메뉴 건너뛰기




Volumn 73, Issue 6, 2010, Pages 1117-1132

Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers

Author keywords

Biomarkers; CSF; Multiple sclerosis; Prognosis; Proteomics; Treatment

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 2 MACROGLOBULIN; ANGIOTENSINOGEN; BIOLOGICAL MARKER; CONTACTIN; COPPER ZINC SUPEROXIDE DISMUTASE; FETUIN A; FIBULIN; NATALIZUMAB; NERVE CELL ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE 1; PROTEIN CONTACTIN 1; PROTEIN FIBULIN 1; PROTEIN NRCAM; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; MONOCLONAL ANTIBODY;

EID: 77950597049     PISSN: 18743919     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jprot.2010.01.004     Document Type: Article
Times cited : (125)

References (53)
  • 1
    • 35548990612 scopus 로고    scopus 로고
    • Confirming the MS diagnosis
    • Garcia Merino A., and Blasco M.R. Confirming the MS diagnosis. Int MS J 14 2 (2007) 58-63
    • (2007) Int MS J , vol.14 , Issue.2 , pp. 58-63
    • Garcia Merino, A.1    Blasco, M.R.2
  • 2
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald W.I., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50 1 (2001) 121-127
    • (2001) Ann Neurol , vol.50 , Issue.1 , pp. 121-127
    • McDonald, W.I.1
  • 3
    • 0036435526 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients
    • Vladic A., et al. Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. Cytokine 20 2 (2002) 86-89
    • (2002) Cytokine , vol.20 , Issue.2 , pp. 86-89
    • Vladic, A.1
  • 4
    • 12444304185 scopus 로고    scopus 로고
    • CSF and serum orosomucoid (alpha-1-acid glycoprotein) in patients with multiple sclerosis: a comparison among particular subgroups of MS patients
    • Adam P., et al. CSF and serum orosomucoid (alpha-1-acid glycoprotein) in patients with multiple sclerosis: a comparison among particular subgroups of MS patients. Clin Chim Acta 334 1-2 (2003) 107-110
    • (2003) Clin Chim Acta , vol.334 , Issue.1-2 , pp. 107-110
    • Adam, P.1
  • 5
    • 11144297111 scopus 로고    scopus 로고
    • Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    • Teunissen C.E., Dijkstra C., and Polman C. Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. Lancet Neurol 4 1 (2005) 32-41
    • (2005) Lancet Neurol , vol.4 , Issue.1 , pp. 32-41
    • Teunissen, C.E.1    Dijkstra, C.2    Polman, C.3
  • 6
    • 8644272511 scopus 로고    scopus 로고
    • Neurofilament and glial fibrillary acidic protein in multiple sclerosis
    • Norgren N., et al. Neurofilament and glial fibrillary acidic protein in multiple sclerosis. Neurology 63 9 (2004) 1586-1590
    • (2004) Neurology , vol.63 , Issue.9 , pp. 1586-1590
    • Norgren, N.1
  • 7
    • 17444424938 scopus 로고    scopus 로고
    • Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
    • Miller D., et al. Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol 4 5 (2005) 281-288
    • (2005) Lancet Neurol , vol.4 , Issue.5 , pp. 281-288
    • Miller, D.1
  • 8
    • 18844365126 scopus 로고    scopus 로고
    • Multiple sclerosis: diagnosis and the management of acute relapses
    • Leary S.M., Porter B., and Thompson A.J. Multiple sclerosis: diagnosis and the management of acute relapses. Postgrad Med J 81 955 (2005) 302-308
    • (2005) Postgrad Med J , vol.81 , Issue.955 , pp. 302-308
    • Leary, S.M.1    Porter, B.2    Thompson, A.J.3
  • 9
    • 35948933394 scopus 로고    scopus 로고
    • Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    • Ray S., et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med 13 11 (2007) 1359-1362
    • (2007) Nat Med , vol.13 , Issue.11 , pp. 1359-1362
    • Ray, S.1
  • 10
    • 67650493912 scopus 로고    scopus 로고
    • Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    • Schulze-Topphoff U., et al. Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nat Med 15 7 (2009) 788-793
    • (2009) Nat Med , vol.15 , Issue.7 , pp. 788-793
    • Schulze-Topphoff, U.1
  • 11
    • 39849101009 scopus 로고    scopus 로고
    • Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
    • Han M.H., et al. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature 451 7182 (2008) 1076-1081
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1076-1081
    • Han, M.H.1
  • 12
    • 3042816692 scopus 로고    scopus 로고
    • Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients
    • Dumont D., et al. Proteomic analysis of cerebrospinal fluid from multiple sclerosis patients. Proteomics 4 7 (2004) 2117-2124
