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Volumn 13, Issue 1, 2014, Pages 113-126

Body fluid biomarkers in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; AQUAPORIN 4 ANTIBODY; BETA INTERFERON; BIOLOGICAL MARKER; CYSTATIN C; GELATINASE B; IMMUNOGLOBULIN G ANTIBODY; MICRORNA; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NATALIZUMAB; NEUTRALIZING ANTIBODY; OSTEOPONTIN; PROTEIN NOGO A;

EID: 84892176685     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(13)70233-3     Document Type: Review
Times cited : (198)

References (170)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95. Biomarkers Definitions Working Group.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 2
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey
    • Lublin FD, Reingold SC Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996, 46:907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 3
    • 26444569231 scopus 로고    scopus 로고
    • 3. MRI as a marker for disease heterogeneity in multiple sclerosis
    • Bielekova B, Kadom N, Fisher E, et al. 3. MRI as a marker for disease heterogeneity in multiple sclerosis. Neurology 2005, 65:1071-1076.
    • (2005) Neurology , vol.65 , pp. 1071-1076
    • Bielekova, B.1    Kadom, N.2    Fisher, E.3
  • 4
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000, 47:707-717.
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 5
    • 84873353587 scopus 로고    scopus 로고
    • Predictors of long-term outcome in multiple sclerosis patients treated with interferon beta
    • Bermel RA, You X, Foulds P, et al. Predictors of long-term outcome in multiple sclerosis patients treated with interferon beta. Ann Neurol 2013, 73:95-103.
    • (2013) Ann Neurol , vol.73 , pp. 95-103
    • Bermel, R.A.1    You, X.2    Foulds, P.3
  • 6
    • 65349157666 scopus 로고    scopus 로고
    • Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis
    • Teunissen CE, Iacobaeus E, Khademi M, et al. Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis. Neurology 2009, 72:1322-1399.
    • (2009) Neurology , vol.72 , pp. 1322-1399
    • Teunissen, C.E.1    Iacobaeus, E.2    Khademi, M.3
  • 7
    • 79551478161 scopus 로고    scopus 로고
    • Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab
    • Gunnarsson M, Malmeström C, Axelsson M, et al. Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab. Ann Neurol 2011, 69:83-89.
    • (2011) Ann Neurol , vol.69 , pp. 83-89
    • Gunnarsson, M.1    Malmeström, C.2    Axelsson, M.3
  • 9
    • 84874391403 scopus 로고    scopus 로고
    • Radiologically isolated syndrome - incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review
    • Granberg T, Martola J, Kristoffersen-Wiberg M, Aspelin P, Fredrikson S Radiologically isolated syndrome - incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review. Mult Scler 2013, 19:271-280.
    • (2013) Mult Scler , vol.19 , pp. 271-280
    • Granberg, T.1    Martola, J.2    Kristoffersen-Wiberg, M.3    Aspelin, P.4    Fredrikson, S.5
  • 10
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: an overview
    • Lassmann H, Brück W, Lucchinetti CF The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007, 17:210-218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.F.3
  • 11
    • 33747030845 scopus 로고    scopus 로고
    • Protein biomarker discovery and validation: the long and uncertain path to clinical utility
    • Rifai N, Gillette MA, Carr SA Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 2006, 24:971-983.
    • (2006) Nat Biotechnol , vol.24 , pp. 971-983
    • Rifai, N.1    Gillette, M.A.2    Carr, S.A.3
  • 13
    • 77950597049 scopus 로고    scopus 로고
    • Multiple sclerosis: identification and clinical evaluation of novel CSF biomarkers
    • Ottervald J, Franzén B, Nilsson K, et al. Multiple sclerosis: identification and clinical evaluation of novel CSF biomarkers. J Proteomics 2010, 73:1117-1132.
    • (2010) J Proteomics , vol.73 , pp. 1117-1132
    • Ottervald, J.1    Franzén, B.2    Nilsson, K.3
  • 14
    • 77957893287 scopus 로고    scopus 로고
    • Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis
    • Stoop MP, Singh V, Dekker LJ, et al. Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. PLoS One 2010, 5:e12442.
    • (2010) PLoS One , vol.5
    • Stoop, M.P.1    Singh, V.2    Dekker, L.J.3
  • 15
    • 79959504808 scopus 로고    scopus 로고
    • Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry
    • Teunissen CE, Koel-Simmelink MJ, Pham TV, et al. Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry. Mult Scler 2011, 17:838-850.
    • (2011) Mult Scler , vol.17 , pp. 838-850
    • Teunissen, C.E.1    Koel-Simmelink, M.J.2    Pham, T.V.3
  • 16
    • 35148898851 scopus 로고    scopus 로고
    • Cleavage of cystatin C is not associated with multiple sclerosis
    • Del Boccio P, Pieragostino D, Lugaresi A, et al. Cleavage of cystatin C is not associated with multiple sclerosis. Ann Neurol 2007, 62:201-204.
    • (2007) Ann Neurol , vol.62 , pp. 201-204
    • Del Boccio, P.1    Pieragostino, D.2    Lugaresi, A.3
  • 17
    • 84859897019 scopus 로고    scopus 로고
    • MiRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing
    • Guerau-de-Arellano M, Alder H, Ozer HG, Lovett-Racke A, Racke MK miRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing. J Neuroimmunol 2012, 248:32-39.
    • (2012) J Neuroimmunol , vol.248 , pp. 32-39
    • Guerau-de-Arellano, M.1    Alder, H.2    Ozer, H.G.3    Lovett-Racke, A.4    Racke, M.K.5
  • 18
    • 80053305225 scopus 로고    scopus 로고
    • Evaluation of soluble HLA-G as a biomarker for multiple sclerosis
    • Waschbisch A, Sandbrink R, Hartung HP, et al. Evaluation of soluble HLA-G as a biomarker for multiple sclerosis. Neurology 2011, 77:596-598.
    • (2011) Neurology , vol.77 , pp. 596-598
    • Waschbisch, A.1    Sandbrink, R.2    Hartung, H.P.3
  • 19
    • 48249103960 scopus 로고    scopus 로고
    • Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis
    • Lindsey JW, Crawford MP, Hatfield LM Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis. Neurology 2008, 71:35-37.
    • (2008) Neurology , vol.71 , pp. 35-37
    • Lindsey, J.W.1    Crawford, M.P.2    Hatfield, L.M.3
  • 20
    • 33846449107 scopus 로고    scopus 로고
    • Lack of association between antimyelin antibodies and progression to multiple sclerosis
    • Kuhle J, Pohl C, Mehling M, et al. Lack of association between antimyelin antibodies and progression to multiple sclerosis. N Engl J Med 2007, 356:371-378.
    • (2007) N Engl J Med , vol.356 , pp. 371-378
    • Kuhle, J.1    Pohl, C.2    Mehling, M.3
  • 21
    • 80053425015 scopus 로고    scopus 로고
    • Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis
    • Correale J, Fiol M Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis. Mult Scler 2011, 17:521-531.
