Trp-26 imparts functional versatility to human α-defensin HNP

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 16275-16285

  Wei, Gang ^a,b   Pazgier, Marzena ^a   De Leeuw, Erik ^a   Rajabi, Mohsen ^a   Li, Jing ^a   Zou, Guozhang ^a   Jung, Grace ^b   Yuan, Weirong ^a   Lu, Wei Yue ^b   Lehrer, Robert I ^c   Lu, Wuyuan ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSOCIATION REACTIONS; BACTERIA; DIMERS; HYDROPHOBICITY; MOLECULES; PEPTIDES; VIRUSES;

ALIPHATIC AMINO ACIDS; DIRECT INTERACTIONS; HUMAN IMMUNODEFICIENCY VIRUS-1; KEY DETERMINANTS; MICROMOLAR CONCENTRATION; POSITIVE CHARGES; QUATERNARY STRUCTURE; SELF-ASSOCIATIONS;

DISEASES;

ALPHA DEFENSIN; DIMER; PROTEIN HNP1; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE MUTATION; HOST RESISTANCE; HUMAN; HYDROPHOBICITY; INNATE IMMUNITY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; STAPHYLOCOCCUS AUREUS; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS 1; STAPHYLOCOCCUS AUREUS;

EID: 77952356835     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.102749     Document Type: Article

References (79)

