , Issue.2 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 48
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for scurfin in cd4+ cd25+t regulatory cells
    • Khattri R, Cox T, Yasayko S-A, Ramsdell F (2003) An essential role for Scurfin in CD4+ CD25+T regulatory cells. Nat Immunol 4:337-342
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.-A.3    Ramsdell, F.4
  • 49
    • 0023900635 scopus 로고
    • Tolerance in T-cellreceptor transgenic mice involves deletion of nonmature CD4+ 8+ thymocytes
    • doi:10.1038/333742a0
    • Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H (1988) Tolerance in T-cellreceptor transgenic mice involves deletion of nonmature CD4+ 8+ thymocytes. Nature 333(6175):742-746. doi:10.1038/333742a0
    • (1988) Nature , vol.333 , Issue.6175 , pp. 742-746
    • Kisielow, P.1    Bluthmann, H.2    Staerz, U.D.3    Steinmetz, M.4    Von Boehmer, H.5
  • 50
    • 27944455288 scopus 로고    scopus 로고
    • Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
    • Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK (2005) Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202:1375-1386
    • (2005) J Exp Med , vol.202 , pp. 1375-1386
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Bluestone, J.A.4    Abbas, A.K.5
  • 51
    • 67650507153 scopus 로고    scopus 로고
    • The thymic medulla: A unique microenvironment for intercellular self-antigen transfer
    • Koble C, Kyewski B (2009) The thymic medulla: A unique microenvironment for intercellular self-antigen transfer. J Exp Med 206:1505-1513
    • (2009) J Exp Med , vol.206 , pp. 1505-1513
    • Koble, C.1    Kyewski, B.2
  • 52
    • 77955602966 scopus 로고    scopus 로고
    • Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    • doi:10.1073/pnas.1004436107, 1004436107 [pii]
    • Koh AS, Kingston RE, Benoist C, Mathis D (2010) Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci USA 107(29):13016-13021. doi:10.1073/pnas.1004436107, 1004436107 [pii]
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.29 , pp. 13016-13021
    • Koh, A.S.1    Kingston, R.E.2    Benoist, C.3    Mathis, D.4
  • 53
    • 1642289268 scopus 로고    scopus 로고
    • CCR7 directs the migration of thymocytes into the thymic medulla
    • Kwan J, Killeen N (2004) CCR7 directs the migration of thymocytes into the thymic medulla. J Immunol 172(7):3999-4007
    • (2004) J Immunol , vol.172 , Issue.7 , pp. 3999-4007
    • Kwan, J.1    Killeen, N.2
  • 54
    • 84866524744 scopus 로고    scopus 로고
    • A broad range of selfreactivity drives thymic regulatory T cell selection to limit responses to self
    • Lee H-M, Bautista JL, Scott-Browne J, Mohan JF, Hsieh C-S (2012) A broad range of selfreactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 37:475-486
    • (2012) Immunity , vol.37 , pp. 475-486
    • Lee, H.-M.1    Bautista, J.L.2    Scott-Browne, J.3    Mohan, J.F.4    Hsieh, C.-S.5
  • 56
    • 70350440009 scopus 로고    scopus 로고
    • TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    • Leung MWL, Shen S, Lafaille JJ (2009) TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med 206:2121-2130
    • (2009) J Exp Med , vol.206 , pp. 2121-2130
    • Leung, M.W.L.1    Shen, S.2    Lafaille, J.J.3
  • 57
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • doi:10.1084/jem.20082232, jem.20082232 [pii]
    • Li J, Park J, Foss D, Goldschneider I (2009) Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med 206(3):607-622. doi:10.1084/jem.20082232, jem.20082232 [pii]
    • (2009) J Exp Med , vol.206 , Issue.3 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 58
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio C-WJ, Hsieh C-S (2008) A two-step process for thymic regulatory T cell development. Immunity 28:100-111
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.-W.J.1    Hsieh, C.-S.2
  • 59
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+ CD25+ Foxp3+ regulatory T cells
    • Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W (2008) A critical function for TGF-beta signaling in the development of natural CD4+ CD25+ Foxp3+ regulatory T cells. Nat Immunol 9:632-640
    • (2008) Nat Immunol , vol.9 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 60
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • doi:10.1016/j.immuni.2006.07.012, S1074-7613(06 00388-8 [ii]
