Oxidative DNA damage from nanoparticle exposure and its application to workers' health: A literature review

Safety and Health at Work

Volumn 4, Issue 4, 2013, Pages 177-186

  Rim, Kyung Taek ^a   Song, Se Wook ^a   Kim, Hyeon Yeong ^a  

^a Korea Occupational Safety and Health Agency   (South Korea)

Author keywords

DNA damage; health; nanoparticle exposure; occupational safety; workers

Indexed keywords

CARBON NANOPARTICLE; FULLERENE DERIVATIVE; GOLD NANOPARTICLE; IRON OXIDE NANOPARTICLE; NANOMATERIAL; NANOPARTICLE; QUANTUM DOT; SILICA NANOPARTICLE; SILVER NANOPARTICLE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE;

DNA DAMAGE; HUMAN; MEDLINE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; OXIDATIVE STRESS; REVIEW;

EID: 84891373038     PISSN: 20937911     EISSN: 20937997     Source Type: Journal    
DOI: 10.1016/j.shaw.2013.07.006     Document Type: Review

References (121)

1. J.J. Li, S. Muralikrishnan, C.T. Ng, L.Y. Yung, and B.H. Bay Nanoparticle-induced pulmonary toxicity Exp Biol Med (Maywood) 235 2010 1025 1033
2. S. Arora, J.M. Rajwade, and K.M. Paknikar Nanotoxicology and in vitro studies: the need of the hour Toxicol Appl Pharmacol 258 2012 151 165
3. J.C. Lee, Y.O. Son, P. Pratheeshkumar, and X. Shi Oxidative stress and metal carcinogenesis Free Radic Biol Med 53 2012 742 757
4. T.A. Kuhlbusch, C. Asbach, H. Fissan, D. Göhler, and M. Stintz Nanoparticle exposure at nanotechnology workplaces: a review Part Fibre Toxicol 8 2011 22
5. W. Liu, P. Chaurand, C. Di Giorgio, M. De Méo, A. Thill, M. Auffan, A. Masion, D. Borschneck, F. Chaspoul, P. Gallice, A. Botta, J.Y. Bottero, and J. Rose Influence of the length of imogolite-like nanotubes on their cytotoxicity and genotoxicity toward human dermal cells Chem Res Toxicol 25 2012 2513 2522
6. T. Eustaquio, and J.F. Leary Single-cell nanotoxicity assays of superparamagnetic iron oxide nanoparticles Methods Mol Biol 926 2012 69 85
7. P. Møller, N.R. Jacobsen, J.K. Folkmann, P.H. Danielsen, L. Mikkelsen, J.G. Hemmingsen, L.K. Vesterdal, L. Forchhammer, H. Wallin, and S. Loft Role of oxidative damage in toxicity of particulates Free Radic Res 44 2010 1 46
8. L. Wang, Y. Liu, W. Li, X. Jiang, Y. Ji, X. Wu, L. Xu, Y. Qiu, K. Zhao, T. Wei, Y. Li, Y. Zhao, and C. Chen Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy Nano Lett 11 2011 772 780
9. W. He, Y.T. Zhou, W.G. Wamer, X. Hu, X. Wu, Z. Zheng, M.D. Boudreau, and J.J. Yin Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging Biomaterials 34 2013 765 773
10. C. Di Guglielmo, J. De Lapuente, C. Porredon, D. Ramos-López, J. Sendra, and M. Borràs In vitro safety toxicology data for evaluation of gold nanoparticles chronic cytotoxicity, genotoxicity and uptake J Nanosci Nanotechnol 12 2012 6185 6191
11. W. Gao, K. Xu, L. Ji, and B. Tang Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells Toxicol Lett 205 2011 86 95
12. K.T. Butterworth, J.A. Coulter, S. Jain, J. Forker, S.J. McMahon, G. Schettino, K.M. Prise, F.J. Currell, and D.G. Hirst Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy Nanotechnology 21 2010 295101
13. N.J. Siddiqi, M.A. Abdelhalim, A.K. El-Ansary, A.S. Alhomida, and W.Y. Ong Identification of potential biomarkers of gold nanoparticle toxicity in rat brains J Neuroinflammation 12 2012 123
