메뉴 건너뛰기




Volumn 436, Issue 3, 2013, Pages 557-562

Pro-inflammatory and pro-apoptotic properties of Human Defensin 5

Author keywords

Antimicrobial peptide; Apoptosis; Human Defensin 5; Interleukin 8; Intestinal epithelium

Indexed keywords

BCL2 RELATED PROTEIN A1; DEFENSIN; DEFENSIN 5; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FAS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MATRILYSIN; STROMELYSIN 2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84879886110     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.015     Document Type: Article
Times cited : (29)

References (44)
  • 1
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415:389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 2
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: antimicrobial peptides of innate immunity
    • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 2003, 3:710-720.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 710-720
    • Ganz, T.1
  • 4
    • 14644435363 scopus 로고    scopus 로고
    • Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes
    • Patil A., Hughes A.L., Zhang G. Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes. Physiol. Genomics 2004, 20:1-11.
    • (2004) Physiol. Genomics , vol.20 , pp. 1-11
    • Patil, A.1    Hughes, A.L.2    Zhang, G.3
  • 5
    • 0025903814 scopus 로고
    • Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization
    • Hill C.P., Yee J., Selsted M.E., Eisenberg D. Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 1991, 251:1481-1485.
    • (1991) Science , vol.251 , pp. 1481-1485
    • Hill, C.P.1    Yee, J.2    Selsted, M.E.3    Eisenberg, D.4
  • 6
    • 33751545243 scopus 로고    scopus 로고
    • Crystal structures of human alpha-defensins HNP4, HD5, and HD6
    • Szyk A., Wu Z., Tucker K., Yang D., Lu W., Lubkowski J. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 2006, 15:2749-2760.
    • (2006) Protein Sci. , vol.15 , pp. 2749-2760
    • Szyk, A.1    Wu, Z.2    Tucker, K.3    Yang, D.4    Lu, W.5    Lubkowski, J.6
  • 9
    • 35748968488 scopus 로고    scopus 로고
    • Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family
    • Grigat J., Soruri A., Forssmann U., Riggert J., Zwirner J. Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family. J. Immunol. 2007, 179:3958-3965.
    • (2007) J. Immunol. , vol.179 , pp. 3958-3965
    • Grigat, J.1    Soruri, A.2    Forssmann, U.3    Riggert, J.4    Zwirner, J.5
  • 10
    • 34548772992 scopus 로고    scopus 로고
    • Beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved
    • Soruri A., Grigat J., Forssmann U., Riggert J., Zwirner J. Beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved. Eur. J. Immunol. 2007, 37:2474-2486.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 2474-2486
    • Soruri, A.1    Grigat, J.2    Forssmann, U.3    Riggert, J.4    Zwirner, J.5
  • 11
    • 0036606951 scopus 로고    scopus 로고
    • Mammalian defensins in immunity: more than just microbicidal
    • Yang D., Biragyn A., Kwak L.W., Oppenheim J.J. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol. 2002, 23:291-296.
    • (2002) Trends Immunol. , vol.23 , pp. 291-296
    • Yang, D.1    Biragyn, A.2    Kwak, L.W.3    Oppenheim, J.J.4
  • 13
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial immune response
    • Selsted M.E., Ouellette A.J. Mammalian defensins in the antimicrobial immune response. Nat. Immunol. 2005, 6:551-557.
    • (2005) Nat. Immunol. , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 17
    • 16844382886 scopus 로고    scopus 로고
    • Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease
    • Wehkamp J., Schmid M., Fellermann K., Stange E.F. Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J. Leukoc. Biol. 2005, 77:460-465.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 460-465
    • Wehkamp, J.1    Schmid, M.2    Fellermann, K.3    Stange, E.F.4
  • 19
    • 11244342346 scopus 로고    scopus 로고
    • Antibacterial activity and specificity of the six human {alpha}-defensins
    • Ericksen B., Wu Z., Lu W., Lehrer R.I. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob. Agents Chemother. 2005, 49:269-275.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 269-275
    • Ericksen, B.1    Wu, Z.2    Lu, W.3    Lehrer, R.I.4
  • 20
    • 4444356630 scopus 로고    scopus 로고
    • Synthesis and characterization of human alpha-defensins 4-6