    • Marie JC, Liggitt D, Rudensky AY (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25(3):441-454. doi:10.1016/j.immuni.2006.07.012, S1074-7613(06)00388-8 [pii]
    • (2006) Immunity , vol.25 , Issue.3 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 61
    • 35748979722 scopus 로고    scopus 로고
    • Thymic emigration revisited
    • doi:10.1084/jem.20070601, S1074-7613(06 00388-8 [ii]
    • McCaughtry TM, Wilken MS, Hogquist KA (2007) Thymic emigration revisited. J Exp Med 204(11):2513-2520. doi:10.1084/jem.20070601, S1074-7613(06)00388-8 [pii]
    • (2007) J Exp Med , vol.204 , Issue.11 , pp. 2513-2520
    • McCaughtry, T.M.1    Wilken, M.S.2    Hogquist, K.A.3
  • 62
    • 26444483956 scopus 로고    scopus 로고
    • A requirement for sustained ERK signaling during thymocyte positive selection in vivo
    • doi:10.1073/pnas.0505110102, 0505110102 [pii]
    • McNeil LK, Starr TK, Hogquist KA (2005) A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci USA 102(38):13574-13579. doi:10.1073/pnas.0505110102, 0505110102 [pii]
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.38 , pp. 13574-13579
    • McNeil, L.K.1    Starr, T.K.2    Hogquist, K.A.3
  • 63
    • 79954463242 scopus 로고    scopus 로고
    • Control of central and peripheral tolerance by Aire
    • Metzger TC, Anderson MS (2011) Control of central and peripheral tolerance by Aire. Immunol Rev 241:89-103
    • (2011) Immunol Rev , vol.241 , pp. 89-103
    • Metzger, T.C.1    Anderson, M.S.2
  • 64
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, Punt J, Hogquist KA (2011) T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 208:1279-1289
    • (2011) J Exp Med , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 66
    • 34249883977 scopus 로고    scopus 로고
    • Regulation of CD8+ T cell development by thymus-specific proteasomes
    • doi:10.1126/science.1141915, 316/5829/1349 [pii]
    • Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K (2007) Regulation of CD8+ T cell development by thymus-specific proteasomes. Science 316(5829):1349-1353. doi:10.1126/science.1141915, 316/5829/1349 [pii]
    • (2007) Science , vol.316 , Issue.5829 , pp. 1349-1353
    • Murata, S.1    Sasaki, K.2    Kishimoto, T.3    Niwa, S.4    Hayashi, H.5    Takahama, Y.6    Tanaka, K.7
  • 67
    • 0025697469 scopus 로고
    • Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo
    • Murphy KM, Heimberger AB, Loh DY (1990) Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCRlo thymocytes in vivo. Science 250(4988):1720-1723
    • (1990) Science , vol.250 , Issue.4988 , pp. 1720-1723
    • Murphy, K.M.1    Heimberger, A.B.2    Loh, D.Y.3
  • 68
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L (2008) Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 455:396-400
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 70
    • 0014667395 scopus 로고
    • Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
    • Nishizuka Y, Sakakura T (1969) Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 166(3906):753-755
    • (1969) Science , vol.166 , Issue.3906 , pp. 753-755
    • Nishizuka, Y.1    Sakakura, T.2
  • 71
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D J recombination
    • Oettinger MA, Schatz DG, Gorka C, Baltimore D (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248(4962):1517-1523
    • (1990) Science , vol.248 , Issue.4962 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 72
    • 45849137524 scopus 로고    scopus 로고
    • The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
    • doi:10.1038/Sj.embor. 11 embor200811 [pii]
    • Org T, Chignola F, Hetenyi C, Gaetani M, Rebane A, Liiv I, Maran U, Mollica L, Bottomley MJ, Musco G, Peterson P (2008) The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep 9(4):370-376. doi:10.1038/sj.embor.2008.11 embor200811 [pii]
    • (2008) EMBO Rep , vol.9 , Issue.4 , pp. 370-376
    • Org, T.1    Chignola, F.2    Hetenyi, C.3    Gaetani, M.4    Rebane, A.5    Liiv, I.6    Maran, U.7    Mollica, L.8    Bottomley, M.J.9    Musco, G.10    Peterson, P.11
  • 73
    • 77953267301 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    • Ouyang W, Beckett O, Ma Q, Li MO (2010) Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 32: 642-653