14. J.J. Li, S.L. Lo, C.T. Ng, R.L. Gurung, D. Hartono, M.P. Hande, C.N. Ong, B.H. Bay, and L.Y. Yung Genomic instability of gold nanoparticle treated human lung fibroblast cells Biomaterials 23 2011 5515 5523
15. M. Schulz, L. Ma-Hock, S. Brill, V. Strauss, S. Treumann, S. Gröters, B. van Ravenzwaay, and R. Landsiedel Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats Mutat Res 745 2012 51 57
16. J.H. Hwang, S.J. Kim, Y.H. Kim, J.R. Noh, G.T. Gang, B.H. Chung, N.W. Song, and C.H. Lee Susceptibility to gold nanoparticle-induced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis Toxicology 294 2012 27 35
17. B. Geffroy, C. Ladhar, S. Cambier, M. Treguer-Delapierre, D. Brèthes, and J.P. Bourdineaud Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: the role of size, concentration and exposure time Nanotoxicology 6 2012 144 160
18. K.K. Panda, V.M. Achary, R. Krishnaveni, B.K. Padhi, S.N. Sarangi, S.N. Sahu, and B.B. Panda In vitro biosynthesis and genotoxicity bioassay of silver nanoparticles using plants Toxicol In Vitro 25 2011 1097 1105
19. X.L. Song, B. Li, K. Xu, J. Liu, W. Ju, J. Wang, X.D. Liu, J. Li, and Y.F. Qi Cytotoxicity of water-soluble mPEG-SH-coated silver nanoparticles in HL-7702 cells Cell Biol Toxicol 28 2012 225 237
20. M.J. Piao, K.A. Kang, I.K. Lee, H.S. Kim, S. Kim, J.Y. Choi, J. Choi, and J.W. Hyun Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis Toxicol Lett 201 2011 92 100
21. J.S. Teodoro, A.M. Simões, F.V. Duarte, A.P. Rolo, R.C. Murdoch, S.M. Hussain, and C.M. Palmeira Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective Toxicol In Vitro 25 2011 664 670
22. M.V. Park, A.M. Neigh, J.P. Vermeulen, L.J. de la Fonteyne, H.W. Verharen, J.J. Briedé, H. van Loveren, and W.H. de Jong The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles Biomaterials 32 2011 9810 9817
23. L. Li, J. Sun, X. Li, Y. Zhang, Z. Wang, C. Wang, J. Dai, and Q. Wang Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity Biomaterials 33 2012 1714 1721
24. R.P. Singh, and P. Ramarao Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles Toxicol Lett 213 2012 249 259
25. Y. Chen, H. Chen, X. Zheng, and H. Mu The impacts of silver nanoparticles and silver ions on wastewater biological phosphorous removal and the mechanisms J Hazard Mater 239-240 2012 88 94
26. M. Ghosh, J. Manivannan, S. Sinha, A. Chakraborty, S.K. Mallick, M. Bandyopadhyay, and A. Mukherjee In vitro and in vivo genotoxicity of silver nanoparticles Mutat Res 749 2012 60 69
27. J. Gromadzka-Ostrowska, K. Dziendzikowska, A. Lankoff, M. Dobrzyñska, C. Instanes, G. Brunborg, A. Gajowik, J. Radzikowska, M. Wojewódzka, and M. Kruszewski Silver nanoparticles effects on epididymal sperm in rats Toxicol Lett 214 2012 251 258
28. C.H. Pham, J. Yi, and M.B. Gu Biomarker gene response in male medaka (Oryzias latipes) chronically exposed to silver nanoparticle Ecotoxicol Environ Saf 78 2012 239 245
29. F. Gagné, C. André, R. Skirrow, M. Gélinas, J. Auclair, G. van Aggelen, P. Turcotte, and C. Gagnon Toxicity of silver nanoparticles to rainbow trout: A toxicogenomic approach Chemosphere 89 2012 615 622
30. Y. Liu, W. Guan, G. Ren, and Z. Yang The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats Toxicol Lett 209 2012 227 231
