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1
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83655193502
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Alpha-Defensins in Human Innate Immunity
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This is a comprehensive review of alpha-defensins by Robert Lehrer who discovered this class of antimicrobial peptides first from the rabbit and later from humans, and who coined the term 'defensin'.
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& Lehrer RI, Lu W. alpha-Defensins in human innate immunity. Immunol Rev 2012; 245 84-112. This is a comprehensive review of alpha-defensins by Robert Lehrer who discovered this class of antimicrobial peptides first from the rabbit and later from humans, and who coined the term 'defensin'.
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(2012)
Immunol Rev
, pp. 24584-25112
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Lehrer, R.I.1
Lu, W.2
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2
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84863307079
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Beta-defensins: Multifunctional modulators of infection, inflammation and more
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Semple F, Dorin Jr. Beta-defensins: Multifunctional modulators of infection, inflammation and more J Innate Immun 2012; 4:337-348.
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(2012)
J Innate Immun
, vol.4
, pp. 337-348
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Semple, F.1
Dorin, J.R.2
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3
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84863716488
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Multifunctional glycoprotein DEFB126: A curious story of defensin-clad spermatozoa
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Tollner TL, Bevins CL, Cherr GN. Multifunctional glycoprotein DEFB126: A curious story of defensin-clad spermatozoa. Nat Rev Urol 2012; 9:365-375.
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(2012)
Nat Rev Urol
, vol.9
, pp. 365-375
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Tollner, T.L.1
Bevins, C.L.2
Cherr, G.N.3
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5
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84864538873
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Theta-defensins: Cyclic peptides with endless potential
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This is a concise review by the three most authoritative theta-defensin researchers.
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Lehrer RI, Cole AM, Selsted ME. Theta-defensins: Cyclic peptides with endless potential. J Biol Chem 2012; 287:27014-27019. This is a concise review by the three most authoritative theta-defensin researchers.
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(2012)
J Biol Chem
, vol.287
, pp. 27014-27019
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Lehrer, R.I.1
Cole, A.M.2
Selsted, M.E.3
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6
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84872856945
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Peptide antimicrobials: Cell wall as a bacterial target
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Yount NY, Yeaman MR. Peptide antimicrobials: Cell wall as a bacterial target. Ann N Y Acad Sci 2013; 1277:127-138.
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(2013)
Ann N y Acad Sci
, vol.1277
, pp. 127-138
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Yount, N.Y.1
Yeaman, M.R.2
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7
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84871338911
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Eurocin, a new fungal defensin: Structure, lipid binding, and its mode of action
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Oeemig JS, Lynggaard C, Knudsen DH, et al. Eurocin, a new fungal defensin: Structure, lipid binding, and its mode of action. J Biol Chem 2012; 287:42361-42372.
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(2012)
J Biol Chem
, vol.287
, pp. 42361-42372
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Oeemig, J.S.1
Lynggaard, C.2
Knudsen, D.H.3
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8
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84866005675
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Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal
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This study describes a new mechanism of action of HNP1 that inhibits S. pyogenes infection and survival by blocking ExPortal-mediated secretion of certain bacterial toxins.
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Vega LA, Caparon MG. Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal. Mol Microbiol 2012; 85:1119-1132. This study describes a new mechanism of action of HNP1 that inhibits S. pyogenes infection and survival by blocking ExPortal-mediated secretion of certain bacterial toxins.
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(2012)
Mol Microbiol
, vol.85
, pp. 1119-1132
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Vega, L.A.1
Caparon, M.G.2
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9
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84864335926
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Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets
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A paradigm-shifting discovery of how the human enteric alpha-defensin 6, which lacks bactericidal activity in vitro, protects against bacterial invasion of the intestinal epithelium by entrapping enteric pathogens.
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Chu H, Pazgier M, Jung G, et al. Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 2012; 337:477-481. A paradigm-shifting discovery of how the human enteric alpha-defensin 6, which lacks bactericidal activity in vitro, protects against bacterial invasion of the intestinal epithelium by entrapping enteric pathogens.
