메뉴 건너뛰기




Volumn 3, Issue 3-4, 2009, Pages 311-322

The role of osteopontin in inflammatory processes

Author keywords

Inflammation; Matricellular protein; Osteopontin

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GELATINASE A; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 17; MATRILYSIN; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STROMELYSIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 72449139507     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-009-0068-0     Document Type: Review
Times cited : (415)

References (119)
  • 1
    • 34247343353 scopus 로고    scopus 로고
    • Osteopontin, a protein with cytokine-like properties, is associated with inflammation in Crohn's disease
    • 17444956
    • J Agnholt J Kelsen L Schack CL Hvas JF Dahlerup ES Sorensen 2007 Osteopontin, a protein with cytokine-like properties, is associated with inflammation in Crohn's disease Scand J Immunol 65 5 453 460 17444956
    • (2007) Scand J Immunol , vol.65 , Issue.5 , pp. 453-460
    • Agnholt, J.1    Kelsen, J.2    Schack, L.3    Hvas, C.L.4    Dahlerup, J.F.5    Sorensen, E.S.6
  • 2
    • 0035958935 scopus 로고    scopus 로고
    • Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)
    • 11375993
    • R Agnihotri HC Crawford H Haro LM Matrisian MC Havrda L Liaw 2001 Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin) J Biol Chem 276 30 28261 28267 11375993
    • (2001) J Biol Chem , vol.276 , Issue.30 , pp. 28261-28267
    • Agnihotri, R.1    Crawford, H.C.2    Haro, H.3    Matrisian, L.M.4    Havrda, M.C.5    Liaw, L.6
  • 4
    • 0035918153 scopus 로고    scopus 로고
    • Identification of dual alpha4 beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin
    • 11278897
    • KJ Bayless GE Davis 2001 Identification of dual alpha4 beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin J Biol Chem 276 16 13483 13489 11278897
    • (2001) J Biol Chem , vol.276 , Issue.16 , pp. 13483-13489
    • Bayless, K.J.1    Davis, G.E.2
  • 5
    • 39749187284 scopus 로고    scopus 로고
    • Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer
    • 18292776
    • A Bellahcene V Castronovo KU Ogbureke LW Fisher NS Fedarko 2008 Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer Nat Rev Cancer 8 3 212 226 18292776
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 212-226
    • Bellahcene, A.1    Castronovo, V.2    Ogbureke, K.U.3    Fisher, L.W.4    Fedarko, N.S.5
  • 7
    • 0036688817 scopus 로고    scopus 로고
    • Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone
    • 12073157
    • AL Boskey L Spevak E Paschalis SB Doty MD McKee 2002 Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone Calcif Tissue Int 71 2 145 154 12073157
    • (2002) Calcif Tissue Int , vol.71 , Issue.2 , pp. 145-154
    • Boskey, A.L.1    Spevak, L.2    Paschalis, E.3    Doty, S.B.4    McKee, M.D.5
  • 11
    • 0029153256 scopus 로고
    • Structural and functional domains of osteopontin
    • W Bulter 1995 Structural and functional domains of osteopontin Ann NY Acad Sci 760 6 11
    • (1995) Ann NY Acad Sci , vol.760 , pp. 6-11
    • Bulter, W.1
  • 15
    • 0026493764 scopus 로고
    • Calcium and collagen binding properties of osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone
    • 1447223
    • Y Chen BS Bal JP Gorski 1992 Calcium and collagen binding properties of osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone J Biol Chem 267 34 24871 24878 1447223
    • (1992) J Biol Chem , vol.267 , Issue.34 , pp. 24871-24878
    • Chen, Y.1    Bal, B.S.2    Gorski, J.P.3
  • 16
    • 0027471503 scopus 로고
    • Developmental expression of osteopontin (OPN) mRNA in rat tissues: Evidence for a role for OPN in bone formation and resorption
    • 8492741
    • J Chen K Singh BB Mukherjee J Sodek 1993 Developmental expression of osteopontin (OPN) mRNA in rat tissues: evidence for a role for OPN in bone formation and resorption Matrix 13 2 113 123 8492741
    • (1993) Matrix , vol.13 , Issue.2 , pp. 113-123
    • Chen, J.1    Singh, K.2    Mukherjee, B.B.3    Sodek, J.4
  • 17
    • 23944440915 scopus 로고    scopus 로고
    • Post-translationally modified residues of native human osteopontin are located in clusters: Identification of 36 phosphorylation and five O-glycosylation sites and their biological implications
    • 15869464
    • B Christensen MS Nielsen KF Haselmann TE Petersen ES Sorensen 2005 Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications Biochem J 390 Pt 1 285 292 15869464
    • (2005) Biochem J , vol.390 , Issue.PART 1 , pp. 285-292
    • Christensen, B.1    Nielsen, M.S.2    Haselmann, K.F.3    Petersen, T.E.4    Sorensen, E.S.5
  • 19
    • 0032533862 scopus 로고    scopus 로고
    • Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo
    • 9823334