31. N. Mei, Y. Zhang, Y. Chen, X. Guo, W. Ding, S.F. Ali, A.S. Biris, P. Rice, M.M. Moore, and T. Chen Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells Environ Mol Mutagen 53 2012 409 419
32. J.S. Kim, J.H. Sung, J.H. Ji, K.S. Song, J.H. Lee, C.S. Kang, and I.J. Yu In vivo genotoxicity of silver nanoparticles after 90-day silver nanoparticle inhalation exposure Saf Health Work 2 2011 34 38
33. 2 nanoparticles in human hepatoma HepG2 cells Nanotoxicology 5 2011 341 353
34. J. Xu, Y. Sagawa, M. Futakuchi, K. Fukamachi, D.B. Alexander, F. Furukawa, Y. Ikarashi, T. Uchino, T. Nishimura, A. Morita, M. Suzui, and H. Tsuda Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats Food Chem Toxicol 49 2011 1298 1302
35. 2 rutile/anatase mixed phase nanoparticles on Caco-2 cells Chem Res Toxicol 25 2012 646 655
36. Z. Magdolenova, D. Bilanièová, G. Pojana, L.M. Fjellsbø, A. Hudecova, K. Hasplova, A. Marcomini, and M. Dusinska Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity J Environ Monitor 14 2012 455 464
37. 2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells Appl Biochem Biotechnol 167 2012 791 808
38. Q. Saquib, A.A. Al-Khedhairy, M.A. Siddiqui, F.M. Abou-Tarboush, A. Azam, and J. Musarrat Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells Toxicol In Vitro 26 2012 351 361
39. D. Zheng, N. Wang, X. Wang, Y. Tang, L. Zhu, Z. Huang, H. Tang, Y. Shi, Y. Wu, M. Zhang, and B. Lu Effects of the interaction of TiO2 nanoparticles with bisphenol A on their physicochemical properties and in vitro toxicity J Hazard Mater 199-200 2012 426 432
40. S. Wang, L.A. Hunter, Z. Arslan, M.G. Wilkerson, and J.K. Wickliffe Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese hamster ovary cells Environ Mol Mutagen 52 2011 614 622
41. 1-DDT in human hepatocytes Environ Mol Mutagen 51 2010 192 204
42. R.K. Shukla, V. Sharma, A.K. Pandey, S. Singh, S. Sultana, and A. Dhawan ROS mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells Toxicol In Vitro 25 2011 231 241
43. L.P. Sycheva, V.S. Zhurkov, V.V. Iurchenko, N.O. Daugel-Dauge, M.A. Kovalenko, E.K. Krivtsova, and A.D. Durnev Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo Mutat Res 726 2011 8 14
44. 2 nanoparticles induce oxidative DNA damage and apoptosis in human liver cells Nanotoxicology 7 2013 48 60
45. 2-NPs exhibit adverse effects at predicted environmental relevant concentrations on nematodes in a modified chronic toxicity assay system J Hazard Mater 243 2012 161 168
46. 2 in mice Mutat Res 745 2012 58 64
47. R. Guan, T. Kang, F. Lu, Z. Zhang, H. Shen, and M. Liu Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles Nanoscale Res Lett 7 2012 602
48. V. Sharma, D. Anderson, and A. Dhawan Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2) Apoptosis 17 2012 852 870
49. M.J. Akhtar, M. Ahamed, S. Kumar, M.M. Khan, J. Ahmad, and S.A. Alrokayan Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species Int J Nanomedicine 7 2012 845 857
50. I.L. Hsiao, and Y.J. Huang Titanium oxide shell coatings decrease the cytotoxicity of ZnO nanoparticles Chem Res Toxicol 24 2011 303 313
51. V. Sharma, P. Singh, A.K. Pandey, and A. Dhawan Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles Mutat Res 745 2012 84 91
