Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

Toxicology Letters

Volumn 201, Issue 1, 2011, Pages 92-100

  Piao, Mei Jing ^a   Kang, Kyoung Ah ^a   Lee, In Kyung ^b   Kim, Hye Sun ^b   Kim, Suhkmann ^c   Choi, Jeong Yun ^d   Choi, Jinhee ^e   Hyun, Jin Won ^a  

^a Jeju National University   (South Korea)

^b Seoul National University   (South Korea)

^c Pusan National University   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

^e University of Seoul   (South Korea)

Author keywords

Apoptosis; Glutathione; Oxidative stress; Silver nanoparticles

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE; CYTOCHROME C; GLUTATHIONE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SILVER NANOPARTICLE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CYTOTOXICITY; DIPLOIDY; DNA FRAGMENTATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIPID MEMBRANE; LIPID PEROXIDATION; LIVER CELL; MEMBRANE DAMAGE; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION;

APOPTOSIS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEPATOCYTES; HUMANS; METAL NANOPARTICLES; MITOCHONDRIA; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SILVER;

EID: 79651472432     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.12.010     Document Type: Article

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