Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells

Diabetes

Volumn 62, Issue 10, 2013, Pages 3448-3458

  Shirakawa, Jun ^a   Togashi, Yu ^a   Sakamoto, Eri ^a   Kaji, Mitsuyo ^a   Tajima, Kazuki ^a   Orime, Kazuki ^a   Inoue, Hideaki ^a   Kubota, Naoto ^b   Kadowaki, Takashi ^b   Terauchi, Yasuo ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALANINE AMINOTRANSFERASE; BRIMONIDINE; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CHOLESTEROL; COMPLEMENTARY DNA; DIAZOXIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FATTY ACID; GLUCOKINASE; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN RECEPTOR SUBSTRATE 2; LINOLEIC ACID; LINSITINIB; LIPID; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN BAX; PROTEIN BCL 2; SUCROSE; TACROLIMUS; TRANSCRIPTION FACTOR PDX 1; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; LIPID BLOOD LEVEL; MALE; MICROARRAY ANALYSIS; MOUSE; NICK END LABELING; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; WEIGHT GAIN; WILD TYPE; ANIMAL; C57BL MOUSE; DEFICIENCY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; HOMEOSTASIS; HYPOTHALAMUS; METABOLISM; PATHOLOGY; PROTEIN MICROARRAY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPOTHALAMUS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; PROTEIN ARRAY ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 84891533293     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0052     Document Type: Article

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