1. Zasloff, M. (2002) Nature 415, 389-395
2. Habermann, E. (1972) Science 177, 314-322
3. Steiner, H., Hultmark, D., Engström, A., Bennich, H., and Boman, H. G. (1981) Nature 292, 246-248
4. Zasloff, M. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 5449-5453
5. Selsted, M. E., and Ouellette, A. J. (2005) Nat. Immunol. 6, 551-557
6. Ganz, T. (2003) Nat. Rev. Immunol. 3, 710-720
7. Lehrer, R. I. (2004) Nat. Rev. Microbiol. 2, 727-738
8. Bevins, C. L. (2006) Biochem. Soc. Trans. 34, 263-266
9. Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K., Bainton, D. F., and Lehrer, R. I. (1985) J. Clin. Invest. 76, 1427-1435
10. Selsted, M. E., Harwig, S. S., Ganz, T., Schilling, J. W., and Lehrer, R. I. (1985) J. Clin. Invest. 76, 1436-1439
11. Gabay, J. E., Scott, R. W., Campanelli, D., Griffith, J., Wilde, C., Marra, M. N., Seeger, M., and Nathan, C. F. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 5610-5614
12. Wilde, C. G., Griffith, J. E., Marra, M. N., Snable, J. L., and Scott, R. W. (1989) J. Biol. Chem. 264, 11200-11203
13. Jones, D. E., and Bevins, C. L. (1992) J. Biol. Chem. 267, 23216-23225
14. Jones, D. E., and Bevins, C. L. (1993) FEBS Lett. 315, 187-192
15. Semple, C. A., Taylor, K., Eastwood, H., Barran, P. E., and Dorin, J. R. (2006) Biochem. Soc. Trans. 34, 257-262
16. Lehrer, R. I., Barton, A., Daher, K. A., Harwig, S. S., Ganz, T., and Selsted, M. E. (1989) J. Clin. Invest. 84, 553-561
17. Kagan, B. L., Selsted, M. E., Ganz, T., and Lehrer, R. I. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 210-214
18. Klotman, M. E., and Chang, T. L. (2006) Nat. Rev. Immunol. 6, 447-456
19. Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., and Oppenheim, J. J. (2004) Annu. Rev. Immunol. 22, 181-215
20. Rehaume, L. M., and Hancock, R. E. (2008) Crit. Rev. Immunol. 28, 185-200
21. Kim, C., Gajendran, N., Mittrücker, H. W., Weiwad, M., Song, Y. H., Hurwitz, R., Wilmanns, M., Fischer, G., and Kaufmann, S. H. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 4830-4835
22. Mayer-Scholl, A., Hurwitz, R., Brinkmann, V., Schmid, M., Jungblut, P., Weinrauch, Y., and Zychlinsky, A. (2005) PLoS Pathog. 1, e23
23. Maemoto, A., Qu, X., Rosengren, K. J., Tanabe, H., Henschen-Edman, A., Craik, D. J., and Ouellette, A. J. (2004) J. Biol. Chem. 279, 44188-44196
24. de Leeuw, E., Burks, S. R., Li, X., Kao, J. P., and Lu, W. (2007) FEBS Lett. 581, 515-520
25. Xie, C., Prahl, A., Ericksen, B., Wu, Z., Zeng, P., Li, X., Lu, W. Y., Lubkowski, J., and Lu, W. (2005) J. Biol. Chem. 280, 32921-32929
26. Wu, Z., Li, X., de Leeuw, E., Ericksen, B., and Lu, W. (2005) J. Biol. Chem. 280, 43039-43047
27. Rosengren, K. J., Daly, N. L., Fornander, L. M., Jönsson, L. M., Shirafuji, Y., Qu, X., Vogel, H. J., Ouellette, A. J., and Craik, D. J. (2006) J. Biol. Chem. 281, 28068-28078
28. Rajabi, M., de Leeuw, E., Pazgier, M., Li, J., Lubkowski, J., and Lu, W. (2008) J. Biol. Chem. 283, 21509-21518
29. Zou, G., de Leeuw, E., Li, C., Pazgier, M., Li, C., Zeng, P., Lu, W. Y., Lubkowski, J., and Lu, W. (2007) J. Biol. Chem. 282, 19653-19665
30. Tanabe, H., Qu, X., Weeks, C. S., Cummings, J. E., Kolusheva, S., Walsh, K. B., Jelinek, R., Vanderlick, T. K., Selsted, M. E., and Ouellette, A. J. (2004) J. Biol. Chem. 279, 11976-11983
31. Hazrati, E., Galen, B., Lu, W., Wang, W., Ouyang, Y., Keller, M. J., Lehrer, R. I., and Herold, B. C. (2006) J. Immunol. 177, 8658-8666
32. Buck, C. B., Day, P. M., Thompson, C. D., Lubkowski, J., Lu, W., Lowy, D. R., and Schiller, J. T. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 1516-1521
33. Giesemann, T., Guttenberg, G., and Aktories, K. (2008) Gastroenterology 134, 2049-2058
34. Lehrer, R. I., Jung, G., Ruchala, P., Wang, W., Micewicz, E. D., Waring, A. J., Gillespie, E. J., Bradley, K. A., Ratner, A. J., Rest, R. F., and Lu, W. (2009) Infect. Immun. 77, 4028-4040
35. Wei, G., de Leeuw, E., Pazgier, M., Yuan, W., Zou, G., Wang, J., Ericksen, B., Lu, W. Y., Lehrer, R. I., and Lu, W. (2009) J. Biol. Chem. 284, 29180-29192
36. Smith, J. G., and Nemerow, G. R. (2008) Cell Host Microbe 3, 11-19
37. Schnölzer, M., Alewood, P., Jones, A., Alewood, D., and Kent, S. B. (1992) Int. J. Pept. Protein Res. 40, 180-193
38. Wu, Z., Powell, R., and Lu, W. (2003) J. Am. Chem. Soc. 125, 2402-2403
39. Wu, Z., Li, X., Ericksen, B., de Leeuw, E., Zou, G., Zeng, P., Xie, C., Li, C., Lubkowski, J., Lu, W. Y., and Lu, W. (2007) J. Mol. Biol. 368, 537-549