52. M. Ahamed, M.J. Akhtar, M. Raja, I. Ahmad, M.K. Siddiqui, M.S. AlSalhi, and S.A. Alrokayan ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress Nanomedicine 7 2011 904 913
53. P. Landa, R. Vankova, J. Andrlova, J. Hodek, P. Marsik, H. Storchova, J.C. White, and T. Vanek Nanoparticle-specific changes in Arabidopsis thaliana gene expression after exposure to ZnO, TiO2, and fullerene soot J Hazard Mater 241-2 2012 55 62
54. S.P. Foy, and V. Labhasetwar Oh the irony: iron as a cancer cause or cure? Biomaterials 32 2011 9155 9158
55. 4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice Int J Nanomedicine 7 2012 4809 4818
56. N. Singh, G.J. Jenkins, B.C. Nelson, B.J. Marquis, T.G. Maffeis, A.P. Brown, P.M. Williams, C.J. Wright, and S.H. Doak The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles Biomaterials 33 2012 163 170
57. M.T. Zhu, B. Wang, Y. Wang, L. Yuan, H.J. Wang, M. Wang, H. Ouyang, Z.F. Chai, W.Y. Feng, and Y.L. Zhao Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: risk factors for early atherosclerosis Toxicol Lett 203 2011 162 171
58. M.I. Khan, A. Mohammad, G. Patil, S.A. Naqvi, L.K. Chauhan, and I. Ahmad Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles Biomaterials 33 2012 1477 1488
59. S. Barillet, M.L. Jugan, M. Laye, Y. Leconte, N. Herlin-Boime, C. Reynaud, and M. Carrière In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: cyto-, genotoxicity and oxidative stress Toxicol Lett 198 2010 324 330
60. M.V. Park, H.W. Verharen, E. Zwart, L.G. Hernandez, J. van Benthem, A. Elsaesser, C. Barnes, G. McKerr, C.V. Howard, A. Salvati, I. Lynch, K.A. Dawson, and W.H. de Jong Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay Nanotoxicology 5 2011 168 181
61. L. Gonzalez, L.C. Thomassen, G. Plas, V. Rabolli, D. Napierska, I. Decordier, M. Roelants, P.H. Hoet, C.E. Kirschhock, J.A. Martens, D. Lison, and M. Kirsch-Volders Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models Nanotoxicology 4 2010 382 395
62. C. Gong, G. Tao, L. Yang, J. Liu, H. He, and Z. Zhuang The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells Mol Biol Rep 39 2012 4915 4925
63. Y. Shi, S. Yadav, F. Wang, and H. Wang Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro J Toxicol Environ Health A 73 2010 748 756
64. L. Sun, Y. Li, X. Liu, M. Jin, L. Zhang, Z. Du, C. Guo, P. Huang, and Z. Sun Cytotoxicity and mitochondrial damage caused by silica nanoparticles Toxicol In Vitro 25 2011 1619 1629
65. J.M. Berg, A.A. Romoser, D.E. Figueroa, C. Spencer West, and C.M. Sayes Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2 Toxicol In Vitro 27 2013 24 33
66. V. Christen, and K. Fent Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity Chemosphere 87 2012 423 434
67. M. Yan, Y. Zhang, K. Xu, T. Fu, H. Qin, and X. Zheng An in vitro study of vascular endothelial toxicity of CdTe quantum dots Toxicology 282 2011 94 103
68. L. Wang, J. Zhang, Y. Zheng, J. Yang, Q. Zhang, and X. Zhu Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells J Nanosci Nanotechnol 10 2010 8591 8596
69. S.J. Soenen, J. Demeester, S.C. De Smedt, and K. Braeckmans The cytotoxic effects of polymer-coated quantum dots and restrictions for live cell applications Biomaterials 33 2012 4882 4888
