An autoimmune response to odorant binding protein 1a is associated with dry eye in the aire-deficient mouse

Journal of Immunology

Volumn 184, Issue 8, 2010, Pages 4236-4246

  DeVoss, Jason J ^a   LeClair, Norbert P ^a   Hou, Yafei ^b   Grewal, Navdeep K ^a   Johannes, Kellsey P ^a   Lu, Wen ^a   Yang, Ting ^a   Meagher, Craig ^a   Fong, Lawrence ^b   Strauss, Erich C ^a   Anderson, Mark S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; ODORANT BINDING PROTEIN 1A; UNCLASSIFIED DRUG; AUTOANTIBODY; AUTOIMMUNE REGULATOR PROTEIN; ODORANT BINDING PROTEIN; ODORANT-BINDING PROTEIN; TRANSCRIPTION FACTOR;

AIRE GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DACRYOADENITIS; DRY EYE; FEMALE; GENE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; KERATOCONJUNCTIVITIS SICCA; LACRIMAL GLAND DISEASE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SJOEGREN SYNDROME; THYMUS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; DACRYOCYSTITIS; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; NUDE MOUSE; OLFACTORY RECEPTOR; PATHOLOGY;

ANIMALS; AUTOANTIBODIES; DACRYOCYSTITIS; DISEASE MODELS, ANIMAL; DRY EYE SYNDROMES; FEMALE; HUMANS; KERATOCONJUNCTIVITIS SICCA; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, NUDE; MICE, SCID; RECEPTORS, ODORANT; SJOGREN'S SYNDROME; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 77952787373     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902434     Document Type: Article

References (43)