    • (2011) Mult Scler , vol.17 , pp. 521-531
    • Correale, J.1    Fiol, M.2
  • 22
    • 50149102578 scopus 로고    scopus 로고
    • Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
    • Corvol JC, Pelletier D, Henry RG, et al. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci USA 2008, 105:11839-11844.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11839-11844
    • Corvol, J.C.1    Pelletier, D.2    Henry, R.G.3
  • 23
    • 11144312293 scopus 로고    scopus 로고
    • Tau protein and 14-3-3 are elevated in the cerebrospinal fluid of patients with multiple sclerosis and correlate with intrathecal synthesis of IgG
    • Bartosik-Psujek H, Archelos JJ Tau protein and 14-3-3 are elevated in the cerebrospinal fluid of patients with multiple sclerosis and correlate with intrathecal synthesis of IgG. J Neurol 2004, 251:414-420.
    • (2004) J Neurol , vol.251 , pp. 414-420
    • Bartosik-Psujek, H.1    Archelos, J.J.2
  • 24
    • 33744780989 scopus 로고    scopus 로고
    • Tau protein seems not to be a useful routine clinical marker of axonal damage in multiple sclerosis
    • Guimarães I, Cardoso MI, Sá MJ Tau protein seems not to be a useful routine clinical marker of axonal damage in multiple sclerosis. Mult Scler 2006, 12:354-356.
    • (2006) Mult Scler , vol.12 , pp. 354-356
    • Guimarães, I.1    Cardoso, M.I.2    Sá, M.J.3
  • 25
    • 0037076504 scopus 로고    scopus 로고
    • Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit
    • Silber E, Semra YK, Gregson NA, Sharief MK Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit. Neurology 2002, 58:1372-1381.
    • (2002) Neurology , vol.58 , pp. 1372-1381
    • Silber, E.1    Semra, Y.K.2    Gregson, N.A.3    Sharief, M.K.4
  • 27
    • 77954080093 scopus 로고    scopus 로고
    • Upregulation of K2P5.1 potassium channels in multiple sclerosis
    • Bittner S, Bobak N, Herrmann AM, et al. Upregulation of K2P5.1 potassium channels in multiple sclerosis. Ann Neurol 2010, 68:58-69.
    • (2010) Ann Neurol , vol.68 , pp. 58-69
    • Bittner, S.1    Bobak, N.2    Herrmann, A.M.3
  • 28
    • 40849094272 scopus 로고    scopus 로고
    • Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis
    • Byun E, Caillier SJ, Montalban X, et al. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol 2008, 65:337-344.
    • (2008) Arch Neurol , vol.65 , pp. 337-344
    • Byun, E.1    Caillier, S.J.2    Montalban, X.3
  • 29
    • 68549085471 scopus 로고    scopus 로고
    • Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis
    • Comabella M, Craig DW, Morcillo-Suárez C, et al. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. Arch Neurol 2009, 66:972-978.
    • (2009) Arch Neurol , vol.66 , pp. 972-978
    • Comabella, M.1    Craig, D.W.2    Morcillo-Suárez, C.3
  • 30
    • 84862741487 scopus 로고    scopus 로고
    • Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS
    • Bushnell SE, Zhao Z, Stebbins CC, et al. Serum IL-17F does not predict poor response to IM IFNβ-1a in relapsing-remitting MS. Neurology 2012, 79:531-537.
    • (2012) Neurology , vol.79 , pp. 531-537
    • Bushnell, S.E.1    Zhao, Z.2    Stebbins, C.C.3
  • 31
    • 2942752168 scopus 로고    scopus 로고
    • An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study
    • Sundström P, Juto P, Wadell G, et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology 2004, 62:2277-2282.
    • (2004) Neurology , vol.62 , pp. 2277-2282
    • Sundström, P.1    Juto, P.2    Wadell, G.3
  • 32
    • 33745107637 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up
    • DeLorenze GN, Munger KL, Lennette ET, Orentreich N, Vogelman JH, Ascherio A Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-up. Arch Neurol 2006, 63:839-844.
    • (2006) Arch Neurol , vol.63 , pp. 839-844
    • DeLorenze, G.N.1    Munger, K.L.2    Lennette, E.T.3    Orentreich, N.4    Vogelman, J.H.5    Ascherio, A.6
  • 33
    • 80053608697 scopus 로고    scopus 로고
    • Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel
    • Munger KL, Levin LI, O'Reilly EJ, Falk KI, Ascherio A Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult Scler 2011, 17:1185-1193.
    • (2011) Mult Scler , vol.17 , pp. 1185-1193
    • Munger, K.L.1    Levin, L.I.2    O'Reilly, E.J.3    Falk, K.I.4    Ascherio, A.5
  • 35
    • 56349116633 scopus 로고    scopus 로고
    • Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis
    • Presslauer S, Milosavljevic D, Brücke T, Bayer P, Hübl W Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol 2008, 255:1508-1514.
    • (2008) J Neurol , vol.255 , pp. 1508-1514
    • Presslauer, S.1    Milosavljevic, D.2    Brücke, T.3    Bayer, P.4    Hübl, W.5
  • 37
    • 85047691237 scopus 로고    scopus 로고
    • Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
    • Villar LM, Sádaba MC, Roldán E, et al. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J Clin Invest 2005, 115:187-194.
    • (2005) J Clin Invest , vol.115 , pp. 187-194
    • Villar, L.M.1    Sádaba, M.C.2    Roldán, E.3
  • 38
    • 79953216040 scopus 로고    scopus 로고
    • Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM
    • Sola P, Mandrioli J, Simone AM, et al. Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM. Mult Scler 2011, 17:303-311.
    • (2011) Mult Scler , vol.17 , pp. 303-311
    • Sola, P.1    Mandrioli, J.2    Simone, A.M.3
  • 39
    • 84857060090 scopus 로고    scopus 로고
    • Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes
    • Magraner MJ, Bosca I, Simó-Castelló M, et al. Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes. Neuroradiology 2012, 54:5-12.
    • (2012) Neuroradiology , vol.54 , pp. 5-12
    • Magraner, M.J.1    Bosca, I.2    Simó-Castelló, M.3
  • 40
    • 84860436777 scopus 로고    scopus 로고
    • Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual
    • Durante L, Zaaraoui W, Rico A, et al. Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual. Mult Scler 2012, 18:587-591.
    • (2012) Mult Scler , vol.18 , pp. 587-591
    • Durante, L.1    Zaaraoui, W.2    Rico, A.3
  • 41
    • 84875805250 scopus 로고    scopus 로고
    • Cerebrospinal fluid oligoclonal IgM bands predict early conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome
    • Ferraro D, Simone AM, Bedin R, et al. Cerebrospinal fluid oligoclonal IgM bands predict early conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome. J Neuroimmunol 2013, 257:76-81.
    • (2013) J Neuroimmunol , vol.257 , pp. 76-81
    • Ferraro, D.1    Simone, A.M.2    Bedin, R.3
  • 42
    • 0036225541 scopus 로고    scopus 로고
    • The role of NCAM in remyelination
    • Massaro AR The role of NCAM in remyelination. Neurol Sci 2002, 22:429-435.