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(2012)
Science
, vol.337
, pp. 477-481
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Chu, H.1
Pazgier, M.2
Jung, G.3
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10
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84873672050
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Paneth cells: Maestros of the small intestinal crypts
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This is a timely review on the human enteric alpha-defensins 5 and 6 by Charles Bevins, who originally discovered them from Paneth cells, and the role of Paneth cells in intestinal homeostasis and innate immunity.
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Clevers HC, Bevins CL. Paneth cells: Maestros of the small intestinal crypts. Annu Rev Physiol 2013; 75:289-311. This is a timely review on the human enteric alpha-defensins 5 and 6 by Charles Bevins, who originally discovered them from Paneth cells, and the role of Paneth cells in intestinal homeostasis and innate immunity.
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(2013)
Annu Rev Physiol
, vol.75
, pp. 289-311
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Clevers, H.C.1
Bevins, C.L.2
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11
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84872688583
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Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells
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This interesting study describes how protozoan parasitic infection kills Paneth cells and blocks antimicrobial responses at the intestinal mucosal surface.
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Raetz M, Hwang SH, Wilhelm CL, et al. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells. Nat Immunol 2013; 14:136-142. This interesting study describes how protozoan parasitic infection kills Paneth cells and blocks antimicrobial responses at the intestinal mucosal surface.
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(2013)
Nat Immunol
, vol.14
, pp. 136-142
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Raetz, M.1
Hwang, S.H.2
Wilhelm, C.L.3
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12
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84863582194
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Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of alphadefensins
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Eriguchi Y, Takashima S, Oka H, et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of alphadefensins. Blood 2012; 120:223-231.
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(2012)
Blood
, vol.120
, pp. 223-231
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Eriguchi, Y.1
Takashima, S.2
Oka, H.3
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13
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84860241737
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Innate immune dysfunction in inflammatory bowel disease
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Gersemann M, Wehkamp J, Stange EF. Innate immune dysfunction in inflammatory bowel disease. J Intern Med 2012; 271:421-428.
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(2012)
J Intern Med
, vol.271
, pp. 421-428
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Gersemann, M.1
Wehkamp, J.2
Stange, E.F.3
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14
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84859196359
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Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease
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Koslowski MJ, Teltschik Z, Beisner J, et al. Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease. PLoS Genet 2012; 8:e1002523.
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(2012)
PLoS Genet
, vol.8
, pp. 1002523
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Koslowski, M.J.1
Teltschik, Z.2
Beisner, J.3
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15
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33745698864
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Defensins in innate antiviral immunity
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Klotman ME, Chang TL. Defensins in innate antiviral immunity. Nat Rev Immunol 2006; 6:447-456.
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(2006)
Nat Rev Immunol
, vol.6
, pp. 447-456
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Klotman, M.E.1
Chang, T.L.2
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16
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84865271846
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Multifaceted mechanisms of HIV-1 entry inhibition by human alpha-defensin
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This is a technically superb piece of work that painstakingly investigates the molecular events leading to the inhibition of HIV-1 entry and fusion by HNP1.
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Demirkhanyan LH, Marin M, Padilla-Parra S, et al. Multifaceted mechanisms of HIV-1 entry inhibition by human alpha-defensin. J Biol Chem 2012; 287: 28821-28838. This is a technically superb piece of work that painstakingly investigates the molecular events leading to the inhibition of HIV-1 entry and fusion by HNP1.
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(2012)
J Biol Chem
, vol.287
, pp. 28821-28838
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Demirkhanyan, L.H.1
Marin, M.2
Padilla-Parra, S.3
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17
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84879530759
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Sub-inhibitory concentrations of human alpha-defensin potentiate neutralizing antibodies against HIV-1 gp41 prehairpin intermediates in the presence of serum
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Demirkhanyan L, Marin M, Lu W, Melikyan GB. Sub-inhibitory concentrations of human alpha-defensin potentiate neutralizing antibodies against HIV-1 gp41 prehairpin intermediates in the presence of serum. PLoS Pathog 2013; 9:e1003431.
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(2013)
PLoS Pathog
, vol.9
, pp. 1003431
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Demirkhanyan, L.1
Marin, M.2
Lu, W.3
Melikyan, G.B.4
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18
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44449098284
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Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: Role in enhanced transmission
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Klotman ME, Rapista A, Teleshova N, et al. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: Role in enhanced transmission. J Immunol 2008; 180:6176-6185.