70. W.K. Khalil, E. Girgis, A.N. Emam, M.B. Mohamed, and K.V. Rao Genotoxicity evaluation of nanomaterials: DNA damage, micronuclei, and 8-hydroxy-2-deoxyguanosine induced by magnetic doped CdSe quantum dots in male mice Chem Res Toxicol 24 2011 640 665
71. M.L. Di Giorgio, S. Di Bucchianico, A.M. Ragnelli, P. Aimola, S. Santucci, and A. Poma Effects of single and multi walled carbon nanotubes on macrophages: cyto and genotoxicity and electron microscopy Mutat Res 722 2011 20 31
72. Y.Y. Guo, J. Zhang, Y.F. Zheng, J. Yang, and X.Q. Zhu Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro Mutat Res 721 2011 184 191
73. K.H. Ahn, S.M. Kim, and I.J. Yu Multi-walled carbon nanotube (MWCNT) dispersion and aerosolization with hot water atomization without addition of any surfactant Saf Health Work 2 2011 65 69
74. J. Kayat, V. Gajbhiye, R.K. Tekade, and N.K. Jain Pulmonary toxicity of carbon nanotubes: a systematic report Nanomedicine 7 2011 40 49
75. C.L. Ursini, D. Cavallo, A.M. Fresegna, A. Ciervo, R. Maiello, G. Buresti, S. Casciardi, F. Tombolini, S. Bellucci, and S. Iavicoli Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells Toxicol In Vitro 26 2012 831 840
76. Y. Xing, W. Xiong, L. Zhu, E. Osawa, S. Hussin, and L. Dai DNA damage in embryonic stem cells caused by nanodiamonds ACS Nano 5 2011 2376 2384
77. C.X. Shen, Q.F. Zhang, J. Li, F.C. Bi, and N. Yao Induction of programmed cell death in Arabidopsis and rice by single-wall carbon nanotubes Am J Bot 97 2010 1602 1609
78. R. Cicchetti, M. Divizia, F. Valentini, and G. Argentin Effects of single-wall carbon nanotubes in human cells of the oral cavity: geno-cytotoxic risk Toxicol In Vitro 25 2011 1811 1819
79. S. Pichardo, D. Gutiérrez-Praena, M. Puerto, E. Sánchez, A. Grilo, A.M. Cameán, and A. Jos Oxidative stress responses to carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2 Toxicol In Vitro 26 2012 672 677
80. J. Wang, P. Sun, Y. Bao, J. Liu, and L. An Cytotoxicity of single-walled carbon nanotubes on PC12 cells Toxicol In Vitro 25 2011 242 250
81. P. Begum, and B. Fugetsu Phytotoxicity of multi-walled carbon nanotubes on red spinach (Amaranthus tricolor L) and the role of ascorbic acid as an antioxidant J Hazard Mater 243 2012 212 222
82. M. Pacurari, Y. Qian, D.W. Porter, M. Wolfarth, Y. Wan, D. Luo, M. Ding, V. Castranova, and N.L. Guo Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology Toxicol Appl Pharmacol 255 2011 18 31
83. S.N. Al-Subiai, V.M. Arlt, P.E. Frickers, J.W. Readman, B. Stolpe, J.R. Lead, A.J. Moody, and A.N. Jha Merging nano-genotoxicology with eco-genotoxicology: an integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C(60) fullerenes and fluoranthene in marine mussels, Mytilus sp Mutat Res 745 2012 92 103
84. Y.J. Cha, J. Lee, and S.S. Choi Apoptosis-mediated in vivo toxicity of hydroxylated fullerene nanoparticles in soil nematode Caenorhabditis elegans Chemosphere 87 2012 49 54
85. C.A. Theriot, R.C. Casey, V.C. Moore, L. Mitchell, J.O. Reynolds, M. Burgoyne, R. Partha, J.L. Huff, J.L. Conyers, A. Jeevarajan, and H. Wu Dendro[C(60)]fullerene DF-1 provides radioprotection to radiosensitive mammalian cells Radiat Environ Biophys 49 2010 437 445
