Rhesus Macaque Theta Defensins Suppress Inflammatory Cytokines and Enhance Survival in Mouse Models of Bacteremic Sepsis

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Schaal, Justin B ^a   Tran, Dat ^a   Tran, Patti ^a   Ösapay, George ^c   Trinh, Katie ^a   Roberts, Kevin D ^a   Brasky, Kathleen M ^d   Tongaonkar, Prasad ^a   Ouellette, André J ^a,b   Selsted, Michael E ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; DEFENSIN; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; RHESUS THETA DEFENSIN 2; RHESUS THETA DEFENSIN 3; RHESUS THETA DEFENSIN 4; RHESUS THETA DEFENSIN 5; THETA DEFENSIN 1; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL PERITONITIS; CYTOKINE RELEASE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; MONOCYTE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; SURVIVAL; TREATMENT RESPONSE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; DEFENSINS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; PAN TROGLODYTES; PROTEIN ISOFORMS; SEPSIS;

ANIMALIA; CERCOPITHECIDAE; MACACA; MACACA MULATTA; MAMMALIA; MUS; PAN; PAPIO ANUBIS;

EID: 84870829224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051337     Document Type: Article

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