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(2008)
J Immunol
, vol.180
, pp. 6176-6185
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Klotman, M.E.1
Rapista, A.2
Teleshova, N.3
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19
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79958248102
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Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment
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Rapista A, Ding J, Benito B, et al. Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment. Retrovirology 2011; 8:45.
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(2011)
Retrovirology
, vol.8
, pp. 45
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Rapista, A.1
Ding, J.2
Benito, B.3
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20
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84861118194
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Modulation of HIV transmission by Neisseria gonorrhoeae: Molecular and immunological aspects
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Jarvis GA, Chang TL. Modulation of HIV transmission by Neisseria gonorrhoeae: Molecular and immunological aspects. Curr HIV Res 2012; 10:211-217.
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(2012)
Curr HIV Res
, vol.10
, pp. 211-217
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Jarvis, G.A.1
Chang, T.L.2
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21
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84866906328
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Inhibition of HIV-1 infection by human alphadefensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae
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Furci L, Tolazzi M, Sironi F, et al. Inhibition of HIV-1 infection by human alphadefensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae. PLoS One 2012; 7:e45208.
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(2012)
PLoS One
, vol.7
, pp. 45208
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Furci, L.1
Tolazzi, M.2
Sironi, F.3
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22
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84879886110
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Pro-inflammatory and pro-apoptotic properties of human defensin
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Lu W, de Leeuw E. Pro-inflammatory and pro-apoptotic properties of human defensin Biochem Biophys Res Commun 2013; 436:557-562.
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(2013)
Biochem Biophys Res Commun
, vol.436
, pp. 557-562
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Lu, W.1
De Leeuw, E.2
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23
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84884564230
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Anti-HIV activity of human defensin 5 in primary CD4 T cells under serum-deprived conditions is a consequence of defensin-mediated toxicity
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Ding J, Tasker C, Valere K, et al. Anti-HIV activity of human defensin 5 in primary CD4 T cells under serum-deprived conditions is a consequence of defensin-mediated toxicity. PLoS One 2013; 8:e76038.
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(2013)
PLoS One
, vol.8
, pp. 76038
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Ding, J.1
Tasker, C.2
Valere, K.3
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24
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84861724380
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Invariant Gly residue is important for alphadefensin folding, dimerization, and function: A case study of the human neutrophil alpha-defensin HNP1
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Zhao L, Ericksen B, Wu X, et al. Invariant Gly residue is important for alphadefensin folding, dimerization, and function: A case study of the human neutrophil alpha-defensin HNP1. J Biol Chem 2012; 287:18900-18912.
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(2012)
J Biol Chem
, vol.287
, pp. 18900-18912
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Zhao, L.1
Ericksen, B.2
Wu, X.3
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25
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84870531632
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NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin
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Wommack AJ, Robson SA, Wanniarachchi YA, et al. NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin Biochemistry 2012 51:9624-9637.
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(2012)
Biochemistry
, vol.51
, pp. 9624-9637
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Wommack, A.J.1
Robson, S.A.2
Wanniarachchi, Y.A.3
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26
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84858591438
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Sometimes it takes two to tango: Contributions of dimerization to functions of human alpha-defensin HNP1 peptide
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This study elegantly demonstrates for the first time functional importance of HNP1 dimerization
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Pazgier M, Wei G, Ericksen B, et al. Sometimes it takes two to tango: Contributions of dimerization to functions of human alpha-defensin HNP1 peptide. J Biol Chem 2012; 287:8944-8953. This study elegantly demonstrates for the first time functional importance of HNP1 dimerization.
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(2012)
J Biol Chem
, vol.287
, pp. 8944-8953
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Pazgier, M.1
Wei, G.2
Ericksen, B.3
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27
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77952356835
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Trp-26 imparts functional versatility to human alpha-defensin HNP1
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Wei G, Pazgier M, de Leeuw E, et al. Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem 2010; 285:16275-16285.
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(2010)
J Biol Chem
, vol.285
, pp. 16275-16285
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Wei, G.1
Pazgier, M.2
De Leeuw, E.3
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28
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84862679509
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Functional determinants of human enteric alpha-defensin HD5: Crucial role for hydrophobicity at dimer interface
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Rajabi M, Ericksen B, Wu X, et al. Functional determinants of human enteric alpha-defensin HD5: Crucial role for hydrophobicity at dimer interface. J Biol Chem 2012; 287:21615-21627.
