Radiologically isolated syndrome - Incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review

Multiple Sclerosis Journal

Volumn 19, Issue 3, 2013, Pages 271-280

  Granberg, Tobias ^a   Martola, Juha ^a   Kristoffersen Wiberg, Maria ^a   Aspelin, Peter ^a   Fredrikson, Sten ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

incidental findings; magnetic resonance imaging; multiple sclerosis; Radiologically isolated syndrome; RIS; unexpected

Indexed keywords

CEREBROSPINAL FLUID ANALYSIS; CERVICAL SPINAL CORD INJURY; COGNITIVE DEFECT; DEMYELINATING DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; FOLLOW UP; HEADACHE; HUMAN; INCIDENTAL FINDING; META ANALYSIS; MULTIPLE SCLEROSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTOR VARIABLE; PREVALENCE; PROGNOSIS; QUALITY OF LIFE; RADIOLOGICALLY ISOLATED SYNDROME; REVIEW; SYMPTOM; SYSTEMATIC REVIEW;

EID: 84874391403     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458512451943     Document Type: Review

References (47)

1. Environmental Health Criteria 232 - Static fields. Geneva, Switzerland: WHO ; 2006 :
2. The Organisation for Economic Co-operation and Development. OECD Health Data 2011, http://www.oecd.org/dataoecd/52/42/48304068.xls (2011, accessed 5 March 2012).
3. Morris Z, Whiteley WN, Longstreth WT, et al. Incidental findings on brain magnetic resonance imaging: Systematic review and meta-analysis. BMJ. 2009 ; 339: b3016
4. Okuda DT, Mowry EM, Beheshtian A, et al. Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome. Neurology. 2009 ; 72: 800-805
5. Derwenskus J, Cohen BA.. Clinically silent multiple sclerosis: Description of a patient cohort without symptoms typical of MS but abnormal brain magnetic resonance imaging. Mult Scler. 2007 ; 13: 1226-1227
6. Lebrun C, Bensa C, Debouverie M, et al. Unexpected multiple sclerosis: Follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile. J Neurol Neurosurg Psychiatry. 2008 ; 79: 195-198
7. Lebrun C, Bensa C, Debouverie M, et al. Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: Follow-up of 70 patients. Arch Neurol. 2009 ; 66: 841-846
8. Siva A, Saip S, Altintas A, et al. Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease. Mult Scler. 2009 ; 15: 918-927
9. Sierra-Marcos A, Mitjana R, Castilló J, et al. Demyelinating lesions as incidental findings in magnetic resonance imaging: A study of 11 cases with clinico-radiological follow-up and a review of the literature. Rev Neurol. 2010 ; 51: 129-134
10. Okuda DT, Mowry EM, Cree BAC, et al. Asymptomatic spinal cord lesions predict disease progression in radiologically isolated syndrome. Neurology. 2011 ; 76: 686-692
11. Maia ACM, da Rocha AJ, Barros BR, et al. Incidental demyelinating inflammatory lesions in asymptomatic patients: A Brazilian cohort with radiologically isolated syndrome and a critical review of current literature. Arq Neuropsiquiatr. 2012 ; 70: 5-11
12. LebrunCle PageEKantarciO. Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort. Mult Scler J. Epub ahead of print 2 February 2012 (accessed 2 March 2012). http://msj.sagepub.com/content/early/2012/02/01/1352458511435931.abstract DOI: 10.1177/135245851143593110.1177/1352458511435931
13. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 ; 69: 292-302
14. Huang HK. PACS and imaging informatics: Basic principles and applications. Hoboken, NJ: Wiley-Blackwell ; 2010 :
15. Weiner HL, Stankiewicz JM. Chichester, UK: John Wiley and Sons ; 2012 :
16. Georgi W.. Multiple sclerosis. Anatomopathological findings of multiple sclerosis in diseases not clinically diagnosed. Schweiz Med Wochenschr. 1961 ; 91: 605-607
17. Gilbert JJ, Sadler M.. Unsuspected multiple sclerosis. Arch Neurol. 1983 ; 40: 533-536
18. Engell T.. A clinical patho-anatomical study of clinically silent multiple sclerosis. Acta Neurol Scand. 1989 ; 79: 428-430
19. Johannsen LG, Stenager E, Jensen K.. Clinically unexpected multiple sclerosis in patients with mental disorders. A series of 7301 psychiatric autopsies. Acta Neurol Belg. 1996 ; 96: 62-65
20. Alonso A, Hernan MA.. Temporal trends in the incidence of multiple sclerosis: A systematic review. Neurology. 2008 ; 71: 129-135
21. Lyoo IK, Seol HY, Byun HS, et al. Unsuspected multiple sclerosis in patients with psychiatric disorders: A magnetic resonance imaging study. J Neuropsychiatry Clin Neurosci. 1996 ; 8: 54-59
