Free light chain monomers in the diagnosis of multiple sclerosis

Journal of Neuroimmunology

Volumn 229, Issue 1-2, 2010, Pages 263-271

  Kaplan, Batia ^a   Aizenbud, Boris M ^b   Golderman, Sizilia ^a   Yaskariev, Regina ^c   Sela, Ben Ami ^c,d  

^a HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^b Elta Electronics Industries Ltd   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cerebrospinal fluid; Diagnosis; Free light chains; Multiple sclerosis; Western blotting

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; OLIGOCLONAL BAND;

ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; COVALENT BOND; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SENSITIVITY AND SPECIFICITY; WESTERN BLOTTING;

FEMALE; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; MALE; MULTIPLE SCLEROSIS; OLIGOCLONAL BANDS; STATISTICS, NONPARAMETRIC;

EID: 78650213861     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.09.002     Document Type: Article

References (37)

1. Abraham R.S., Charlesworth M.C., Owen B.A.L., Benson L.M., Katzmann J.A., Reeder C.B., Kyle R.A. Trimolecular complexes of light chain dimers in serum of a patient with multiple myeloma. Clin. Chem. 2002, 48:1805-1811.
2. Bracco F., Gallo P., Menna R., Battistin L., Tavolato B. Free light chains in the CSF in multiple sclerosis. J. Neurol. 1987, 234:303-307.
3. Bradwell A.R. Serum Free Light Chain Assays 2003, 7-38. The Binding Site Ltd., Birmingham, UK.
4. Cavuoti D., Baskin L., Jialal I. Detection of oligoclonal bands in cerebrospinal fluid by immunofixation electrophoresis. Am. J. Clin. Pathol. 1998, 109:585-588.
5. Connors L.H., Jiang Y., Budnik M., Theberge R., Prokaeva T., Bodi K.L., Seldin D.C., Costello C.E., Skinner M. Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic k1 immunoglobulin light chains. Biochemistry 2007, 46:14259-14271.
6. DeCarli C., Menegous M.A., Rudick R.A. Free light chains in multiple sclerosis and infectious diseases. Neurology 1987, 37:1334-1338.
7. Desplat-Jego S., Feuillet L., Pelletier J., Bernard D., Ali Cherif A., Boucraut J. Quantification of immunoglobulin free light chains in cerebrospinal fluid by nephelometry. J. Clin. Immunol. 2005, 25:338-345.
8. Eickhoff K., Heipertz R., Wikstrom J. Determination of k/l immunoglobulin light chain ratios in CSF from patients with multiple sclerosis and other neurological diseases. Acta Neurol. Scand. 1978, 57:385-395.
9. Fischer Ch., Arneth B., Kehler L., Lotz J., Lackner K.J. Kappa free light chains in cerebrospinal fluid as markers of intrathecal immunoglobulin synthesis. Clin. Chem. 2004, 50:1809-1813.
10. Fortini A.S., Sanders E.L., Weinshenker B.G., Katzmann J.A. Isoelectric focusing with IgG immunoblotting compared with high-resolution agarose gel electrophoresis and cerebrospinal fluid IgG index. Am. J. Clin. Pathol. 2003, 120:672-675.
11. Freedman M.S., Thomson E.J., Deisenhammer F., Giovannoni G., Grimsley G., Keir G., Ohman S., Racke M.K., Sharief M., Sindic C.J.M., Sellebjerg F., Tourtellotte W.W. Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis. A consensus statement. Arch. Neurol. 2005, 62:865-870.
12. Goffette S., Schluep M., Henry H., Duprez T., Sindic C.J.M. Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 2004, 75:308-310.
13. Jenkins M.A., Cheng L., Ratnaike S. Multiple sclerosis: use of light-chain typing to assist diagnosis. Ann. Clin. Biochem. 2001, 38:235-241.
14. Jozefczyk P.B., Kelly R.H., Rabin B.S. Clinical significance of immunologic and immunogenetic evaluation in multiple sclerosis. Immunol. Commun. 1984, 13:371-379.
15. Kaplan B., Cojocaru M., Unsworth E., Knecht A., Martin B.M. Search for peptidic "middle molecules" in uremic sera: isolation and chemical identification of fibrinogen fragments. J. Chromatogr. B 2003, 796:141-153.
16. Kaplan B., Livneh A., Gallo G. Charge properties of monoclonal immunoglobulin light chain deposits in tissues are determinants of amyloid versus non-amyloid aggregates. Br. J. Haematol. 2007, 136:723-728.