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(2012)
J Biol Chem
, vol.287
, pp. 21615-21627
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Rajabi, M.1
Ericksen, B.2
Wu, X.3
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30
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84876441987
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An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin
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Flatt JW, Kim R, Smith JG, et al. An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin PLoS One 2013; 8:e61571.
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(2013)
PLoS One
, vol.8
, pp. 61571
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Flatt, J.W.1
Kim, R.2
Smith, J.G.3
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31
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84874728559
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Integrin and defensin modulate the mechanical properties of adenovirus
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Snijder J, Reddy VS, May ER, et al. Integrin and defensin modulate the mechanical properties of adenovirus. J Virol 2013; 87:2756-2766.
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(2013)
J Virol
, vol.87
, pp. 2756-2766
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Snijder, J.1
Reddy, V.S.2
May, E.R.3
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32
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84863794822
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Critical determinants of human alpha-defensin 5 activity against nonenveloped viruses
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This interesting study describes a systematic mutational study of HD5 with respect to its capsid-binding and antiviral activity against human adenovirus.
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Gounder AP, Wiens ME, Wilson SS, et al. Critical determinants of human alpha-defensin 5 activity against nonenveloped viruses. J Biol Chem 2012; 287:24554-24562. This interesting study describes a systematic mutational study of HD5 with respect to its capsid-binding and antiviral activity against human adenovirus.
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(2012)
J Biol Chem
, vol.287
, pp. 24554-24562
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Gounder, A.P.1
Wiens, M.E.2
Wilson, S.S.3
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33
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84862646898
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Arginine in alpha-defensins: Differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior
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Schmidt NW, Tai KP, Kamdar K, et al. Arginine in alpha-defensins: Differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. J Biol Chem 2012; 287:21866-21872.
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(2012)
J Biol Chem
, vol.287
, pp. 21866-21872
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Schmidt, N.W.1
Tai, K.P.2
Kamdar, K.3
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34
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Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites
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Wang A, Chen F, Wang Y, et al. Enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. J Virol 2013; 87:2835-2845.
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(2013)
J Virol
, vol.87
, pp. 2835-2845
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Wang, A.1
Chen, F.2
Wang, Y.3
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35
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84870524827
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Structural characterization of the cyclic cystine ladder motif of theta-defensins
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Conibear AC, Rosengren KJ, Harvey PJ, Craik DJ. Structural characterization of the cyclic cystine ladder motif of theta-defensins. Biochemistry 2012; 51:9718-9726.
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(2012)
Biochemistry
, vol.51
, pp. 9718-9726
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Conibear, A.C.1
Rosengren, K.J.2
Harvey, P.J.3
Craik, D.J.4
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36
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84876206211
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The cyclic cystine ladder in thetadefensins is important for structure and stability, but not antibacterial activity
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Conibear AC, Rosengren KJ, Daly NL, et al. The cyclic cystine ladder in thetadefensins is important for structure and stability, but not antibacterial activity. J Biol Chem 2013; 288:10830-10840.
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(2013)
J Biol Chem
, vol.288
, pp. 10830-10840
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Conibear, A.C.1
Rosengren, K.J.2
Daly, N.L.3
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37
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84856697951
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MicroRNA-21 targets the vitamin Ddependent antimicrobial pathway in leprosy
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This study demonstrates that induction of vitamin D-dependent endogenous antimicrobial responses via gene regulation can be a potential therapeutic strategy for the treatment of infectious diseases where cellular immune responses are dysregulated.
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Liu PT, Wheelwright M, Teles R, et al. MicroRNA-21 targets the vitamin Ddependent antimicrobial pathway in leprosy. Nat Med 2012; 18:267-273. This study demonstrates that induction of vitamin D-dependent endogenous antimicrobial responses via gene regulation can be a potential therapeutic strategy for the treatment of infectious diseases where cellular immune responses are dysregulated.