86. A. Kazimirova, Z. Magdolenova, M. Barancokova, M. Staruchova, K. Volkovova, and M. Dusinska Genotoxicity testing of PLGA-PEO nanoparticles in TK6 cells by the comet assay and the cytokinesis-block micronucleus assay Mutat Res 748 2012 42 47
87. O. Bondarenko, A. Ivask, A. Käkinen, and A. Kahru Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action Environ Pollut 169 2012 81 89
88. Z. Wang, N. Li, J. Zhao, J.C. White, P. Qu, and B. Xing CuO nanoparticle interaction with human epithelial cells: cellular uptake, location, export, and genotoxicity Chem Res Toxicol 25 2012 1512 1521
89. M. Ahamed, M.A. Siddiqui, M.J. Akhtar, I. Ahmad, A.B. Pant, and H.A. Alhadlaq Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells Biochem Biophys Res Commun 396 2010 578 583
90. A. Sarkar, J. Das, P. Manna, and P.C. Sil Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways Toxicology 290 2011 208 217
91. T. Gomes, C.G. Pereira, C. Cardoso, J.P. Pinheiro, I. Cancio, and M.J. Bebianno Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis Aquat Toxicol 118-9 2012 72 79
92. Y. Cho, R. Shi, and R. Ben Borgens Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury J Biol Eng 4 2010 2
93. K. Bhattacharya, P.C. Naha, I. Naydenova, S. Mintova, and H.J. Byrne Reactive oxygen species mediated DNA damage in human lung alveolar epithelial (A549) cells from exposure to non-cytotoxic MFI-type zeolite nanoparticles Toxicol Lett 215 2012 151 160
94. M. Ahamed Toxic response of nickel nanoparticles in human lung epithelial A549 cells Toxicol In Vitro 25 2011 930 936
95. A. Srinivas, P.J. Rao, G. Selvam, P.B. Murthy, and P.N. Reddy Acute inhalation toxicity of cerium oxide nanoparticles in rats Toxicol Lett 205 2011 105 115
96. A.Y. Estevez, S. Pritchard, K. Harper, J.W. Aston, A. Lynch, J.J. Lucky, J.S. Ludington, P. Chatani, W.P. Mosenthal, J.C. Leiter, S. Andreescu, and J.S. Erlichman Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia Free Radic Biol Med 51 2011 1155 1163
97. T.L. Lee, J.M. Raitano, O.M. Rennert, S.W. Chan, and W.Y. Chan Accessing the genomic effects of naked nanoceria in murine neuronal cells Nanomedicine 8 2012 599 608
98. R. Frick, B. Müller-Edenborn, A. Schlicker, B. Rothen-Rutishauser, D.O. Raemy, D. Günther, B. Hattendorf, W. Stark, and B. Beck-Schimmer Comparison of manganese oxide nanoparticles and manganese sulfate with regard to oxidative stress, uptake and apoptosis in alveolar epithelial cells Toxicol Lett 205 2011 163 172
99. S.J. Kang, I.G. Ryoo, Y.J. Lee, and M.K. Kwak Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity Toxicol Appl Pharmacol 258 2012 89 98
100. E.J. Yang, S. Kim, J.S. Kim, and I.H. Choi Inflammasome formation and IL-1b release by human blood monocytes in response to silver nanoparticles Biomaterials 33 2012 6858 6867
101. N. Gou, A. Onnis-Hayden, and A.Z. Gu Mechanistic toxicity assessment of nanomaterials by whole-cell-array stress genes expression analysis Environ Sci Technol 44 2010 5964 5970
102. R. Hu, L. Zheng, T. Zhang, G. Gao, Y. Cui, Z. Cheng, J. Cheng, M. Hong, M. Tang, and F. Hong Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles J Hazard Mater 191 2011 32 40
103. H. Gehrke, A. Frühmesser, J. Pelka, M. Esselen, L.L. Hecht, H. Blank, H.P. Schuchmann, D. Gerthsen, C. Marquardt, S. Diabaté, C. Weiss, and D. Marko In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells Nanotoxicology 7 2013 274 293