40. Wu, Z., Prahl, A., Powell, R., Ericksen, B., Lubkowski, J., and Lu, W. (2003) J. Pept. Res. 62, 53-62
41. Dawson, P. E., and Kent, S. B. (2000) Annu. Rev. Biochem. 69, 923-960
42. Dawson, P. E., Muir, T. W., Clark-Lewis, I., and Kent, S. B. (1994) Science 266, 776-779
43. Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., and Gray, T. (1995) Protein Sci. 4, 2411-2423
44. Braunschweiler, L., and Ernst, R. R. (1983) J. Magn. Reson. 53, 521-528
45. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293
46. Wuthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, Inc., New York
47. Keller, R. (2004) The Computer Aided Resonance Assignment Tutorial, 1st Ed., CANTINA Verlag, Switzerland
48. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
49. Storoni, L. C., McCoy, A. J., and Read, R. J. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 432-438
50. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
51. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
52. DeLano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, CA
53. Qasim, M. A., Lu, W., Lu, S. M., Ranjbar, M., Yi, Z., Chiang, Y. W., Ryan, K., Anderson, S., Zhang, W., Qasim, S., and Laskowski, M., Jr. (2003) Biochemistry 42, 6460-6466
54. Ericksen, B., Wu, Z., Lu, W., and Lehrer, R. I. (2005) Antimicrob. Agents Chemother. 49, 269-275
55. Fujii, G., Selsted, M. E., and Eisenberg, D. (1993) Protein Sci 2, 1301-1312
56. Wang, W., Cole, A. M., Hong, T., Waring, A. J., and Lehrer, R. I. (2003) J. Immunol. 170, 4708-4716
57. Siebert, H. C., Lu, S. Y., Wechselberger, R., Born, K., Eckert, T., Liang, S., von der Lieth, C. W., Jiménez-Barbero, J., Schauer, R., Vliegenthart, J. F., Lütteke, T., and Kozár, T. (2009) Carbohydr. Res. 344, 1515-1525
58. Szyk, A., Wu, Z., Tucker, K., Yang, D., Lu, W., and Lubkowski, J. (2006) Protein Sci. 15, 2749-2760
59. Zhang, X. L., Selsted, M. E., and Pardi, A. (1992) Biochemistry 31, 11348-11356
60. Rosengren, K. J., Daly, N. L., Plan, M. R., Waine, C., and Craik, D. J. (2003) J. Biol. Chem. 278, 8606-8616
61. Lu, W., Apostol, I., Qasim, M. A., Warne, N., Wynn, R., Zhang, W. L., Anderson, S., Chiang, Y. W., Ogin, E., Rothberg, I., Ryan, K., and Laskowski, M., Jr. (1997) J. Mol. Biol. 266, 441-461
62. Lehrer, R. I., Jung, G., Ruchala, P., Andre, S., Gabius, H. J., and Lu, W. (2009) J. Immunol. 183, 480-490
63. Lu, S. M., Lu, W., Qasim, M. A., Anderson, S., Apostol, I., Ardelt, W., Bigler, T., Chiang, Y. W., Cook, J., James, M. N., Kato, I., Kelly, C., Kohr, W., Komiyama, T., Lin, T. Y., Ogawa, M., Otlewski, J., Park, S. J., Qasim, S., Ranjbar, M., Tashiro, M., Warne, N., Whatley, H., Wieczorek, A., Wieczorek, M., Wilusz, T., Wynn, R., Zhang, W., and Laskowski, M., Jr. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 1410-1415
64. Pazgier, M., Hoover, D. M., Yang, D., Lu, W., and Lubkowski, J. (2006) Cell. Mol. Life Sci. 63, 1294-1313
65. Harder, J., Bartels, J., Christophers, E., and Schröder, J. M. (1997) Nature 387, 861
66. Harder, J., Bartels, J., Christophers, E., and Schroder, J. M. (2001) J. Biol. Chem. 276, 5707-5713
67. Schibli, D. J., Hunter, H. N., Aseyev, V., Starner, T. D., Wiencek, J. M., McCray, P. B., Jr., Tack, B. F., and Vogel, H. J. (2002) J. Biol. Chem. 277, 8279-8289
68. Kouno, T., Fujitani, N., Mizuguchi, M., Osaki, T., Nishimura, S., Kawabata, S., Aizawa, T., Demura, M., Nitta, K., and Kawano, K. (2008) Biochemistry 47, 10611-10619
69. Saito, T., Kawabata, S., Shigenaga, T., Takayenoki, Y., Cho, J., Nakajima, H., Hirata, M., and Iwanaga, S. (1995) J Biochem. 117, 1131-1137
70. Clackson, T., and Wells, J. A. (1995) Science 267, 383-386
71. Kortemme, T., and Baker, D. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 14116-14121
72. Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. (1996) Science 274, 948-953
73. Massova, I., and Kollman, P. A. (1999) J. Am. Chem. Soc. 121, 8133-8143
74. Hill, C. P., Yee, J., Selsted, M. E., and Eisenberg, D. (1991) Science 251, 1481-1485
75. Figueredo, S. M., Weeks, C. S., Young, S. K., and Ouellette, A. J. (2009) J. Biol. Chem. 284, 6826-6831
76. Llenado, R. A., Weeks, C. S., Cocco, M. J., and Ouellette, A. J. (2009) Infect. Immun. 77, 5035-5043
77. Zou, G., de Leeuw, E., Lubkowski, J., and Lu, W. (2008) J. Mol. Biol. 381, 1281-1291
78. Dill, K. A. (1997) J. Biol. Chem. 272, 701-704
79. Wells, J. A. (1990) Biochemistry 29, 8509-8517