    • (2002) Neurol Sci , vol.22 , pp. 429-435
    • Massaro, A.R.1
  • 43
    • 27744497956 scopus 로고    scopus 로고
    • Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes
    • Strekalova H, Buhmann C, Kleene R, et al. Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes. Neurobiol Aging 2006, 27:1-9.
    • (2006) Neurobiol Aging , vol.27 , pp. 1-9
    • Strekalova, H.1    Buhmann, C.2    Kleene, R.3
  • 44
    • 77955665202 scopus 로고    scopus 로고
    • Neural cell adhesion molecule-description of a CSF ELISA method and evidence of reduced levels in selected neurological disorders
    • Gnanapavan S, Grant D, Illes-Toth E, Lakdawala N, Keir G, Giovannoni G Neural cell adhesion molecule-description of a CSF ELISA method and evidence of reduced levels in selected neurological disorders. J Neuroimmunol 2010, 225:118-122.
    • (2010) J Neuroimmunol , vol.225 , pp. 118-122
    • Gnanapavan, S.1    Grant, D.2    Illes-Toth, E.3    Lakdawala, N.4    Keir, G.5    Giovannoni, G.6
  • 45
    • 0032698655 scopus 로고    scopus 로고
    • Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease
    • Giovannoni G, Silver NC, O'Riordan J, et al. Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. Mult Scler 1999, 5:335-341.
    • (1999) Mult Scler , vol.5 , pp. 335-341
    • Giovannoni, G.1    Silver, N.C.2    O'Riordan, J.3
  • 46
    • 0033397459 scopus 로고    scopus 로고
    • Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker
    • Brundin L, Morcos E, Olsson T, Wiklund NP, Andersson M Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker. Eur J Neurol 1999, 6:585-590.
    • (1999) Eur J Neurol , vol.6 , pp. 585-590
    • Brundin, L.1    Morcos, E.2    Olsson, T.3    Wiklund, N.P.4    Andersson, M.5
  • 48
    • 7044253039 scopus 로고    scopus 로고
    • CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis
    • Rejdak K, Eikelenboom MJ, Petzold A, et al. CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis. Neurology 2004, 63:1439-1445.
    • (2004) Neurology , vol.63 , pp. 1439-1445
    • Rejdak, K.1    Eikelenboom, M.J.2    Petzold, A.3
  • 49
    • 0037435501 scopus 로고    scopus 로고
    • IFN-beta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS
    • Waubant E, Goodkin D, Bostrom A, et al. IFN-beta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS. Neurology 2003, 60:52-57.
    • (2003) Neurology , vol.60 , pp. 52-57
    • Waubant, E.1    Goodkin, D.2    Bostrom, A.3
  • 50
    • 0037333750 scopus 로고    scopus 로고
    • Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes
    • Avolio C, Ruggieri M, Giuliani F, et al. Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes. J Neuroimmunol 2003, 136:46-53.
    • (2003) J Neuroimmunol , vol.136 , pp. 46-53
    • Avolio, C.1    Ruggieri, M.2    Giuliani, F.3
  • 51
    • 33744811943 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis
    • Fainardi E, Castellazzi M, Bellini T, et al. Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis. Mult Scler 2006, 12:294-301.
    • (2006) Mult Scler , vol.12 , pp. 294-301
    • Fainardi, E.1    Castellazzi, M.2    Bellini, T.3
  • 52
    • 61849164425 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis
    • Benesová Y, Vasku A, Novotná H, et al. Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis. Mult Scler 2009, 15:316-322.
    • (2009) Mult Scler , vol.15 , pp. 316-322
    • Benesová, Y.1    Vasku, A.2    Novotná, H.3
  • 53
    • 0018898166 scopus 로고
    • Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders
    • Whitaker JN, Lisak RP, Bashir RM, et al. Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders. Ann Neurol 1980, 7:58-64.
    • (1980) Ann Neurol , vol.7 , pp. 58-64
    • Whitaker, J.N.1    Lisak, R.P.2    Bashir, R.M.3
  • 54
    • 0026529002 scopus 로고
    • A correlative triad of gadolinium-DTPA MRI, EDSS, and CSF-MBP in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone
    • Barkhof F, Frequin ST, Hommes OR, et al. A correlative triad of gadolinium-DTPA MRI, EDSS, and CSF-MBP in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone. Neurology 1992, 42:63-67.
    • (1992) Neurology , vol.42 , pp. 63-67
    • Barkhof, F.1    Frequin, S.T.2    Hommes, O.R.3
  • 55
    • 0031661556 scopus 로고    scopus 로고
    • Myelin basic protein in CSF as indicator of disease activity in multiple sclerosis
    • Lamers KJ, de Reus HP, Jongen PJ Myelin basic protein in CSF as indicator of disease activity in multiple sclerosis. Mult Scler 1998, 4:124-126.
    • (1998) Mult Scler , vol.4 , pp. 124-126
    • Lamers, K.J.1    de Reus, H.P.2    Jongen, P.J.3
  • 56
    • 4444307798 scopus 로고    scopus 로고
    • Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients
    • Vogt MH, Floris S, Killestein J, et al. Osteopontin levels and increased disease activity in relapsing-remitting multiple sclerosis patients. J Neuroimmunol 2004, 155:155-160.
    • (2004) J Neuroimmunol , vol.155 , pp. 155-160
    • Vogt, M.H.1    Floris, S.2    Killestein, J.3
  • 57
    • 10344246601 scopus 로고    scopus 로고
    • Plasma osteopontin levels in multiple sclerosis
    • Comabella M, Pericot I, Goertsches R, et al. Plasma osteopontin levels in multiple sclerosis. J Neuroimmunol 2005, 158:231-239.
    • (2005) J Neuroimmunol , vol.158 , pp. 231-239
    • Comabella, M.1    Pericot, I.2    Goertsches, R.3
  • 58
    • 78650973099 scopus 로고    scopus 로고
    • Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
    • Börnsen L, Khademi M, Olsson T, Sørensen PS, Sellebjerg F Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis. Mult Scler 2011, 17:32-42.
    • (2011) Mult Scler , vol.17 , pp. 32-42
    • Börnsen, L.1    Khademi, M.2    Olsson, T.3    Sørensen, P.S.4    Sellebjerg, F.5
  • 59
    • 73349109797 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS
    • Sellebjerg F, Börnsen L, Khademi M, et al. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 2009, 73:2003-2010.
    • (2009) Neurology , vol.73 , pp. 2003-2010
    • Sellebjerg, F.1    Börnsen, L.2    Khademi, M.3
  • 60
    • 79953179371 scopus 로고    scopus 로고
    • Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course
    • Khademi M, Kockum I, Andersson ML, et al. Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course. Mult Scler 2011, 17:335-343.
    • (2011) Mult Scler , vol.17 , pp. 335-343
    • Khademi, M.1    Kockum, I.2    Andersson, M.L.3
  • 61
    • 79959494654 scopus 로고    scopus 로고
    • Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid
    • Ragheb S, Li Y, Simon K, et al. Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid. Mult Scler 2011, 17:819-829.