    • HC Crawford LM Matrisian L Liaw 1998 Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo Cancer Res 58 22 5206 5215 9823334
    • (1998) Cancer Res , vol.58 , Issue.22 , pp. 5206-5215
    • Crawford, H.C.1    Matrisian, L.M.2    Liaw, L.3
  • 20
    • 34247341829 scopus 로고    scopus 로고
    • Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome
    • 17200105
    • RA Dean CM Overall 2007 Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome Mol Cell Proteomics 6 4 611 623 17200105
    • (2007) Mol Cell Proteomics , vol.6 , Issue.4 , pp. 611-623
    • Dean, R.A.1    Overall, C.M.2
  • 21
    • 0031813775 scopus 로고    scopus 로고
    • Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential role for this integrin-ligand interaction in kidney morphogenesis
    • 9614184
    • S Denda L Reichardt U Muller 1998 Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential role for this integrin-ligand interaction in kidney morphogenesis Molecular biology of the cell 9 6 1425 1435 9614184
    • (1998) Molecular Biology of the Cell , vol.9 , Issue.6 , pp. 1425-1435
    • Denda, S.1    Reichardt, L.2    Muller, U.3
  • 24
    • 47249145601 scopus 로고    scopus 로고
    • Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells
    • 18576331
    • K Fan J Dai H Wang H Wei Z Cao S Hou W Qian B Li J Zhao H Xu C Yang Y Guo 2008 Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells Arthritis Rheum 58 7 2041 2052 18576331
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 2041-2052
    • Fan, K.1    Dai, J.2    Wang, H.3    Wei, H.4    Cao, Z.5    Hou, S.6    Qian, W.7    Li, B.8    Zhao, J.9    Xu, H.10    Yang, C.11    Guo, Y.12
  • 26
    • 9644281627 scopus 로고    scopus 로고
    • Expression and characterization of recombinant osteopontin peptides representing matrix metalloproteinase proteolytic fragments
    • 15579312
    • YA Gao R Agnihotri CP Vary L Liaw 2004 Expression and characterization of recombinant osteopontin peptides representing matrix metalloproteinase proteolytic fragments Matrix Biol 23 7 457 466 15579312
    • (2004) Matrix Biol , vol.23 , Issue.7 , pp. 457-466
    • Gao, Y.A.1    Agnihotri, R.2    Vary, C.P.3    Liaw, L.4
  • 27
    • 33846523069 scopus 로고    scopus 로고
    • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages
    • C Gao H Guo Z Mi MJ Grusby PC Kuo 2007 Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages J Immunol 178 3 1870 1881 17237438 (Pubitemid 46154660)
    • (2007) Journal of Immunology , vol.178 , Issue.3 , pp. 1870-1881
    • Gao, C.1    Guo, H.2    Mi, Z.3    Grusby, M.J.4    Kuo, P.C.5
  • 28
    • 0027367239 scopus 로고
    • Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
    • 8408622
    • CM Giachelli N Bae M Almeida DT Denhardt CE Alpers SM Schwartz 1993 Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques J Clin Invest 92 4 1686 1696 8408622
    • (1993) J Clin Invest , vol.92 , Issue.4 , pp. 1686-1696
    • Giachelli, C.M.1    Bae, N.2    Almeida, M.3    Denhardt, D.T.4    Alpers, C.E.5    Schwartz, S.M.6
  • 29
    • 0031906847 scopus 로고    scopus 로고
    • Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
    • 9466560
    • CM Giachelli D Lombardi RJ Johnson CE Murry M Almeida 1998 Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo Am J Pathol 152 2 353 358 9466560
    • (1998) Am J Pathol , vol.152 , Issue.2 , pp. 353-358
    • Giachelli, C.M.1    Lombardi, D.2    Johnson, R.J.3    Murry, C.E.4    Almeida, M.5
  • 31
    • 0035839024 scopus 로고    scopus 로고
    • Structural elements of the osteopontin SVVYGLR motif important for the interaction with alpha(4) integrins
    • 11513858
    • PM Green SB Ludbrook DD Miller CM Horgan ST Barry 2001 Structural elements of the osteopontin SVVYGLR motif important for the interaction with alpha(4) integrins FEBS Lett 503 1 75 79 11513858
    • (2001) FEBS Lett , vol.503 , Issue.1 , pp. 75-79
    • Green, P.M.1    Ludbrook, S.B.2    Miller, D.D.3    Horgan, C.M.4    Barry, S.T.5
  • 32
    • 0035863824 scopus 로고    scopus 로고
    • Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages
    • 11145688
    • H Guo CQ Cai RA Schroeder PC Kuo 2001 Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages J Immunol 166 2 1079 1086 11145688
    • (2001) J Immunol , vol.166 , Issue.2 , pp. 1079-1086
    • Guo, H.1    Cai, C.Q.2    Schroeder, R.A.3    Kuo, P.C.4
  • 35
    • 0028853560 scopus 로고
    • A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
    • 7592829
    • DD Hu EC Lin NL Kovach JR Hoyer JW Smith 1995 A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5 J Biol Chem 270 44 26232 26238 7592829
    • (1995) J Biol Chem , vol.270 , Issue.44 , pp. 26232-26238
    • Hu, D.D.1    Lin, E.C.2    Kovach, N.L.3    Hoyer, J.R.4    Smith, J.W.5
  • 36
    • 33846998653 scopus 로고    scopus 로고
    • Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
    • 17143274