    • Wu Z., Ericksen B., Tucker K., Lubkowski J., Lu W. Synthesis and characterization of human alpha-defensins 4-6. J. Pept. Res. 2004, 64:118-125.
    • (2004) J. Pept. Res. , vol.64 , pp. 118-125
    • Wu, Z.1    Ericksen, B.2    Tucker, K.3    Lubkowski, J.4    Lu, W.5
  • 24
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman N.H., Ghosh D., Huttner K.M., Paterson Y., Bevins C.L. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003, 422:522-526.
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 26
    • 40449103288 scopus 로고    scopus 로고
    • Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin
    • Elphick D., Liddell S., Mahida Y.R. Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin. Am. J. Pathol. 2008, 172:702-713.
    • (2008) Am. J. Pathol. , vol.172 , pp. 702-713
    • Elphick, D.1    Liddell, S.2    Mahida, Y.R.3
  • 27
    • 33846424608 scopus 로고    scopus 로고
    • Structure-dependent functional properties of human defensin 5
    • de Leeuw E., Burks S.R., Li X., Kao J.P., Lu W. Structure-dependent functional properties of human defensin 5. FEBS Lett. 2007, 581:515-520.
    • (2007) FEBS Lett. , vol.581 , pp. 515-520
    • de Leeuw, E.1    Burks, S.R.2    Li, X.3    Kao, J.P.4    Lu, W.5
  • 29
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
    • Simms L.A., Doecke J.D., Walsh M.D., Huang N., Fowler E.V., Radford-Smith G.L. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 2008.
    • (2008) Gut
    • Simms, L.A.1    Doecke, J.D.2    Walsh, M.D.3    Huang, N.4    Fowler, E.V.5    Radford-Smith, G.L.6
  • 31
    • 42149171210 scopus 로고    scopus 로고
    • Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation
    • Steinbrecher K.A., Harmel-Laws E., Sitcheran R., Baldwin A.S. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J. Immunol. 2008, 180:2588-2599.
    • (2008) J. Immunol. , vol.180 , pp. 2588-2599
    • Steinbrecher, K.A.1    Harmel-Laws, E.2    Sitcheran, R.3    Baldwin, A.S.4
  • 32
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    • Abreu M.T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat. Rev. Immunol. 2010, 10:131-144.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 33
    • 77954314592 scopus 로고    scopus 로고
    • Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation
    • Gong J., Xu J., Zhu W., Gao X., Li N., Li J. Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation. Clin. Immunol. 2010, 136:245-256.
    • (2010) Clin. Immunol. , vol.136 , pp. 245-256
    • Gong, J.1    Xu, J.2    Zhu, W.3    Gao, X.4    Li, N.5    Li, J.6
  • 35
    • 0033844287 scopus 로고    scopus 로고
    • Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
    • Yang D., Chen Q., Chertov O., Oppenheim J.J. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J. Leukoc. Biol. 2000, 68:9-14.
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 9-14
    • Yang, D.1    Chen, Q.2    Chertov, O.3    Oppenheim, J.J.4
  • 36
    • 0024797674 scopus 로고
    • Monocyte-chemotactic activity of defensins from human neutrophils
    • Territo M.C., Ganz T., Selsted M.E., Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 1989, 84:2017-2020.
    • (1989) J. Clin. Invest. , vol.84 , pp. 2017-2020
    • Territo, M.C.1    Ganz, T.2    Selsted, M.E.3    Lehrer, R.4
  • 40
    • 0035879198 scopus 로고    scopus 로고
    • Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity
    • Cole A.M., Ganz T., Liese A.M., Burdick M.D., Liu L., Strieter R.M. Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 2001, 167:623-627.
    • (2001) J. Immunol. , vol.167 , pp. 623-627
    • Cole, A.M.1    Ganz, T.2    Liese, A.M.3    Burdick, M.D.4    Liu, L.5    Strieter, R.M.6
  • 41
    • 0036892922 scopus 로고    scopus 로고
    • Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense
    • Durr M., Peschel A. Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense. Infect. Immun. 2002, 70:6515-6517.
    • (2002) Infect. Immun. , vol.70 , pp. 6515-6517
    • Durr, M.1    Peschel, A.2
  • 44
    • 67849115958 scopus 로고    scopus 로고
    • Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5
    • de Leeuw E., Rajabi M., Zou G., Pazgier M., Lu W. Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5. FEBS Lett. 2009, 583:2507-2512.
    • (2009) FEBS Lett. , vol.583 , pp. 2507-2512
    • de Leeuw, E.1    Rajabi, M.2    Zou, G.3    Pazgier, M.4    Lu, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.