1. Fox, R. I., F. V. Howell, R. C. Bone, and P. Michelson. 1984. Primary Sjogren syndrome: clinical and immunopathologic features. Semin. Arthritis Rheum. 14: 77-105.
2. van Blokland, S. C., and M. A. Versnel. 2002. Pathogenesis of Sjögren's syndrome: characteristics of different mouse models for autoimmune exocrinopathy. Clin. Immunol. 103: 111-124.
3. Nguyen, C., E. Singson, J. Y. Kim, J. G. Cornelius, R. Attia, M. E. Doyle, M. Bulosan, S. Cha, and A. B. Peck. 2006. Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus. Scand. J. Immunol. 64: 295-307.
4. Cha, S., A. B. Peck, and M. G. Humphreys-Beher. 2002. Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit. Rev. Oral Biol. Med. 13: 5-16.
5. Yanagi, K., N. Ishimaru, N. Haneji, K. Saegusa, I. Saito, and Y. Hayashi. 1998. Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjögren's syndrome. Eur. J. Immunol. 28: 3336-3345.
6. Ishimaru, N., K. Yanagi, K. Ogawa, T. Suda, I. Saito, and Y. Hayashi. 2001. Possible role of organ-specific autoantigen for Fas ligand-mediated activation-induced cell death in murine Sjögren's syndrome. J. Immunol. 167: 6031-6037. (Pubitemid 33062802)
7. Kuroda, N., T. Mitani, N. Takeda, N. Ishimaru, R. Arakaki, Y. Hayashi, Y. Bando, K. Izumi, T. Takahashi, T. Nomura, et al. 2005. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J. Immunol. 174: 1862-1870. (Pubitemid 40223925)
8. Haneji, N., T. Nakamura, K. Takio, K. Yanagi, H. Higashiyama, I. Saito, S. Noji, H. Sugino, and Y. Hayashi. 1997. Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science 276: 604-607. (Pubitemid 27193686)
9. Sordet, C., J. E. Gottenberg, J. Goetz, D. Bengoufa, R. L. Humbel, X. Mariette, and J. Sibilia. 2005. Anti-alpha-fodrin autoantibodies are not useful diagnostic markers of primary Sjögren's syndrome. Ann. Rheum. Dis. 64: 1244-1245.
10. Watanabe, T., T. Tsuchida, N. Kanda, K. Mori, Y. Hayashi, and K. Tamaki. 1999. Anti-alpha-fodrin antibodies in Sjögren syndrome and lupus erythematosus. Arch. Dermatol. 135: 535-539.
11. Okura, Y., R. Shiari, Y. Hattori, T. Matsuzawa, Y. Miyazaki, Y. Hayashi, and I. Kobayashi. 2008. Epitope mapping of anti-alpha-fodrin antibody in a case of early-onset multiple sclerosis. Pediatr. Int. 50: 135-137.
12. Ogawa, K., S. Nagahiro, R. Arakaki, N. Ishimaru, M. Kobayashi, and Y. Hayashi. 2003. Anti-alpha-fodrin autoantibodies in Moyamoya disease. Stroke 34: e244-e246.
13. Grus, F. H., S. C. Joachim, K. Bruns, K. J. Lackner, N. Pfeiffer, and M. B. Wax. 2006. Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States. Invest. Ophthalmol. Vis. Sci. 47: 968-976.
14. Nagamine, K., P. Peterson, H. S. Scott, J. Kudoh, S. Minoshima, M. Heino, K. J. Krohn, M. D. Lalioti, P. E. Mullis, S. E. Antonarakis, et al. 1997. Positional cloning of the APECED gene. Nat. Genet. 17: 393-398.
15. Finnish-German APECED Consortium. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17: 399-403.
16. Perheentupa, J. 2002. APS-I/APECED: the clinical disease and therapy. Endocrinol. Metab. Clin. North Am. 31: 295-320, vi (vi.).
17. Chang, B., D. Brosnahan, K. McCreery, M. Dominguez, and C. Costigan. 2006. Ocular complications of autoimmune polyendocrinopathy syndrome type 1. J. AAPOS 10: 515-520. (Pubitemid 44960076)
18. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
19. Jiang, W., M. S. Anderson, R. Bronson, D. Mathis, and C. Benoist. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202: 805-815.
20. DeVoss, J., Y. Hou, K. Johannes, W. Lu, G. I. Liou, J. Rinn, H. Chang, R. R. Caspi, R. Caspi, L. Fong, and M. S. Anderson. 2006. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J. Exp. Med. 203: 2727-2735.
21. Henzel, W. J., T. M. Billeci, J. T. Stults, S. C. Wong, C. Grimley, and C. Watanabe. 1993. Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases. Proc. Natl. Acad. Sci. USA 90: 5011-5015.
22. James, P., M. Quadroni, E. Carafoli, and G. Gonnet. 1993. Protein identification by mass profile fingerprinting. Biochem. Biophys. Res. Commun. 195: 58-64.
23. Pappin, D. J., P. Hojrup, and A. J. Bleasby. 1993. Rapid identification of proteins by peptide-mass fingerprinting. Curr. Biol. 3: 327-332.
24. Yates, J. R., 3rd, S. Speicher, P. R. Griffin, and T. Hunkapiller. 1993. Peptide mass maps: a highly informative approach to protein identification. Anal. Biochem. 214: 397-408.
25. Gray, D. H., A. P. Chidgey, and R. L. Boyd. 2002. Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 260: 15-28. (Pubitemid 34132869)
26. Anderson, M. S., E. S. Venanzi, Z. Chen, S. P. Berzins, C. Benoist, and D. Mathis. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23: 227-239.
27. Yeh, S., C. S. de Paiva, C. S. Hwang, K. Trinca, A. Lingappan, J. K. Rafati, W. J. Farley, D. Q. Li, and S. C. Pflugfelder. 2009. Spontaneous T-cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol.
28. Takahashi, M., N. Ishimaru, K. Yanagi, N. Haneji, I. Saito, and Y. Hayashi. 1997. High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. Clin. Exp. Immunol. 109: 555-561.
29. Devoss, J. J., A. K. Shum, K. P. Johannes, W. Lu, A. K. Krawisz, P. Wang, T. Yang, N. P. Leclair, C. Austin, E. C. Strauss, and M. S. Anderson. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J. Immunol. 181: 4072-4079.
30. Gavanescu, I., C. Benoist, and D. Mathis. 2008. B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. Proc. Natl. Acad. Sci. USA 105: 13009-13014.
31. Nguyen, C. Q., S. R. Cha, and A. B. Peck. 2007. Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Front. Biosci. 12: 1767-1789.
32. Gavanescu, I., B. Kessler, H. Ploegh, C. Benoist, and D. Mathis. 2007. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc. Natl. Acad. Sci. USA 104: 4583-4587.
33. Niki, S., K. Oshikawa, Y. Mouri, F. Hirota, A. Matsushima, M. Yano, H. Han, Y. Bando, K. Izumi, M. Matsumoto, et al. 2006. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116: 1292-1301.
34. Doyle, M. E., L. Boggs, R. Attia, L. R. Cooper, D. R. Saban, C. Q. Nguyen, and A. B. Peck. 2007. Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. Am. J. Pathol. 171: 1224-1236.
35. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148: 1198-1215.
36. Hang, L., A. N. Theofilopoulos, and F. J. Dixon. 1982. A spontaneous rheumatoid arthritis-like disease in MRL/l mice. J. Exp. Med. 155: 1690-1701.
37. Hoffman, R. W., M. A. Alspaugh, K. S. Waggie, J. B. Durham, and S. E. Walker. 1984. Sjögren's syndrome in MRL/l and MRL/n mice. Arthritis Rheum. 27: 157-165.
38. Sellam, J., C. Miceli-Richard, J. E. Gottenberg, A. Proust, M. Ittah, F. Lavie, P. Loiseau, and X. Mariette. 2008. Is Inhibitor of differentiation 3 involved in human primary Sjögren's syndrome? Rheumatology (Oxford) 47: 437-441.
39. Haneji, N., H. Hamano, K. Yanagi, and Y. Hayashi. 1994. A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice. J. Immunol. 153: 2769-2777. (Pubitemid 24278146)
40. Takahashi, K., O. Tatsuzawa, K. Yanagi, Y. Hayashi, and H. Takahashi. 2001. Alpha-fodrin auto-antibody in Sjögren syndrome and other auto-immune diseases in childhood. Eur. J. Pediatr. 160: 520-521.
41. Li, H., M. Dai, and Y. Zhuang. 2004. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity 21: 551-560. (Pubitemid 39370510)
42. Ho, S. B., K. Takamura, R. Anway, L. L. Shekels, N. W. Toribara, and H. Ota. 2004. The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins. Dig. Dis. Sci. 49: 1598-1606.
43. Navone, R., C. Lunardi, R. Gerli, E. Tinazzi, D. Peterlana, C. Bason, R. Corrocher, and A. Puccetti. 2005. Identification of tear lipocalin as a novel autoantigen target in Sjögren's syndrome. J. Autoimmun. 25: 229-234. (Pubitemid 41654468)