    • EM Hur S Youssef ME Haws SY Zhang RA Sobel L Steinman 2007 Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells Nat Immunol 8 1 74 83 17143274
    • (2007) Nat Immunol , vol.8 , Issue.1 , pp. 74-83
    • Hur, E.M.1    Youssef, S.2    Haws, M.E.3    Zhang, S.Y.4    Sobel, R.A.5    Steinman, L.6
  • 37
    • 0037067461 scopus 로고    scopus 로고
    • Osteopontin plays an important role in the development of medial thickening and neointimal formation
    • 12114325
    • K Isoda K Nishikawa Y Kamezawa M Yoshida M Kusuhara M Moroi N Tada F Ohsuzu 2002 Osteopontin plays an important role in the development of medial thickening and neointimal formation Circ Res 91 1 77 82 12114325
    • (2002) Circ Res , vol.91 , Issue.1 , pp. 77-82
    • Isoda, K.1    Nishikawa, K.2    Kamezawa, Y.3    Yoshida, M.4    Kusuhara, M.5    Moroi, M.6    Tada, N.7    Ohsuzu, F.8
  • 39
    • 0036499086 scopus 로고    scopus 로고
    • Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice
    • 11859094
    • M Jansson V Panoutsakopoulou J Baker L Klein H Cantor 2002 Cutting edge: attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin- deficient mice J Immunol 168 5 2096 9 11859094
    • (2002) J Immunol , vol.168 , Issue.5 , pp. 2096-9
    • Jansson, M.1    Panoutsakopoulou, V.2    Baker, J.3    Klein, L.4    Cantor, H.5
  • 40
    • 0034733562 scopus 로고    scopus 로고
    • Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification
    • 10766759
    • S Jono C Peinado CM Giachelli 2000 Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification J Biol Chem 275 26 20197 20203 10766759
    • (2000) J Biol Chem , vol.275 , Issue.26 , pp. 20197-20203
    • Jono, S.1    Peinado, C.2    Giachelli, C.M.3
  • 41
    • 67849083066 scopus 로고    scopus 로고
    • Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus
    • 19339987
    • SN Kariuki JG Moore KA Kirou MK Crow TO Utset TB Niewold 2009 Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus Genes Immun 10 487 494 19339987
    • (2009) Genes Immun , vol.10 , pp. 487-494
    • Kariuki, S.N.1    Moore, J.G.2    Kirou, K.A.3    Crow, M.K.4    Utset, T.O.5    Niewold, T.B.6
  • 42
    • 0032926684 scopus 로고    scopus 로고
    • CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
    • 9892210
    • YU Katagiri J Sleeman H Fujii P Herrlich H Hotta K Tanaka S Chikuma H Yagita K Okumura M Murakami I Saiki AF Chambers T Uede 1999 CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis Cancer Res 59 1 219 226 9892210
    • (1999) Cancer Res , vol.59 , Issue.1 , pp. 219-226
    • Katagiri, Y.U.1    Sleeman, J.2    Fujii, H.3    Herrlich, P.4    Hotta, H.5    Tanaka, K.6    Chikuma, S.7    Yagita, H.8    Okumura, K.9    Murakami, M.10    Saiki, I.11    Chambers, A.F.12    Uede, T.13
  • 43
    • 12544251243 scopus 로고    scopus 로고
    • Differentiation, maturation, and survival of dendritic cells by osteopontin regulation
    • 15643009
    • K Kawamura K Iyonaga H Ichiyasu J Nagano M Suga Y Sasaki 2005 Differentiation, maturation, and survival of dendritic cells by osteopontin regulation Clin Diagn Lab Immunol 12 1 206 212 15643009
    • (2005) Clin Diagn Lab Immunol , vol.12 , Issue.1 , pp. 206-212
    • Kawamura, K.1    Iyonaga, K.2    Ichiyasu, H.3    Nagano, J.4    Suga, M.5    Sasaki, Y.6
  • 44
    • 35648934023 scopus 로고    scopus 로고
    • Control of osteopontin signaling and function by post-translational phosphorylation and protein folding
    • 17910028
    • CC Kazanecki DJ Uzwiak DT Denhardt 2007 Control of osteopontin signaling and function by post-translational phosphorylation and protein folding J Cell Biochem 102 4 912 924 17910028
    • (2007) J Cell Biochem , vol.102 , Issue.4 , pp. 912-924
    • Kazanecki, C.C.1    Uzwiak, D.J.2    Denhardt, D.T.3
  • 47
    • 0029858539 scopus 로고    scopus 로고
    • Differential screening identifies genetic markers of monocyte to macrophage maturation
    • 8864140
    • SW Krause M Rehli M Kreutz PJD Schwarzfischer R Andreesen 1996 Differential screening identifies genetic markers of monocyte to macrophage maturation J Leukoc Biol 60 4 540 5 8864140
    • (1996) J Leukoc Biol , vol.60 , Issue.4 , pp. 540-5
    • Krause, S.W.1    Rehli, M.2    Kreutz, M.3    Schwarzfischer, P.J.D.4    Andreesen, R.5
  • 48
    • 39449091122 scopus 로고    scopus 로고
    • Osteopontin expression is required for myofibroblast differentiation
    • 18079410
    • Y Lenga A Koh AS Perera CA McCulloch J Sodek R Zohar 2008 Osteopontin expression is required for myofibroblast differentiation Circ Res 102 3 319 327 18079410
    • (2008) Circ Res , vol.102 , Issue.3 , pp. 319-327
    • Lenga, Y.1    Koh, A.2    Perera, A.S.3    McCulloch, C.A.4    Sodek, J.5    Zohar, R.6
  • 49
    • 0028118893 scopus 로고
    • Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro
    • 8293561