    • (2011) Mult Scler , vol.17 , pp. 819-829
    • Ragheb, S.1    Li, Y.2    Simon, K.3
  • 62
    • 0036314155 scopus 로고    scopus 로고
    • Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations
    • Petzold A, Eikelenboom MJ, Gveric D, et al. Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Brain 2002, 125:1462-1473.
    • (2002) Brain , vol.125 , pp. 1462-1473
    • Petzold, A.1    Eikelenboom, M.J.2    Gveric, D.3
  • 64
    • 79959967979 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis
    • Axelsson M, Malmeström C, Nilsson S, Haghighi S, Rosengren L, Lycke J Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. J Neurol 2011, 258:882-888.
    • (2011) J Neurol , vol.258 , pp. 882-888
    • Axelsson, M.1    Malmeström, C.2    Nilsson, S.3    Haghighi, S.4    Rosengren, L.5    Lycke, J.6
  • 65
    • 0036849269 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in patients with multiple sclerosis
    • Sarchielli P, Greco L, Stipa A, Floridi A, Gallai V Brain-derived neurotrophic factor in patients with multiple sclerosis. J Neuroimmunol 2002, 132:180-188.
    • (2002) J Neuroimmunol , vol.132 , pp. 180-188
    • Sarchielli, P.1    Greco, L.2    Stipa, A.3    Floridi, A.4    Gallai, V.5
  • 66
    • 23844458919 scopus 로고    scopus 로고
    • Neurotrophic factors and clinical recovery in relapsing-remitting multiple sclerosis
    • Caggiula M, Batocchi AP, Frisullo G, et al. Neurotrophic factors and clinical recovery in relapsing-remitting multiple sclerosis. Scand J Immunol 2005, 62:176-182.
    • (2005) Scand J Immunol , vol.62 , pp. 176-182
    • Caggiula, M.1    Batocchi, A.P.2    Frisullo, G.3
  • 67
    • 67349243002 scopus 로고    scopus 로고
    • Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse
    • Frota ER, Rodrigues DH, Donadi EA, Brum DG, Maciel DR, Teixeira AL Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse. Neurosci Lett 2009, 460:130-132.
    • (2009) Neurosci Lett , vol.460 , pp. 130-132
    • Frota, E.R.1    Rodrigues, D.H.2    Donadi, E.A.3    Brum, D.G.4    Maciel, D.R.5    Teixeira, A.L.6
  • 68
    • 84863649686 scopus 로고    scopus 로고
    • Potassium channel KIR4.1 as an immune target in multiple sclerosis
    • Srivastava R, Aslam M, Kalluri SR, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med 2012, 367:115-123.
    • (2012) N Engl J Med , vol.367 , pp. 115-123
    • Srivastava, R.1    Aslam, M.2    Kalluri, S.R.3
  • 69
    • 0002348524 scopus 로고    scopus 로고
    • Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The Optic Neuritis Study Group
    • Tumani H, Tourtellotte WW, Peter JB, Felgenhauer K Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The Optic Neuritis Study Group. J Neurol Sci 1998, 155:44-49.
    • (1998) J Neurol Sci , vol.155 , pp. 44-49
    • Tumani, H.1    Tourtellotte, W.W.2    Peter, J.B.3    Felgenhauer, K.4
  • 70
    • 70450179954 scopus 로고    scopus 로고
    • IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome
    • Brettschneider J, Tumani H, Kiechle U, et al. IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome. PLoS One 2009, 4:e7638.
    • (2009) PLoS One , vol.4
    • Brettschneider, J.1    Tumani, H.2    Kiechle, U.3
  • 71
    • 77950854119 scopus 로고    scopus 로고
    • Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis
    • Comabella M, Fernández M, Martin R, et al. Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis. Brain 2010, 133:1082-1093.
    • (2010) Brain , vol.133 , pp. 1082-1093
    • Comabella, M.1    Fernández, M.2    Martin, R.3
  • 72
    • 77952991177 scopus 로고    scopus 로고
    • Complement regulator factor H as a serum biomarker of multiple sclerosis disease state
    • Ingram G, Hakobyan S, Hirst CL, et al. Complement regulator factor H as a serum biomarker of multiple sclerosis disease state. Brain 2010, 133:1602-1611.
    • (2010) Brain , vol.133 , pp. 1602-1611
    • Ingram, G.1    Hakobyan, S.2    Hirst, C.L.3
  • 73
    • 72649106903 scopus 로고    scopus 로고
    • A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis
    • Comabella M, Lünemann JD, Río J, et al. A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain 2009, 132:3353-3365.
    • (2009) Brain , vol.132 , pp. 3353-3365
    • Comabella, M.1    Lünemann, J.D.2    Río, J.3
  • 74
    • 69549135691 scopus 로고    scopus 로고
    • Glypican 5 is an interferon-beta response gene: a replication study
    • Cenit MD, Blanco-Kelly F, de las Heras V, et al. Glypican 5 is an interferon-beta response gene: a replication study. Mult Scler 2009, 15:913-917.
    • (2009) Mult Scler , vol.15 , pp. 913-917
    • Cenit, M.D.1    Blanco-Kelly, F.2    de las Heras, V.3
  • 75
    • 48349093740 scopus 로고    scopus 로고
    • HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis
    • Hoffmann S, Cepok S, Grummel V, et al. HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. Am J Hum Genet 2008, 83:219-227.
    • (2008) Am J Hum Genet , vol.83 , pp. 219-227
    • Hoffmann, S.1    Cepok, S.2    Grummel, V.3
  • 76
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos JS, Friese MA, Craner MJ, et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008, 172:146-155.
    • (2008) Am J Pathol , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3
  • 77
    • 84866740068 scopus 로고    scopus 로고
    • Cerebrospinal fluid BAFF and APRIL levels in neuromyelitis optica and multiple sclerosis patients during relapse
    • Wang H, Wang K, Zhong X, et al. Cerebrospinal fluid BAFF and APRIL levels in neuromyelitis optica and multiple sclerosis patients during relapse. J Clin Immunol 2012, 32:1007-1011.
    • (2012) J Clin Immunol , vol.32 , pp. 1007-1011
    • Wang, H.1    Wang, K.2    Zhong, X.3
  • 78
    • 79955646245 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: an ongoing story
    • Caminero A, Comabella M, Montalban X Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: an ongoing story. J Neuroimmunol 2011, 234:1-6.
    • (2011) J Neuroimmunol , vol.234 , pp. 1-6
    • Caminero, A.1    Comabella, M.2    Montalban, X.3
  • 79
    • 78650178184 scopus 로고    scopus 로고
    • Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?
    • Lovett-Racke AE, Yang Y, Racke MK Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?. Biochim Biophys Acta 2011, 1812:246-251.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 246-251
    • Lovett-Racke, A.E.1    Yang, Y.2    Racke, M.K.3
  • 80
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • The ANZgene Consortium
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 2009, 41:824-828. The ANZgene Consortium.
    • (2009) Nat Genet , vol.41 , pp. 824-828
  • 81
    • 58949099391 scopus 로고    scopus 로고
    • Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    • Baranzini SE, Wang J, Gibson RA, et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 2009, 18:767-778.
