Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2

Toxicology in Vitro

Volumn 27, Issue 1, 2013, Pages 24-33

  Michael Berg, J ^a,b   Romoser, Amelia A ^a   Figueroa, David E ^c   Spencer West, C ^d   Sayes, Christie M ^a,d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Center for Toxicology and Environmental Health   (United States)

^c Texas A M University   (United States)

^d RTI INTERNATIONAL   (United States)

Author keywords

A549; Antioxidant response; Epithelial; Mesothelial; MeT 5A; NRF2; Silica nanoparticle

Indexed keywords

CATALASE; GLUTATHIONE; HYDROGEN PEROXIDE; MESSENGER RNA; NANOPARTICLE; SILICON DIOXIDE NANOPARTICLE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLOGY; CYTOTOXICITY TEST; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENETIC STABILITY; HUMAN; IN VITRO STUDY; LONG TERM EXPOSURE; LUNG ALVEOLUS EPITHELIUM; MESOTHELIUM CELL; NANOANALYSIS; NANOCHEMISTRY; NANOTOXICOLOGY; NONHUMAN; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; TRANSCRIPTION FACTOR NRF2 GENE;

CATALASE; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; EPITHELIAL CELLS; EPITHELIUM; GLUTATHIONE; HUMANS; LUNG; NANOPARTICLES; NF-E2-RELATED FACTOR 2; SILICON DIOXIDE; SUPEROXIDE DISMUTASE;

EID: 84869432878     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.09.002     Document Type: Article

References (47)