17. Kaplan B., Ramirez-Alvarado M., Dispenzieri A., Zeldenrust S.R., Leung N., Livneh A., Gallo G. Isolation and biochemical characterization of plasma monoclonal free light chains in amyloidosis AL and multiple myeloma: intact and truncated forms of light chains and their charge properties. Clin. Chem. Lab. Med. 2008, 46:335-341.
18. Kaplan B., Ramirez-Alvarado M., Sikkink L., Golderman S., Dispenzieri A., Livneh A., Gallo G. Free light chains in plasma of patients with light chain amyloidosis and non-amyloid light chain deposition disease. High proportion and heterogeneity of disulfide-linked monoclonal free light chains as pathogenic features of amyloid disease. Br. J. Haematol. 2009, 144:705-715.
19. Keren D.F. Optimizing detection of oligoclonal bands in cerebrospinal fluid by use of isoelectric focusing with IgG immunoblotting. Am. J. Clin. Pathol. 2003, 120:649-651.
20. Kolar O.J., Rice P.H., Jones F.H., Defalgue R.J., Kincaid J. Cerebrospinal fluid imunoelectrophoresis in sclerosis. J. Neurol. Sci. 1997, 47:221-230.
21. Krakauer M., Nielsen H.S., Jensen J., Sellebjerg F. Intrathecal synthesis of immunoglobulin light chains in multiple sclerosis. Acta Neurol. Scand. 1998, 98:161-165.
22. Lunding J., Midgard R., Vedeler C.A. Oligoclonal bands in cerebrospinal fluid: a comparative study of isoelectric focusing, agarose gel electrophoresis and IgG index. Acta Neurol. Scand. 2000, 102:322-325.
23. Mygland A., Trydal T., Vinje B.U., Vedeler C. Isolectric focusing is superior to immunofixation electrophoresis in diagnosing CNS inflammation. Acta Neurol. Scand. 2007, 115:122-125.
24. Perini J.M., Lebas J., Roussel P., Biserte G. Evidence for heterogeneous or incomplete immunoglobulins in oligoclonal CSF studied by electroimmunofixation. Clin. Chim. Acta 1979, 96:205-214.
25. Presslauer S., Milosavljevic D., Brucke T., Bayer P., Hubl W. Elevated levels of kappa free light chains in CSF to support the diagnosis of multiple sclerosis. J. Neurol. 2008, 255:1508-1514.
26. Redegeld F.A., Nijkamp F.P. Immunoglobulin free light chains and mast cells: pivotal role in T-cell mediatiated reactions?. Trends Immunol. 2003, 24:181-185.
27. Riberi M., Bernard D., Depieds R. Evidence for the presence of Λ chain dimers in cerebral fluid of patients suffering from subacute sclerosing panencephalitis. Clin. Exp. Immunol. 1975, 19:45-53.
28. Rinker J.R., Trinkaus K., Cross A.H. Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis. Neurology 2006, 67:1288-1290.
29. Roberts-Thompson P.J., Esiri M.M., Young A.C., MacLennan I.C.M. Cerebrospinal fluid immunoglobulin quotients, kappa/lambda ratios, and viral antibody titres in neurological disease. J. Clin. Pathol. 1976, 29:1105-1115.
30. Rocken M., Hultner L. Heavy functions for light chains. Nat. Med. 2002, 8:668-670.
31. Rudick R.A., Peter D.R., Bidlack J.M., Knutson D.W. Multiple sclerosis: free light chains in cerebrospinal fluid. Neurology 1985, 35:1443-1449.
32. Rudick R.A., Pallant A., Bidlack J.M., Herndon R.M. Free light chains in multiple sclerosis spinal fluid. Ann. Neurol. 1986, 20:63-69.
33. Rudick R.A., Medendorp S.V., Namey M., Boyle S., Fischer J. Multiple sclerosis progression in a natural history study: predictive value of cerebrospinal fluid free kappa light chains. Mult. Scler. 1995, 1:150-155.
34. Sindic C.J.M., Laterre E.C. Oligoclonal free kappa and lambda bands in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases: an immunoaffinity-mediated capillary blot study. J. Neuroimmunol. 1991, 33:63-72.
35. Tate J., Bazeley S., Sykes S., Mollee P. Quantitative serum free light chain assay - analytical issues. Clin. Biochem. Rev. 2009, 30:131-140.
36. Thio M., Blokhuis B.R., Nijkamp F.P., Redegeld F.A. Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases. Trends Pharmacol. Sci. 2008, 29:170-174.
37. Vandvik B. Oligoclonal IgG and free light chains in the cerebrospinal fluid of patients with multiple sclerosis and infectious diseases of the central nervous system. Scand. J. Immunol. 1977, 6:913-922.