    • L Liaw M Almeida CE Hart SM Schwartz CM Giachelli 1994 Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro Circ Res 74 2 214 224 8293561
    • (1994) Circ Res , vol.74 , Issue.2 , pp. 214-224
    • Liaw, L.1    Almeida, M.2    Hart, C.E.3    Schwartz, S.M.4    Giachelli, C.M.5
  • 50
    • 0028855585 scopus 로고
    • The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
    • 7532190
    • L Liaw MP Skinner EW Raines R Ross DA Cheresh SM Schwartz CM Giachelli 1995 The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro J Clin Invest 95 2 713 724 7532190
    • (1995) J Clin Invest , vol.95 , Issue.2 , pp. 713-724
    • Liaw, L.1    Skinner, M.P.2    Raines, E.W.3    Ross, R.4    Cheresh, D.A.5    Schwartz, S.M.6    Giachelli, C.M.7
  • 52
    • 0035733907 scopus 로고    scopus 로고
    • Distinct roles of osteopontin fragments in the development of the pulmonary involvement in sarcoidosis
    • 11976896
    • K Maeda K Takahashi F Takahashi N Tamura M Maeda S Kon T Uede Y Fukuchi 2001 Distinct roles of osteopontin fragments in the development of the pulmonary involvement in sarcoidosis Lung 179 5 279 291 11976896
    • (2001) Lung , vol.179 , Issue.5 , pp. 279-291
    • Maeda, K.1    Takahashi, K.2    Takahashi, F.3    Tamura, N.4    Maeda, M.5    Kon, S.6    Uede, T.7    Fukuchi, Y.8
  • 53
    • 55049109753 scopus 로고    scopus 로고
    • In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression
    • 18678363
    • MC Marcondes M Poling DD Watry D Hall HS Fox 2008 In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression Cell Immunol 254 1 56 62 18678363
    • (2008) Cell Immunol , vol.254 , Issue.1 , pp. 56-62
    • Marcondes, M.C.1    Poling, M.2    Watry, D.D.3    Hall, D.4    Fox, H.S.5
  • 54
    • 4344561931 scopus 로고    scopus 로고
    • Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells
    • 15325806
    • CE Marroquin L Downey H Guo PC Kuo 2004 Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells Immunol Lett 95 1 109 112 15325806
    • (2004) Immunol Lett , vol.95 , Issue.1 , pp. 109-112
    • Marroquin, C.E.1    Downey, L.2    Guo, H.3    Kuo, P.C.4
  • 55
    • 3042722398 scopus 로고    scopus 로고
    • Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating
    • 15174104
    • SM Martin JL Schwartz CM Giachelli BD Ratner 2004 Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating J Biomed Mater Res A 70 1 10 19 15174104
    • (2004) J Biomed Mater Res A , vol.70 , Issue.1 , pp. 10-19
    • Martin, S.M.1    Schwartz, J.L.2    Giachelli, C.M.3    Ratner, B.D.4
  • 57
    • 33745605192 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
    • 16474180
    • Z Mi H Guo PY Wai C Gao PC Kuo 2006 Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells Carcinogenesis 27 6 1134 1145 16474180
    • (2006) Carcinogenesis , vol.27 , Issue.6 , pp. 1134-1145
    • Mi, Z.1    Guo, H.2    Wai, P.Y.3    Gao, C.4    Kuo, P.C.5
  • 58
    • 38749106966 scopus 로고    scopus 로고
    • Molecular mechanisms linking wound inflammation and fibrosis: Knockdown of osteopontin leads to rapid repair and reduced scarring
    • 18180311
    • R Mori T Shaw P Martin 2008 Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring J Exp Med 205 1 43 51 18180311
    • (2008) J Exp Med , vol.205 , Issue.1 , pp. 43-51
    • Mori, R.1    Shaw, T.2    Martin, P.3
  • 60
    • 0028152707 scopus 로고
    • Macrophages express osteopontin during repair of myocardial necrosis
    • 7992848
    • CE Murry CM Giachelli SM Schwartz R Vracko 1994 Macrophages express osteopontin during repair of myocardial necrosis Am J Pathol 145 6 1450 1462 7992848
    • (1994) Am J Pathol , vol.145 , Issue.6 , pp. 1450-1462
    • Murry, C.E.1    Giachelli, C.M.2    Schwartz, S.M.3    Vracko, R.4
  • 61
    • 71849086031 scopus 로고    scopus 로고
    • Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    • 19017937
    • G Murugaiyan A Mittal HL Weiner 2008 Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis J Immunol 181 11 7480 7488 19017937
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 7480-7488
    • Murugaiyan, G.1    Mittal, A.2    Weiner, H.L.3
  • 62
    • 0024359247 scopus 로고
    • Sulphation of secreted phosphoprotein i (SPPI, osteopontin) is associated with mineralized tissue formation
    • 2686645
    • T Nagata R Todescan HA Goldberg Q Zhang J Sodek 1989 Sulphation of secreted phosphoprotein I (SPPI, osteopontin) is associated with mineralized tissue formation Biochem Biophys Res Commun 165 1 234 240 2686645
    • (1989) Biochem Biophys Res Commun , vol.165 , Issue.1 , pp. 234-240
    • Nagata, T.1    Todescan, R.2    Goldberg, H.A.3    Zhang, Q.4    Sodek, J.5
  • 64
    • 0032770008 scopus 로고    scopus 로고
    • Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
    • 10417195
