NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5

Biochemistry

Volumn 51, Issue 48, 2012, Pages 9624-9637

  Wommack, Andrew J ^a   Robson, Scott A ^b   Wanniarachchi, Yoshitha A ^a   Wan, Andrea ^a   Turner, Christopher J ^c   Wagner, Gerhard ^b   Nolan, Elizabeth M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL ACTION; ANTIMICROBIAL PEPTIDE; CYSTEINE RESIDUES; DEFENSINS; DIMER INTERFACE; DISULFIDE BONDS; ENVIRONMENTALLY SENSITIVE; EQUILIBRIUM STUDY; EXPERIMENTAL CONDITIONS; IN-VITRO; MILLIMOLAR CONCENTRATIONS; NEUTRAL PH; NMR SPECTRUM; PH-DEPENDENT; QUATERNARY STRUCTURE; ROTATIONAL CORRELATION TIME; SEDIMENTATION COEFFICIENTS; SEDIMENTATION VELOCITIES; SOLUTION STRUCTURES; SOLUTION STUDY; STRUCTURE/ACTIVITY RELATIONSHIP; URINARY TRACT;

AMINO ACIDS; CALCIUM CHLORIDE; CENTRIFUGATION; COVALENT BONDS; DIMERS; EXPERIMENTS; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; SODIUM CHLORIDE; SOLUTIONS;

PEPTIDES;

CALCIUM CHLORIDE; CYSTEINE; DIMER; DISULFIDE; GLUTAMIC ACID; HUMAN DEFENSIN 5; MAGNESIUM CHLORIDE; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VALINE; WATER;

ANALYTIC METHOD; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; CRYSTAL STRUCTURE; DIMERIZATION; DISULFIDE BOND; EQUILIBRIUM CONSTANT; IN VITRO STUDY; MEASUREMENT; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MUTANT; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PH; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; ROTATION; SEDIMENTATION RATE; SIGNAL PROCESSING; STAPHYLOCOCCUS AUREUS; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; BIOPOLYMERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEFENSINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STAPHYLOCOCCUS AUREUS;

EID: 84870531632     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301255u     Document Type: Article

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