    • (2009) Hum Mol Genet , vol.18 , pp. 767-778
    • Baranzini, S.E.1    Wang, J.2    Gibson, R.A.3
  • 82
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, Jia X, Wang J, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009, 41:776-782.
    • (2009) Nat Genet , vol.41 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3
  • 83
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219. International Multiple Sclerosis Genetics Consortium.
    • (2011) Nature , vol.476 , pp. 214-219
  • 84
    • 79954568567 scopus 로고    scopus 로고
    • Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis
    • Kuhle J, Leppert D, Petzold A, et al. Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis. Neurology 2011, 76:1206-1213.
    • (2011) Neurology , vol.76 , pp. 1206-1213
    • Kuhle, J.1    Leppert, D.2    Petzold, A.3
  • 85
    • 25844462863 scopus 로고    scopus 로고
    • Acute axonal damage predicts clinical outcome in patients with multiple sclerosis
    • Lim ET, Sellebjerg F, Jensen CV, et al. Acute axonal damage predicts clinical outcome in patients with multiple sclerosis. Mult Scler 2005, 11:532-536.
    • (2005) Mult Scler , vol.11 , pp. 532-536
    • Lim, E.T.1    Sellebjerg, F.2    Jensen, C.V.3
  • 86
    • 33645806333 scopus 로고    scopus 로고
    • Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis
    • Brettschneider J, Petzold A, Junker A, Tumani H Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis. Mult Scler 2006, 12:143-148.
    • (2006) Mult Scler , vol.12 , pp. 143-148
    • Brettschneider, J.1    Petzold, A.2    Junker, A.3    Tumani, H.4
  • 87
    • 84890808806 scopus 로고    scopus 로고
    • Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis
    • published online May 23.
    • Axelsson M, Malmeström C, Gunnarsson M, et al. Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis. Mult Scler 2013, published online May 23. 10.1177/1352458513490544.
    • (2013) Mult Scler
    • Axelsson, M.1    Malmeström, C.2    Gunnarsson, M.3
  • 88
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006, 296:2832-2838.
    • (2006) JAMA , vol.296 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3    Howard, N.S.4    Ascherio, A.5
  • 89
    • 79954652299 scopus 로고    scopus 로고
    • Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study
    • Banwell B, Bar-Or A, Arnold DL, et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol 2011, 10:436-445.
    • (2011) Lancet Neurol , vol.10 , pp. 436-445
    • Banwell, B.1    Bar-Or, A.2    Arnold, D.L.3
  • 90
    • 84865584614 scopus 로고    scopus 로고
    • Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis
    • Mowry EM, Waubant E, McCulloch CE, et al. Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol 2012, 72:234-240.
    • (2012) Ann Neurol , vol.72 , pp. 234-240
    • Mowry, E.M.1    Waubant, E.2    McCulloch, C.E.3
  • 91
    • 84866106890 scopus 로고    scopus 로고
    • Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS
    • Stewart N, Simpson S, van der Mei I, et al. Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS. Neurology 2012, 79:254-260.
    • (2012) Neurology , vol.79 , pp. 254-260
    • Stewart, N.1    Simpson, S.2    van der Mei, I.3
  • 92
    • 65249138318 scopus 로고    scopus 로고
    • Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
    • Bielekova B, Howard T, Packer AN, et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 2009, 66:483-489.
    • (2009) Arch Neurol , vol.66 , pp. 483-489
    • Bielekova, B.1    Howard, T.2    Packer, A.N.3
  • 93
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta
    • Wynn D, Kaufman M, Montalban X, et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol 2010, 9:381-390.
    • (2010) Lancet Neurol , vol.9 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3
  • 94
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006, 354:899-910.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 95
    • 33644608613 scopus 로고    scopus 로고
    • Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • Rudick RA, Stuart WH, Calabresi PA, et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 2006, 354:911-923.
    • (2006) N Engl J Med , vol.354 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 96
    • 84860396489 scopus 로고    scopus 로고
    • Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab
    • Sørensen PS, Jensen PE, Haghikia A, et al. Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab. Mult Scler 2011, 17:1074-1078.
    • (2011) Mult Scler , vol.17 , pp. 1074-1078
    • Sørensen, P.S.1    Jensen, P.E.2    Haghikia, A.3
  • 97
    • 79959452689 scopus 로고    scopus 로고
    • A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis
    • Holmén C, Piehl F, Hillert J, et al. A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis. Mult Scler 2011, 17:708-719.
    • (2011) Mult Scler , vol.17 , pp. 708-719
    • Holmén, C.1    Piehl, F.2    Hillert, J.3
  • 98
    • 79953177025 scopus 로고    scopus 로고
    • Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months
    • Oliver B, Fernández O, Orpez T, et al. Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months. Mult Scler 2011, 17:368-371.
    • (2011) Mult Scler , vol.17 , pp. 368-371
    • Oliver, B.1    Fernández, O.2    Orpez, T.3
  • 99
    • 84877633406 scopus 로고    scopus 로고
    • Characterization of anti-natalizumab antibodies in multiple sclerosis patients
    • Lundkvist M, Engdahl E, Holmén C, et al. Characterization of anti-natalizumab antibodies in multiple sclerosis patients. Mult Scler 2013, 19:757-764.
    • (2013) Mult Scler , vol.19 , pp. 757-764
    • Lundkvist, M.1    Engdahl, E.2    Holmén, C.3
  • 100
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis
    • Sorensen P, Deisenhammer F, Duda P, et al. Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis. Eur J Neurol 2005, 12:817-827.
    • (2005) Eur J Neurol , vol.12 , pp. 817-827
    • Sorensen, P.1    Deisenhammer, F.2    Duda, P.3
  • 101
    • 34147161297 scopus 로고    scopus 로고
    • Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Goodin D, Frohman E, Hurwitz B, et al. Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2007, 68:977-984.
    • (2007) Neurology , vol.68 , pp. 977-984
    • Goodin, D.1    Frohman, E.2    Hurwitz, B.3
  • 102
    • 77953454473 scopus 로고    scopus 로고
    • Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis
    • Polman C, Bertolotto A, Deisenhammer F, et al. Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurol 2010, 9:740-750.
    • (2010) Lancet Neurol , vol.9 , pp. 740-750
    • Polman, C.1    Bertolotto, A.2    Deisenhammer, F.3
  • 103
    • 20844436120 scopus 로고    scopus 로고
    • Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement
    • Freedman MS, Thompson EJ, Deisenhammer F, et al. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement. Arch Neurol 2005, 62:865-870.
    • (2005) Arch Neurol , vol.62 , pp. 865-870
    • Freedman, M.S.1    Thompson, E.J.2    Deisenhammer, F.3
  • 104
    • 33750604563 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness
    • Link H, Huang YM Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol 2006, 180:17-28.
    • (2006) J Neuroimmunol , vol.180 , pp. 17-28
    • Link, H.1    Huang, Y.M.2
  • 106
    • 10344250945 scopus 로고    scopus 로고
    • A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    • Lennon V, Wingerchuk D, Kryzer T, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004, 364:2106-2112.