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(2012)
Nat Med
, vol.18
, pp. 267-273
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Liu, P.T.1
Wheelwright, M.2
Teles, R.3
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38
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84875425732
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Type i interferon suppresses type II interferon-triggered human antimycobacterial responses
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Teles RM, Graeber TG, Krutzik SR, et al. Type I interferon suppresses type II interferon-triggered human antimycobacterial responses. Science 2013; 339:1448-1453.
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(2013)
Science
, vol.339
, pp. 1448-1453
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Teles, R.M.1
Graeber, T.G.2
Krutzik, S.R.3
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39
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0033569410
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A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins
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Tang YQ, Yuan J, Osapay G, et al. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 1999; 286:498-502.
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Science
, vol.286
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Tang, Y.Q.1
Yuan, J.2
Osapay, G.3
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40
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84857815824
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Hapivirins and diprovirins: Novel thetadefensin analogs with potent activity against influenza A virus
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Doss M, Ruchala P, Tecle T, et al. Hapivirins and diprovirins: Novel thetadefensin analogs with potent activity against influenza A virus. J Immunol 2012; 188:2759-2768.
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(2012)
J Immunol
, vol.188
, pp. 2759-2768
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Doss, M.1
Ruchala, P.2
Tecle, T.3
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41
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84869218137
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Inhibition of dengue ns2b-ns3 protease and viral replication in vero cells by recombinant retrocyclin-1
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Rothan HA, Han HC, Ramasamy TS, et al. Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1. BMC Infect Dis 2012; 12:314.
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(2012)
BMC Infect Dis
, vol.12
, pp. 314
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Rothan, H.A.1
Han, H.C.2
Ramasamy, T.S.3
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42
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Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis
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This is an interesting study that demonstrates therapeutic potential of thetadefensins as a novel class of anti-inflammatory agents for the treatment of bacteremic sepsis and possibly autoimmune diseases.
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Schaal JB, Tran D, Tran P, et al. Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One 2012; 7:e51337. This is an interesting study that demonstrates therapeutic potential of thetadefensins as a novel class of anti-inflammatory agents for the treatment of bacteremic sepsis and possibly autoimmune diseases.
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(2012)
PLoS One
, vol.7
, pp. 51337
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Schaal, J.B.1
Tran, D.2
Tran, P.3
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43
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84857136095
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Mechanisms and modifications of naturally occurring host defense peptides for anti-HIV microbicide development
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Eade CR, Wood MP, Cole AM. Mechanisms and modifications of naturally occurring host defense peptides for anti-HIV microbicide development. Curr HIV Res 2012; 10:61-72.
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(2012)
Curr HIV Res
, vol.10
, pp. 61-72
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Eade, C.R.1
Wood, M.P.2
Cole, A.M.3
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44
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84872965125
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Antiviral activity of retrocyclin RC-101, a candidate microbicide against cell-associated HIV-1
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Gupta P, Lackman-Smith C, Snyder B, et al. Antiviral activity of retrocyclin RC-101, a candidate microbicide against cell-associated HIV-1. AIDS Res Hum Retroviruses 2013; 29:391-396.
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(2013)
AIDS Res Hum Retroviruses
, vol.29
, pp. 391-396
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Gupta, P.1
Lackman-Smith, C.2
Snyder, B.3
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45
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84873508451
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A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion
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Wood MP, Cole AL, Ruchala P, et al. A compensatory mutation provides resistance to disparate HIV fusion inhibitor peptides and enhances membrane fusion. PLoS One 2013; 8:e55478.
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(2013)
PLoS One
, vol.8
, pp. 55478
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Wood, M.P.1
Cole, A.L.2
Ruchala, P.3
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46
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84872263951
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The anti-HIV microbicide candidate RC-101 inhibits pathogenic vaginal bacteria without harming endogenous flora or mucosa
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Eade CR, Cole AL, Diaz C, et al. The anti-HIV microbicide candidate RC-101 inhibits pathogenic vaginal bacteria without harming endogenous flora or mucosa. Am J Reprod Immunol 2013; 69:150-158.
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(2013)
Am J Reprod Immunol
, vol.69
, pp. 150-158
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Eade, C.R.1
Cole, A.L.2
Diaz, C.3
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47
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65949105709
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Reawakening retrocyclins: Ancestral human defensins active against HIV-1
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Venkataraman N, Cole AL, Ruchala P, et al. Reawakening retrocyclins: Ancestral human defensins active against HIV-1. PLoS Biol 2009; 7: E95.