    • GJ Nau L Liaw GL Chupp JS Berman BL Hogan RA Young 1999 Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin Infect Immun 67 8 4223 4230 10417195
    • (1999) Infect Immun , vol.67 , Issue.8 , pp. 4223-4230
    • Nau, G.J.1    Liaw, L.2    Chupp, G.L.3    Berman, J.S.4    Hogan, B.L.5    Young, R.A.6
  • 65
    • 67649336941 scopus 로고    scopus 로고
    • Polymeric osteopontin employs integrin alpha 9beta 1 as a receptor and attracts neutrophils by presenting a de novo binding site
    • 19346516
    • N Nishimichi F Higashikawa HH Kinoh Y Tateishi H Matsuda Y Yokosaki 2009 Polymeric osteopontin employs integrin alpha 9beta 1 as a receptor and attracts neutrophils by presenting a de novo binding site J Biol Chem 284 14769 14776 19346516
    • (2009) J Biol Chem , vol.284 , pp. 14769-14776
    • Nishimichi, N.1    Higashikawa, F.2    Kinoh, H.H.3    Tateishi, Y.4    Matsuda, H.5    Yokosaki, Y.6
  • 66
    • 33947249865 scopus 로고    scopus 로고
    • A constitutive endogenous osteopontin production is important for macrophage function and differentiation
    • 17306792
    • T Nystrom P Duner A Hultgardh-Nilsson 2007 A constitutive endogenous osteopontin production is important for macrophage function and differentiation Exp Cell Res 313 6 1149 1160 17306792
    • (2007) Exp Cell Res , vol.313 , Issue.6 , pp. 1149-1160
    • Nystrom, T.1    Duner, P.2    Hultgardh-Nilsson, A.3
  • 67
    • 0028148368 scopus 로고
    • Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques
    • 7918316
    • ER O'Brien MR Garvin DK Stewart T Hinohara JB Simpson SM Schwartz CM Giachelli 1994 Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques Arterioscler Thromb 14 10 1648 1656 7918316
    • (1994) Arterioscler Thromb , vol.14 , Issue.10 , pp. 1648-1656
    • O'Brien, E.R.1    Garvin, M.R.2    Stewart, D.K.3    Hinohara, T.4    Simpson, J.B.5    Schwartz, S.M.6    Giachelli, C.M.7
  • 68
    • 26944447155 scopus 로고    scopus 로고
    • Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways
    • 15790955
    • D Ogawa JF Stone Y Takata F Blaschke VH Chu DA Towler RE Law WA Hsueh D Bruemmer 2005 Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways Circ Res 96 7 e59 67 15790955
    • (2005) Circ Res , vol.96 , Issue.7 , pp. 59-67
    • Ogawa, D.1    Stone, J.F.2    Takata, Y.3    Blaschke, F.4    Chu, V.H.5    Towler, D.A.6    Law, R.E.7    Hsueh, W.A.8    Bruemmer, D.9
  • 69
    • 22344448703 scopus 로고    scopus 로고
    • Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin
    • 15812576
    • R Ohri E Tung R Rajachar CM Giachelli 2005 Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin Calcif Tissue Int 76 4 307 315 15812576
    • (2005) Calcif Tissue Int , vol.76 , Issue.4 , pp. 307-315
    • Ohri, R.1    Tung, E.2    Rajachar, R.3    Giachelli, C.M.4
  • 72
    • 0033555820 scopus 로고    scopus 로고
    • Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro
    • 9916729
    • AW O'Regan GL Chupp JA Lowry M Goetschkes N Mulligan JS Berman 1999 Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro J Immunol 162 2 1024 1031 9916729
    • (1999) J Immunol , vol.162 , Issue.2 , pp. 1024-1031
    • O'Regan, A.W.1    Chupp, G.L.2    Lowry, J.A.3    Goetschkes, M.4    Mulligan, N.5    Berman, J.S.6
  • 73
    • 0033780805 scopus 로고    scopus 로고
    • Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells
    • 11037970
    • AW O'Regan JM Hayden JS Berman 2000 Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells J Leukoc Biol 68 4 495 502 11037970
    • (2000) J Leukoc Biol , vol.68 , Issue.4 , pp. 495-502
    • O'Regan, A.W.1    Hayden, J.M.2    Berman, J.S.3
  • 75
    • 0035050845 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 and osteopontin differentially regulate monocytes recruitment in experimental glomerulonephritis
    • 11318946
    • U Panzer F Thaiss G Zahner P Barth M Reszka R Reinking G Wolf U Helmchen R Stahl 2001 Monocyte chemoattractant protein-1 and osteopontin differentially regulate monocytes recruitment in experimental glomerulonephritis Kidney Int 59 5 1762 1769 11318946
    • (2001) Kidney Int , vol.59 , Issue.5 , pp. 1762-1769
    • Panzer, U.1    Thaiss, F.2    Zahner, G.3    Barth, P.4    Reszka, M.5    Reinking, R.6    Wolf, G.7    Helmchen, U.8    Stahl, R.9
  • 76
    • 0024337752 scopus 로고
    • Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection
    • 2787378
    • R Patarca GJ Freeman RP Singh FY Wei T Durfee F Blattner DC Regnier CA Kozak BA Mock HC Morse 3rd TR Jerrells H Cantor 1989 Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection J Exp Med 170 1 145 161 2787378
    • (1989) J Exp Med , vol.170 , Issue.1 , pp. 145-161
    • Patarca, R.1    Freeman, G.J.2    Singh, R.P.3    Wei, F.Y.4    Durfee, T.5    Blattner, F.6    Regnier, D.C.7    Kozak, C.A.8    Mock, B.A.9    Morse III, H.C.10    Jerrells, T.R.11    Cantor, H.12
  • 77
    • 0027130137 scopus 로고