    • (2004) Lancet , vol.364 , pp. 2106-2112
    • Lennon, V.1    Wingerchuk, D.2    Kryzer, T.3
  • 108
    • 84861022041 scopus 로고    scopus 로고
    • Risk of natalizumab-associated progressive multifocal leukoencephalopathy
    • Bloomgren G, Richman S, Hotermans C, et al. Risk of natalizumab-associated progressive multifocal leukoencephalopathy. N Engl J Med 2012, 366:1870-1880.
    • (2012) N Engl J Med , vol.366 , pp. 1870-1880
    • Bloomgren, G.1    Richman, S.2    Hotermans, C.3
  • 110
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132:3329-3341.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 111
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS, MRI Analysis GroupMRI Analysis Group
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 1999, 53:457-465. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS, MRI Analysis GroupMRI Analysis Group.
    • (1999) Neurology , vol.53 , pp. 457-465
  • 112
    • 80052926089 scopus 로고    scopus 로고
    • Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination
    • Brambilla R, Ashbaugh JJ, Magliozzi R, et al. Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain 2011, 134:2736-2754.
    • (2011) Brain , vol.134 , pp. 2736-2754
    • Brambilla, R.1    Ashbaugh, J.J.2    Magliozzi, R.3
  • 113
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    • Segal BM, Constantinescu CS, Raychaudhuri A, et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol 2008, 7:796-804.
    • (2008) Lancet Neurol , vol.7 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3
  • 114
    • 66449113393 scopus 로고    scopus 로고
    • Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?
    • Longbrake EE, Racke MK Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?. Expert Rev Neurother 2009, 9:319-321.
    • (2009) Expert Rev Neurother , vol.9 , pp. 319-321
    • Longbrake, E.E.1    Racke, M.K.2
  • 115
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. International Multiple Sclerosis Genetics Consortium (IMSGC)
    • for the International Multiple Sclerosis Genetics Consortium (IMSGC)
    • Beecham AH, Patsopoulos NA, Xifara DK Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. International Multiple Sclerosis Genetics Consortium (IMSGC). Nat Genet 2013, 45:1353-1360. for the International Multiple Sclerosis Genetics Consortium (IMSGC).
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3
  • 116
    • 79551484517 scopus 로고    scopus 로고
    • Aggregation of multiple sclerosis genetic risk variants in multiple and single case families
    • Gourraud PA, McElroy JP, Caillier SJ, et al. Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol 2011, 69:65-74.
    • (2011) Ann Neurol , vol.69 , pp. 65-74
    • Gourraud, P.A.1    McElroy, J.P.2    Caillier, S.J.3
  • 117
    • 33645812129 scopus 로고    scopus 로고
    • Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    • Bielekova B, Catalfamo M, Reichert-Scrivner S, et al. Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci USA 2006, 103:5941-5946.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5941-5946
    • Bielekova, B.1    Catalfamo, M.2    Reichert-Scrivner, S.3
  • 118
    • 82955225356 scopus 로고    scopus 로고
    • Intrathecal effects of daclizumab treatment of multiple sclerosis
    • Bielekova B, Richert N, Herman ML, et al. Intrathecal effects of daclizumab treatment of multiple sclerosis. Neurology 2011, 77:1877-1886.
    • (2011) Neurology , vol.77 , pp. 1877-1886
    • Bielekova, B.1    Richert, N.2    Herman, M.L.3
  • 119
    • 34848816850 scopus 로고    scopus 로고
    • The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
    • Calabresi PA, Giovannoni G, Confavreux C, et al. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 2007, 69:1391-1403.
    • (2007) Neurology , vol.69 , pp. 1391-1403
    • Calabresi, P.A.1    Giovannoni, G.2    Confavreux, C.3
  • 120
    • 0037432257 scopus 로고    scopus 로고
    • Neuromyelitis optica: clinical predictors of a relapsing course and survival
    • Wingerchuk DM, Weinshenker BG Neuromyelitis optica: clinical predictors of a relapsing course and survival. Neurology 2003, 60:848-853.
    • (2003) Neurology , vol.60 , pp. 848-853
    • Wingerchuk, D.M.1    Weinshenker, B.G.2
  • 121
    • 83255193049 scopus 로고    scopus 로고
    • Anti-John Cunnigham virus antibody prevalence in multiple sclerosis patients: baseline results of STRATIFY-1
    • Bozic C, Richman S, Plavina T, et al. Anti-John Cunnigham virus antibody prevalence in multiple sclerosis patients: baseline results of STRATIFY-1. Ann Neurol 2011, 70:742-750.
    • (2011) Ann Neurol , vol.70 , pp. 742-750
    • Bozic, C.1    Richman, S.2    Plavina, T.3
  • 122
  • 124
    • 0032893876 scopus 로고    scopus 로고
    • Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies
    • Deisenhammer F, Reindl M, Harvey J, Gasse T, Dilitz E, Berger T Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies. Neurology 1999, 52:1239-1243.
    • (1999) Neurology , vol.52 , pp. 1239-1243
    • Deisenhammer, F.1    Reindl, M.2    Harvey, J.3    Gasse, T.4    Dilitz, E.5    Berger, T.6
  • 125
    • 0037465461 scopus 로고    scopus 로고
    • Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients
    • Bertolotto A, Gilli F, Sala A, et al. Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. Neurology 2003, 60:634-639.
    • (2003) Neurology , vol.60 , pp. 634-639
    • Bertolotto, A.1    Gilli, F.2    Sala, A.3
  • 126
    • 68249162126 scopus 로고    scopus 로고
    • Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity
    • Hesse D, Sellebjerg F, Sorensen P Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity. Neurology 2009, 73:372-377.
    • (2009) Neurology , vol.73 , pp. 372-377
    • Hesse, D.1    Sellebjerg, F.2    Sorensen, P.3
  • 127
    • 41549098712 scopus 로고    scopus 로고
    • Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
    • Tintoré M, Rovira A, Río J, et al. Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?. Neurology 2008, 70:1079-1083.
    • (2008) Neurology , vol.70 , pp. 1079-1083
    • Tintoré, M.1    Rovira, A.2    Río, J.3
  • 128
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011, 69:292-302.
    • (2011) Ann Neurol , vol.69 , pp. 292-302
    • Polman, C.H.1    Reingold, S.C.2    Banwell, B.3
  • 130
    • 34247093688 scopus 로고    scopus 로고
    • Immunosuppressive therapy is more effective than interferon in neuromyelitis optica
    • Papeix C, Vidal J-S, de Seze J, et al. Immunosuppressive therapy is more effective than interferon in neuromyelitis optica. Mult Scler 2007, 13:255-259.
    • (2007) Mult Scler , vol.13 , pp. 255-259
    • Papeix, C.1    Vidal, J.-S.2    de Seze, J.3
  • 131
    • 33845439133 scopus 로고    scopus 로고
    • Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination
    • Warabi Y, Matsumoto Y, Hayashi H Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination. J Neurol Sci 2007, 252:257-261.