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(2009)
PLoS Biol
, vol.7
, pp. 95
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Venkataraman, N.1
Cole, A.L.2
Ruchala, P.3
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48
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84864557191
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Thematic minireview series on circular proteins
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This is a concise review by an authority on many important aspects of cyclic peptides and circular proteins.
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Craik DJ, Allewell NM. Thematic minireview series on circular proteins. J Biol Chem 2012; 287:26999-27000. This is a concise review by an authority on many important aspects of cyclic peptides and circular proteins.
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(2012)
J Biol Chem
, vol.287
, pp. 26999-27000
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Craik, D.J.1
Allewell, N.M.2
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49
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Synthesis of native proteins by chemical ligation
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Dawson PE, Kent SB. Synthesis of native proteins by chemical ligation. Annu Rev Biochem 2000; 69:923-960.
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Annu Rev Biochem
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Dawson, P.E.1
Kent, S.B.2
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51
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84862830207
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Efficient one-pot cyclization/folding of Rhesus theta-defensin-1 (RTD-1)
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This study describes an efficient chemical approach to the production of synthetic theta-defensins.
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Aboye TL, Li Y, Majumder S, et al. Efficient one-pot cyclization/folding of Rhesus theta-defensin-1 (RTD-1). Bioorg Med Chem Lett 2012; 22:2823-2826. This study describes an efficient chemical approach to the production of synthetic theta-defensins.
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(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 2823-2826
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Aboye, T.L.1
Li, Y.2
Majumder, S.3
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52
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0037548053
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Semisynthesis of proteins by expressed protein ligation
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Muir TW. Semisynthesis of proteins by expressed protein ligation. Annu Rev Biochem 2003; 72:249-289.
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(2003)
Annu Rev Biochem
, vol.72
, pp. 249-289
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Muir, T.W.1
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53
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84863229416
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Recombinant production of rhesus thetadefensin-1 (RTD-1) using a bacterial expression system
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This study describes an efficient bacterial expression system for the production of recombinant theta-defensins.
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Gould A, Li Y, Majumder S, et al. Recombinant production of rhesus thetadefensin-1 (RTD-1) using a bacterial expression system. Mol Biosyst 2012; 8:1359-1365. This study describes an efficient bacterial expression system for the production of recombinant theta-defensins.
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(2012)
Mol Biosyst
, vol.8
, pp. 1359-1365
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Gould, A.1
Li, Y.2
Majumder, S.3
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54
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84857883452
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RTD-1mimic containing gammaPNA scaffold exhibits broad-spectrum antibacteril activities
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Rapireddy S, Nhon L, Meehan RE, et al. RTD-1mimic containing gammaPNA scaffold exhibits broad-spectrum antibacterial activities. J Am Chem Soc 2012; 134:4041-4044.
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(2012)
J Am Chem Soc
, vol.134
, pp. 4041-4044
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Rapireddy, S.1
Nhon, L.2
Meehan, R.E.3
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56
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84858629612
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High fidelity processing and activation of the human alpha-defensin HNP1 precursor by neutrophil elastase and proteinase
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Tongaonkar P, Golji AE, Tran P, et al. High fidelity processing and activation of the human alpha-defensin HNP1 precursor by neutrophil elastase and proteinase PLoS One 2012; 7:e32469.
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(2012)
PLoS One
, vol.7
, pp. 32469
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Tongaonkar, P.1
Golji, A.E.2
Tran, P.3
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57
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79960940581
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Paneth cell alpha-defensins in enteric innate immunity
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Ouellette AJ. Paneth cell alpha-defensins in enteric innate immunity. Cell Mol Life Sci 2011; 68:2215-2229.
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(2011)
Cell Mol Life Sci
, vol.68
, pp. 2215-2229
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Ouellette, A.J.1
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58
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20644462344
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Mammalian defensins in the antimicrobial immune response
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Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nature Immunol 2005; 6:551-557.
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(2005)
Nature Immunol
, vol.6
, pp. 551-557
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Selsted, M.E.1
Ouellette, A.J.2
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