22. Weber F, Knopf H.. Incidental findings in magnetic resonance imaging of the brains of healthy young men. J Neurol Sci. 2006 ; 240: 81-84
23. Wasay M, Rizvi F, Azeemuddin M, et al. Incidental MRI lesions suggestive of multiple sclerosis in asymptomatic patients in Karachi, Pakistan. J Neurol Neurosurg Psychiatry. 2011 ; 82: 83-85
24. Dua T. Atlas: Multiple sclerosis resources in the world, 2008. Geneva, Switzerland: World Health Organization; Multiple Sclerosis International Federation ; 2008 :
25. D'Amico D, La Mantia L, Rigamonti A, et al. Prevalence of primary headaches in people with multiple sclerosis. Cephalalgia. 2004 ; 24: 980-984
26. McDonnell GV, Cabrera-Gomez J, Calne DB, et al. Clinical presentation of primary progressive multiple sclerosis 10 years after the incidental finding of typical magnetic resonance imaging brain lesions: The subclinical stage of primary progressive multiple sclerosis may last 10 years. Mult Scler. 2003 ; 9: 204-209
27. De Seze J, Vermersch P. Sequential magnetic resonance imaging follow-up of multiple sclerosis before the clinical phase. Mult Scler. 2005 ; 11: 395-397
28. Hakiki B, Goretti B, Portaccio E, et al. 'Subclinical MS': Follow-up of four cases. Eur J Neurol. 2008 ; 15: 858-861
29. Mäurer M.. Radiologisch isoliertes syndrom - Differenzialdiagnose und vorgehen. Aktuel Neurol. 2009 ; 36: 265-267
30. Meuth S, Bittner S, Kleinschnitz C.. Preclinical multiple sclerosis and therapeutical options. Aktuel Neurol. 2009 ; 36: S268 - S270
31. Bau L, Matas E, Romero-Pinel L, et al. Subclinical demyelinating lesions: Clinical and magnetic resonance imaging follow-up of 13 patients. J Neurol. 2009 ; 256: S121
32. Spain R, Bourdette D.. The radiologically isolated syndrome: Look (again) before you treat. Curr Neurol Neurosci Rep. 2011 ; 11: 498-506
33. De Stefano N, Stromillo ML, Rossi F, et al. Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis. PLoS ONE. 2011 ; 6: e19452
34. LangdonDAmatoMBoringaJ. Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Mult Scler. Epub ahead of print 21 December 2011 (accessed 2 March 2012), http://www.ncbi.nlm.nih.gov/ pubmed/22190573 DOI: 10.1177/135245851143107610.1177/1352458511431076
35. Lebrun C, Blanc F, Brassat D, et al. Cognitive function in radiologically isolated syndrome. Mult Scler. 2010 ; 16: 919-925
36. AmatoMPHakikiBGorettiB. Association of MRI metrics and cognitive impairment in radiologically isolated syndromes. Neurology. Epub ahead of print 18 January 2012 (accessed 2 Mar 2012), http://www.ncbi.nlm.nih.gov/pubmed/ 22262744 DOI: 10.1212/WNL.0b013e31824528c910.1212/WNL.0b013e31824528c9
37. Eraksoy M, Kurtuncu M, Akman-Demir G, et al. Clinically unsuspected multiple sclerosis: Report of 22 cases and review of the literature. Mult Scler. 2007 ; 13: S105
38. Sempere AP, López-Celada S, Berenguer-Ruiz L, et al. Radiologically isolated syndrome. Rev Neurol. 2009 ; 49: 599-600
39. Giorgio A, Stromillo ML, Rossi F, et al. Cortical lesions in radiologically isolated syndrome. Neurology. 2011 ; 77: 1896-1899
40. Medscape Great Debate: Radiologically isolated syndrome, http://www.medscape.com/viewarticle/720673 (accessed 4 March 2012).Published: 04/27/2010
41. Chataway J.. When confronted by a patient with the radiologically isolated syndrome. Pract Neurol. 2010 ; 10: 271-277
42. Sellner J, Schirmer L, Hemmer B, et al. The radiologically isolated syndrome: Take action when the unexpected is uncovered?. J Neurol. 2010 ; 257: 1602-1611
43. Miller DH, Weinshenker BG, Filippi M, et al. Differential diagnosis of suspected multiple sclerosis: A consensus approach. Mult Scler. 2008 ; 14: 1157-1174
44. Goodin DS, Bates D.. Treatment of early multiple sclerosis: The value of treatment initiation after a first clinical episode. Mult Scler. 2009 ; 15: 1175-1182
45. Bourdette D, Simon J.. The radiologically isolated syndrome: Is it very early multiple sclerosis?. Neurology. 2009 ; 72: 780-781
46. Bourdette D, Yadav V.. The radiologically isolated syndrome revisited: When is it presymptomatic multiple sclerosis?. Neurology. 2011 ; 76: 680-681
47. Montalban X, Tintoré M, Swanton J, et al. MRI criteria for MS in patients with clinically isolated syndromes. Neurology. 2010 ; 74: 427-434