    • (2007) J Neurol Sci , vol.252 , pp. 257-261
    • Warabi, Y.1    Matsumoto, Y.2    Hayashi, H.3
  • 132
    • 77949279537 scopus 로고    scopus 로고
    • Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases
    • Clifford DB, De Luca A, Simpson DM, Arendt G, Giovannoni G, Nath A Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol 2010, 9:438-446.
    • (2010) Lancet Neurol , vol.9 , pp. 438-446
    • Clifford, D.B.1    De Luca, A.2    Simpson, D.M.3    Arendt, G.4    Giovannoni, G.5    Nath, A.6
  • 133
    • 77956387401 scopus 로고    scopus 로고
    • Anti-JC virus antibodies: implications for PML risk stratification
    • Gorelik L, Lerner M, Bixler S, et al. Anti-JC virus antibodies: implications for PML risk stratification. Ann Neurol 2010, 68:295-303.
    • (2010) Ann Neurol , vol.68 , pp. 295-303
    • Gorelik, L.1    Lerner, M.2    Bixler, S.3
  • 134
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010, 362:402-415.
    • (2010) N Engl J Med , vol.362 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 135
    • 79953185422 scopus 로고    scopus 로고
    • Primary varicella zoster infection associated with fingolimod treatment
    • Uccelli A, Ginocchio F, Mancardi GL, Bassetti M Primary varicella zoster infection associated with fingolimod treatment. Neurology 2011, 76:1023-1024.
    • (2011) Neurology , vol.76 , pp. 1023-1024
    • Uccelli, A.1    Ginocchio, F.2    Mancardi, G.L.3    Bassetti, M.4
  • 136
    • 75049084206 scopus 로고    scopus 로고
    • Measles outbreak in Barcelona. Clinical and epidemiological characteristics
    • Monfort L, Muñoz D, Trenchs V, et al. Measles outbreak in Barcelona. Clinical and epidemiological characteristics. Enferm Infecc Microbiol Clin 2010, 28:82-86.
    • (2010) Enferm Infecc Microbiol Clin , vol.28 , pp. 82-86
    • Monfort, L.1    Muñoz, D.2    Trenchs, V.3
  • 137
    • 0036273146 scopus 로고    scopus 로고
    • Effect of feeding on bone turnover markers and its impact on biological variability of measurements
    • Clowes JA, Hannon RA, Yap TS, Hoyle NR, Blumsohn A, Eastell R Effect of feeding on bone turnover markers and its impact on biological variability of measurements. Bone 2002, 30:886-890.
    • (2002) Bone , vol.30 , pp. 886-890
    • Clowes, J.A.1    Hannon, R.A.2    Yap, T.S.3    Hoyle, N.R.4    Blumsohn, A.5    Eastell, R.6
  • 139
    • 84862800136 scopus 로고    scopus 로고
    • Anticoagulants affect matrix metalloproteinase 9 levels in blood samples of stroke patients and healthy controls
    • Rababah M, Worthmann H, Deb M, et al. Anticoagulants affect matrix metalloproteinase 9 levels in blood samples of stroke patients and healthy controls. Clin Biochem 2012, 45:483-489.
    • (2012) Clin Biochem , vol.45 , pp. 483-489
    • Rababah, M.1    Worthmann, H.2    Deb, M.3
  • 140
    • 84873899437 scopus 로고    scopus 로고
    • Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood
    • Nikula T, Mykkänen J, Simell O, Lahesmaa R Genome-wide comparison of two RNA-stabilizing reagents for transcriptional profiling of peripheral blood. Transl Res 2013, 161:181-188.
    • (2013) Transl Res , vol.161 , pp. 181-188
    • Nikula, T.1    Mykkänen, J.2    Simell, O.3    Lahesmaa, R.4
  • 141
    • 73349120602 scopus 로고    scopus 로고
    • A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
    • Teunissen CE, Petzold A, Bennett JL, et al. A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking. Neurology 2009, 73:1914-1922.
    • (2009) Neurology , vol.73 , pp. 1914-1922
    • Teunissen, C.E.1    Petzold, A.2    Bennett, J.L.3
  • 142
    • 35148822472 scopus 로고    scopus 로고
    • Pre-analytical influence on the low molecular weight cerebrospinal fluid proteome
    • Berven FS, Kroksveen AC, Berle M, et al. Pre-analytical influence on the low molecular weight cerebrospinal fluid proteome. Proteomics Clin Appl 2007, 1:699-711.
    • (2007) Proteomics Clin Appl , vol.1 , pp. 699-711
    • Berven, F.S.1    Kroksveen, A.C.2    Berle, M.3
  • 144
    • 33645519115 scopus 로고    scopus 로고
    • The effects of test temperature and storage temperature on platelet aggregation: a whole blood in vitro study
    • Scharbert G, Kalb M, Marschalek C, Kozek-Langenecker SA The effects of test temperature and storage temperature on platelet aggregation: a whole blood in vitro study. Anesth Analg 2006, 102:1280-1284.
    • (2006) Anesth Analg , vol.102 , pp. 1280-1284
    • Scharbert, G.1    Kalb, M.2    Marschalek, C.3    Kozek-Langenecker, S.A.4
  • 145
    • 0042367742 scopus 로고    scopus 로고
    • Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment
    • Ledue TB, Rifai N Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment. Clin Chem 2003, 49:1258-1271.
    • (2003) Clin Chem , vol.49 , pp. 1258-1271
    • Ledue, T.B.1    Rifai, N.2
  • 147
    • 78650328715 scopus 로고    scopus 로고
    • The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers
    • Zhang Z, Chan DW The road from discovery to clinical diagnostics: lessons learned from the first FDA-cleared in vitro diagnostic multivariate index assay of proteomic biomarkers. Cancer Epidemiol Biomarkers Prev 2010, 19:2995-2999.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2995-2999
    • Zhang, Z.1    Chan, D.W.2
  • 148
    • 34347248415 scopus 로고    scopus 로고
    • Genomics in multiple sclerosis-current state and future directions
    • Comabella M, Martin R Genomics in multiple sclerosis-current state and future directions. J Neuroimmunol 2007, 187:1-8.
    • (2007) J Neuroimmunol , vol.187 , pp. 1-8
    • Comabella, M.1    Martin, R.2
  • 149
    • 84887524454 scopus 로고    scopus 로고
    • Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis
    • published online May 21.
    • Teunissen C, Menge T, Altintas A, et al. Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis. Mult Scler 2013, published online May 21. 10.1177/1352458513488232.
    • (2013) Mult Scler
    • Teunissen, C.1    Menge, T.2    Altintas, A.3
  • 150
    • 83255181788 scopus 로고    scopus 로고
    • Pharmacogenomics in neurology: current state and future steps
    • Chan A, Pirmohamed M, Comabella M Pharmacogenomics in neurology: current state and future steps. Ann Neurol 2011, 70:684-697.
    • (2011) Ann Neurol , vol.70 , pp. 684-697
    • Chan, A.1    Pirmohamed, M.2    Comabella, M.3
  • 151
    • 58149122959 scopus 로고    scopus 로고
    • The complex genetics of multiple sclerosis: pitfalls and prospects
    • Sawcer S The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 2008, 131:3118-3131.