    • Molecular and cellular basis of genetic resistance to bacterial infection: The role of the early T-lymphocyte activation-1/osteopontin gene
    • 8110377
    • R Patarca R Saavedra H Cantor 1993 Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene Crit Rev Immunol 13 3-4 225 246 8110377
    • (1993) Crit Rev Immunol , vol.13 , Issue.34 , pp. 225-246
    • Patarca, R.1    Saavedra, R.2    Cantor, H.3
  • 78
    • 0037246185 scopus 로고    scopus 로고
    • Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice
    • 12631119
    • V Persy A Verhulst D Ysebaert K De Greef M De Broe 2003 Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice Kidney Int 63 2 543 553 12631119
    • (2003) Kidney Int , vol.63 , Issue.2 , pp. 543-553
    • Persy, V.1    Verhulst, A.2    Ysebaert, D.3    De Greef, K.4    De Broe, M.5
  • 79
    • 23044431647 scopus 로고    scopus 로고
    • Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype
    • 15855273
    • AC Renkl J Wussler T Ahrens K Thoma S Kon T Uede SF Martin JC Simon JM Weiss 2005 Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype Blood 106 3 946 955 15855273
    • (2005) Blood , vol.106 , Issue.3 , pp. 946-955
    • Renkl, A.C.1    Wussler, J.2    Ahrens, T.3    Thoma, K.4    Kon, S.5    Uede, T.6    Martin, S.F.7    Simon, J.C.8    Weiss, J.M.9
  • 81
    • 0029790518 scopus 로고    scopus 로고
    • Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages
    • 8830797
    • EE Rollo DL Laskin DT Denhardt 1996 Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages J Leukoc Biol 60 3 397 404 8830797
    • (1996) J Leukoc Biol , vol.60 , Issue.3 , pp. 397-404
    • Rollo, E.E.1    Laskin, D.L.2    Denhardt, D.T.3
  • 82
    • 51749094838 scopus 로고    scopus 로고
    • Regulated osteopontin expression by dendritic cells decisively affects their migratory capacity
    • 18449212
    • G Schulz AC Renkl A Seier L Liaw JM Weiss 2008 Regulated osteopontin expression by dendritic cells decisively affects their migratory capacity J Invest Dermatol 128 10 2541 2544 18449212
    • (2008) J Invest Dermatol , vol.128 , Issue.10 , pp. 2541-2544
    • Schulz, G.1    Renkl, A.C.2    Seier, A.3    Liaw, L.4    Weiss, J.M.5
  • 83
    • 0028228866 scopus 로고
    • Adhesive properties of osteopontin: Regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain
    • 7522656
    • DR Senger CA Perruzzi A Papadopoulos-Sergiou L Van de Water 1994 Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain Mol Biol Cell 5 5 565 574 7522656
    • (1994) Mol Biol Cell , vol.5 , Issue.5 , pp. 565-574
    • Senger, D.R.1    Perruzzi, C.A.2    Papadopoulos-Sergiou, A.3    Van De Water, L.4
  • 84
    • 0030575895 scopus 로고    scopus 로고
    • Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
    • 8972713
    • DR Senger CA Perruzzi 1996 Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin Biochim Biophys Acta 1314 1-2 13 24 8972713
    • (1996) Biochim Biophys Acta , vol.1314 , Issue.12 , pp. 13-24
    • Senger, D.R.1    Perruzzi, C.A.2
  • 85
    • 0024416919 scopus 로고
    • Elevated expression of secreted phosphoprotein i (osteopontin, 2ar) as a consequence of neoplastic transformation
    • 2686530
    • DR Senger CA Perruzzi A Papadopoulos 1989 Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation Anticancer Res 9 5 1291 1299 2686530
    • (1989) Anticancer Res , vol.9 , Issue.5 , pp. 1291-1299
    • Senger, D.R.1    Perruzzi, C.A.2    Papadopoulos, A.3
  • 86
    • 46949088027 scopus 로고    scopus 로고
    • Circulating levels of osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor-kappa B ligand, and high-sensitivity C-reactive protein in patients with active rheumatoid arthritis randomized to etanercept alone or in combination with methotrexate
    • 18612923
    • H Sennels S Sorensen M Ostergaard L Knudsen M Hansen H Skjodt N Peters A Colic K Grau S Jacobsen 2008 Circulating levels of osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor-kappa B ligand, and high-sensitivity C-reactive protein in patients with active rheumatoid arthritis randomized to etanercept alone or in combination with methotrexate Scand J Rheumatol 37 4 241 247 18612923
    • (2008) Scand J Rheumatol , vol.37 , Issue.4 , pp. 241-247
    • Sennels, H.1    Sorensen, S.2    Ostergaard, M.3    Knudsen, L.4    Hansen, M.5    Skjodt, H.6    Peters, N.7    Colic, A.8    Grau, K.9    Jacobsen, S.10
  • 88
    • 33645963170 scopus 로고    scopus 로고
    • Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells
    • 16604075
    • ML Shinohara L Lu J Bu MB Werneck KS Kobayashi LH Glimcher H Cantor 2006 Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells Nat Immunol 7 5 498 506 16604075
    • (2006) Nat Immunol , vol.7 , Issue.5 , pp. 498-506
    • Shinohara, M.L.1    Lu, L.2    Bu, J.3    Werneck, M.B.4    Kobayashi, K.S.5    Glimcher, L.H.6    Cantor, H.7