    • (2004) Proteomics , vol.4 , Issue.7 , pp. 2117-2124
    • Dumont, D.1
  • 13
    • 21044455621 scopus 로고    scopus 로고
    • Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease
    • Finehout E.J., Franck Z., and Lee K.H. Complement protein isoforms in CSF as possible biomarkers for neurodegenerative disease. Dis Markers 21 2 (2005) 93-101
    • (2005) Dis Markers , vol.21 , Issue.2 , pp. 93-101
    • Finehout, E.J.1    Franck, Z.2    Lee, K.H.3
  • 14
    • 0030604908 scopus 로고    scopus 로고
    • Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid
    • Zerr I., et al. Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Lancet 348 9031 (1996) 846-849
    • (1996) Lancet , vol.348 , Issue.9031 , pp. 846-849
    • Zerr, I.1
  • 15
    • 23044487628 scopus 로고    scopus 로고
    • Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants
    • Dupont N.C., et al. Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol 66 2 (2005) 175-191
    • (2005) J Reprod Immunol , vol.66 , Issue.2 , pp. 175-191
    • Dupont, N.C.1
  • 16
    • 0037413467 scopus 로고    scopus 로고
    • A controlled trial of natalizumab for relapsing multiple sclerosis
    • Miller D.H., et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 348 1 (2003) 15-23
    • (2003) N Engl J Med , vol.348 , Issue.1 , pp. 15-23
    • Miller, D.H.1
  • 17
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman C.H., et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 354 9 (2006) 899-910
    • (2006) N Engl J Med , vol.354 , Issue.9 , pp. 899-910
    • Polman, C.H.1
  • 18
    • 58649098959 scopus 로고    scopus 로고
    • Identification of novel candidate protein biomarkers for the post-polio syndrome - implications for diagnosis, neurodegeneration and neuroinflammation
    • Gonzalez H., et al. Identification of novel candidate protein biomarkers for the post-polio syndrome - implications for diagnosis, neurodegeneration and neuroinflammation. J Proteomics 71 6 (2009) 670-681
    • (2009) J Proteomics , vol.71 , Issue.6 , pp. 670-681
    • Gonzalez, H.1
  • 19
    • 10944231566 scopus 로고    scopus 로고
    • Autonomous protein sample processing on-chip using solid-phase microextraction, capillary force pumping, and microdispensing
    • Wallman L., et al. Autonomous protein sample processing on-chip using solid-phase microextraction, capillary force pumping, and microdispensing. Electrophoresis 25 21-22 (2004) 3778-3787
    • (2004) Electrophoresis , vol.25 , Issue.21-22 , pp. 3778-3787
    • Wallman, L.1
  • 21
    • 33846829987 scopus 로고    scopus 로고
    • The pls package: principal component and partial least squares regression in R
    • Mevik B.-H., and Wehrens R. The pls package: principal component and partial least squares regression in R. J Stat Softw 18 2 (2007)
    • (2007) J Stat Softw , vol.18 , Issue.2
    • Mevik, B.-H.1    Wehrens, R.2
  • 22
    • 70349267599 scopus 로고    scopus 로고
    • Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity
    • Platten M., et al. Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A (2009)
    • (2009) Proc Natl Acad Sci U S A
    • Platten, M.1
  • 23
    • 70349273755 scopus 로고    scopus 로고
    • Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
    • Stegbauer J., et al. Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci U S A (2009)
    • (2009) Proc Natl Acad Sci U S A
    • Stegbauer, J.1
  • 24
    • 0030756860 scopus 로고    scopus 로고
    • Serum angiotensin-converting enzyme in multiple sclerosis
    • Constantinescu C.S., et al. Serum angiotensin-converting enzyme in multiple sclerosis. Arch Neurol 54 8 (1997) 1012-1015
    • (1997) Arch Neurol , vol.54 , Issue.8 , pp. 1012-1015
    • Constantinescu, C.S.1
  • 25
    • 34548145190 scopus 로고    scopus 로고
    • Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis
    • Wosik K., et al. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J Neurosci 27 34 (2007) 9032-9042
    • (2007) J Neurosci , vol.27 , Issue.34 , pp. 9032-9042
    • Wosik, K.1
  • 26
    • 59849091253 scopus 로고    scopus 로고
    • Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice
    • Inaba S., et al. Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice. Hypertension 53 2 (2009) 356-362
    • (2009) Hypertension , vol.53 , Issue.2 , pp. 356-362
    • Inaba, S.1
  • 27
    • 0242569370 scopus 로고    scopus 로고
