Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis

Neurology

Volumn 71, Issue 1, 2008, Pages 35-37

  Lindsey, J William ^a,b   Crawford, Michael P ^a   Hatfield, Landon M ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN; NOGO A ANTIBODY; PROTEIN G; PROTEIN NOGO A; BIOLOGICAL MARKER; MYELIN PROTEIN; PROTEIN NOGO;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RELAPSE; WESTERN BLOTTING; ANTIBODY SPECIFICITY; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; IMMUNOLOGY; METABOLISM; MOLECULAR WEIGHT; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING;

ANTIBODY SPECIFICITY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM; DENSITOMETRY; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAINS; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; MYELIN PROTEINS; PREDICTIVE VALUE OF TESTS;

EID: 48249103960     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000314831.08803.21     Document Type: Article

References (7)

1. Caroscio JT, Kochwa S, Sacks H, Cohen JA, Yahr MD. Quantitative CSF IgG measurements in multiple sclerosis and other neurologic diseases. An update. Arch Neurol 1983;40:409-413.
2. Tourtellotte WW, Staugaitis SM, Walsh MJ, et al. The basis of intra-blood-brain-barrier IgG synthesis. Ann Neu-rol 1985;17:21-27.
3. Jurewicz A, Matysiak M, Raine CS, Selmaj K. Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomar-ker for multiple sclerosis. Neurology 2007;68:283-287.
4. Chen MS, Huber AB, van der Haar ME, et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000;403:434-439.
5. Oertle T, Huber C, van der Putten H, Schwab ME. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. J Mol Biol 2003;325:299-323.
6. Wiederkehr F. Analysis of cerebrospinal fluid proteins by electrophoresis. J Chromatogr 1991;569:281-296.
7. Kabat EA, Freedman DA, Murray JP, Knaub V. A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases. Am J Med Sci 1950;219:55-64.