  • 89
    • 44449131554 scopus 로고    scopus 로고
    • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells
    • 18480255
    • ML Shinohara HJ Kim JH Kim VA Garcia H Cantor 2008 Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells Proc Natl Acad Sci U S A 105 20 7235 7239 18480255
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.20 , pp. 7235-7239
    • Shinohara, M.L.1    Kim, H.J.2    Kim, J.H.3    Garcia, V.A.4    Cantor, H.5
  • 90
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type i interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • 18619869
    • ML Shinohara JH Kim VA Garcia H Cantor 2008 Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin Immunity 29 1 68 78 18619869
    • (2008) Immunity , vol.29 , Issue.1 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 92
    • 0025014026 scopus 로고
    • Physiological properties and differential glycosylation of phosphorylated and nonphosphorylated forms of osteopontin secreted by normal rat kidney cells
    • 2211731
    • K Singh MW DeVouge BB Mukherjee 1990 Physiological properties and differential glycosylation of phosphorylated and nonphosphorylated forms of osteopontin secreted by normal rat kidney cells J Biol Chem 265 30 18696 18701 2211731
    • (1990) J Biol Chem , vol.265 , Issue.30 , pp. 18696-18701
    • Singh, K.1    Devouge, M.W.2    Mukherjee, B.B.3
  • 93
    • 0031845051 scopus 로고    scopus 로고
    • Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin
    • 9665832
    • LL Smith CM Giachelli 1998 Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin Exp Cell Res 242 1 351 360 9665832
    • (1998) Exp Cell Res , vol.242 , Issue.1 , pp. 351-360
    • Smith, L.L.1    Giachelli, C.M.2
  • 94
    • 0029946457 scopus 로고    scopus 로고
    • Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin
    • 8910476
    • LL Smith HK Cheung LE Ling J Chen D Sheppard R Pytela CM Giachelli 1996 Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin J Biol Chem 271 45 28485 28491 8910476
    • (1996) J Biol Chem , vol.271 , Issue.45 , pp. 28485-28491
    • Smith, L.L.1    Cheung, H.K.2    Ling, L.E.3    Chen, J.4    Sheppard, D.5    Pytela, R.6    Giachelli, C.M.7
  • 96
    • 0028875692 scopus 로고
    • Posttranslational modifications of bovine osteopontin: Identification of twenty-eight phosphorylation and three O-glycosylation sites
    • 8535240
    • ES Sorensen P Hojrup TE Petersen 1995 Posttranslational modifications of bovine osteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sites Protein Sci 4 10 2040 2049 8535240
    • (1995) Protein Sci , vol.4 , Issue.10 , pp. 2040-2049
    • Sorensen, E.S.1    Hojrup, P.2    Petersen, T.E.3
  • 97
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    • 17290272
    • L Steinman 2007 A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage Nat Med 13 2 139 45 17290272
    • (2007) Nat Med , vol.13 , Issue.2 , pp. 139-45
    • Steinman, L.1
  • 98
    • 0036900001 scopus 로고    scopus 로고
    • Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification
    • 12466120
    • SA Steitz MY Speer MD McKee L Liaw M Almeida H Yang CM Giachelli 2002 Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification Am J Pathol 161 6 2035 2046 12466120
    • (2002) Am J Pathol , vol.161 , Issue.6 , pp. 2035-2046
    • Steitz, S.A.1    Speer, M.Y.2    McKee, M.D.3    Liaw, L.4    Almeida, M.5    Yang, H.6    Giachelli, C.M.7
  • 100
    • 34547885530 scopus 로고    scopus 로고
    • An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
    • 17452979
    • V Takafuji M Forgues E Unsworth P Goldsmith XW Wang 2007 An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma Oncogene 26 44 6361 6371 17452979
    • (2007) Oncogene , vol.26 , Issue.44 , pp. 6361-6371
    • Takafuji, V.1    Forgues, M.2    Unsworth, E.3    Goldsmith, P.4    Wang, X.W.5
  • 101
    • 0032425544 scopus 로고    scopus 로고
    • The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion
    • 9891840
    • K Takahashi F Takahashi KK Tanabe H Takahashi Y Fukuchi 1998 The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion Biochem Mol Biol Int 46 6 1081 1092 9891840
    • (1998) Biochem Mol Biol Int , vol.46 , Issue.6 , pp. 1081-1092
    • Takahashi, K.1    Takahashi, F.2    Tanabe, K.K.3    Takahashi, H.4    Fukuchi, Y.5
  • 103
    • 6344258588 scopus 로고    scopus 로고
    • The role of osteopontin in tumor metastasis
    • 15501463
    • PY Wai PC Kuo 2004 The role of osteopontin in tumor metastasis J Surg Res 121 2 228 241 15501463
    • (2004) J Surg Res , vol.121 , Issue.2 , pp. 228-241
    • Wai, P.Y.1    Kuo, P.C.2
  • 104
    • 38549097166 scopus 로고    scopus 로고
    • Osteopontin: Regulation in tumor metastasis
    • 18049863
    • PY Wai PC Kuo 2008 Osteopontin: regulation in tumor metastasis Cancer Metastasis Rev 27 1 103 118 18049863
