Association of a functional variant in the wnt co-receptor LRP6 with early onset ileal Crohn's Disease

PLoS Genetics

Volumn 8, Issue 2, 2012, Pages

  Koslowski, Maureen J ^a   Teltschik, Zora ^a   Beisner, Julia ^a   Schaeffeler, Elke ^a   Wang, Guoxing ^a   Kübler, Irmgard ^b   Gersemann, Michael ^a,b   Cooney, Rachel ^c   Jewell, Derek ^c   Reinisch, Walter ^d   Vermeire, Séverine ^e   Rutgeerts, Paul ^e   Schwab, Matthias ^a,f   Stange, Eduard F ^b   Wehkamp, Jan ^a,b  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b ROBERT BOSCH HOSPITAL   (Germany)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; WNT PROTEIN;

ADOLESCENT; ADULT; ARTICLE; COHORT ANALYSIS; COLON CROHN DISEASE; CONTROLLED STUDY; CROHN DISEASE; CYTOLOGY; ENZYME ACTIVITY; ETHNIC GROUP; EUROPEAN; EXON; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; ILEUM DISEASE; ILEUM MUCOSA; INTESTINE BIOPSY; LRP6 GENE; MAJOR CLINICAL STUDY; ONSET AGE; PANETH CELL; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSIENT TRANSFECTION; ULCERATIVE COLITIS;

ADULT; AGE FACTORS; ALPHA-DEFENSINS; BETA CATENIN; CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ILEUM; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; PANETH CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; WNT PROTEINS;

EID: 84859196359     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002523     Document Type: Article

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