Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay

Nanotoxicology

Volumn 5, Issue 2, 2011, Pages 168-181

  Park, Margriet V D Z ^a,b   Verharen, Henny W ^a   Zwart, Edwin ^a   Hernandez, Lya G ^a   Van Benthem, Jan ^a   Elsaesser, Andreas ^c   Barnes, Clifford ^c   McKerr, George ^c   Howard, C Vyvyan ^c   Salvati, Anna ^d   Lynch, Iseult ^d   Dawson, Kenneth A ^d   De Jong, Wim H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF ULSTER   (United Kingdom)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Genotoxicity; micronucleus; mutagenic effects; nanoparticles; silica

Indexed keywords

BETA GALACTOSIDASE; DNA; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CELL VACUOLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; GENE MUTATION; GENETIC ANALYSIS; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPORTER GENE; TRANSMISSION ELECTRON MICROSCOPY;

3T3-L1 CELLS; ANIMALS; DNA DAMAGE; LAC OPERON; MICE; MUTAGENICITY TESTS; MUTATION; NANOPARTICLES; OXIDATION-REDUCTION; PARTICLE SIZE; PLASMIDS; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE;

EID: 79957873724     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2010.506016     Document Type: Article

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