    • (2008) Brain , vol.131 , pp. 3118-3131
    • Sawcer, S.1
  • 152
    • 33744786784 scopus 로고    scopus 로고
    • Errors in clinical laboratories or errors in laboratory medicine?
    • Plebani M Errors in clinical laboratories or errors in laboratory medicine?. Clin Chem Lab Med 2006, 44:750-759.
    • (2006) Clin Chem Lab Med , vol.44 , pp. 750-759
    • Plebani, M.1
  • 153
    • 33846563409 scopus 로고    scopus 로고
    • Why most published research findings are false
    • Ioannidis JP Why most published research findings are false. PLoS Med 2005, 2:e124.
    • (2005) PLoS Med , vol.2
    • Ioannidis, J.P.1
  • 154
    • 33846240326 scopus 로고    scopus 로고
    • Statistical strategies for avoiding false discoveries in metabolomics and related experiments
    • Broadhurst DI, Kell DB Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2007, 2:171-196.
    • (2007) Metabolomics , vol.2 , pp. 171-196
    • Broadhurst, D.I.1    Kell, D.B.2
  • 155
    • 29244448340 scopus 로고    scopus 로고
    • Microarray data analysis: from disarray to consolidation and consensus
    • Allison DB, Cui X, Page GP, Sabripour M Microarray data analysis: from disarray to consolidation and consensus. Nat Rev Genet 2006, 7:55-65.
    • (2006) Nat Rev Genet , vol.7 , pp. 55-65
    • Allison, D.B.1    Cui, X.2    Page, G.P.3    Sabripour, M.4
  • 156
    • 33745929029 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and autoimmune diseases
    • Ram M, Sherer Y, Shoenfeld Y Matrix metalloproteinase-9 and autoimmune diseases. J Clin Immunol 2006, 26:299-307.
    • (2006) J Clin Immunol , vol.26 , pp. 299-307
    • Ram, M.1    Sherer, Y.2    Shoenfeld, Y.3
  • 158
    • 0028298926 scopus 로고
    • Correlation of clinical features and findings on cranial magnetic resonance imaging with urinary myelin basic protein-like material in patients with multiple sclerosis
    • Whitaker JN, Williams PH, Layton BA, et al. Correlation of clinical features and findings on cranial magnetic resonance imaging with urinary myelin basic protein-like material in patients with multiple sclerosis. Ann Neurol 1994, 35:577-585.
    • (1994) Ann Neurol , vol.35 , pp. 577-585
    • Whitaker, J.N.1    Williams, P.H.2    Layton, B.A.3
  • 159
    • 0024520844 scopus 로고
    • Surrogate endpoints in clinical trials: definition and operational criteria
    • Prentice RL Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989, 8:431-440.
    • (1989) Stat Med , vol.8 , pp. 431-440
    • Prentice, R.L.1
  • 160
    • 84859813422 scopus 로고    scopus 로고
    • Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects
    • for the International Advisory Committee on Clinical Trials in Multiple Sclerosis
    • Cohen JA, Reingold SC, Polman CH, Wolinsky JS Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects. Lancet Neurol 2012, 11:467-476. for the International Advisory Committee on Clinical Trials in Multiple Sclerosis.
    • (2012) Lancet Neurol , vol.11 , pp. 467-476
    • Cohen, J.A.1    Reingold, S.C.2    Polman, C.H.3    Wolinsky, J.S.4
  • 162
    • 84885427253 scopus 로고    scopus 로고
    • Cerebrospinal fluid and urinary biomarkers in multiple sclerosis
    • published online March 7.
    • Dobson R, Topping J, Davis A, Thompson E, Giovannoni G Cerebrospinal fluid and urinary biomarkers in multiple sclerosis. Acta Neurol Scand 2013, published online March 7. 10.1111/ane.12119.
    • (2013) Acta Neurol Scand
    • Dobson, R.1    Topping, J.2    Davis, A.3    Thompson, E.4    Giovannoni, G.5
  • 163
    • 0034929220 scopus 로고    scopus 로고
    • Silver stained isoelectrophoresis of tears and cerebrospinal fluid in multiple sclerosis
    • Devos D, Forzy G, de Seze J, et al. Silver stained isoelectrophoresis of tears and cerebrospinal fluid in multiple sclerosis. J Neurol 2001, 248:672-675.
    • (2001) J Neurol , vol.248 , pp. 672-675
    • Devos, D.1    Forzy, G.2    de Seze, J.3
  • 164
    • 73949127705 scopus 로고    scopus 로고
    • Tear analysis in clinically isolated syndrome as new multiple sclerosis criterion
    • Calais G, Forzy G, Crinquette C, et al. Tear analysis in clinically isolated syndrome as new multiple sclerosis criterion. Mult Scler 2010, 16:87-92.
    • (2010) Mult Scler , vol.16 , pp. 87-92
    • Calais, G.1    Forzy, G.2    Crinquette, C.3
  • 165
    • 84865508313 scopus 로고    scopus 로고
    • Bio-Rad's Bio-Plex® suspension array system, xMAP technology overview
    • Houser B Bio-Rad's Bio-Plex® suspension array system, xMAP technology overview. Arch Physiol Biochem 2012, 118:192-196.
    • (2012) Arch Physiol Biochem , vol.118 , pp. 192-196
    • Houser, B.1
  • 166
    • 0030932213 scopus 로고    scopus 로고
    • Vocabulary for use in measurement procedures and description of reference materials in laboratory medicine
    • Dybkaer R Vocabulary for use in measurement procedures and description of reference materials in laboratory medicine. Eur J Clin Chem Clin Biochem 1997, 35:141-173.
    • (1997) Eur J Clin Chem Clin Biochem , vol.35 , pp. 141-173
    • Dybkaer, R.1
  • 167
    • 67349253618 scopus 로고    scopus 로고
    • Clinical performance characteristics of a laboratory test. A practical approach in the autoimmune laboratory
    • Bossuyt X Clinical performance characteristics of a laboratory test. A practical approach in the autoimmune laboratory. Autoimmun Rev 2009, 8:543-548.
    • (2009) Autoimmun Rev , vol.8 , pp. 543-548
    • Bossuyt, X.1
  • 169
    • 0034621009 scopus 로고    scopus 로고
    • Science, medicine, and the future: pharmacogenetics
    • Wolf CR, Smith G, Smith RL Science, medicine, and the future: pharmacogenetics. BMJ 2000, 320:987-990.
    • (2000) BMJ , vol.320 , pp. 987-990
    • Wolf, C.R.1    Smith, G.2    Smith, R.L.3
  • 170
    • 32044463386 scopus 로고    scopus 로고
    • Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients
    • Río J, Nos C, Tintoré M, et al. Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients. Ann Neurol 2006, 59:344-352.
    • (2006) Ann Neurol , vol.59 , pp. 344-352
    • Río, J.1    Nos, C.2    Tintoré, M.3


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