Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3800-3809

  Iino, Tomoharu ^a   Hashimoto, Noriaki ^a   Sasaki, Kaori ^a   Ohyama, Sumika ^a   Yoshimoto, Riki ^a   Hosaka, Hideka ^a   Hasegawa, Takuro ^a   Chiba, Masato ^a   Nagata, Yasufumi ^a   Eiki, Jun ichi ^a   Nishimura, Teruyuki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

3,5 Disubstituted benzamides; Glucokinase; Glucokinase activator; Glucose lowering efficacy; Log D

Indexed keywords

3 (2 HYDROXY 1 METHYLETHOXY) 5 [4 (METHYLSULFONYL)PHENOXY] N 1,3 THIAZOL 2 YLBENZAMIDE; BENZAMIDE DERIVATIVE; GLUCOKINASE; GLUCOSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DIABETES MELLITUS; DISTRIBUTION VOLUME; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; GLUCOSE BLOOD LEVEL; HYDROPHOBICITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; DOGS; ENZYME ACTIVATION; ENZYME ACTIVATORS; GLUCOKINASE; HUMANS; MALE; MICE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 65549120038     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.040     Document Type: Article

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