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.1 , pp. 103-118
    • Wai, P.Y.1    Kuo, P.C.2
  • 105
    • 33746825450 scopus 로고    scopus 로고
    • Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation
    • 16904962
    • PY Wai L Guo C Gao Z Mi H Guo PC Kuo 2006 Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation Surgery 140 2 132 140 16904962
    • (2006) Surgery , vol.140 , Issue.2 , pp. 132-140
    • Wai, P.Y.1    Guo, L.2    Gao, C.3    Mi, Z.4    Guo, H.5    Kuo, P.C.6
  • 106
    • 0030064334 scopus 로고    scopus 로고
    • Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
    • 8560266
    • GF Weber S Ashkar MJ Glimcher H Cantor 1996 Receptor-ligand interaction between CD44 and osteopontin (Eta-1) Science 271 5248 509 512 8560266
    • (1996) Science , vol.271 , Issue.5248 , pp. 509-512
    • Weber, G.F.1    Ashkar, S.2    Glimcher, M.J.3    Cantor, H.4
  • 107
    • 20244386058 scopus 로고    scopus 로고
    • Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    • 12377945
    • GF Weber S Zawaideh S Hikita VA Kumar H Cantor S Ashkar 2002 Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation J Leukoc Biol 72 4 752 761 12377945
    • (2002) J Leukoc Biol , vol.72 , Issue.4 , pp. 752-761
    • Weber, G.F.1    Zawaideh, S.2    Hikita, S.3    Kumar, V.A.4    Cantor, H.5    Ashkar, S.6
  • 108
    • 0035167115 scopus 로고    scopus 로고
    • Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes
    • 11696588
    • JM Weiss AC Renkl CS Maier M Kimmig L Liaw T Ahrens S Kon M Maeda H Hotta T Uede JC Simon 2001 Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes J Exp Med 194 9 1219 1229 11696588
    • (2001) J Exp Med , vol.194 , Issue.9 , pp. 1219-1229
    • Weiss, J.M.1    Renkl, A.C.2    Maier, C.S.3    Kimmig, M.4    Liaw, L.5    Ahrens, T.6    Kon, S.7    Maeda, M.8    Hotta, H.9    Uede, T.10    Simon, J.C.11
  • 111
    • 0028214511 scopus 로고
    • Recombinant GST-human osteopontin fusion protein i.[J Cell Biochem. 1994]-PubMed Result
    • 8175899
    • J Xuan C Hota A Chambers 1994 Recombinant GST-human osteopontin fusion protein i...[J Cell Biochem. 1994]-PubMed Result J Cell Biochem 54 2 247 255 8175899
    • (1994) J Cell Biochem , vol.54 , Issue.2 , pp. 247-255
    • Xuan, J.1    Hota, C.2    Chambers, A.3
  • 113
    • 34548142961 scopus 로고    scopus 로고
    • Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody
    • 17761350
    • N Yamamoto T Nakashima M Torikai T Naruse J Morimoto S Kon F Sakai T Uede 2007 Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody Int Immunopharmacol 7 11 1460 1470 17761350
    • (2007) Int Immunopharmacol , vol.7 , Issue.11 , pp. 1460-1470
    • Yamamoto, N.1    Nakashima, T.2    Torikai, M.3    Naruse, T.4    Morimoto, J.5    Kon, S.6    Sakai, F.7    Uede, T.8
  • 115
    • 28844482875 scopus 로고    scopus 로고
    • Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin
    • 16005200
    • Y Yokosaki K Tanaka F Higashikawa K Yamashita A Eboshida 2005 Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin Matrix Biol 24 6 418 427 16005200
    • (2005) Matrix Biol , vol.24 , Issue.6 , pp. 418-427
    • Yokosaki, Y.1    Tanaka, K.2    Higashikawa, F.3    Yamashita, K.4    Eboshida, A.5
  • 117
    • 51249084799 scopus 로고    scopus 로고
    • Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis
    • 18555021
    • J Zhao L Dong B Lu G Wu D Xu J Chen K Li X Tong J Dai S Yao M Wu Y Guo 2008 Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis Gastroenterology 135 3 956 968 18555021
    • (2008) Gastroenterology , vol.135 , Issue.3 , pp. 956-968
    • Zhao, J.1    Dong, L.2    Lu, B.3    Wu, G.4    Xu, D.5    Chen, J.6    Li, K.7    Tong, X.8    Dai, J.9    Yao, S.10    Wu, M.11    Guo, Y.12
  • 118
    • 1642316557 scopus 로고    scopus 로고
    • Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: Evidence of a role for an intracellular form of osteopontin
    • 14584055
    • B Zhu K Suzuki HA Goldberg SR Rittling DT Denhardt CA McCulloch J Sodek 2004 Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin J Cell Physiol 198 1 155 167 14584055
    • (2004) J Cell Physiol , vol.198 , Issue.1 , pp. 155-167
    • Zhu, B.1    Suzuki, K.2    Goldberg, H.A.3    Rittling, S.R.4    Denhardt, D.T.5    McCulloch, C.A.6    Sodek, J.7
  • 119
    • 0034093124 scopus 로고    scopus 로고
    • Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration
    • 10825241
    • R Zohar N Suzuki K Suzuki P Arora M Glogauer CA McCulloch J Sodek 2000 Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration J Cell Physiol 184 1 118 130 10825241
    • (2000) J Cell Physiol , vol.184 , Issue.1 , pp. 118-130
    • Zohar, R.1    Suzuki, N.2    Suzuki, K.3    Arora, P.4    Glogauer, M.5    McCulloch, C.A.6    Sodek, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.