1. Arts J.H., Muijser H., Duistermaat E., Junker K., Kuper C.F. Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3months. Food and Chemical Toxicology 2007, 45:1856-1867.
2. Atkinson R.L., Zhang M., Diagaradjane P., Peddibhotla S., Contreras A., Hilsenbeck S.G., Woodward W.A., Krishnan S., Chang J.C., Rosen J.M. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Science Translational Medicine 2010, 2:55ra79.
3. Berg J.M., Romoser A.R., Banerjee N., Zebda R., Sayes C. The relationship between pH and zeta potential of ∼30nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations. Nanotoxicology 2009, 3:276-283.
4. Brown J.S., Zeman K.L., Bennett W.D. Ultrafine particle deposition and clearance in the healthy and obstructed lung. American Journal of Respiratory and Critical Care Medicine 2002, 166:1240-1247.
5. Brunauer S., Emmett P.H., Teller E. Adsorption of gases in multimolecular layers. Journal of the American Chemical Society 1938, 60:309-319.
6. Brunner T., Wick P., Manser P., Spohn P., Grass R.N., Limbach L.K., Bruinink A., Stark W.J. In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effects of particle solubility. Environmental Science and Technology 2006, 40:3474-4381.
7. Chang J.S., Chang K.L.B., Hwang D.F., Kong Z.L. In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environmental Science and Technology 2007, 41:2064-2068.
8. Dai R. IBISWorld Industry Report 54171 Scientific Research & Development in the US 2010, IBISWorld.
9. 2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicology Letters 2009, 187:77-83.
10. Eom H.J., Choi J. SiO(2) nanoparticles induced cytotoxicity by oxidative stress in human bronchial epithelial cell, beas-2B. Environmental Health and Toxicology 2011, 26:e2011013.
11. Foucaud L., Wilson M.R., Brown D.M., Stone V. Measurement of reactive species production by nanoparticles prepared in biologically relevant media. Toxicology Letters 2007, 174:1-9.
12. Frohlich E., Samberger C., Kueznik T., Absenger M., Roblegg E., Zimmer A., Pieber T.R. Cytotoxicity of nanoparticles independent from oxidative stress. Journal of Toxicological Sciences 2009, 34:363-375.
13. Fubini B., Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biology & Medicine 2003, 34:1507-1516.
14. Jalili M., Moradian S., Dastmalchian H., Karbasi A. Investigating the variations in properties of 2-pack polyurethane clear coat through separate incorporation of hydrophilic and hydrophobic nano-silica. Progress in Organic Coatings 2007, 59:81-87.
15. Jarvinen K., Pietarinin-Runtti P., Linnainmaa K., Raivia K., Krejsa C., Kavanagh T., Kinnula V. Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. American Journal of Physiology. Lung Cellular and Molecular Physiology 2000, L696-L702.
16. Kaewamatawong T., Kawamura N., Okajima M., Sawada M., Morita T., Shimada A. Acute pulmonary toxicity caused by exposure to colloidal silica: particle size dependent pathological changes in mice. Toxicologic Pathology 2005, 33:745-751.
17. Kensler T.W., Wakabayashi N. Nrf2: friend or foe for chemoprevention?. Carcinogenesis 2010, 31:90-99.
18. Kreyling W.G., Semmler M., Erbe F., Mayer P., Takenaka S., Schulz H., Oberdorster G., Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Toxicology and Environmental Health - Part A 2002, 65:1513-1530.
19. Kumar R., Roy I., Ohulchanskky T.Y., Vathy L.A., Bergey E.J., Sajjad M., Prasad P.N. In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles. ACS Nano 2010, 4:699-708.
20. Li J.J., Oberley L.W., Stclair D.K., Ridnour L.A., Oberley T.D. Phenotypic changes induced in human breast-cancer cells by overexpression of manganese-containing superoxide-dismutase. Oncogene 1995, 10:1989-2000.
21. Limbach L.K., Wick P., Manser P., Grass R.N., Bruinink A., Stark W.J. Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. Environmental Science and Technology 2007, 41:4158-4163.
22. Lin W., Huang Y., Zhou X., Ma Y. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicology and Applied Pharmacology 2006, 217:252-259.
23. Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Tochigi S., Kondoh S., Hirai T., Akase T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Itoh N., Tsunoda S., Tsutsumi Y. Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes. Particle and Fibre Toxicology 2011, 8:1.
24. Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
25. Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K. Silica nanoparticles as hepatotoxicants. European Journal of Pharmaceutics and Biopharmaceutics 2009, 72:496-501.
26. Oberdorster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W., Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology 2004, 16:437-445.
27. Oberley L.W., Buettner G.R. Role of superoxide-dismutase in cancer - review. Cancer Research 1979, 39:1141-1149.
28. Oberley L.W., Bize I.B., Sahu S.K., Chanleuthauser S.W.H., Gruber H.E. Superoxide-dismutase activity of normal murine liver, regenerating liver, and H6-hepatoma. Journal of the National Cancer Institute 1978, 61:375-379.
29. Park E.J., Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicology Letters 2009, 184:18-25.
30. Puhakka A., Ollikainen T., Soini Y., Kahlos K., Saily M., Koistinen P., Paakko P., Linnainmaa K., Kinnula V.L. Modulation of DNA single-strand breaks by intracellular glutathione in human lung cells exposed to asbestos fibers. Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2002, 514:7-17.
31. Rothen-Rutishauser B., Muhlfeld C., Blank F., Musso C., Gehr P. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Particle and Fibre Toxicology 2007, 4:9.
32. Santra S., Zhang P., Wang K., Tapec R., Weihong T. Conjugation of biomolecules with luminophore-doped silica nanoparticle for photostable biomarkers. Analytical Chemistry 2001, 73:4993-4998.
33. Sayes C.M., Marchione A.A., Reed K.L., Warheit D.B. Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Letters 2007, 7:2399-2406.
34. Singh A., Misra V., Thimmulappa R.K., Lee H., Ames S., Hoque M.O., Herman J.G., Baylin S.B., Sidransky D., Gabrielson E., Brock M.V., Biswal S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS One 2006, 3:e420.
35. Sun L., Li Y., Liu X., Jin M., Zhang L., Du Z., Guo C., Huang P., Sun Z. Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicology in Vitro 2011, 25:1619-1629.
36. Tirumalai R., Kumar T., Mai K., Biswal S. Acrolein causes transcriptional induction of phase II genes by activation of Nrf-2 in human lung type II epithelial (A549) cells. Toxicology Letters 2002, 27-36.
37. Unfried K., Albrecht C., Klotz L., Von Mikeca A., Grether-Beck S., Schins R.P. Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 2007, 52-71.
38. Vallyathan V., Shi X.L., Dalal N.S., Irr W., Castranova V. Generation of free-radicals from freshly fractured silica dust - potential role in acute silica-induced lung injury. American Review of Respiratory Disease 1988, 138:1213-1219.
39. Wang H., Joseph J.A. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radical Biology and Medicine 1999, 27:612-616.
40. Wang X.J., Sun Z., Villeneuve N.F., Zhang S., Zhao F., Li Y.J., Chen W.M., Yi X.F., Zheng W.X., Wondrak G.T., Wong P.K., Zhang D.D. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis 2008, 29:1235-1243.
41. Wang F., Jiao C., Liu J., Yuan H., Lan M., Gao F. Oxidative mechanisms contribute to nanosize silican dioxide-induced developmental neurotoxicity in PC12 cells. Toxicology in Vitro 2011, 25:1548-1556.
42. Xie G., Sun J., Zhong G., Shi L., Zhang D. Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Archives of Toxicology 2009, 183-190.
43. Yamanaka N., Deamer D. Superoxide-dismutase activity in Wi-38 cell-cultures - effects of age, trypsinization and Sv40 transformation. Physiological Chemistry and Physics 1974, 6:95-106.
44. Yu K., Grabinski C., Schrand A., Murdock R., Wang W., Gu B., Schlager J., Hussain S. Toxicity of amorphous silica nanoparticles in mouse keratinocytes. Journal of Nanoparticle Research 2009, 11:15-24.
45. Zhang F.F., Wan Q., Li C.X., Wang X.L., Zhu Z.Q., Xian Y.Z., Jin L.T., Yamamoto K. Simultaneous assay of glucose, lactate, L-glutamate and hypoxanthine levels in a rat striatum using enzyme electrodes based on neutral red-doped silica nanoparticles. Analytical and Bioanalytical Chemistry 2004, 380:637-642.
46. Zhou S., Wu L., Sun J., Shen W. The change of the properties of acrylic-based polyurethane via addition of nano-silica. Progress in Organic Coatings 2002, 45:33-42.
47. Zhu H., Itoh K., Yamamoto M., Zweier J.L., Li Y.B. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Letters 2005, 579:3029-3036.