Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model

Environmental Health Perspectives

Volumn 119, Issue 2, 2011, Pages 176-181

  Kang, Gi Soo ^a   Gillespie, Patricia Anne ^a   Gunnison, Albert ^a   Moreira, Andre Luis ^b   Tchou Wong, Kam Meng ^a   Chen, Lung Chi ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Atherosclerosis; Cardiovascular toxicity; Inhalation; Nanoparticles; Nickel

Indexed keywords

APOLIPOPROTEIN E; HEME OXYGENASE 1; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL DNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOPARTICLE; NICKEL HYDROXIDE NANOPARTICLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; THIOREDOXIN REDUCTASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; METAL NANOPARTICLE; NICKEL;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING AORTA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOTOXICITY; CARDIOVASCULAR INFLAMMATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; GENE EXPRESSION REGULATION; HEART; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPOPROTEIN DEFICIENCY; LIVER PARENCHYMA; LONG TERM EXPOSURE; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MITOCHONDRIAL DNA DISORDER; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SPLEEN; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; EXPOSURE; LUNG; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; ATHEROSCLEROSIS; DNA, MITOCHONDRIAL; INHALATION EXPOSURE; LUNG; MALE; METAL NANOPARTICLES; MICE; NICKEL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79955848928     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002508     Document Type: Article

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