Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles

Nanoscale Research Letters

Volumn 7, Issue , 2012, Pages

  Guan, Rongfa ^a   Kang, Tianshu ^a   Lu, Fei ^b   Zhang, Zhiguo ^c   Shen, Haitao ^d   Liu, Mingqi ^a  

^a CHINA JILIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c INSTITUTE OF PLANT PROTECTION AND MICROBIOLOGY   (China)

^d ZHEJIANG PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cytotoxicity; Human embryonic kidney cells; Human hepatocyte; Oxidative stress; ZnO nanoparticles

Indexed keywords

CELL DEATH; CYTOTOXICITY; DAMAGE DETECTION; ENZYMES; II-VI SEMICONDUCTORS; METAL NANOPARTICLES; MITOCHONDRIA; OXIDATIVE STRESS; TOXICITY; ZINC OXIDE;

EMBRYONIC KIDNEY CELLS; HEPATOCYTES; HUMAN EMBRYONIC KIDNEY CELLS; HUMAN EMBRYONIC KIDNEYS; MITOCHONDRIAL DYSFUNCTION; MORPHOLOGICAL MODIFICATION; OXIDATIVE STRESS MARKERS; ZINC OXIDE NANOPARTICLES;

ZNO NANOPARTICLES;

EID: 84871029415     PISSN: 19317573     EISSN: 1556276X     Source Type: Journal    
DOI: 10.1186/1556-276X-7-602     Document Type: Article

References (28)

1. Gopikrishnan R, Zhang K, Ravichandran P, Baluchamy S, Ramesh V, Biradar S, Ramesh P, Pradhan J, Hall JC, Pradhan AK, Ramesh GT: Synthesis, characterization and biocompatibility studies of zinc oxide (ZnO) nanorods for biomedical application. Nano-Micro Lett 2010, 2:31-36.
2. Zhang YF, Zhang B, Hu NT, Wang YF, Wang Z, Wang Y, Kong ES: Poly(glycidyl methacrylates)-grafted zinc oxide nanowire by surface-initiated atom transfer radical poly-merization. Nano-Micro Lett 2010, 2:285-289.
3. Suh WH, Suslick KS, Stucky GD, Suh YH: Nanotechnology, nanotoxicology and neuroscience. Prog Neurobiol 2009, 87:133-170.
4. Wiench K, Wohlleben W, Hisgen V, Radke K, Salinas E, Zok S, Landsiedel R: Acute and chronic effects of nano-and non-nano-scale TiO2 and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna. Chemosphere 2009, 76:1356-1365.
5. Serpone N, Dondi D, Albini A: Inorganic and organic UV filters: their role and efficacy in sunscreens and suncare products. Inorg Chim Acta 2007, 360:794-802.
6. Hu XK, Cook S, Wang P, Hwang HM: In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles. Total Environ 2009, 407:3070-3072.
7. Yuan JH, Chen Y, Zha HX, Song LJ, Li CY, Li JQ, Xia XH: Determination, characterization and cytotoxicity on HELF cells of ZnO nanoparticles. Colloid Surf B 2010, 76:145-150.
8. Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawa A: DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 2009, 185:211-218.
9. Berardis BD, Civitelli G, Condello M, Lista P, Pozzi R, Arancia G, Meschini S: Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol Appl Pharm 2010, 246:116-127.
10. Huang CC, Aronstam RS, Chen DR, Huang YW: Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol in Vitro 2010, 24:44-45.
11. Li JY, Guo DD, Wang XM, Wang HP, Jiang H, Chen BA: The photodynamic effect of different size ZnO nanoparticles on cancer cell proliferation in vitro. Nanoscale Res Lett 2010, 5:1063-1071.
12. Nair S, Sasidharan A, Rani VV, Menon D, Nair S, Manzoor K, Raina S: Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. J Mater Sci 2009, 20:S235-S241.
13. Lowry O, Rosebrough N, Farr A, Randall R: Protein measurement with the folin phenol reagent. J Biol Chem 1951, 193:265-275.
14. Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H: ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group: Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2005, 2:28-42.
15. Yang ST, Liu JH, Wang J, Yuan Y, Cao AN, Wang HF, Liu YF, Zhao YL: Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment. J Nanosci Nanotechnol 2010, 10:8638-8645.
16. Jeng HA, Swanson J: Toxicity of metal oxide nanoparticles on mammalian cells. J Environ Sci Health A 2006, 41:2699-2711.
17. Nel A, Xia T, MadleL R, Li N: Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
18. Lin WS, Xu Y, Huang CC, Ma YF, Shannon KB, Chen DR, Huang YW: Toxicity of nano-and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 2009, 11:25-39.
19. Deng XY, Luan QX, Chen WT, Wang YL, Wu MH, Zhang HJ, Jiao Z: Nanosized zinc oxide particles induce neural stem apoptosis. Nanotechnology 2009, 20:115101.
20. Yang H, Liu C, Yang DF, Zhang HS, Xi ZG: Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 2009, 29:69-78.
21. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP: Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol 2009, 4:876-883.
22. +-doped La(OH)3 nanophosphors for bioimaging. Nanoscale Res Lett 2011, 6:24-30.
23. Chen HB, Zheng Y, Tian G, Tian Y, Zeng XW, Liu G, Liu KX, Li L, Li Z, Lin M, Huang LQ: Oral delivery of DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles for cancer chemotherapy. Nanoscale Res Lett 2011, 6:4-13.
24. Bishop GM, Dringen R, Robinson SR: Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits gluatathione reductase in astrocytes. Free Radic Biol Med 2007, 42:1222-1230.
25. Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nanashima N, Niki E, Yoshida Y: Protein absorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells. Chem Res Toxicol 2009, 22:543-553.
26. Liu D, Wang LJ, Wang ZG, Cuschieri A: Different cellular response mechanisms contribute to the length-dependent cytotoxicity of multi-walled carbon nanotubes. Nanoscale Res Lett 2012, 7:361.
27. Ye JP, Wang SW, Leonard SS, Sun Y, Butterworth L, Antonini J, Ding M, Rojanasakul Y, Vallyathan V, Castranova V, Shi XL: Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis. J Biol Chem 1999, 274:34974-34980.
28. Wang YG, Aker WG, Hwang HM, Yedjou CG, Yu HT, Tchounwou PB: A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ 2011, 409:4753-4762.