Brain-derived neurotrophic factor in patients with multiple sclerosis

Journal of Neuroimmunology

Volumn 132, Issue 1-2, 2002, Pages 180-188

  Sarchielli, Paola ^a   Greco, Laura ^a   Stipa, Antonio ^a   Floridi, Ardesio ^a   Gallai, Virgilio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Brain derived neurotrophic factor; Cerebrospinal fluid; Disease activity; Disease progression; Multiple sclerosis; Peripheral blood mononuclear cells; Relapse

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MYELIN BASIC PROTEIN; OKT 3; PHYTOHEMAGGLUTININ;

ADULT; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISABILITY; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RELAPSE; REMISSION; SUPERNATANT;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MULTIPLE SCLEROSIS; MUROMONAB-CD3; MYELIN BASIC PROTEINS; PHYTOHEMAGGLUTININS;

EID: 0036849269     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00319-3     Document Type: Article

References (43)

1. Awatsuji H., Furukawa Y., Hirota M., Furukawa S., Hayashi K. Interferons suppress nerve growth factor synthesis as a result of interference with cell growth in astrocytes cultured from neonatal mouse brain. J. Neurochem. 64:1995;1476-1482.
2. Barde Y.-A. Help from within for damaged axons. Nature. 385:1997;391-393.
3. Barouch R., Appel E., Kazimirsky G., Braun A., Renz H., Brodie C. Differential regulation of neurotrophin expression by mitogens and neurotransmitters in mouse lymphocytes. J. Neuroimmunol. 103:2000;112-121.
4. Boutros T., Croze E., Yong V.W. Interferon-beta is a potent promoter of nerve growth factor production by astrocytes. J. Neurochem. 69:1997;939-946.
5. Calza L., Giardino L., Pozza M., Micera A., Aloe L. Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. U. S. A. 94:1997;3368-3373.
6. Calza L., Giardino L., Pozza M., Bettelli C., Micera A., Aloe L. Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3209-3214.
7. Cohen I.R. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:1992;490-494.
8. Dowling P., Ming X., Raval S., Husar W., Casaccia-Bonnefil P., Chao M., Cook S., Blumberg B. Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques. Neurology. 53:1999;1676-1682.
9. Ferguson B., Matyszak M.K., Esiri M.M., Perry V.H. Axonal damage in acute multiple sclerosis lesions. Brain. 120:1997;393-399.
10. Flügel A., Willem M., Berkowicz T., Wekerle H. Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat. Med. 5:1999;843-847.
11. Hammarberg H., Lidman O., Lundberg C., Eltayeb S.Y., Gielen A.W., Muhallab S., Svenningsson A., Linda H., van Der Meide P.H., Cullheim S., Olsson T., Piehl F. Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. J. Neurosci. 20:2000;5283-5291.
12. Hohlfeld R., Kerschensteiner M., Stadelmannn C., Lassmann H., Wekerle H. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J. Neuroimmunol. 107:2000;161-166.
13. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E., Kolbeck R., Hoppe E.et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J. Exp. Med. 189:1999;865-870.
14. Klein R., Nanduri V., Jing S.A., Lamballe F., Tapley P., Bryant S.et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell. 66:1991;395-403.
15. Kramer R., Zhang Y., Gehrmann J., Gold R., Thoenen H., Wekerle H. Gene transfer through the blood-nerve barrier: NGF-engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis. Nat. Med. 1:1995;1162-1166.
16. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33:1983;1444-1452.
17. Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.-A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 341:1989;149-152.
18. Lewin G.R., Barde Y.-A. Physiology of the neurotrophins. Annu. Rev. Neurosci. 19:1996;289-317.
19. Lomen-Hoerth C., Shooter E.M. Widespread neurotrophin receptor expression in the immune system and other nonneuronal rat tissues. J. Neurochem. 64:1995;1780-1789.
20. Massaro A.R., Soranzo C., Carnevale A. Cerebrospinal-fluid ciliary neurotrophic factor in neurological patients. Eur. Neurol. 37:1997;243-246.
21. McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 18:1998;5354-5365.
22. Micera A., De Simone R., Aloe L. Elevated levels of nerve growth factor in the thalamus and spinal cord of rats affected by experimental allergic encephalomyelitis. Arch. Ital. Biol. 133:1995;131-142.
23. Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I.R., Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5:1999;49-55.
24. Muhallab S., Lundberg C., Gielen A.W., Lidman O., Svenningsson A., Piehl F., Olsson T. Differential expression of neurotrophic factors and inflammatory cytokines by myelin basic protein-specific and other recruited T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis. Scand. J. Immunol. 55:2002;264-273.
25. Neumann H., Wekerle H. Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. J. Neuropathol. Exp. Neurol. 57:1998;1-9.
26. Neumann H., Misgeld T., Matsumuro K., Wekerle H. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. U. S. A. 95:1998;5779-5784.
27. Noseworthy J.H., Gold R., Hartung H.P. Treatment of multiple sclerosis: recent trials and future perspectives. Curr. Opin. Neurol. 12:1999;279-293.
28. Ormerod I.E., Miller D.H., McDonald W.I., du Boulay E.P., Rudge P., Kendall B.E.et al. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 110:1987;1579-1616.
29. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 37:1998;1553-1561.
30. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C.et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
31. Rapalino O., Lazarov-Spiegler O., Agranov E., Velan G.J., Yoles E., Fraidakis M.et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4:1998;814-821.
32. Santambrogio L., Benedetti M., Chao M.V., Muzaffar R., Kulig K., Gabellini N., Hochwald G. Nerve growth factor production by lymphocytes. J. Immunol. 153:1994;4488-4495.
33. Schwartz M., Moalem G., Leibowitz-Amit R., Cohen I.R. Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci. 22:1999;295-299.
34. Sendtner M., Holtmann B., Kolbeck R., Thoenen H., Barde Y.-A. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature. 360:1992;757-759.
35. Steinman L. Connections between the immune system and the nervous system. Proc. Natl. Acad. Sci. U. S. A. 90:1993;7912-7914.
36. Suzaki I., Hara T., Maegaki Y., Narai S., Takeshita K. Nerve growth factor levels in cerebrospinal fluid from patients neurologic disorders. J. Child Neurol. 12:1997;205-207.
37. Thoenen H. Neurotrophins and neuronal plasticity. Science. 270:1995;593-598.
38. Torcia M., Bracci-Laudiero L., Lucibello M., Nencioni L., Labardi D., Rubartelli A., Cozzolino F., Aloe L., Garaci E. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell. 85:1996;345-356.
39. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mork S., Bo L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338:1998;278-285. (Comment in: N. Engl. J. Med., 338 (1998) 323-325).
40. Villoslada P., Hauser S.L., Bartke I., Unger J., Heald N., Rosenberg D., Cheung S.W., Mobley W.C., Fisher S., Genain C.P.et al. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J. Exp. Med. 191:2000;1799-1806.
41. Wei R., Jonakait G.M. Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGF-beta 1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia. J. Neuroimmunol. 95:1999;8-18.
42. Weiss S., Reynolds B.A., Vescovi A.L., Morshead C., Craig C.G., van der Kooy D. Is there a neural stem cell in the mammalian forebrain? Trends Neurosci. 19:1996;387-393.
43. Yamamoto H., Gurney M.E. Human platelets contain brain-derived neurotrophic factor. J. Neurosci. 10:1990;3469-3478.