104. J. Ahmad, M. Ahamed, M.J. Akhtar, S.A. Alrokayan, M.A. Siddiqui, J. Musarrat, and A.A. Al-Khedhairy Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2 Toxicol Appl Pharmacol 259 2012 160 168
105. I. Passagne, M. Morille, M. Rousset, I. Pujalté, and B. L'azou Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells Toxicology 299 2012 112 124
106. K. Donaldson, and C.A. Poland Inhaled nanoparticles and lung cancer - what we can learn from conventional particle toxicology Swiss Med Wkly 142 2012 w13547
107. M. Ahamed, M.J. Akhtar, M.A. Siddiqui, J. Ahmad, J. Musarrat, A.A. Al-Khedhairy, M.S. AlSalhi, and S.A. Alrokayan Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells Toxicology 283 2011 101 108
108. G.S. Kang, P.A. Gillespie, A. Gunnison, A.L. Moreira, K.M. Tchou-Wong, and L.C. Chen Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model Environ Health Perspect 119 2011 176 181
109. K. Inoue, and H. Takano Aggravating impact of nanoparticles on immune-mediated pulmonary inflammation Sci World J 11 2011 382 390
110. I. Gosens, J.A. Post, L.J. de la Fonteyne, E.H. Jansen, J.W. Geus, F.R. Cassee, and W.H. de Jong Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation Part Fibre Toxicol 7 2011 37
111. E.A. Kim, J. Park, K.H. Kim, N. Lee, D.S. Kim, and S.K. Kang Outbreak of sudden cardiac deaths in a tire manufacturing facility: can it be caused by nanoparticles? Saf Health Work 3 2012 58 66
112. E.K. Rushton, J. Jiang, S.S. Leonard, S. Eberly, V. Castranova, P. Biswas, A. Elder, X. Han, R. Gelein, J. Finkelstein, and G. Oberdörster Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics J Toxicol Environ Health 73 2010 445 461
113. E.D. Kuempel, C.L. Geraci, and P.A. Schulte Risk assessment and risk management of nanomaterials in the workplace: translating research to practice Ann Occup Hyg 56 2012 491 505
114. I. Ahmad, M.I. Khan, G. Patil, and L.K. Chauhan Evaluation of cytotoxic, genotoxic and inflammatory responses of micro- and nano-particles of granite on human lung fibroblast cell IMR-90 Toxicol Lett 208 2012 300 307
115. Z. Markovic, and V. Trajkovic Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60) Biomaterials 29 2008 3561 3573
116. A. Dhawan, J.S. Taurozzi, A.K. Pandey, W. Shan, S.M. Miller, S.A. Hashsham, and V.V. Tarabara Stable colloidal dispersions of C60 fullerenes in water: evidence for genotoxicity Environ Sci Technol 40 2006 7394 7401 (Pubitemid 44871853)
117. N.R. Jacobsen, G. Pojana, P. White, P. Møller, C.A. Cohn, K.S. Korsholm, U. Vogel, A. Marcomini, S. Loft, and H. Wallin Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells Environ Mol Mutagen 49 2008 476 487
118. L. Zhu, D.W. Chang, L. Dai, and Y. Hong DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells Nano Lett 7 2007 3592 3597
119. R.A. Brooks, E. Jones, A. Storer, and N. Rushton Biological evaluation of carbon fibre-reinforced polybutyleneterephtahalate (CFRPBT) employed in a novel acetabular cup Biomaterials 25 2004 3429 3438 (Pubitemid 38327033)
120. 2 particulate in cultured human lymphoblastoid cells Environ Mol Mutagen 48 2007 151 157 (Pubitemid 46365331)
121. 2 nanoparticles induce DNA damage towards human dermal fibroblasts in vitro Nanotoxicology 3 2009 161 171