    • (2010) Immunity , vol.32 , pp. 642-653
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Li, M.O.4
  • 74
    • 37549060329 scopus 로고    scopus 로고
    • AIRE recruits PTEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
    • doi:10.1128/MCB.01085-07, MCB.01085-07 [pii]
    • Oven I, Brdickova N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM (2007) AIRE recruits PTEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol 27(24):8815-8823. doi:10.1128/MCB.01085- 07, MCB.01085-07 [pii]
    • (2007) Mol Cell Biol , vol.27 , Issue.24 , pp. 8815-8823
    • Oven, I.1    Brdickova, N.2    Kohoutek, J.3    Vaupotic, T.4    Narat, M.5    Peterlin, B.M.6
  • 75
    • 33747099523 scopus 로고    scopus 로고
    • Origin and T cell receptor diversity of Foxp3+ CD4+ CD25+ T cells
    • Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L (2006) Origin and T cell receptor diversity of Foxp3+ CD4+ CD25+ T cells. Immunity 25:249-259
    • (2006) Immunity , vol.25 , pp. 249-259
    • Pacholczyk, R.1    Ignatowicz, H.2    Kraj, P.3    Ignatowicz, L.4
  • 78
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • 00928674 9380067-O [ii]
    • Sadlack B, Merz H, Schorle H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75(2):253-261, 0092- 8674(93)80067-O [pii]
    • (1993) Cell , vol.75 , Issue.2 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schorle, H.4    Schimpl, A.5    Feller, A.C.6    Horak, I.7
  • 79
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 80
    • 0020451946 scopus 로고
    • Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
    • Sakaguchi S, Takahashi T, Nishizuka Y (1982) Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J Exp Med 156:1577-1586
    • (1982) J Exp Med , vol.156 , pp. 1577-1586
    • Sakaguchi, S.1    Takahashi, T.2    Nishizuka, Y.3
  • 81
    • 0024846088 scopus 로고
    • The V(D J recombination activating gene, RAG- 1
    • 0092-867489 90760-5 [ii]
    • Schatz DG, Oettinger MA, Baltimore D (1989) The V(D)J recombination activating gene, RAG- 1. Cell 59(6):1035-1048. 0092-8674(89)90760-5 [pii]
    • (1989) Cell , vol.59 , Issue.6 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 82
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • doi:10.1038/352621a0
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352(6336):621-624. doi:10.1038/352621a0
    • (1991) Nature , vol.352 , Issue.6336 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 83
    • 72949093686 scopus 로고    scopus 로고
    • Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance
    • doi:10.1126/scitranslmed.3000284, 1/9/9ra20 [pii]
    • Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS (2009) Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med 1(9):9ra20. doi:10.1126/scitranslmed.3000284, 1/9/9ra20 [pii]
    • (2009) Sci Transl Med , vol.1 , Issue.9
    • Shum, A.K.1    DeVoss, J.2    Tan, C.L.3    Hou, Y.4    Johannes, K.5    O'Gorman, C.S.6    Jones, K.D.7    Sochett, E.B.8    Fong, L.9    Anderson, M.S.10
  • 84
    • 0030796631 scopus 로고    scopus 로고
    • Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
    • Smith KM, Olson DC, Hirose R, Hanahan D (1997) Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance. Int Immunol 9(9):1355-1365
    • (1997) Int Immunol , vol.9 , Issue.9 , pp. 1355-1365
    • Smith, K.M.1    Olson, D.C.2    Hirose, R.3    Hanahan, D.4
  • 85
    • 34648846176 scopus 로고    scopus 로고
    • Apoptosis during negative selection of autoreactive thymocytes
    • doi:10.1016/j.coi.2007.06.001, S0952- 7915(07 00104-5 [ii]
    • Sohn SJ, Thompson J, Winoto A (2007) Apoptosis during negative selection of autoreactive thymocytes. Curr Opin Immunol 19(5):510-515. doi:10.1016/j.coi.2007.06.001, S0952- 7915(07)00104-5 [pii]
    • (2007) Curr Opin Immunol , vol.19 , Issue.5 , pp. 510-515
    • Sohn, S.J.1    Thompson, J.2    Winoto, A.3
  • 86
    • 38949101205 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development
    • Spence PJ, Green EA (2008) Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development. Proc Natl Acad Sci USA 105:973-978
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 973-978
    • Spence, P.J.1    Green, E.A.2
  • 87
    • 0042470456 scopus 로고    scopus 로고
    • Positive and negative selection of T cells