    • Proteomics analysis of phosphotyrosyl-proteins in human lumbar cerebrospinal fluid
    • Yuan X., and Desiderio D.M. Proteomics analysis of phosphotyrosyl-proteins in human lumbar cerebrospinal fluid. J Proteome Res 2 5 (2003) 476-487
    • (2003) J Proteome Res , vol.2 , Issue.5 , pp. 476-487
    • Yuan, X.1    Desiderio, D.M.2
  • 28
    • 0035096910 scopus 로고    scopus 로고
    • Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function
    • Ohsawa I., Takamura C., and Kohsaka S. Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. J Neurochem 76 5 (2001) 1411-1420
    • (2001) J Neurochem , vol.76 , Issue.5 , pp. 1411-1420
    • Ohsawa, I.1    Takamura, C.2    Kohsaka, S.3
  • 29
    • 63449105260 scopus 로고    scopus 로고
    • Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis
    • Mattsson N., et al. Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis. Mult Scler 15 4 (2009) 448-454
    • (2009) Mult Scler , vol.15 , Issue.4 , pp. 448-454
    • Mattsson, N.1
  • 30
    • 67650105637 scopus 로고    scopus 로고
    • Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration
    • Benvegnu S., et al. Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration. PLoS One 4 6 (2009) e5968
    • (2009) PLoS One , vol.4 , Issue.6
    • Benvegnu, S.1
  • 31
    • 40849106528 scopus 로고    scopus 로고
    • Serum matrix metalloproteinase-2 levels indicate blood-CSF barrier damage in patients with infectious meningitis
    • Kanoh Y., et al. Serum matrix metalloproteinase-2 levels indicate blood-CSF barrier damage in patients with infectious meningitis. Inflammation 31 2 (2008) 99-104
    • (2008) Inflammation , vol.31 , Issue.2 , pp. 99-104
    • Kanoh, Y.1
  • 32
    • 37749035385 scopus 로고    scopus 로고
    • Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients
    • Tchetverikov I., et al. Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients. Ann Rheum Dis 67 1 (2008) 128-130
    • (2008) Ann Rheum Dis , vol.67 , Issue.1 , pp. 128-130
    • Tchetverikov, I.1
  • 33
    • 17644414532 scopus 로고    scopus 로고
    • MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis
    • Tchetverikov I., et al. MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. Ann Rheum Dis 64 5 (2005) 694-698
    • (2005) Ann Rheum Dis , vol.64 , Issue.5 , pp. 694-698
    • Tchetverikov, I.1
  • 34
    • 69949190038 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease
    • Fernandes K.S., et al. Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease. J Neuroimmunol (2009)
    • (2009) J Neuroimmunol
    • Fernandes, K.S.1
  • 35
    • 69949146315 scopus 로고    scopus 로고
    • Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population
    • Mirowska-Guzel D., et al. Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population. J Neuroimmunol (2009)
    • (2009) J Neuroimmunol
    • Mirowska-Guzel, D.1
  • 36
    • 66149167334 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinases and their inhibitors by interferon-beta: a longitudinal study in multiple sclerosis patients
    • Bernal F., et al. Regulation of matrix metalloproteinases and their inhibitors by interferon-beta: a longitudinal study in multiple sclerosis patients. Mult Scler 15 6 (2009) 721-727
    • (2009) Mult Scler , vol.15 , Issue.6 , pp. 721-727
    • Bernal, F.1
  • 37
    • 0033635193 scopus 로고    scopus 로고
    • Astroglial expression of human alpha(1)-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice
    • Mucke L., et al. Astroglial expression of human alpha(1)-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice. Am J Pathol 157 6 (2000) 2003-2010
    • (2000) Am J Pathol , vol.157 , Issue.6 , pp. 2003-2010
    • Mucke, L.1
  • 38
    • 0032146242 scopus 로고    scopus 로고
    • Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype
    • Licastro F., et al. Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype. J Neuroimmunol 88 1-2 (1998) 105-110
    • (1998) J Neuroimmunol , vol.88 , Issue.1-2 , pp. 105-110
    • Licastro, F.1
  • 39
    • 0024399057 scopus 로고
    • Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA
    • Pasternack J.M., et al. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. Am J Pathol 135 5 (1989) 827-834
    • (1989) Am J Pathol , vol.135 , Issue.5 , pp. 827-834
    • Pasternack, J.M.1
  • 40
    • 33750582958 scopus 로고    scopus 로고
    • Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons
    • Padmanabhan J., et al. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain 129 Pt 11 (2006) 3020-3034
    • (2006) Brain , vol.129 , Issue.PART 11 , pp. 3020-3034
    • Padmanabhan, J.1
  • 41
    • 35848937127 scopus 로고    scopus 로고
    • Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies
    • Nielsen H.M., et al. Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies. Neurology 69 16 (2007) 1569-1579
    • (2007) Neurology , vol.69 , Issue.16 , pp. 1569-1579
    • Nielsen, H.M.1
  • 42
    • 0037231452 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    • DeKosky S.T., et al. Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment. Ann Neurol 53 1 (2003) 81-90
    • (2003) Ann Neurol , vol.53 , Issue.1 , pp. 81-90
    • DeKosky, S.T.1
  • 43
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale J., Ysrraelit M.C., and Gaitan M.I. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain (2009)
    • (2009) Brain
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 44
    • 59249106554 scopus 로고    scopus 로고
    • Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis
    • Smolders J., et al. Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis. Mult Scler 14 9 (2008) 1220-1224
    • (2008) Mult Scler , vol.14 , Issue.9 , pp. 1220-1224
    • Smolders, J.1
  • 45
    • 85047694301 scopus 로고    scopus 로고
    • The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    • Schafer C., et al. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112 3 (2003) 357-366
    • (2003) J Clin Invest , vol.112 , Issue.3 , pp. 357-366
    • Schafer, C.1
  • 46
    • 0344011149 scopus 로고    scopus 로고
    • The inflammation-induced down-regulation of plasma fetuin-A (alpha2HS-glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites
    • Gangneux C., et al. The inflammation-induced down-regulation of plasma fetuin-A (alpha2HS-glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites. Nucleic Acids Res 31 20 (2003) 5957-5970
    • (2003) Nucleic Acids Res , vol.31 , Issue.20 , pp. 5957-5970
    • Gangneux, C.1
  • 47
    • 35748983579 scopus 로고    scopus 로고
    • Decreased levels of circulating alpha2-Heremans-Schmid glycoprotein/fetuin-A (AHSG) in patients with rheumatoid arthritis
    • Sato H., et al. Decreased levels of circulating alpha2-Heremans-Schmid glycoprotein/fetuin-A (AHSG) in patients with rheumatoid arthritis. Intern Med 46 20 (2007) 1685-1691
    • (2007) Intern Med , vol.46 , Issue.20 , pp. 1685-1691
    • Sato, H.1
  • 48
    • 60249090585 scopus 로고    scopus 로고
    • CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis
    • Tumani H., et al. CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis. Neurosci Lett 452 2 (2009) 214-217
    • (2009) Neurosci Lett , vol.452 , Issue.2 , pp. 214-217
    • Tumani, H.1
  • 49
    • 65649103331 scopus 로고    scopus 로고
    • Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis
    • Vucic S., and Kierna M.C. Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis. Curr Mol Med 9 3 (2009) 255-272
    • (2009) Curr Mol Med , vol.9 , Issue.3 , pp. 255-272
    • Vucic, S.1    Kierna, M.C.2
  • 50
    • 48449094910 scopus 로고    scopus 로고
    • Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases
    • Boll M.C., et al. Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases. Neurochem Res 33 9 (2008) 1717-1723
    • (2008) Neurochem Res , vol.33 , Issue.9 , pp. 1717-1723
    • Boll, M.C.1
  • 51
    • 15744398884 scopus 로고    scopus 로고
    • Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases
    • Choi J., et al. Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem 280 12 (2005) 11648-11655
    • (2005) J Biol Chem , vol.280 , Issue.12 , pp. 11648-11655
    • Choi, J.1
  • 52
    • 61749083654 scopus 로고    scopus 로고
    • Revisiting Notch in remyelination of multiple sclerosis lesions
    • Brosnan C.F., and John G.R. Revisiting Notch in remyelination of multiple sclerosis lesions. J Clin Invest 119 1 (2009) 10-13
    • (2009) J Clin Invest , vol.119 , Issue.1 , pp. 10-13
    • Brosnan, C.F.1    John, G.R.2
  • 53
    • 62849098757 scopus 로고    scopus 로고
    • The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers
    • Khademi M., et al. The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers. Eur J Neurol 16 4 (2009) 528-536
    • (2009) Eur J Neurol , vol.16 , Issue.4 , pp. 528-536
    • Khademi, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.