Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

Toxicology and Applied Pharmacology

Volumn 259, Issue 2, 2012, Pages 160-168

  Ahmad, Javed ^a   Ahamed, Maqusood ^b   Akhtar, Mohd Javed ^c   Alrokayan, Salman A ^b   Siddiqui, Maqsood A ^a   Musarrat, Javed ^a   Al Khedhairy, Abdulaziz A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Apoptosis; HepG2 cells; Liver toxicity; P53; ROS; Silica nanoparticles

Indexed keywords

ASCORBIC ACID; CASPASE 3; GLUTATHIONE; MESSENGER RNA; NANOPARTICLE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SILICA NANOPARTICLE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE CHECKPOINT; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GENE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VIVO STUDY; LIPID PEROXIDATION; LIVER CELL; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL SURVIVAL; GLUTATHIONE; HEP G2 CELLS; HUMANS; LIVER; MICROSCOPY, ELECTRON; NANOPARTICLES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SILICON DIOXIDE; SPECTROMETRY, X-RAY EMISSION; TUMOR SUPPRESSOR PROTEIN P53; X-RAY DIFFRACTION;

EID: 84857238950     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.12.020     Document Type: Article

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