    • doi:10.1146/annurev.immunol.21.120601.141107 120601141107 [pii]
    • Starr TK, Jameson SC, Hogquist KA (2003) Positive and negative selection of T cells. Annu Rev Immunol 21:139-176. doi:10.1146/annurev.immunol.21.120601. 141107, .141107 [pii]
    • (2003) Annu Rev Immunol , vol.21 , pp. 139-176
    • Starr, T.K.1    Jameson, S.C.2    Hogquist, K.A.3
  • 90
    • 84861212351 scopus 로고    scopus 로고
    • Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
    • Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS (2012) Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci USA 109:7847-7852
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7847-7852
    • Taniguchi, R.T.1    DeVoss, J.J.2    Moon, J.J.3    Sidney, J.4    Sette, A.5    Jenkins, M.K.6    Anderson, M.S.7
  • 91
    • 43549097825 scopus 로고    scopus 로고
    • During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain
    • doi:10.1084/jem.20080101, jem.20080101 [pii]
    • Thompson J, Winoto A (2008) During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med 205(5):1029-1036. doi:10.1084/jem. 20080101, jem.20080101 [pii]
    • (2008) J Exp Med , vol.205 , Issue.5 , pp. 1029-1036
    • Thompson, J.1    Winoto, A.2
  • 92
    • 4344668118 scopus 로고    scopus 로고
    • CCR7 signals are essential for cortex-medulla migration of developing thymocytes
    • doi:10.1084/jem.20040643 jem.20040643 [pii]
    • Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y (2004) CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200(4):493-505. doi:10.1084/jem.20040643 jem.20040643 [pii]
    • (2004) J Exp Med , vol.200 , Issue.4 , pp. 493-505
    • Ueno, T.1    Saito, F.2    Gray, D.H.3    Kuse, S.4    Hieshima, K.5    Nakano, H.6    Kakiuchi, T.7    Lipp, M.8    Boyd, R.L.9    Takahama, Y.10
  • 93
    • 38449096249 scopus 로고    scopus 로고
    • Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected
    • 179/9/5693 [pii]
    • Venanzi ES, Gray DH, Benoist C, Mathis D (2007) Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol 179(9):5693-5700, 179/9/5693 [pii]
    • (2007) J Immunol , vol.179 , Issue.9 , pp. 5693-5700
    • Venanzi, E.S.1    Gray, D.H.2    Benoist, C.3    Mathis, D.4
  • 94
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
    • doi:10.1073/pnas.0808069105 0808069105-[ii]
    • Villasenor J, Besse W, Benoist C, Mathis D (2008) Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci USA 105(41):15854-15859. doi:10.1073/pnas. 0808069105, 0808069105 [pii]
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.41 , pp. 15854-15859
    • Villasenor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 95
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's corpuscles instruct dendritic cells to induce CD4+ CD25+ regulatory T cells in human thymus
    • Watanabe N, Wang Y-H, Lee HK, Ito T, Wang Y-H, Cao W, Liu Y-J (2005) Hassall's corpuscles instruct dendritic cells to induce CD4+ CD25+ regulatory T cells in human thymus. Nature 436:1181-1185
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.-H.2    Lee, H.K.3    Ito, T.4    Wang, Y.-H.5    Cao, W.6    Liu, Y.-J.7
  • 97
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • 1074-761395 90180-9 [ii]
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3(4):521-530, 1074-7613(95)90180-9 [pii]
    • (1995) Immunity , vol.3 , Issue.4 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 98
    • 34249814016 scopus 로고    scopus 로고
    • Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells
    • Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C (2007) Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol 178:7032-7041
    • (2007) J Immunol , vol.178 , pp. 7032-7041
    • Wong, J.1    Obst, R.2    Correia-Neves, M.3    Losyev, G.4    Mathis, D.5    Benoist, C.6
  • 100
    • 38849088093 scopus 로고    scopus 로고
    • CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision
    • 179/11/7358 [ii]
    • Yin X, Ladi E, Chan SW, Li O, Killeen N, Kappes DJ, Robey EA (2007) CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision. J Immunol 179(11):7358-7364, 179/11/7358 [pii]
    • (2007) J Immunol , vol.179 , Issue.11 , pp. 7358-77364
    • Yin, X.1    Ladi, E.2    Chan, S.W.3    Li, O.4    Killeen, N.5    Kappes, D.J.6    Robey, E.A.7


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