Nano-TiO2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells

Applied Biochemistry and Biotechnology

Volumn 167, Issue 4, 2012, Pages 791-808

  Meena, Ramovatar ^a   Rani, Madhu ^a   Pal, Ruchita ^a   Rajamani, Paulraj ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Apoptosis; Cytotoxicity; Nano TiO2; Oxidative stress; P53

Indexed keywords

APOPTOTIC PROTEINS; CASPASE-3; CELLULAR PARAMETERS; CYTOTOXIC; DNA DAMAGES; DNA LADDER; DOSE-DEPENDENT; DOSE-DEPENDENT MANNER; GENOTOXIC EFFECTS; GLUTATHIONE PEROXIDASE; HEK-293; HEK293 CELLS; HUMAN EMBRYONIC KIDNEY CELLS; HUMAN EMBRYONIC KIDNEYS; INDUCED APOPTOSIS; LIPID PEROXIDATION; MECHANISTIC PATHWAYS; METABOLIC ACTIVITY; NANO-TIO; NANO-TIO2; OXIDATIVE DNA DAMAGE; P53; REACTIVE OXYGEN SPECIES; SUPER OXIDE DISMUTASE; TIO; WESTERN BLOTS;

CYTOTOXICITY; OXIDATIVE STRESS; OXYGEN; TOXICITY;

CELL DEATH;

CASPASE 3; CATALASE; GLUTATHIONE PEROXIDASE; NANOPARTICLE; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TITANIUM DIOXIDE;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA DAMAGE; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ASSAY; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; KIDNEY CELL; LIPID PEROXIDATION; MITOSIS INHIBITION; NEPHROTOXICITY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL SURVIVAL; CYTOTOXINS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; NANOPARTICLES; OXIDATIVE STRESS; TIME FACTORS; TITANIUM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84863719795     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-012-9699-3     Document Type: Article

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